Munyori: Virginia Floyd
Zuva Rekusika: 13 Nyamavhuvhu 2021
Gadziridza Zuva: 14 Mbudzi 2024
Anonim
Deferasirox Formulations in Iron Overload
Vhidhiyo: Deferasirox Formulations in Iron Overload

Zvemukati

Deferasirox inogona kukonzera zvakakomba kana kutyisidzira hupenyu kuitsvo. Njodzi yekuti unozokuvara neitsvo yakakura kana iwe uine mamiriro mazhinji ekurapa, kana kurwara zvakanyanya nekuda kwechirwere cheropa. Udza chiremba wako kana iwe kana wakamborwara neitsvo. Chiremba wako anogona kukuudza kuti usatora deferasirox. Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchiona. Kune vana vanotora mushonga uyu, pane ngozi yakawandisa yekuti unozoita matambudziko eitsvo kana ukarwara uchitora deferasirox uye kugadzira manyoka, kurutsa, fivhiri, kana kumira kunwa zvinwiwa zvakajairika. Fonera chiremba wako nekukasira kana iwe uchinge waona chero cheizvi zviratidzo.

Deferasirox inogona zvakare kukonzera zvakakomba kana kutyisidzira hupenyu kuchiropa. Iyo njodzi yekuti iwe uchave nekukuvara kwechiropa yakakura kana iwe uri mukuru kupfuura makore makumi mashanu nemashanu ekuberekwa, kana kana iwe uine zvimwe zvakakomba zvehutano mamiriro. Udza chiremba wako kana iwe wakambove kana wakambove nechirwere chechiropa. Kana iwe ukagadzira chero cheanotevera zviratidzo, dana chiremba wako nekukasira: yero yeganda kana maziso, furuu-kunge zviratidzo, kushaya simba, kurasikirwa nenzara, kurwadziwa munzvimbo yepamusoro yekurudyi yemudumbu, kana kujairika kupwanya kana kubuda ropa.


Deferasirox inogona zvakare kukonzera zvakakomba kana hupenyu kutyisidzira kubuda ropa mudumbu kana mumatumbu. Iyo njodzi yekuti iwe unozokura kubuda kwakanyanya kubuda mudumbu kana ura inogona kuve yakakura kana iwe wakura, kana uchirwara zvakanyanya kubva muropa mamiriro. Udza chiremba wako kana iwe wakambove kana uine yakaderera mwero wemaplatelet (rudzi rwesero reropa runodikanwa kudzora kubuda kweropa), kana kana iwe uri kutora chero ipi yeinotevera mishonga: anticoagulants (ropa rakatetepa) senge warfarin (Coumadin , Jantoven); maaspirin kana mamwe asinganetsi-kupisa mishonga (NSAIDs) senge ibuprofen (Advil, Motrin, vamwe) uye naproxen (Aleve, Naprosyn, vamwe); mimwe mishonga yekusimbisa mapfupa anosanganisira alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), uye zoledronic acid (Reclast, Zometa); kana steroids yakadai se dexamethasone, methylprednisolone (A-methapred, Depo-medrol, Medrol, Solu-medrol), kana prednisone (Rayos). Kana iwe ukasangana nechimwe chezviratidzo zvinotevera, fonera chiremba wako nekukasira: kupisa marwadzo emudumbu, kurutsa izvo zvakatsvuka kupenya kana kutaridzika senge nzvimbo yekofi, ropa rakatsvuka rakatsvuka muzvituru, kana zvitema kana zvituru.


Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako anozoraira bvunzo dzemarabhoritari usati uye panguva yekurapwa kwako kuti uve nechokwadi chekuti zvakachengeteka kuti iwe utore deferasirox uye kuti uone kana iwe uri kukura izvi zvakakomba mhedzisiro.

Deferasirox inoshandiswa kurapa vanhu vakuru uye vana makore maviri ekuberekwa uye vane simbi yakawandisa mumuviri wavo nekuti vakawedzerwa kuwedzerwa ropa. Inoshandiswa zvakare kurapa vanhu vakuru nevana vane makore gumi ekuberekwa nevakura vane iron yakawandisa mumuviri wavo nekuda kwechirwere cheropa chinodaidzwa kuti non-transfusion-dependent thalassemia (NTDT). Deferasirox ari mukirasi yemishonga inonzi iron chelators. Inoshanda nekubatanidza simbi mumuviri kuti igone kuburitswa (kubviswa mumuviri) mutsvina.

