Lopinavir uye Ritonavir

Zvemukati

• Usati watora lopinavir uye ritonavir,
• Lopinavir uye ritonavir zvinogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheanotevera zviratidzo, dana chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Lopinavir uye ritonavir parizvino zviri kuongororwa muzvidzidzo zvakati wandei zvekurapwa kwechirwere checoronavirus 2019 (COVID-19) kungave ndega kana nemimwe mishonga. Iko kushandiswa kwe lopinavir uye ritonavir yekurapa kwe COVID-19 haisati yasimbiswa. Mamwe masayendisiti ane tariro nekuti iyi mishonga yakashandiswa kurapa hutachiona hwakafanana.

Lopinavir uye ritonavir inofanirwa kutorwa CHETE pasi pekutungamirirwa nachiremba pakurapwa kweCOVID-19.

Iko kusanganiswa kwe lopinavir uye ritonavir inoshandiswa nemimwe mishonga yekurapa hutachiona hwehutachiona hwehutachiona hweHIV. Lopinavir uye ritonavir vari mukirasi yemishonga inonzi protease inhibitors. Ivo vanoshanda nekuderedza huwandu hweHIV muropa. Kana lopinavir uye ritonavir zvatorwa pamwechete, ritonavir inobatsirawo kuwedzera huwandu hwe lopinavir mumuviri kuitira kuti mushonga uve nesimba rakakura. Kunyangwe lopinavir uye ritonavir isingarape HIV, mishonga iyi inogona kudzikisira mukana wako wekuwana immunodeficiency syndrome (AIDS) nezvirwere zvine chekuita neHIV zvakadai sehutachiona hwakakomba kana gomarara. Kutora mishonga iyi pamwe nekuita bonde rakachengeteka uye nekuita mamwe mararamire shanduko kunogona kudzora mukana wekutapurira hutachiona hweHIV kune vamwe vanhu.

Iko kusanganiswa kwe lopinavir uye ritonavir kunouya sehwendefa uye mhinduro (mvura) yekutora nemuromo. Kazhinji inotorwa kaviri pazuva, asi inogona kutorwa kamwe chete pazuva nevamwe vanhu vakuru. Mhinduro yacho inofanira kutorwa nechikafu. Mahwendefa anogona kutorwa pamwe kana pasina chikafu. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora lopinavir uye ritonavir chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza mapiritsi akazara; usatsemure, kutsenga, kana kuvapwanya.

Kana iwe uri kushandisa mhinduro, zunza mushe musati mushandisa yega yega kusanganisa mushonga zvakaenzana. Shandisa chipimo-kuyera chipunu kana mukombe kuyera huwandu hwakaringana hwemvura padosi yega yega, kwete chipunu chenguva dzose.

Ramba uchitora lopinavir uye ritonavir kunyangwe uchinzwa mushe. Usarega kutora lopinavir uye ritonavir usina kutaura nachiremba wako. Kana ukarasikirwa nemadhizaini, tora zvishoma pane yakatarwa huwandu, kana kurega kutora lopinavir uye ritonavir, mamiriro ako anogona kuve akaoma kurapa.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora lopinavir uye ritonavir,

