Natalizumab Jekiseni

Zvemukati

• Natalizumab inoshandiswa kudzivirira zvikamu zvezviratidzo uye kunonoka kuwedzera kwekuremara kune vanhu vakuru vakadzokazve mafomu eakawanda sclerosis (MS; chirwere umo tsinga dzisingashande nemazvo uye vanhu vanogona kuona kushaya simba, kupera simba, kurasikirwa kwekubatana kwetsandanyama, uye matambudziko nekuona, kutaura, uye kudzora dundira), kusanganisira:
• Usati wagamuchira injalizumab jekiseni,
• Natalizumab inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo zvinotevera kana izvo zvataurwa muchikamu CHENYANYA kana CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Kugamuchira injalizabab jekiseni kunogona kuwedzera njodzi yekuti iwe uchave nekufambira mberi multifocal leukoencephalopathy (PML; chirwere chisingawanzo chehuropi chisingakwanise kurapwa, kudzivirirwa, kana kurapwa uye izvo zvinowanzo kukonzera kufa kana kuremara kwakanyanya). Mukana wekuti iwe ugokudziridza PML panguva yekurapa kwako natalizumab yakakwira kana iwe uine imwe kana yakawanda yezvinotevera njodzi zvinhu.

• Iwe wagamuchira mizinga mizhinji ye natalizumab, kunyanya kana iwe wakagamuchira kurapwa kwenguva yakareba kupfuura makore maviri.
• Iwe wakamborapwa nemishonga inoderedza immune system, kusanganisira azathioprine (Azasan, Imuran), cyclophosphamide, methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), mitoxantrone, uye mycophenolate mofetil (CellCept).
• Kuongororwa kweropa kunoratidza kuti wakambobatwa nehutachiona hwaJohn Cunningham (JCV; hutachiona hunowanikwa nevanhu munguva yehucheche hunowanzo kukonzera zviratidzo asi hunogona kukonzera PML muvanhu vane immune system isina kusimba).

Chiremba wako angangoda kuraira kuongororwa kweropa usati kana panguva yekurapwa kwako nenjalalizab jekiseni kuti uone kana iwe wakamboburitswa kuJCV. Kana iyo bvunzo ichiratidza kuti iwe wakaratidzirwa kuJCV, iwe pamwe nachiremba wako mungasarudza kuti haufanire kugamuchira injalazab jekiseni, kunyanya kana iwe zvakare uine imwe kana zvese zviri zviviri zveimwe njodzi zvinhu zvakanyorwa pamusoro. Kana bvunzo ikasaratidza kuti wakaratidzirwa kuJCV, chiremba wako anogona kudzokorora bvunzo nguva nenguva panguva yekurapa kwako nejazisi ye natalizumab. Haufanire kuongororwa kana wakambochinjana plasma (kurapwa uko chikamu cheropa chinobviswa mumuviri chotsiviwa nezvimwe zvinwiwa) mukati memasvondo maviri apfuura nekuti zvabuda hazvizove zvechokwadi.

Kune zvimwe zvinhu zvinogona zvakare kuwedzera njodzi yekuti iwe uchave nekukudziridza PML. Udza chiremba wako kana wakambove ne PML, kupinzwa muviri, kana chimwe chiitiko chinokanganisa immune system yako sehutachiona hwehutachiona hweHIV, yakawana immunodeficiency syndrome (AIDS), leukemia (cancer inokonzera masero eropa akawandisa kugadzirwa uye kuburitswa muropa), kana lymphoma (gomarara rinobuda mumasero ezvirwere zvemuviri). Uyezve udza chiremba wako kana uri kutora kana kuti wakambotora chero mimwe mishonga inobata immune system yakadai saadalimumab (Humira); cyclosporine (Gengraf, Neoral, Sandimmune); etanercept (Enbrel); glatiramer (Copaxone, Glatopa); infliximab (Remicade); interferon beta (Avonex, Betaseron, Rebif); mishonga yekenza; mercaptopurine (Purinethol, Purixan); muromo steroid senge dexamethasone, methylprednisolone (Depo-medrol, Medrol, Solu-medrol), prednisolone (Prelone), uye prednisone (Rayos); sirolimus (Rapamune); uye tacrolimus (Astagraf, Envarsus XR, Prograf). Chiremba wako anogona kukuudza kuti haufanire kugamuchira injalizumab jekiseni.

Chirongwa chinonzi TOUCH chirongwa chakamisikidzwa kubatsira kubata njodzi dzekurapa natalizumab. Unogona chete kugamuchira injalazab jekiseni kana iwe wakanyoreswa neiyo TOUCH chirongwa, kana natalizumab yakatemerwa iwe nachiremba uyo akanyoreswa nechirongwa, uye kana iwe ukatambira mishonga kunzvimbo yekumukisa iyo yakanyoreswa nechirongwa. Chiremba wako achakupa rumwe ruzivo nezvechirongwa ichi, anoita kuti usayine fomu rekunyoresa, uye anopindura chero mibvunzo yauinayo nezve chirongwa ichi uye kurapwa kwako nenjalalizab jekiseni.

