Biologics yeAS: Ndezvipi Zvaunosarudza?

Zvemukati

• Chii chinonzi biologics yeAS?
• 1. Tumor necrosis factor (TNF) inodzivirira
• 2. Interleukin 17 (IL-17) inhibitors
• Ko biologics yeAS inopihwa sei?
• Mutengo webiologics weAS
• Migumisiro yebiologics yeAS
• Nzira yekuwana chaiyo biologic kurapa kweAS
• Tora woenda nazvo

Ankylosing spondylitis (AS) chirwere chisingaperi chinodzivirira muviri chinonyanya kukanganisa mapfundo emusana, asi majoini mahombe, akadai sehudyu nemapfudzi, anogona zvakare kuverengerwa.

Kuzvimba, kunokonzerwa ne immune system chiitiko, kunokonzeresa kusanganisa kusanganisa muzvikamu zvemuviri, izvo zvinowanzo kutungamira pakurwadziwa, kuzvimba, uye kuomarara.

Izvi zvinogona kudzikamisa kufamba, zvichiita kuti zvive zvakaoma kupedzisa mabasa ezuva nezuva.

Iko hakuna kurapwa kwechirwere ichi, asi marapirwo akasiyana anogona kudzora kufambira mberi uye nekukubatsira iwe kurarama hupenyu hunoshanda. Anopa hutano hwako anokudziridza chirongwa chekurapa iwe mushure mekuongororwa kwako.

Nekuti zviratidzo zveAS zvinogona kubva pane zvinyoro kusvika kune zvakakomba, vamwe vanhu vanogona kubata zviratidzo zvavo nema nonsteroidal anti-anogumbura zvinodhaka (NSAIDs), senge ibuprofen (Motrin, Advil) uye naproxen sodium (Aleve).

Kana zviratidzo zvako zvikasapindura kune izvo zvinodhaka, mishonga yekunyorera ndiyo inotevera mutsara wekudzivirira.

Prescription zvinodhaka zvinoshandiswa zveAS zvinosanganisira chirwere-kugadzirisa anti-rheumatic zvinodhaka (DMARDs) kudzikisira kuzvimba immune immune inokonzera.

Kunyangwe ivo vasingakwanise kunongedza chaicho chikonzero chacho, maNSAID nemaDMARD ese akagadzirirwa kumisa kuzvimba.

Dzimwe nguva kurwadziwa uye kuomarara AS kunounza hazviite kune iyi mishonga yemishonga. Kuti ikubatsire kubata zviratidzo, chiremba wako anogona kukurudzira imwe mhando yekurapa inonzi biologics.

Chii chinonzi biologics yeAS?

Biologics majini anogadzirwa nemajini anogadzirwa kubva kuzvinhu zvipenyu zvinoteedzera zvakajairika mabasa ehupenyu.

Idzo ndidzo tarisiro yekurapa yakanangana nemapuroteni chaiwo mu immune system inoburitsa kuzvimba, anoti:

• bundu necrosis factor (TNF)
• interleukin 17 (IL-17)

Chikafu neDrug Administration (FDA) yakabvumidza yekutanga biologic muna 1988 kurapa rheumatoid arthritis. Kubva ipapo, mamwe akawanda biologics akagadzirwa.

Parizvino, marudzi manomwe ebiologics anotenderwa kurapwa kweAS. Izvi zvinosanganisira:

1. Tumor necrosis factor (TNF) inodzivirira

• adalimumab (Humira)
• certolizumab pegol (Cimzia)
• etanercept (Enbrel)
• golimumab (Simponi, Simponi Aria)
• infliximab (Remicade)

2. Interleukin 17 (IL-17) inhibitors

• secukinumab (Cosentyx)
• ixekizumab (Taltz)

Ko biologics yeAS inopihwa sei?

Biologics inofanirwa kuendeswa munyama iri pasi peganda kana kudzika mumhasuru. Hazvina kuwanikwa mupiritsi kana fomu yemuromo. Unovagamuchira kuburikidza nemajekiseni kana infusions.

Kuwanda kwemajekiseni kana infusions anodiwa anozosiyana zvichienderana nechero biologic kurapwa.

Iwe unogona kugamuchira infusion mwedzi mishoma. Kana, iwe ungangoda akawanda ekutanga majekiseni uye wobva watevera-kumusoro majekiseni mukati megore.

Semuenzaniso, iyo biologic Simponi inoda majekiseni matatu ekutanga:

• majekiseni maviri pazuva rekutanga rekurapwa
• jekiseni rimwe chete kwapera vhiki mbiri

Mushure mezvo, iwe unozozvipa iwe jekiseni rimwe chete masvondo mana.

Kune rimwe divi, kana iwe ukatora Humira, iwe unozozvipa iwe jekiseni rimwe rega rega vhiki imwe neimwe mushure mematanho mana ekutanga.

