Lumacaftor uye Ivacaftor

Zvemukati

• Usati watora lumacaftor uye ivacaftor,
• Lumacaftor uye ivacaftor zvinogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukasira:
• Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

Lumacaftor uye ivacaftor inoshandiswa kurapa mamwe marudzi ecystic fibrosis (chirwere chinozvarwa chinokonzeresa matambudziko nekufema, kugaya, uye kubereka) muvanhu vakuru nevana vana makore maviri nekure. Lumacaftor iri mukirasi yemishonga inonzi cystic fibrosis transmembrane conductance regulator (CFTR) inogadzirisa. Ivacaftor iri mukirasi yemishonga inonzi cystic fibrosis transmembrane conductance regulator (CFTR) potentiators.Ose ari maviri emishonga iyi anoshanda nekuvandudza mashandiro eprotein mumuviri kudzikisira kuvaka-kwemukati mamota mumapapu nekuvandudza zvimwe zviratidzo zvecystic fibrosis.

Iko kusanganiswa kwe lumacaftor uye ivacaftor kunouya sehwendefa uye semagiriza ekutora nemuromo. Inowanzo kutorwa nezvakakora zvine mafuta kaviri pazuva, maawa gumi nemaviri akaparadzana. Tora lumacaftor uye ivacaftor panguva dzakatenderedza nguva dzakafanana mazuva ese. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora lumacaftor uye ivacaftor chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Kugadzirira muyero we lumacaftor uye ivacaftor granules, sanganisa iyo yose packet yeganuanu mu 1 teaspoon (5 mL) yechikafu chisina kunyorova kana mvura (inotonhorera kana tembiricha yemukati) senge yogati, applesauce, pudding, mukaka, kana muto. Tora musanganiswa wese mukati me1 awa yekusanganisa granules nechikafu kana mvura.

Tora lumacaftor uye ivacaftor nezvakakora zvine mafuta senge mazai, makotapeya, nzungu, ruomba, nzungu ruomba, chizi pizza, mukaka wakakwana uye zvimwe zvigadzirwa zvemukaka zvese senge chizi uye yakazara mafuta yogati. Taura nachiremba wako nezve zvimwe zvekudya zvine mafuta zvekudya ne lumacaftor uye ivacaftor.

Lumacaftor uye ivacaftor inodzora cystic fibrosis asi hairape. Ramba uchitora lumacaftor uye ivacaftor kunyangwe iwe uchinzwa zvakanaka. Usarega kutora lumacaftor uye ivacaftor usina kutaura nachiremba wako.

Kana iwe ukasatora lumacaftor uye ivacaftor kwemazuva manomwe kana kupfuura, usatange kuitora zvakare usina kutaura nachiremba wako. Chiremba wako angangoda kuchinja dhizaini yako yemushonga kana mimwe mishonga yauri kutora.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora lumacaftor uye ivacaftor,