Deferasirox inouya sehwendefa, granules, uye piritsi rekumiswa (piritsi yekunyunguduka mune mvura) kutora nemuromo. Inofanirwa kutorwa isina chinhu mudumbu kamwe pazuva, ingangoita maminetsi makumi matatu usati wadya, Mahwendefa uye granules zvinogona kutorwa nechikafu chakareruka senge yakazara gorosi yeChirungu muffin ine jelly uye skim mukaka, kana diki turkey sangweji pane chingwa chegorosi rose. Tora deferasirox kwakatenderedza nguva yakafanana zuva rega rega. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora deferasirox chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.


Mhando dzakasiyana dzederairoirox dzinosanganiswa nemuviri nenzira dzakasiyana uye hazvigone kuchinjaniswa. Kana iwe uchida kuchinja kubva kune imwe deferasirox chigadzirwa kuenda kune imwe, chiremba wako angangoda kugadzirisa yako dosi. Nguva imwe neimwe yaunogamuchira mishonga yako, tarisa kuti uve nechokwadi chekuti wagamuchira chigadzirwa chereferiroirox chawakatemerwa iwe. Bvunza wako wemishonga kana iwe usina chokwadi chekuti wakagamuchira chaiyo mishonga.

Medza deferasirox mapiritsi (Jadenu) nemvura kana imwe mvura. Kana uchinetseka kumedza piritsi racho, unogona kupwanya piritsi uye kusanganisa nechikafu chisina kunyorova senge yogati kana maapurouce pakarepo usati watora. Nekudaro, usapwanya iyo 90 mg piritsi (Jadenu) uchishandisa nyanzvi yekupwanya chishandiso chakakwenenzvera micheto.

Kuti utore deferasirox granules (Jadenu), svina magiranyu pachikafu chisina kunyorova chakadai yogati kana maapurouce pakarepo usati watora.

Kutora deferasirox mapiritsi ekumiswa (Exjade), tevera nhanho idzi:

  1. Nguva dzose nyungudutsa mapiritsi ekumiswa mumvura usati waanwa. Usatsenga kana kumedza mapiritsi ekumiswa zvakakwana.
  2. Kana iwe uri kutora isingasviki 1000 mg ye deferasirox, zadza kapu hafu (inenge 3.5 oz / 100 mL) nemvura, muto weapuro, kana muto weorenji. Kana iwe uri kutora zvinopfuura 1000 mg ye deferasirox, zadza mukombe (anenge 7 oz / 200 mL) nemvura, muto weapuro, kana jisi reorenji. Kana iwe usina chokwadi chekutora deferasirox yaunofanira kutora, bvunza chiremba wako kana wemishonga.
  3. Isa nhamba yemapiritsi akanzi nachiremba utore mumukombe.
  4. Mutsai mvura kwemaminetsi matatu kuti inyatso nyungudutsa mapiritsi Musanganiswa unogona kuve wakakora paunenge uchimutsa.
  5. Inwa mvura yacho pakarepo.
  6. Wedzera chiduku chemvura mumukombe usina chinhu uye fambisa. Swish mukombe kuputsa chero mishonga iyo ichiri mugirazi kana pane inomutsa.
  7. Inwa zvasara zvemvura.

Chiremba wako anogona kugadzirisa dhizaini yako ye deferasirox kwete kanopfuura kamwe pamwedzi mitatu kusvika kumitanhatu, zvinoenderana nemhedzisiro yekuongororwa kwako murabhoritari.

Deferasirox inobvisa imwe simbi kubva mumuviri wako zvishoma nezvishoma nekufamba kwenguva. Ramba uchitora deferasirox kunyangwe iwe uchinzwa zvakanaka. Usarega kutora deferasirox usina kutaura nachiremba wako.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora deferasirox,