• udza chiremba wako uye wemishonga kana uri weergoria kune lopinavir, ritonavir (Norvir), chero mimwe mishonga, kana chimwe chezvinhu zviri mupepinavir uye mapiritsi e ritonavir kana mhinduro. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako kana iwe uri kutora chero einotevera mishonga: alfuzosin (Uroxatral); apalutamide (Erleada); cisapride (Propulsid) (haisipo muU.S.); colchicine (Colcrys, Mitigare) mune vanhu vane chirwere cheitsvo kana chiropa; dronedarone (Multaq); elbasvir uye grazoprevir (Zepatier); ergot mishonga yakadai se dihydroergotamine (DHE 45, Migranal), ergotamine (Ergomar, muCafergot, muMigergot), uye methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam yakatorwa nemuromo (Vhesi); pimozide (Orap); ranolazine (Ranexa); rifampin (Rimactane, Rifadin, muRifamate, muRifater); sildenafil (chete Revatio brand inoshandiswa pachirwere chemapapu); simvastatin (Zocor, muVytorin); Wort St. kana triazolam (Halcion). Chiremba wako angangokuudza kuti usatore lopinavir uye ritonavir kana uri kutora imwe kana yakawanda yemishonga iyi.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, uye zvinovaka muviri zvaunotora. Ive neshuwa yekutaura chero eanotevera: anticoagulants ('blood thinner') senge warfarin (Coumadin, Jantoven) uye rivaroxaban powder (Xarelto); antifungals senge itraconazole (Onmel, Sporanox), isavuconazonium (Cresemba), ketoconazole (Nizoral), uye voriconazole (Vfend); atovaquone (Mepron, muMalarone); bedaquiline (Sirturo); beta-blockers; bosentan (Tracleer); bupropion (Wellbutrin, Zyban, vamwe); calcium-chiteshi blockers senge felodipine, nicardipine (Cardene), uye nifedipine (Adalat, Afeditab CR, Procardia); cholesterol-kudzikisa mishonga yakadai seatorvastatin (Lipitor, muCaduet), uye rosuvastatin (Crestor); clarithromycin (Biaxin, muPrevpac); digoxin (Lanoxin); elagolix (Orilissa); fentanyl (Actiq, Duragesic, Onsolis, vamwe); fosamprenavir (Lexiva); mimwe mishonga yekenza yakadai abemaciclib (Verzenio), dasatinib (Sprycel), encorafenib (Braftovi), ibrutinib (Imbruvica), ivosidenib (Tibsovo), neratinib (Nerlynx), nilotinib (Tasigna), venetoclax (Venclextine), vin ; mimwe mishonga yekushaya moyo zvisina kujairika senge amiodarone (Cordarone, Nexterone, Pacerone), bepridil (haichawanikwi muUS; Vascor), lidocaine (Lidoderm; muXylocaine neEpinephrine), uye quinidine (muNuedexta); mimwe mishonga yehutachiona hwehepatitis C (HCV) yakadai seboceprevir (Victrelis; haichawanikwi muU.S.); glecaprevir uye pibrentasvir (Mavyret); simeprevir (haichawanikwi muU.S.; Olysio); sofosbuvir, velpatasvir, uye voxilaprevir (Sovaldi, Epclusa, Vosevi); uye paritaprevir, ritonavir, ombitasvir, uye / kana dasabuvir (Viekira Pak); mimwe mishonga yekubatwa kwakadai se carbamazepine (Equetro, Tegretol, Teril, vamwe), lamotrigine (Lamictal), phenobarbital, phenytoin (Dilantin, Phenytek), uye valproate; mishonga inodzvinyirira immune system se cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), uye tacrolimus (Astagraf, Prograf); methadone (Dolophine, Methadose); muromo kana inhaled steroids senge betamethasone, budesonide (Pulmicort), ciclesonide (Alvesco, Omnaris), dexamethasone, fluticasone (Flonase, Flovent, muAdvair), methylprednisolone (Medrol), mometasone (muDulera). prednisone (Rayos), uye triamcinolone; mimwe mishonga yemaantiviral senge abacavir (Ziagen, muEpzicom, muTrizivir, vamwe); atazanavir (Reyataz, muEvotaz), delavirdine (Rescriptor), efavirenz (Sustiva, muAtripla), indinavir (Crixivan), maraviroc (Selzentry), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kalevir, (Viread, muAtripla, muTruvada), tipranavir (Aptivus), saquinavir (Invirase), uye zidovudine (Retrovir, muCombivir, muTrizivir); quetiapine (Seroquel); rifabutin (Mycobutin); salmeterol (Serevent, muAdvair); sildenafil (Viagra); tadalafil (Adcirca, Cialis); trazodone; uye vardenafil (Levitra). Kana iwe uri kutora mhinduro yemumuromo, udzawo chiremba wako kana uri kutora disulfiram (Antabuse) kana metronidazole (Flagyl, muNuvessa, muVandazole). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• kana uri kutora didanosine, tora iyo 1 awa usati kana maawa maviri mushure mekutora lopinavir uye ritonavir solution nechikafu. Kana iwe uri kutora lopinavir uye ritonavir mapiritsi, unogona kuzvitora pane isina chinhu mudumbu panguva imwecheteyo sezvaunotora didanosine.
• udza chiremba wako kana iwe kana wakambove nenguva yakareba yeQT (dambudziko remwoyo risingawanzo rinogona kukonzera kurova kwemoyo zvisina kujairika, kufenda, kana kufa kamwe kamwe), kurova kwemoyo zvisina kujairika, yakaderera potasiamu muropa rako, hemophilia, cholesterol yakawanda kana triglycerides (mafuta) muropa, pancreatitis (kuzvimba kwepancreas), kana chirwere chemwoyo kana chiropa.
• iwe unofanirwa kuziva kuti lopinavir uye ritonavir inogona kudzikisira kushanda kwemadzimai ekudzivirira nhumbu (mapiritsi ekudzivirira kubereka, zvigamba, mhete, kana majekiseni). Taura nachiremba wako nezve kushandisa imwe nzira yekudzivirira kuberekwa.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Kana iwe ukava nepamuviri uchitora lopinavir uye ritonavir, fonera chiremba wako. Haufanire kuyamwisa mwana kana uine hutachiwana hweHIV kana kuti uri kutora lopinavir uye ritonavir.
• iwe unofanirwa kuziva kuti zvimwe zvinongedzo mu lopinavir uye ritonavir mhinduro inogona kukonzera zvakakomba uye kutyisidzira hupenyu mhedzisiro muvacheche vachangozvarwa. Lopinavir uye ritonavir mhinduro yemumuromo haifanire kupihwa kune yakazara-nguva vacheche vari pasi pemazuva gumi nemana ekuberekwa kana kune vacheche vasati vasvika vari pasi pemazuva gumi nemana apfuura zuva ravo rekutanga, kunze kwekunge chiremba achifunga kuti pane chikonzero chakanaka chekuti mwana agamuchire mushonga zvakanaka mushure mekuberekwa. Kana chiremba wemwana wako akasarudza kupa mwana wako lopinavir uye ritonavir mhinduro nekukurumidza mushure mekuzvarwa, mwana wako anozotariswa nekuchenjera kune zviratidzo zvekukanganisa kwakakomba. Fonera chiremba wemwana wako nekukasira kana mwana wako akarara zvakanyanya kana ane shanduko mukufema panguva yekurapwa kwake ne lopinavir uye ritonavir yemuromo mhinduro.
• iwe unofanirwa kuziva kuti mafuta emuviri wako anogona kuwedzera kana kuenda kunzvimbo dzakasiyana dzemuviri wako, senge rako repamusoro musana, mutsipa ('' nyati hump ''), mazamu, uye kutenderedza dumbu rako. Iwe unogona kucherechedza kurasikirwa kwemafuta emuviri kubva kumeso kwako, makumbo, uye maoko.
• iwe unofanirwa kuziva kuti iwe unogona kusangana ne hyperglycemia (inowedzera mushuga yeropa rako) paunenge uchitora mushonga uyu, kunyangwe kana usati uine chirwere cheshuga. Udza chiremba wako nekukasira kana uine chimwe chezviratidzo zvinotevera paunenge uchitora lopinavir uye ritonavir: nyota yakanyanya, kuita weti kakawanda, nzara yakanyanyisa, kusaona zvakanaka, kana kushaya simba. Zvakakosha kusheedza chiremba wako nekukurumidza kana uchinge uine chero cheizvi zviratidzo, nekuti shuga yepamusoro yeropa isingarapwe inogona kukonzera chirwere chakakomba chinonzi ketoacidosis. Ketoacidosis inogona kutyisidzira hupenyu kana ikasarapwa padanho rekutanga. Zviratidzo zve ketoacidosis zvinosanganisira: kuoma muromo, kuda kurutsa uye kurutsa, kufema kufema, mweya unonhuwira muchero, uye kudzikira kwekuziva.
• Unofanirwa kuziva kuti paunenge uchinwa mishonga yekurapa hutachiona hweHIV, immune system yako inogona kusimba uye yotanga kurwisa zvimwe zvirwere zvaive mumuviri wako kare. Izvi zvinogona kukonzera kuti iwe uwedzere zviratidzo zveawo hutachiona. Kana uine zviratidzo zvitsva kana zvichikura mushure mekutanga kurapwa ne lopinavir uye ritonavir, ita chokwadi chekuudza chiremba wako.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira. Zvisinei, kana yava nguva yenguva inotevera, svetuka chirwere chakarasika uye ramba uchiita purogiramu yako yenguva dzose. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Lopinavir uye ritonavir zvinogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• kushaya simba
• manyoka
• gasi
• chirungurira
• kuonda
• musoro
• kunetseka kurara kana kuramba wakarara
• kurwadziwa kwemhasuru
• chiveve, kupisa, kana kugwinha maoko kana tsoka
• kurwadziwa mudumbu, kuda kurutsa, uye kurutsa