• udza chiremba wako uye wemishonga kana uri weergoria kune lumacaftor uye ivacaftor, chero mimwe mishonga, kana chero chinhu chinosanganiswa mu lumacaftor uye ivacaftor mapiritsi kana granules. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi mishonga yekunyorera uye isina kunyoreswa, mavitamini, uye zvinovaka muviri zvaunotora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: mamwe maantifungal akadai itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), uye voriconazole (Vfend); mamwe maantibhakitiriya akadai secacithromycin (Biaxin, muPrevpac), erythromycin (EES, Erythrocin, Eryped, vamwe), rifabutin (Mycobutin) uye rifampin (Rifadin, Rifamate, Rifater, Rimactane); mimwe mishonga yechirwere cheshuga yakadai seklorpropamide (Diabinese), glimepiride (Amaryl, muDuetact), glipizide (Glucotrol), glyburide (Diabeta, Glynase, muGlucovance), repaglinide (Prandin), tolazamide uye tolbutamide; digoxin (Lanoxin); ibuprofen (Advil, Motrin, muVicoprofen); mamwe immunosuppressants akadai cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune) uye tacrolimus (Astagraf, Prograf); midazolam; montelukast (Singulair); methylprednisolone (Medrol); prednisone (Rayos); zvimwe proton pump inhibitors (PPIs) senge esomeprazole (Nexium, muVimovo), lansoprazole (Prevacid, muPrevpac), uye omeprazole (Prilosec, muZegerid); ranitidine (Zantac); mimwe mishonga yekubatwa kwakadai se carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, uye phenytoin (Dilantin, Phenytek); mamwe anosarudza serotonin reuptake inhibitors (SSRIs) senge citalopram (Celexa), escitalopram (Lexapro), uye sertraline (Zoloft); triazolam (Halcion); uye warfarin (Coumadin, Jantoven). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kubatana ne lumacaftor uye ivacaftor, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's wort. Chiremba wako angangokuudza kuti usatora St. John's wort uchitora lumacaftor uye ivacaftor.
• udza chiremba wako kana iwe kana wakambove nematambudziko ekufema kana mamiriro, nhengo yekuisira, kana chiropa kana chirwere cheitsvo.
• iwe unofanirwa kuziva kuti lumacaftor uye ivacaftor inogona kudzikisira kushanda kwehomoni yekudzivirira kubata pamuviri (mapiritsi ekudzivirira kubereka, zvigamba, mhete, majekiseni, mapiritsi, kana zvishandiso zvepamuviri). Taura nachiremba wako nezve dzimwe nzira dzekudzivirira kuberekwa dzinokushandira iwe paunenge uchitora lumacaftor uye ivacaftor.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Kana iwe ukava nepamuviri uchitora lumacaftor uye ivacaftor, fonera chiremba wako.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Kana iwe uchirangarira iro rakarasika dhizaini mukati maawa matanhatu yenguva iwe yawakarongerwa kuitora, tora iyo yakarasika dosi ipapo ipapo. Nekudaro, kana anopfuura maawa matanhatu apfuura kubva panguva yaunowanzo tora lumacaftor uye ivacaftor, ruka iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Lumacaftor uye ivacaftor zvinogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• mweya wekufema
• kuomesa pachipfuva kana kurwadziwa
• matambudziko ekufema
• manyoka
• gasi
• kuneta zvakanyanya
• mapundu
• zvisina kujairika, zvakapotsa, zvinorema kana zvinorwadza zvekuenda kumwedzi, kunyanya mumadzimai anotora mahormone ekudzivirira kubata pamuviri
• inoyerera mhino, kuhotsira, kukosora, kurwadziwa pahuro, kana zviratidzo zvakaita sefuru
• huro inorwadza
• yakakora kana inomhanya mhino
• musoro

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukasira:

• kusvotwa
• kurutsa
• kurasikirwa nenzara
• kurwadziwa kumusoro kwepamusoro chikamu chedumbu
• weti yakasviba
• kuvhiringidzika
• yero yeganda kana maziso

Lumacaftor uye ivacaftor zvinogona kukonzera cataract (kufukidza kweziso reziso iro rinogona kukonzera matambudziko ekuona) muvana nevechiri kuyaruka. Vana nevachiri kuyaruka vanotora lumacaftor uye ivacaftor vanofanirwa kuona chiremba wemaziso vasati uye panguva yekurapwa kwavo. Taura nachiremba wemwana wako nezve njodzi dzekupa lumacaftor uye ivacaftor kumwana wako.

Lumacaftor uye ivacaftor zvinogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe uye kusvika kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakavharira makapu ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye kubva kwavari uye kusvika. http://www.upandaway.org

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

• musoro
• mapundu

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako anozoraira bvunzo bvunzo usati watanga kurapwa kwako kuti uone kana mamiriro ako achigona kurapwa ne lumacaftor uye ivacaftor sezvo ichifanira kungoshandiswa chete kune vanhu vane mamwe magene ekugadzira. Chiremba wako acharaira kuongororwa kwemaziso uye kumwe kuongorora kwelebhu usati uye panguva yekurapwa kwako kuti utarise mhinduro yemuviri wako ku lumacaftor uye ivacaftor. Ropa rako rinofanira kuongororwa nguva nenguva paunenge uchitora mushonga uyu.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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