Empliciti (elotuzumab)

Zvemukati

• Chii chinonzi Empliciti?
• Kubudirira
• Empliciti generic
• Empliciti mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Rutivi mhedzisiro mhedzisiro
• Mari yeempliciti
• Mari uye inishuwarenzi rubatsiro
• Empliciti chipimo chemushonga
• Mafomu emishonga uye simba
• Dosage yeakawanda myeloma
• Ko kana ndikapotsa dosi?
• Ndichada here kushandisa mushonga uyu kwenguva refu?
• Dzimwe nzira dzeEmpliciti
• Empliciti (elotuzumab) vs. Darzalex (daratumumab)
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Empliciti vs. Ninlaro
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Empliciti yeakawanda myeloma
• Kubudirira kurapa akawanda myeloma
• Empliciti shandisa nemamwe madhiragi
• Multiple myeloma mishonga inoshandiswa neEmpliciti
• Pre-infusion mishonga inoshandiswa neEmpliciti
• Mashandiro anoita Empliciti
• Zvinotora nguva yakareba sei kuti zvishande?
• Empliciti uye doro
• Kubatana kweEmpliciti
• Empliciti uye bvunzo dzemarabhoritari
• Kumwe kudyidzana kwemishonga
• Iyo Empliciti inopihwa sei
• Nguva yekutora
• Empliciti uye nhumbu
• Empliciti uye kudzora kuberekwa
• Kudzora kuberekwa kwevakadzi
• Kudzora kubereka kwevarume
• Empliciti uye kuyamwisa
• Mibvunzo yakajairika nezve Empliciti
• Icho Empliciti chemotherapy?
• Chii chichaitika pakurapwa kwangu kweEmpliciti?
• Ndichaziva sei kana Empliciti iri kundishandira?
• Kushandisa Empliciti kunogona kundikonzera kuva nemamwe marudzi ekenza here?
• Empliciti matanho
• Ruzivo rwehunyanzvi rweEmpliciti
• Zviratidzo
• Nzira yekuita
• Pharmacokinetics uye metabolism
• Contraindications
• Kuchengetedza

Chii chinonzi Empliciti?

Empliciti izita-zita mushonga mushonga. Inoshandiswa kurapa mhando yekenza yeropa inonzi multiple myeloma muvanhu vakuru.

Empliciti inorayirwa vanhu vanopinda mune imwe yeaya maviri mamiriro ekurapa:

• Vakuru vane imwe kana matatu kurapwa munguva yakapfuura yavo yakawanda myeloma. Kune vanhu ava, Empliciti inoshandiswa mukubatana nelenalidomide (Revlimid) uye dexamethasone.
• Vakuru vane angangoita maviri apfuura akawanda myeloma mishonga yaisanganisira lenalidomide (Revlimid) uye proteasome inhibitor, senge bortezomib (Velcade) kana carfilzomib (Kyprolis). Kune vanhu ava, Empliciti inoshandiswa musanganiswa ne pomalidomide (Pomalyst) uye dexamethasone.

Empliciti ndeyekirasi yemishonga inonzi monoclonal antibodies. Iyi mishonga inogadzirwa murabhoritari kubva kumasero ezvirwere zvemuviri. Empliciti inoshanda nekumisikidza immune system yako uye nekuita yako maseru ekudzivirira akasimba. Mushonga uyu zvakare unobatsira kuratidza immune system yako apo akawanda myeloma maseru ari mumuviri wako kuitira kuti aya maseru aparadzwe.

Empliciti inowanikwa musimba mbiri: 300 mg uye 400 mg. Iyo inouya sehupfu hwakagadzirwa kuva gadziriso yemvura uye yaunopihwa neiyo inravenous (IV) infusion (jekiseni mumutsipa wako kwenguva yakati rebei). Iyo infusions inopihwa kune yehutano nzvimbo uye inopedza ingangoita awa kana kupfuura.

Kubudirira

Zvidzidzo zvekuchipatara zvakaratidza kuti Empliciti inoshanda pakumisa kufambira mberi (kuwedzera) kweakawanda myeloma. Mhedzisiro yezvimwe zvezvidzidzo izvi zvinotsanangurwa pazasi.

Empliciti ine lenalidomide (Revlimid) uye dexamethasone

Mumakiriniki ekuedzwa, vanhu vane myeloma yakawanda vakapihwa Empliciti ine lenalidomide uye dexamethasone, kana lenalidomide uye dexamethasone chete.