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheanotevera zviratidzo, dana chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kusvotwa
• kurutsa
• kurwadziwa nemudumbu
• kuneta zvakanyanya
• kurasikirwa nenzara
• kurwadziwa kumusoro kwepamusoro chikamu chedumbu
• yero yeganda kana maziso
• ganda rinonhuwa
• dzungu
• musoro wakareruka
• kufenda
• kurova kwemoyo zvisina kujairika
• mhoni
• mapundu

Lopinavir uye ritonavir zvinogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Chengetedza mahwendefa pakushambidzika kwemukati uye uvadzivirire kubva pakunyorova kwakanyanya. Zviri nani kuchengeta mahwendefa mumudziyo wavakauya nawo; kana uchifanira kutora kubva mumudziyo, unofanirwa kuishandisa mukati memasvondo maviri. Iwe unogona kuchengeta mhinduro yemumuromo mufiriji kusvikira zuva rekuguma rapera rakadhindwa pane zvakanyorwa, kana kuti iwe unogona kuzvichengeta pane tembiricha yemukati kwemwedzi miviri.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Izvo zvinonyanya kukosha kuti uwane rubatsiro rwechiremba ipapo kana mwana akanwa zvinopfuura zvakajairwa muyero wemhinduro. Mhinduro yacho ine huwandu hwedoro uye zvimwe zvinoshandiswa zvinogona kukuvadza mwana.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira mamwe marabhoritari kuti aongorore mhinduro yemuviri wako kuna lopinavir uye ritonavir.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Kaletra^® (iine Lopinavir, Ritonavir)