Chiremba wako anokuudza iwe kangani iwe pauchada biologic kurapa, uye ivo vachakupa iwe rairo yekuti ungapa sei majekiseni ako.

Biologics haigadzirise zviratidzo zveAS husiku, asi iwe unofanirwa kutanga kunzwa zvirinani mune angangoita mavhiki mana kusvika gumi nemaviri, dzimwe nguva nekukurumidza.

Chinangwa chekurapa ndechekudzvinyirira zviratidzo zvako kuitira kuti mamiriro acho asapindire nehupenyu hwako. Izvo zvakakosha kuti uzive kuti biologics haizopore AS.

Mutengo webiologics weAS

Biologics inowanzo shanda, asi inodhura kwazvo muUnited States. Paavhareji, mutengo we biologics uye uye dzimwe nguva zvakanyanya kudhura kune avo anodhura emumiriri.

Inishuwarenzi ingangovhara chikamu chemitengo, asi zvinozoenderana nekuvharirwa kwako.

Taura nachiremba wako nezve sarudzo dze biosimilars (akafanana mafomati kune biologics) uye chero mapurogiramu ebatsiro evarwere kuburikidza nevagadziri vezvinodhaka.

Migumisiro yebiologics yeAS

Iko kune njodzi yemhedzisiro kana kuwiriranwa nemhando dzakawanda dzemishonga, uye biologics haisi iyo yega.

Migumisiro yechirwere yebiologic therapy inogona kusanganisira:

• kurwadziwa, kutsvuka, kuputika, kana kupwanya panzvimbo yejojo
• musoro
• mikoko kana mapundu
• kurwadziwa nemudumbu
• kurwadziwa shure
• kusvotwa
• kukosora kana kurwadziwa pahuro
• kupisa kana kutonhora
• kunetseka kufema
• yakaderera BP

Iyi mhedzisiro inowanzo kuve yakapfava uye inowanzo kudzikira uye pakupedzisira inoenda.

Nekudaro, iwe unofanirwa kufonera chiremba wako kana iwe uine zviratidzo zvakaita semukoko, kuzvimba, kana kunetseka kufema. Izvi zvinogona kuve zviratidzo zvekusagadzikana.

Nekuti biologics inodzvinyirira immune system yako, ivo vanogona kuwedzera mukana wako wehutachiona nekenza.

Chiremba wako anogona kuraira bvunzo bvunzo usati wajova kwako kwekutanga kana kuiswa infusion kuti utarise:

• tibhii
• hepatitis B uye C
• zvimwe zvirwere

Ona chiremba wako kana iwe ukava nezviratidzo zvehutachiona mushure mekutanga kurapwa, senge:

• kupindwa nechando
• chills
• mweya wekufema
• kukosora

Zvakare, zivisa chiremba wako kana iwe usina kutsanangurwa:

• kukuvadza
• kuonda
• kuneta zvisina kujairika

Biologics inogona kuwedzera njodzi yekuva nekenza yeropa senge lymphoma.

Nzira yekuwana chaiyo biologic kurapa kweAS

Kunyangwe zvese biologics zveAS zvakaitirwa kudzora kufambira mberi kwechirwere uye kumisa kuzvimba, biologics haishande zvakafanana kune wese munhu.

Kana iwe ukatanga biologic kurapwa, chiremba wako anogona kukutanga iwe nerudzi rumwe uye kuongorora mamiriro ako pamusoro pemwedzi mitatu inotevera kuti uone kana paine chero kuvandudzwa.

Usanzwe kuora mwoyo kana zviratidzo zvako zvikasadzikira mushure mekutanga kwako infusions kana majekiseni. Kana AS yako isingavandudzike, chiremba wako anogona kukurudzira kuchinjira kune imwe biologic yakatenderwa AS.

Biologic therapy chete haisi yega sarudzo.

Iwe haufanire kutora zvinopfuura imwe biologic panguva imwe nekuda kwenjodzi yehutachiona, asi iwe unogona kutora biologics nemimwe mishonga yeAS. Kuwana zororo kubva kuAS dzimwe nguva inyaya yekuyedza uye kukanganisa.

Iva nemwoyo murefu. Zvinogona kutora nguva kuti uwane chaiyo musanganiswa wemishonga.

Semuenzaniso, kunyange zviratidzo zvako zvisina kuvandudzika uchitora maNSAID kana maDMARD, kusanganisa biologic nemishonga iyi kunogona kushanda.

Tora woenda nazvo

Pasina kurapwa kwakakodzera, AS inogona zvishoma nezvishoma kufambira mberi uye inokonzeresa kurwadziwa, kuomarara, uye kudzikisira kufamba.

Taura nachiremba wako kana iwe uchinzwa kuti kurapa kwako kwazvino hakusi kushanda. Iwe unogona kuve mukwikwidzi webiologics.

Asi usati watanga biologic kurapwa (sekune chero kurapwa), ita shuwa kuti iwe unoziva zvaunogona uye wobvunza mibvunzo.