Chisingaperi Myeloid Leukemia

Zvemukati

• Pfupiso
• Chii chinonzi leukemia?
• Chii chinonzi chronic myeloid leukemia (CML)?
• Chii chinokonzera chisingaperi myeloid leukemia (CML)?
• Ndiani ari panjodzi yekusingaperi myeloid leukemia (CML)?
• Ndezvipi zviratidzo zvekusingaperi myeloid leukemia (CML)?
• Chirwere chemyeloid leukemia (CML) chinowanikwa sei?
• Ndeapi matanho echirwere chemyeloid leukemia (CML)?
• Ndeapi marapirwo echirwere chemyeloid leukemia (CML)?

Pfupiso

Chii chinonzi leukemia?

Leukemia ishoko rekenza yemasero eropa. Leukemia inotanga muzvinhu zvinogadzira ropa senge mwongo wefupa. Pfupa rako rinogadzira maseru anozokura kuita machena masero eropa, masero matsvuku eropa, uye maplatelet. Mhando yega yega yesero ine rimwe basa rakasiyana:

• Masero machena eropa anobatsira muviri wako kurwisa hutachiona
• Masero matsvuku eropa anounza okisijeni kubva mumapapu ako kusvika kumatumbu ako uye nhengo
• Maplatelet anobatsira kuumba mavhu kumisa kubuda kweropa

Paunenge uine leukemia, mapfupa ako anoita huwandu hwakawanda hweasero asina kujairika. Dambudziko iri rinowanzoitika nemasero machena eropa. Aya maseru asina kujairika anovaka mumapfupa ako uye muropa. Vanounganidza masero eropa ane hutano uye voita kuti zviomere masero ako neropa kuti zviite basa razvo.

Chii chinonzi chronic myeloid leukemia (CML)?

Chisingaperi myeloid leukemia (CML) rudzi rwechirwere cheleukemia chisingaperi. "Chisingaperi" zvinoreva kuti leukemia inowanzo dzikira zvishoma nezvishoma. MuCML, pfupa remapfupa rinogadzira zvisina kujairika granulocytes (rudzi rwechena reropa). Aya maseru asina kujairika anonzi zvakare kuputika. Kana masero asina kujairika achinge akabuda kunze kwemasero ane hutano, zvinogona kutungamira kuhutachiona, kupererwa neropa, uye kubuda ropa nyore. Iwo maseru asina kujairika anogonawo kupararira kunze kweropa kune zvimwe zvikamu zvemuviri.

CML inowanzoitika kune vanhu vakuru panguva kana mushure mezera repakati. Kashoma muvana.

Chii chinokonzera chisingaperi myeloid leukemia (CML)?

Vazhinji vanhu vane CML vane shanduko yemagetsi inonzi iyo Philadelphia chromosome. Inodanwa kudaro nekuti vaongorori muPhiladelphia vakaiwana. Vanhu vanowanzove nemapara makumi maviri nematatu emakromosomes musero rega rega. Aya ma chromosomes ane yako DNA (genetic zvinhu). MuCML, chikamu cheDNA kubva kune imwe chromosome inoenda kune imwe chromosome. Iyo inosangana neimwe DNA ipapo, iyo inogadzira geni idzva rinonzi BCR-ABL. Iri geni rinokonzeresa kuti mwongo wemapfupa ako ugadzire isina kujairika protein. Iyi protein inobvumira masero eleukemia kukura kunze kwekudzora.

Chromosome yePhiladelphia haina kupfuudzwa kubva kumubereki kuenda kumwana. Zvinoitika panguva yehupenyu hwako. Chikonzero hachizivikanwe.

Ndiani ari panjodzi yekusingaperi myeloid leukemia (CML)?

Zvakaoma kufanotaura kuti ndiani achatora CML. Pane zvinhu zvishoma zvinogona kukwidza njodzi yako:

• Zera - njodzi yako inokwira paunenge uchikura
• Gender - CML inowanzoitika zvakanyanya muvarume
• Kuratidzira kune yakakwira-dose radiation

Ndezvipi zviratidzo zvekusingaperi myeloid leukemia (CML)?

Dzimwe nguva CML haina kukonzera zviratidzo. Kana iwe uine zviratidzo, zvinogona kusanganisira

• Kunzwa kuneta chaizvo
• Kurera huremu pasina chikonzero chinozivikanwa
• Kudiridza husiku kudikitira
• Kupindwa nechando
• Marwadzo kana kunzwa kwekuzara pazasi pembabvu kuruboshwe

Chirwere chemyeloid leukemia (CML) chinowanikwa sei?