  • udza chiremba wako uye wemishonga kana iwe uri weergoria kune deferasirox, chero mimwe mishonga, kana chero chinhu chinogadzirwa mumapiritsi e deferairox, granules, kana mapiritsi ekumiswa. Kumbira chiremba wako kana wemishonga kuti uwane mazita ezvigadzirwa.
  • udza chiremba wako uye wemishonga kuti ndeipi mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvekuwedzera pane zvekudya, uye mishonga yemakwenzi yauri kutora kana kuronga kutora. Ive neshuwa yekutaura mishonga yakanyorwa mune CHINOKOSHA CHENYENZO chikamu uye chero cheanotevera: alosetron (Lotronex), aprepitant (Cinvanti, Emend), budesonide (Entocort, Pulmicort, Uceris, mu Symbicort), buspirone, cholestyramine (Prevalite), colesevelam (Welchol), colestipol (Colestid), conivaptan (Vaprisol), cyclosporine (Gengraf, Neoral, Sandimmune), darifenacin (Enablex), darunavir (Prezista, mu Prezcobix), dasatinib (Sprycel), dihydroergotamine (DHE 45, Migranalone (Multaq), duloxetine (Cymbalta), eletriptan (Relpax), eplerenone (Inspra), ergotamine (Ergomar, muCafergot, Migergot), everolimus (Afinitor, Zortress), felodipine, fentanyl (Actiq, Duragesic, Subsysic (Arnuity Ellipta, Flovent, in Breo Ellipta, Advair), mahormone ekudzivirira kubata pamuviri (mapiritsi ekudzivirira kubereka, zvigamba, mhete, kana majekiseni), indinavir (Crixivan), lopinavir (muKaletra), lovastatin (Altoprev), lurasidone (Latuda), maravirococ (Selzentry), midazolam, nisoldipine (Sular), paclitax el (Abraxane, Taxol), phenytoin (Dilantin, Phenytek), phenobarbital, pimozide (Orap), quetiapine (Seroquel), quinidine (muNuedexta), ramelteon (Rozerem), repaglinide (Prandin, mu Prandimet), rifampin (Radimin) , muRifamate, muRifater), ritonavir (Norvir, muKaletra, Technivie, Viekira Pak), saquinavir (Invirase), sildenafil (Revatio, Viagra), simvastatin (Flolopid, Zocor, muVytorin), siroliumus (Rapamuneus), tacrol Astagraf, Envarsus, Prograf), theophylline (Theo-24), ticagrelor (Brilinta), tipranavir (Aptivus), tizanidine (Zanaflex), triazolam (Halcion), tolvaptan (Samsca), uye vardenafil (Levitra, Staxyn). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
  • kana iwe uri kutora aruminiyamu-ine maantacid akadai seAmphojel, Alternagel, Gaviscon, Maalox, kana Mylanta, tora iwo maawa maviri pamberi kana mushure me deferasirox.
  • udza chiremba wako kuti chii pamusoro pezvigadzirwa zvauri kutora, kunyanya melatonin, kana zvinwiwa zvine caffeine.
  • udza chiremba wako kana uine myelodysplastic syndrome (dambudziko rakakomba nemongo wemapfupa une njodzi huru yekuva gomarara), kana gomarara. Chiremba wako anogona kukuudza kuti usatora deferasirox.
  • udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Kana iwe ukava nepamuviri uchitora deferasirox, danaidza chiremba wako.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Tora dosi rakarasika gare gare muzuva, kanenge maawa maviri mushure mekudya kwako kwekupedzisira uye maminetsi makumi matatu usati wadya. Zvisinei, kana yava nguva yenguva inotevera kana kana iwe usingazokwanisi kutora deferasirox pane isina chinhu mudumbu, ruka iro rakarasika dosi uye pfuurira yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Deferasirox inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

  • kurwadziwa nemudumbu
  • kusvotwa
  • kurutsa
  • manyoka

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana icho chakataurwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukasira:

  • kunzwa kurasikirwa
  • matambudziko ekuona
  • mapundu, mikoko, peeling kana kubvaruka ganda, fivha, kuzvimba lymph node
  • kunetseka kufema kana kumedza; kuzvimba kwechiso, huro, rurimi, miromo, kana maziso; hoarseness
  • kupwanya kusingawanzo kana kubuda ropa

Deferasirox inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe uye kusvika kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakavharira makapu ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye kubva kwavari uye kusvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira zvinotevera:

  • yero yeganda kana maziso
  • kurwadziwa kumusoro kwepamusoro chikamu chedumbu
  • kupwanya kusingawanzo kana kubuda ropa
  • kushaya simba
  • kurasikirwa nenzara
  • furu-kunge zviratidzo
  • manyoka
  • kusvotwa
  • kurutsa
  • kuderera kwekuita weti
  • kuzvimba makumbo kana makumbo

Chengetedza zvese zvakagadzwa nachiremba wako. Iwe unozofanirwa kuve nekunzwa uye bvunzo bvunzo usati watanga deferasirox uye kamwe pagore uchitora mushonga uyu.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

  • Exjade®
  • Jadenu®
Yekupedzisira Yakagadziridzwa - 09/15/2019

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