Zvidzidzo zvakaratidza kuti vanhu vanotora musanganiswa weEmpliciti vaive nenjodzi yakaderera yekuti chirwere chavo chifambire mberi. Kwemakore anopfuura maviri, avo vanotora Empliciti nelenalidomide uye dexamethasone vaive ne30% njodzi yakaderera pane vanhu vaitora iyo mishonga vasina Empliciti.

Mune kumwe kuongorora kwakatora makore mashanu, vanhu vaitora mubatanidzwa weEmpliciti vaive ne 27% panjodzi yakaderera yechirwere chavo ichiwedzera kupfuura vanhu vanotora lenalidomide uye dexamethasone voga.

Empliciti ine pomalidomide (Pomalyst) uye dexamethasone

Mumakiriniki ekuedzwa, vanhu vane myeloma yakawanda vakapihwa Empliciti ine pomalidomide uye dexamethasone, kana pomalidomide uye dexamethasone chete.

Vanhu vanotora mubatanidzwa weEmpliciti vaive ne46% panjodzi yakaderera yechirwere chavo ichiwedzera kuwedzera mushure memwedzi mipfumbamwe yekurapwa, zvichienzaniswa nevanhu vanotora pomalidomide uye dexamethasone voga.

Empliciti generic

Empliciti inowanikwa chete sezita-zita mushonga. Haisi ikozvino inowanikwa mune generic fomu.

Empliciti ine mushonga unoshanda elotuzumab.

Empliciti mhedzisiro

Empliciti inogona kukonzera manyoro kana zvakakomba mhedzisiro. Iri rinotevera runyorwa rine mamwe akakosha mhedzisiro mhedzisiro anogona kuitika uchitora Empliciti. Rondedzero iyi haisanganisi zvese zvinokanganisa mhedzisiro.

Yako mhedzisiro inogona kusiyana zvichienderana nekuti uri kutora Empliciti uye dexamethasone ine lenalidomide (Revlimid) kana pomalidomide (Pomalyst).

Kuti uwane rumwe ruzivo nezve zvinogona kuitika mhedzisiro yeEmpliciti, taura nachiremba wako kana wemishonga. Ivo vanogona kukupa iwe matipi ekuti ungatarise sei nechero mhedzisiro mhedzisiro inogona kunetsa.

Zvimwe zvakajairika mhedzisiro

Iyo yakajairika mhedzisiro mhedzisiro yeEmpliciti painotorwa nelenalidomide uye dexamethasone inogona kusanganisira:

• kuneta (kushaya simba)
• manyoka
• kupindwa nechando
• kuvimbiswa
• kukosora
• hutachiona, hwakadai sehutachiona hwechivi kana mabayo
• kuderera kwekuda kudya kana kurasikirwa uremu
• peripheral nerve chirwere (kukuvara kune dzimwe tsinga dzako)
• kurwadziwa mumaoko ako kana makumbo
• musoro
• kurutsa
• cataract (kuchena mumaziso eziso rako)
• kurwadziwa mumuromo uye pahuro
• shanduko mune mamwe mazinga pakuongororwa kweropa rako

Iyo yakajairika mhedzisiro mhedzisiro yeEmpliciti painotorwa ne pomalidomide uye dexamethasone inogona kusanganisira:

• kuvimbiswa
• kuwedzerwa shuga yeropa
• hutachiona, senge pneumonia kana sinus hutachiona
• manyoka
• kurwadziwa kwepfupa
• kunetseka kufema
• mhasuru
• kuzvimba mumaoko ako kana makumbo
• shanduko mune mamwe mazinga pakuongororwa kweropa rako

Mazhinji emhedzisiro iyi anogona kuenda mukati memazuva mashoma kana vhiki dzinoverengeka. Kana vakanyanya kuoma kana kuti vasingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Yakakomba mhedzisiro mhedzisiro inogona kuitika neEmpliciti. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

• Mamwe marudzi ekenza, senge gomarara reganda. Zviratidzo zvinogona kusanganisira:
  • kushaya simba
  • kunzwa kuneta
  • shanduko pakuonekwa kweganda rako uye mamota
  • kuzvimba lymph nodes
• Zvinetso zvechiropa. Zviratidzo zvinogona kusanganisira:
  • kunzwa kuneta
  • kushaya simba
  • yero yechena yemeso ako kana yako ganda
  • kuderera kwechido
  • kuzvimba munzvimbo yako yedumbu
  • kunzwa kunetseka

Mimwe mibairo yakakomba, iyo inokurukurwa zvakadzama pazasi, inogona kusanganisira zvinotevera:

• infusion reaction (inogona kukonzereswa nekuve nemushonga unodzvinyirira wemushonga)
• zvakanyanya kukanganiswa nemagetsi
• zvirwere

Rutivi mhedzisiro mhedzisiro

Unogona kushamisika kuti kangani mamwe maratidziro anoitika nemushonga uyu. Heano mamwe marondedzero pane mamwe emhedzisiro mhedzisiro iyi inogona kukonzera.

