Chiremba Nhaurirano Nhungamiro: Matipi ekukurukura PIK3CA Kuchinja pamwe naChiremba Wako

Zvemukati

• Chii chinonzi PIK3CA mutation?
• Iwe unowana sei iko shanduko?
• Kuchinja kwangu kunoita sei kurapwa kwangu?
• Kuchinja kwangu kunoita sei maonero angu?
• Tora woenda nazvo

Miedzo yakati wandei inogona kubatsira chiremba wako kuongorora metastatic kenza yemazamu, kufanotaura kuti ichaita sei, uye kuwana kurapwa kwakanyanya kwauri. Genetic bvunzo dzinotarisa shanduko kumajini, zvikamu zveDNA mukati memasero ako zvinodzora mashandiro anoita muviri wako.

Imwe yekuchinja kwemajini chiremba wako anogona kuyedza ndeye PIK3CA. Verenga pamusoro kuti udzidze kuti kuve neiyi geni shanduko kunogona kukanganisa kurapwa kwako uye nemaonero.

Chii chinonzi PIK3CA mutation?

Iyo PIK3CA geni inobata mirairo yekugadzira puroteni inonzi p110cy. Iyi protein yakakosha kune akawanda maseru mashandiro, kusanganisira kuudza maseru ako nguva yekukura nekukamurwa.

Vamwe vanhu vanogona kuve neshanduko mune ino geni. PIK3CA kuchinja kwemajini kunokonzera kuti maseru akure asingadzoreki, izvo zvinogona kukonzeresa kugomarara.

PIK3CA genes mutations inosangana nekenza yemazamu, pamwe nekenza yegomarara, mapapu, mudumbu, uye huropi. Gomarara repazamu rinogona kunge rinobva mukubatanidzwa kweshanduko kusvika PIK3CA uye mamwe majini.

PIK3CA shanduko dzinokanganisa pamusoro pekenza dzese dzamazamu, uye makumi mana muzana yevanhu vane estrogen receptor (ER) -inobatsira, epidermal yekukura kwechikonzero receptor 2 (HER2) - isina kunaka kenza yemazamu.

ER-positive zvinoreva kuti kenza yako yemazamu inokura mukupindura iyo hormone estrogen. HER2-negative zvinoreva kuti hauna mapuroteni ehurombo eHER2 pamusoro pemasero ekenza yemazamu.

Iwe unowana sei iko shanduko?

Kana iwe uine ER-yakanaka, HER2-isina kenza yemazamu, chiremba anobata kenza yako anogona kukuedza iwe PIK3CA gene mutation. Muna 2019, iyo FDA yakabvumidza bvunzo inonzi therascreen yekuona shanduko mu PIK3CA geni.

Muedzo uyu unoshandisa muyenzaniso weropa rako kana zvinyama kubva pazamu rako. Kuongororwa kweropa kunoitwa senge chero kumwe kuongorora kweropa. Mukoti kana nyanzvi inoburitsa ropa kubva paruoko rwako netsono.

Muenzaniso weropa unobva waenda kurabhoritari kunoongororwa. Kanzera yemazamu inodurura zvidimbu zvidiki zveDNA yavo muropa. Iyo lab ichaedza iyo PIK3CA geni muropa rako.

Kana iwe ukawana mhedzisiro yakaipa pakuongororwa kweropa, iwe unofanirwa kuve nebhiopsy yekuzvisimbisa. Chiremba wako achabvisa sampuli yeturu kubva pachipfuva chako panguva yekuvhiya kudiki. Muenzaniso weshutu unobva waenda kurabhoritari, uko matekinoroji anoiyedza iyo PIK3CA gene mutation.

Kuchinja kwangu kunoita sei kurapwa kwangu?

Kuva ne PIK3CA shanduko inogona kudzivirira kenza yako kubva pakupindura pamwe neiyo hormone kurapa inoshandiswa kurapa metastatic kenza yemazamu. Zvinoreva zvakare kuti iwe uri mukwikwidzi wemushonga mutsva unonzi alpelisib (Piqray).

Piqray iri PI3K inhibitor. Ndiyo mushonga wekutanga chaiwo werudzi rwayo. Iyo FDA yakabvumidza Piqray muna Chivabvu 2019 kurapa postmenopausal vakadzi nevarume vane mamota ezamu vane PIK3CA shanduko uye iri HR-yakanaka uye HER2-isina.

Mvumo yacho yaive yakavakirwa pamhedzisiro yeiyo SOLAR-1 kudzidza. Kuedzwa kwacho kwaisanganisira mazana mashanu nemakumi mashanu evanhukadzi nevarume vane HR-positive uye HER2-isina kenza yemazamu. Kenza yevatori vechikamu yakaramba ichikura uye ichipararira mushure mekunge varapwa ne aromatase inhibitor senge anastrozole (Arimidex) kana letrozole (Femara).

Vatsvagiri vakaona kuti kutora Piqray kwakavandudza huwandu hwenguva iyo vanhu vairarama pasina kenza yemazamu yavo ichiwedzera. Kune vanhu vakatora mushonga, gomarara ravo harina kufambira mberi kwemwedzi gumi nerimwe, zvichienzaniswa neavhareji yemwedzi 5.7 muvanhu vasina kutora Piqray.

Piqray inosanganiswa neiyo hormone therapy fulvestrant (Faslodex). Kutora mishonga miviri pamwechete kunovabatsira kushanda zvirinani.

Kuchinja kwangu kunoita sei maonero angu?

Kana iwe uine PIK3CA shanduko, unogona kusapindura zvakare kumishonga inowanzo shandiswa kurapa metastatic kenza yemazamu. Asi kuunzwa kwaPiqray kunoreva kuti iko zvino pane mushonga unonyatso tarisa maitiro ako ekuchinja.

Vanhu vanotora Piqray pamwe neFaslodex vanorarama kwenguva yakareba pasina chirwere chavo chichienderera mberi zvichienzaniswa nevaya vasingatore mushonga uyu.

Tora woenda nazvo

Kuziva yako PIK3CA chimiro chemajini chinogona kubatsira kana kenza yako isina kusimuka kana kudzoka mushure mekurapwa. Kumbira chiremba wako kana iwe uchifanira kuongororwa iyi geni. Kana iwe ukaedza bvunzo, kurapwa kutsva kunogona kubatsira kuvandudza maonero ako.