Munyori: Marcus Baldwin
Zuva Rekusika: 16 Chikumi 2021
Gadziridza Zuva: 23 Ndira 2025
Anonim
Fenfluramine Assessment in Rare Epilepsy (FAiRE) Clinical Trial
Vhidhiyo: Fenfluramine Assessment in Rare Epilepsy (FAiRE) Clinical Trial

Zvemukati

Fenfluramine inogona kukonzera zvakakomba matambudziko emoyo nemapapu. Udza chiremba wako kana iwe wakambove kana uine moyo kana chirwere chemapapu. Chiremba wako achaita echocardiogram (bvunzo inoshandisa masaisai eruzha kuyera kugona kwemoyo wako kupomba ropa) usati watanga kutora fenfluramine, yega yega mwedzi mitanhatu panguva yekurapwa, uye kamwechete mwedzi 3 kusvika kumatanhatu mushure meyako yekupedzisira fenfluramine.Fonera chiremba wako ipapo ipapo kana uine chimwe chezviratidzo nezviratidzo panguva yekurapwa: kupfupika kwekufema, kurwadziwa pachipfuva, kuneta kana kushaya simba, kukurumidza kana kurova kurova kwemoyo kunyanya nekuwedzera chiitiko, huro husina musoro, kupera simba, kurovera zvisina kujairika, kuzvimba makumbo kana tsoka, kana bhuruu ruvara kune miromo uye ganda.

Nekuda kwenjodzi nemushonga uyu, fenfluramine inowanikwa chete kuburikidza neyakaganhurirwa chirongwa chekugovera. Chirongwa chinonzi Fintepla Risk Evaluation uye Mitigation Strategies (REMS) chirongwa. Iwe, chiremba wako, uye chitoro chako chemishonga unofanirwa kunyoreswa muchirongwa cheFintepla REMS usati wagamuchira.


Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira zvimwe bvunzo kuti atarise mhinduro yemuviri wako kune fenfluramine.

Chiremba wako kana wemishonga anokupa iro gadziriro yeruzivo yemurwere (Medication Guide) paunotanga kurapwa ne fenfluramine uye nguva yega yega paunozadza tsamba yako. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Fenfluramine inoshandiswa kudzora kubatwa muvana kubva pamakore maviri ekuberekwa uye vakuru vane Dravet syndrome (chirwere chinotanga muhudiki uye chinokonzeresa uye gare gare chinogona kutungamira mukukura kunonoka uye shanduko mukudya, kuenzanisa, uye kufamba). Fenfluramine iri mukirasi yemishonga inonzi anticonvulsants. Hazvizivikanwe chaizvo kuti fenfluramine inoshanda sei, asi inowedzera huwandu hwezvinhu zvakasikwa muuropi izvo zvinogona kudzora kubatwa.


Fenfluramine inouya semhinduro (mvura) kutora nemuromo. Inowanzo kutorwa kaviri pazuva kana kana pasina chikafu. Tora fenfluramine kwakatenderedza nguva dzakafanana zuva rega rega. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora fenfluramine chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Chiremba wako angangotanga iwe pane yakaderera dosi fenfluramine uye zvishoma nezvishoma wedzera yako dosi, kwete kupfuura kamwe chete pasvondo.

Shandisa sirinji yemuromo yakauya nemushonga kuyera mhinduro. Usashandise kapu yeimba kuyera muyero wako. Mashupuni emhuri haasi ekuyera chaiwo, uye unogona kuwana mishonga yakawandisa kana isina kukwana mishonga kana ukayera dosi rako nepuniji yemumba. Shenesa sirinji yemuromo nemvura yakachena yemupombi uye ita kuti iome yakaoma mushure mekushandisa kwese. Shandisa sirinji yakaoma yemuromo nguva dzese dzaunotora mushonga.


Kana iwe uine nasogastric (NG) kana gastric chubhu, chiremba wako kana wemishonga anotsanangura kuti ungagadzirira sei fenfluramine kuishandisa.