Allergic reaction

Sezvazvakaita nemishonga yakawanda, vamwe vanhu vanogona kuita zvinopesana nehutachiona mushure mekutora Empliciti. Zviratidzo zvehunhu husina kugadzikana hunogona kusanganisira:

• kuputika kweganda
• kuvava
• kuburitsa (kudziya uye kutsvuka mukati meganda rako)

Imwe yakanyanya kukonzeresa kusagadzikana isingawanzo asi inogoneka. Zviratidzo zveakanyanya kusagadzikana maitiro zvinogona kusanganisira:

• kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka
• kuzvimba kwerurimi rwako, muromo, kana huro
• kunetseka kufema

Fonera chiremba wako ipapo kana iwe uine chirwere chakakomba chekuita kuEmpliciti. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Infusion maitiro

Iwe unogona kunge uine infusion reaction mushure mekugamuchira Empliciti. Aya maitiro anogona kuitika kusvika maawa makumi maviri nemana mushure mekunge wagashira mushonga kuburikidza nemukati (IV) yekumukiswa.

Mumakiriniki ekuedzwa, 10% yevanhu vanotora Empliciti nelenalidomide uye dexamethasone vane infusion reaction. Vazhinji vevanhu ava vaive neiyo infusion reaction panguva yavo yekutanga Empliciti infusion. Nekudaro, chete 1% yevanhu vaitora musanganiswa wekurapa uyu vaifanira kumisa kurapwa nekuda kwekukanganisa kwakanyanya kwekumukiswa.

Zvakare mumakiriniki ekuedzwa, 3.3% yevanhu vanotora Empliciti ine pomalidomide uye dexamethasone vane infusion reaction. Chiratidzo chega chekupindirwa kwavo kwaive kurwadziwa muchipfuva.

Zviratidzo zvekupindirwa kwekuita zvinogona kusanganisira:

• kupindwa nechando
• chills
• kuwedzera kana kuderera kweropa
• kunonoka kurova kwemoyo
• kunetseka kufema
• dzungu
• kuputika kweganda
• kurwadziwa pachipfuva

Pamberi pe IV yako infusion yeEmpliciti, chiremba wako kana mukoti achakupa imwe mishonga yekubatsira kudzivirira infusion kuita kubva kuitika.

Kana iwe uine chero zviratidzo zveiyo infusion reaction iwe paunenge uchigamuchira Empliciti, kana kusvika maawa makumi maviri nemana mushure mekumukiswa kwako, udza chiremba wako ipapo ipapo. Muzviitiko zvakakomba, chiremba wako anogona kukurudzira kuti umise kurapwa kweEmpliciti.

Dzimwe nguva, kurapwa kweEmpliciti kunogona kutangwazve mushure mekumisikidzwa kuita. Asi mune dzimwe nguva, kusarudza imwe mishonga inogona kunge iri sarudzo iri nani kwauri.

Zvirwere

Iwe unogona kuve nenjodzi yakawedzera yezvirwere paunenge uchitora Empliciti. Izvi zvinosanganisira hutachiona, hutachiona, uye hutachiona hutachiona. Dzimwe nguva, hutachiona uhwu hunogona kuve hwakakomba kana husina kurapwa. Mune zvimwe zviitiko, zvinogona kukonzera kurwara kwakakomba kana kutofa.

Mumakiriniki ekuedzwa, hutachiona hwakaitika mu81% yevanhu vanotora Empliciti ine lenalidomide uye dexamethasone. Pakati pevanhu vanotora lenalidomide uye dexamethasone chete, 74% yaive nezvirwere.

Zvakare mumakiriniki ekuedzwa, hutachiona hwakaitika mu65% yevanhu vanotora Empliciti ine pomalidomide uye dexamethasone. Hutachiona hwakaitika muzana rakaenzana revanhu vanotora pomalidomide uye dexamethasone voga.