Sechikamu chechirongwa cheTOUCH, chiremba wako kana mukoti achakupa kopi yeMedication Gwara usati watanga kurapwa ne injalizumab jekiseni uye usati wagamuchira kumwe kuiswa. Verenga ruzivo urwu zvakanyatsonaka nguva dzese dzaunorigamuchira uye bvunza chiremba wako kana mukoti kana uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Zvakare sechikamu chechirongwa cheTOUCH, chiremba wako anozoda kukuona iwe kwese kwemwedzi mitatu pakutanga kwekurapwa kwako uyezve pamwedzi mitanhatu yega yega kuti uone kana uchifanira kuramba uchishandisa natalizumab. Iwe zvakare unofanirwa kupindura mimwe mibvunzo usati wagamuchira yega infusion kuti uve nechokwadi chekuti natalizumab ichakakukodzera.

Fonera chiremba wako nekukasira kana iwe ukagadzira chero nyowani kana yakaipa matambudziko ekurapa panguva yekurapwa kwako, uye kwemwedzi mitanhatu mushure mekupedzisira dosi. Iva nechokwadi chekufonera chiremba wako kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge wakaona muviri, kusindimara kwemaoko kana makumbo; shanduko mukufunga kwako, ndangariro, kufamba, kuenzanisa, kutaura, kuona, kana simba rinogara mazuva mazhinji; musoro; pfari; kuvhiringidzika; kana hunhu hunoshanduka.

Kana kurapwa kwako nenjalalizab jekiseni kukamiswa nekuti iwe une PML, unogona kukura imwe mamiriro anonzi immune reconstitution inflammatory syndrome (IRIS; kuzvimba uye kuwedzera kwezviratidzo zvinogona kuitika sezvo immune system inotanga kushanda zvakare mushure mekunge mimwe mishonga inoikanganisa yatangwa. kana kumira), kunyanya kana iwe uchigamuchira kurapwa kubvisa natalizumab kubva muropa rako nekukurumidza. Chiremba wako anokucherekedza nokungwarira zviratidzo zveIRIS uye acharapa zviratidzo izvi kana zvikaitika.

Udza vese vanachiremba vanokubata iwe kuti urikutambira jekiseni reza natalizumab.

Taura nachiremba wako nezve njodzi dzekugamuchira natalizumab jekiseni.

Natalizumab inoshandiswa kudzivirira zvikamu zvezviratidzo uye kunonoka kuwedzera kwekuremara kune vanhu vakuru vakadzokazve mafomu eakawanda sclerosis (MS; chirwere umo tsinga dzisingashande nemazvo uye vanhu vanogona kuona kushaya simba, kupera simba, kurasikirwa kwekubatana kwetsandanyama, uye matambudziko nekuona, kutaura, uye kudzora dundira), kusanganisira:

• kiriniki yakasarudzika syndrome (CIS; yekutanga nerve chiratidzo chiratidzo chinotora maawa angangoita makumi maviri nemana),
• kudzokerazve-kurerutsa chirwere (kosi yechirwere uko zviratidzo zvinoputika nguva nenguva),
• inoshanda yechipiri inofambira mberi chirwere (yekupedzisira nhanho yechirwere nekuenderera mberi kuwedzera zviratidzo.)

Natalizumab inoshandiswawo kurapa uye kudzivirira zvikamu zvezviratidzo muvanhu vakuru vane chirwere cheCrohn (mamiriro ezvinhu umo muviri unorwisa kumhara kwegwara rekudya, zvichikonzera marwadzo, manyoka, kuonda, uye kupisa fivha) vasina kubatsirwa nevamwe mishonga kana ndiani asingatore mimwe mishonga. Natalizumab iri mukirasi yemishonga inonzi monoclonal antibodies. Inoshanda nekumisa mamwe maseru ezvirwere zvemuviri kuti asvike kuuropi nemuzongoza kana mudumbu uye zvichikonzera kukuvara.

Natalizumab inouya semhinduro yakakwenenzverwa (mvura) inosvinudzwa uye kujowa zvishoma nezvishoma mutsinga nachiremba kana mukoti. Inowanzo kupihwa kamwe chete pavhiki ina mune yakanyoreswa infusion nzvimbo. Zvinotora rinenge awa rimwe chete kuti iwe ugamuchire yako yese dosi yeatalizumab.