Fenfluramine inobatsira kudzora pfari, asi haivarape. Ramba uchitora fenfluramine kunyangwe iwe uchinzwa zvakanaka. Usarega kutora fenfluramine usina kutaura nachiremba wako. Kana iwe ukangoerekana warega kutora fenfluramine, unogona kusangana nezviratidzo zvekudzora senge kutsva kana kuwedzera kukuvara. Chiremba wako angangoderedza dhizaini yako zvishoma nezvishoma.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora fenfluramine,

  • udza chiremba wako uye wemishonga kana uri weergoria kune fenfluramine, chero mimwe mishonga, kana chero chinhu chinosanganiswa mu fenfluramine yemumuromo mhinduro. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
  • udza chiremba wako kana uri kutora kana kugamuchira mishonga inotevera kana kuti warega kuinwa mumazuva gumi nemana apfuura: monoamine oxidase (MAO) inhibitors inosanganisira isocarboxazid (Marplan), linezolid (Zyvox), methylene bhuruu, phenelzine (Nardil), selegiline ( Eldepryl, Emsam, Zelapar), uye tranylcypromine (Parnate). Kana iwe ukarega kutora fenfluramine, iwe unofanirwa kumirira kwemazuva gumi nemana usati watanga kutora MAO inhibitor.
  • udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemakwenzi yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: mishonga yekudzvinyirira senge bupropion (Aplenzin, Wellbutrin); mishonga yekushushikana; cyproheptadine; dextromethorphan (inowanikwa mumishonga yakawanda yekukosora; muNuedexta); efavirenz (Sustiva); lithium (Lithobid); mishonga yekurwara kwepfungwa; mishonga yemigraine misoro yakadai sa almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), uye zolmitriptan (Zomig); omeprazole (Prilosec); rifampin (Rifadin, Rimactane, muRifamate, muRifater); kunyaradza; mishonga yekubatwa kwakadai sa carbamazepine (Carbatrol, Equetro, Tegretol, Teril), clobazam (Onfi, Sympazan), phenobarbital, phenytoin (Dilantin, Phenytek), uye stiripentol (Diamcomit); inosarudza serotonin-reuptake inhibitors se fluoxetine (Prozac, Sarafem, Selfemra), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), uye sertraline (Zoloft); serotonin-norepinephrine reuptake inhibitors (SNRI) senge desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), milnacipran (Savella), uye venlafaxine (Effexor); mapiritsi ekurara; tranquilizers; trazodone; uye tricyclic antidepressants ('mood elevators') senge desipramine (Norpramin) kana protriptyline (Vivactil). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kusangana ne fenfluramine, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
  • udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi uye zvinovaka muviri zvekuwedzera zvaunotora, kunyanya St. John's wort uye tryptophan.
  • udza chiremba wako kana iwe wakambove kana uine glaucoma (kuwedzerwa kumanikidza muziso kunogona kukonzera kurasikirwa kwemaonero) kana kuwedzerwa kweropa. Zvakare, udza chiremba wako kana iwe kana wakambove nekuora mwoyo, matambudziko emanzwiro, pfungwa dzekuzviuraya kana hunhu kana itsvo kana chirwere chechiropa.
  • udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Kana iwe ukava nepamuviri uchitora fenfluramine, fonera chiremba wako.
  • iwe unofanirwa kuziva kuti fenfluramine inogona kukuwisira iwe uye kuti zviomere iwe kuita zviitwa zvinoda kungwarira kana kubatana kwemuviri. Usatyaire mota kana kushandisa michina kusvikira iwe waziva kuti uyu mushonga unokubata sei.
  • bvunza chiremba wako nezvekushandiswa kwakachengeteka kwezvinwiwa zvinodhaka uye mishonga ine doro (kukosora uye zvigadzirwa zvinotonhora, senge Nyquil, uye zvimwe zvigadzirwa zvemvura) paunenge uchitora fenfluramine. Doro rinogona kuwedzera kukukotsira kunokonzerwa nemushonga uyu.
  • iwe unofanirwa kuziva kuti hutano hwako hwepfungwa hunogona kuchinja nenzira dzisingatarisirwe uye unogona kuzviuraya (kufunga nezvekuzvikuvadza kana kuzviuraya kana kuronga kana kuyedza kuzviita) iwe uchitora fenfluramine. Chiverengero chidiki chevakuru nevana vane makore mashanu ekuberekwa uye kupfuura (vangangoita 1 muvanhu mazana mashanu) vakatora anticonvulsants, senge fenfluramine, kurapa mamiriro akasiyana siyana panguva yekiriniki yekudzidzira kuzviuraya panguva yekurapwa kwavo. Vamwe vevanhu ava vakaita pfungwa dzekuzviuraya pamwe nehunhu pakutanga kwevhiki rimwe chete vatanga kutora mushonga. Iwe nachiremba wako muchasarudza kana njodzi dzekutora mushonga weanticonvulsant dzakakura kudarika njodzi dzekusatora mushonga. Iwe, mhuri yako, kana mutarisiri wako unofanirwa kufonera chiremba wako ipapo kana iwe ukawana chero cheanotevera zviratidzo: kuvhunduka kwekutya; kusagadzikana kana kusagadzikana; kutsva kana kuwedzera kutsamwa, kushushikana, kana kushushikana; kuita zvishuvo zvine ngozi; kunetseka kudonha kana kuramba wakarara; hasha, hasha, kana kuita zvechisimba; mania (kupenga, kusanzwisisika zvisingaite); kufunga nezvekukuvadza kana kuzviuraya iwe, kana kuronga kana kuyedza kuzviita; kana chero imwe shanduko isina kujairika mumaitiro kana manzwiro. Iva nechokwadi chekuti mhuri yako kana muchengeti anoziva kuti ndezvipi zviratidzo zvingave zvakakomba saka vanogona kufonera chiremba kana iwe usingakwanise kutsvaga kurapwa iwe wega.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira. Zvisinei, kana yava nguva yenguva inotevera, svetuka chirwere chakarasika uye ramba uchiita purogiramu yako yenguva dzose. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Fenfluramine inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