Wako wekuchengeta hutano anogona kushandisa maturusi mazhinji kuti aongorore CML:

• Kuongorora kwepanyama
• Nhoroondo yezvechiremba
• Ropa bvunzo, senge rakazara ropa kuverenga (CBC) nemisiyano uye neropa chemistry bvunzo. Ropa kemisitiri bvunzo dzinoyera zvakasiyana zvinhu muropa, zvinosanganisira elektrolyte, mafuta, mapuroteni, glucose (shuga), uye ma enzymes. Dzakananga ropa kemesita bvunzo dzinosanganisira yakakosha metabolic pani (BMP), yakazara metabolic pani (CMP), itsvo basa bvunzo, chiropa mashandiro ebvunzo, uye electrolyte pani.
• Bone mongo bvunzo. Kune maviri akakosha mhando - bone marrow aspiration uye bone marrow biopsy. Kwose kuyedzwa kunosanganisira kubvisa muyenzaniso wefupa remongo uye bone. Iwo masampuli anotumirwa kune lab yekuyedzwa.
• Mageneti ekuyedza kutsvaga geni uye chromosome shanduko, kusanganisira bvunzo dzekutarisa chromosome yePhiladelphia

Kana iwe ukaonekwa uine CML, unogona kunge uine mimwe bvunzo senge yekufungidzira bvunzo kuti uone kana gomarara rapararira.

Ndeapi matanho echirwere chemyeloid leukemia (CML)?

CML ine zvikamu zvitatu. Izvo zvikamu zvinoenderana nekuti yakawanda sei iyo CML yakakura kana kupararira:

• Chikamu chisingaperi, uko isingasviki gumi muzana yemasero muropa uye mwongo wemapfupa ari maseroma (maseru eukemia). Vanhu vazhinji vanoonekwa muchikamu chino, uye vazhinji havana zviratidzo. Kurapa kwakasununguka kazhinji kunobatsira muchikamu chino.
• Yakawedzera chikamu, 10% kusvika 19% yemasero ari muropa uye mwongo wemapfupa masero ekuputika. Muchikamu chino, vanhu vanowanzo kuve nezviratidzo uye kurapwa kwakaringana kunogona kunge kusiri kushanda senge kuchikamu chisingaperi.
• Blastic chikamu, uko makumi maviri kubva muzana kana anopfuura masero muropa kana mwongo wemapfupa ari blast maseru. Aya maseru anoputika akapararira kune mamwe maturusi uye nhengo. Kana iwe uine kuneta, fivhiri, uye yakawedzera spleen panguva yekutsvaira chikamu, inonzi dambudziko rekufema. Ichi chikamu chakaoma kurapa.

Ndeapi marapirwo echirwere chemyeloid leukemia (CML)?

Kune akatiwandei akasiyana marapirwo eCML:

• Targeted therapy, iyo inoshandisa zvinodhaka kana zvimwe zvinhu zvinorwisa chaiwo maseru ekenza asina kukuvadza zvishoma kune zvakajairika maseru. Kune CML, iyo mishonga ndeye tyrosine kinase inhibitors (TKIs). Ivo vanovhara tyrosine kinase, inova iyo enzyme iyo inokonzeresa rako bhora mongo kuita kuwanda kwakanyanya.
• Chemotherapy
• Immunotherapy
• Yakakwira-dose chemotherapy ine stem cell yekuisa
• Vanopa lymphocyte infusion (DLI). DLI kurapwa kunogona kushandiswa mushure mekudzikiswa kwesero. Izvo zvinosanganisira kukupa iwe infusion (muropa rako) yema lymphocyte ane hutano kubva kune iyo stem cell yekuisa mupi. MaLymphocyte rudzi rweye chena yeropa. Aya ma lymphocyte evanopa anogona kuuraya maseru egomarara asara.
• Kuvhiya kubvisa iyo spleen (splenectomy)

Ndeapi marapirwo aunowana anoenderana nechikamu chauri, zera rako, hutano hwako hwese, nezvimwe zvinhu. Kana zviratidzo nezviratidzo zveCML zvadzikira kana kuti zvanyangarika, zvinodaidzwa kuti kuregererwa. Iyo CML inogona kudzoka mushure mekuregererwa, uye ungangoda kumwe kurapwa.

NIH: National Cancer Institute