Natalizumab inogona kukonzeresa kugadzikana kwekukonzeresa izvo zvinowanzoitika mukati memaawa maviri mushure mekutanga kwekumisikidzwa asi zvinogona kuitika chero nguva panguva yekurapwa kwako. Iwe uchafanirwa kugara panzvimbo yekumukirwa kweawa imwe mushure mekunge yako infusion yapera. Chiremba kana mukoti anozokutarisa panguva ino kuti aone kana uri kuita zvakakomba pamushonga. Udza chiremba wako kana mukoti kana ukaona chero zviratidzo zvisina kujairika senge mikoko, mapundu, kumwaya, kunetseka kumedza kana kufema, fivha, dzungu, kurwadziwa nemusoro, kurwadziwa pachipfuva, kufashaira, kuda kurutsa, kana kutonhora, kunyanya kana zvikaitika mukati maawa maviri kutanga wako infusion.

Kana iwe uri kugamuchira injalizumab jekiseni yekurapa chirwere cheCrohn, zviratidzo zvako zvinofanirwa kuvandudza mukati memwedzi mishoma yekutanga yekurapa kwako. Udza chiremba wako kana zviratidzo zvako zvisina kuvandudzwa mushure memasvondo gumi nemaviri ekurapwa. Chiremba wako anogona kumira kukurapa iwe neinalizumab jekiseni.

Natalizumab inogona kubatsira kudzora zviratidzo zvako asi haizorape mamiriro ako. Chengeta zvese zvakagadzwa kuti ugamuchire jekiseni reNalizalizab kunyangwe uchinzwa zvakanaka.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati wagamuchira injalizumab jekiseni,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune natalizumab, chero mimwe mishonga, kana chero chinhu chinosanganiswa mu injalizumab jekiseni. Kumbira chiremba wako kana wemishonga kuti uwane mazita ezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemakwenzi yauri kutora. Ive neshuwa yekutaura mishonga yakanyorwa mune CHINOKOSHA CHENYENZO chikamu. Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• udza chiremba wako kana iwe wakambogamuchira jekiseni rekunalizumab kare uye kana iwe kana wakambove nechero yemamiriro akanyorwa muchikamu CHINOKOSHA CHENYENZO. Usati wagashira kumisikidzwa kwese kwe natalizumab, udza chiremba wako kana uine fivhiri kana chero rudzi rwehutachiona, kusanganisira hutachiona hunogara kwenguva yakareba senge shingles (rash inogona kuitika nguva nenguva kune vanhu vane chickenpox mu zvakapfuura).
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Kana iwe ukava nepamuviri iwe uchinge uchigamuchira jekiseni rekunalizumab, fonera chiremba wako.
• hauna majekiseni pasina kutaura nachiremba wako.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Kana iwe ukarasikirwa musangano wekugamuchira natalizumab infusion, fonera chiremba wako nekukurumidza sezvazvinogona.

Natalizumab inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• musoro
• kuneta zvakanyanya
• kutsimwaira
• kurwadziwa pamwe chete kana kuzvimba
• kurwadziwa mumaoko kana makumbo
• kurwadziwa shure
• kuzvimba kwemaoko, maoko, tsoka, makumbo, kana makumbo ezasi
• tsandanyama
• kurwadziwa nemudumbu
• manyoka
• chirungurira
• kuvimbiswa
• gasi
• kurema kana kurasikirwa
• kuora mwoyo
• husiku hweziya
• zvinorwadza, zvisina kujairika, kana kurasikirwa nemwedzi (nguva)
• kuzvimba, kutsvuka, kutsva, kana kuvaviwa kwemukadzi
• chena kusangana nekutsi kwemukadzi kubuda
• kuoma kudzora weti
• kurwadziwa kwemeno
• maronda emuromo
• mapundu
• ganda rakaoma
• kuvava

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo zvinotevera kana izvo zvataurwa muchikamu CHENYANYA kana CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kurwadziwa pahuro, fivhiri, kukosora, kutonhora, dzihwa sezviratidzo, kurwadziwa mudumbu, manyoka, kazhinji kana kurwadza kuita weti, kamwe kamwe kuda kuita weti ipapo ipapo, kana zvimwe zviratidzo zvehutachiona.
• yero yeganda kana maziso, kuda kurutsa, kurutsa, kuneta zvakanyanya, kurasikirwa nechido, weti yakasviba, kurwadziwa kwepamusoro padumbu
• kuona kuchinja, kutsvuka kweziso, kana kurwadziwa
• kubuda ropa zvisina kujairika kana kupwanya
• diki, denderedzwa, dzvuku kana ruvara rwepepuru-paganda
• kubuda ropa kwakanyanya kumwedzi

Natalizumab jekiseni inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika paunenge uchigamuchira mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako anogona kuraira mamwe marabhoritari bvunzo kuti atarise mhinduro yemuviri wako kune jekiseni rekunazuma.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Tysabri^®