  • manyoka
  • kuvimbiswa
  • kurutsa
  • kusagadzikana kana matambudziko nekufamba
  • kumedzera mate kana kunyanyisa mate
  • kunetseka kurara kana kuramba wakarara
  • kudonha
  • fivha, kukosora, kana zvimwe zviratidzo zvehutachiona

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana izvo zvakanyorwa mune ZVINOKOSHA YENYENZO kana ZVINOKOSHA ZVINONYANYA, rega kutora fenfluramine uye kufonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

  • kushushikana, kufungidzira, kupisa muviri, kudikitira, kuvhiringidzika, kurova kwehana nekukurumidza, kutonhora, kuomarara kwemhasuru kana kupunzika, kurasikirwa nekubatana, kuda kurutsa, kurutsa, kana manyoka.
  • kuona kwakakanganiswa kana kuchinja kwemaonero, kusanganisira kuona halos (rondedzero yakakomberedza zvakapoteredza zvinhu) kana mavara ane mavara

Fenfluramine inogona kukonzera kurasikirwa kwenzara uye kuonda. Kana iwe ukaona kuti mwana wako ari kurasikirwa uremu, dana chiremba wako. Chiremba wako anozotarisa kukura uye kurema kwemwana wako zvakanyatsonaka. Taura nachiremba wako kana iwe uine zvinetsekana nezve kukura kwemwana wako kana huremu paanenge achitora mushonga uyu.

Fenfluramine inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Chengetedza mhinduro yemumuromo pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi). Usaisa mufiriji kana kuisa mhinduro yacho. Rasa mhinduro isingashandiswi yemuromo inosara mwedzi mitatu mushure mekutanga kuvhura bhodhoro kana mushure mekuti "rasa mushure" remusi pakanyorwa, chero zuva riri kukurumidza.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe uye kusvika kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakavharira makapu ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye kubva kwavari uye kusvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

  • vakawedzeredzwa vadzidzi
  • back arching
  • nekukurumidza kana zvisina kujairika kurova kwemoyo
  • kufashaira
  • kusagadzikana
  • kushushikana
  • kudengenyeka
  • pfari
  • coma (kurasikirwa kwekuziva kwenguva yakati)
  • kushushikana, kuona zvisizvo, kupisa muviri, kudikitira, kuvhiringidzika, kurova kwehana nekukurumidza, kudedera, kuomarara kwemhasuru kana kupunzika, kurasikirwa nekubatana, kuda kurutsa, kurutsa, kana manyoka.

Usarega mumwe munhu achitora mushonga wako. Fenfluramine chinhu chinodzorwa. Zvinyorwa zvinogona kuzadzikiswa chete akaganhurirwa nhamba yenguva; bvunza wako wemishonga kana iwe uine chero mibvunzo.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

  • Fintepla®
Yekupedzisira Yakagadziridzwa - 08/15/2020

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