Zviratidzo zvehutachiona zvinogona kusiyana zvichienderana nerudzii rwehutachiona hwauinaro. Mienzaniso yezviratidzo zvinogona kusanganisira:

• kupindwa nechando
• kunetseka kufema
• dzihwa-senge zviratidzo, senge muviri kurwadza uye kutonhora
• kukosora
• kuputika kweganda
• kusvira kunzwa paunenge uchiita weti

Kana iwe uine chero zviratidzo zvehutachiona, taura nachiremba wako ipapo. Ivo vanogona kukurudzira kuti iwe umire kutora Empliciti kudzamara utachiona hwako hwaenda. Ivo zvakare vanokurudzira kana hutachiona hwako huchifanira kurapwa.

Peripheral tsinga chirwere

Iwe unogona kukuvara tsinga kana iwe uri kutora Empliciti. Kukuvara kwemutsipa kunogona zvakare kunzi chirwere chetsinga chirwere. Aya mamiriro anogona kukonzera kushaya simba uye kurwadziwa kunowanzoitika mumaoko ako kana tsoka. Peripheral nerve chirwere kazhinji hachiendi, asi chinogona kurapwa nemamwe mishonga.

Mumakiriniki ekuedzwa, peripheral nerve chirwere chakaitika mu27% yevanhu vanotora Empliciti ine lenalidomide uye dexamethasone. Aya mamiriro akaitika mu21% yevanhu vanotora lenalidomide uye dexamethasone voga.

Taura nachiremba wako kana iwe uine zviratidzo zvehurwere hwehurwere chirwere. Vanogona kukurudzira kurapwa kana iwe uchida.

Kuneta

Unogona kuva nekuneta (kushaya simba) paunenge uchishandisa Empliciti. Ichi chaive chakajairika divi mhedzisiro yakaonekwa panguva yezvidzidzo muvanhu vachitora Empliciti nelenalidomide uye dexamethasone.

Mune zvidzidzo, kuneta kwakaitika mu62% yevanhu vanotora Empliciti nelenalidomide uye dexamethasone. Kune vanhu vanotora lenalidomide uye dexamethasone voga, 52% vaive nekuneta.

Taura nachiremba wako kana iwe uchinzwa wakaneta panguva yako yekurapwa kweEmpliciti. Vanogona kukurudzira kurapwa kana iwe uchida chero uye nekupa nzira dzekudzora zviratidzo zvako.

Manyoka

Unogona kunge uine manyoka paunenge uchitora Empliciti. Mumakiriniki ekuedzwa, manyoka akaitika mu47% yevanhu vanotora Empliciti nelenalidomide uye dexamethasone. Kune vanhu vanotora lenalidomide uye dexamethasone voga, 36% vakaita manyoka.

Dhairrhea yaivewo mhedzisiro inoonekwa muvanhu vachitora Empliciti ine pomalidomide uye dexamethasone. Mumakiriniki ekuedzwa, manyoka akaitika mu18% yevanhu vanotora musanganiswa wemishonga. Pakati pevanhu vanotora pomalidomide uye dexamethasone voga, 9% yaive nemanyoka.

Taura nachiremba wako kana uine manyoka panguva yekurapwa kwako kweEmpliciti. Vanogona kukurudzira kurapwa kana iwe uchida chero uye nekupa nzira dzekudzora zviratidzo zvako.

Shanduko mumarabhoritari maitiro kana bvunzo

Iwe unogona kunge uine shanduko mune mamwe mazinga ekuedzwa kweropa paunenge uchitora Empliciti. Mienzaniso inosanganisira shanduko mu:

• masero eropa anoverengwa
• chiropa kana itsvo basa rekuyedza
• mazinga eglucose, calcium, potasium, kana sodium

Chiremba wako anogona kutarisa kuongororwa kweropa kakawanda kupfuura zvagara uchiri kutora Empliciti. Izvi zvinoita kuti chiremba wako aone kana paine shanduko mumatanho ako eropa. Kana shanduko dzakadai dzikaitika, chiremba wako anogona kuongorora kuongororwa kweropa kunyangwe kazhinji kana kukurudzira kuti umise kurapwa kweEmpliciti.

Mari yeempliciti

Sezvo nemishonga yese, mutengo weEmpliciti unogona kusiyana. Mushonga uyu unopihwa nemutsinga (IV) kumisikidzwa mumakiriniki ekuchengetedza hutano.

Mutengo chaiwo wauchabhadhara unoenderana nehurongwa hweinishuwarenzi, nzvimbo yauri, uye nzvimbo yekurapa kwaunogamuchira kurapwa kwako.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara Empliciti, kana kana iwe uchida rubatsiro kuti unzwisise yako inishuwarenzi kufukidza, rubatsiro rwuripo.

Bristol-Myers Squibb, iyo inogadzira Empliciti, inopa chirongwa chinonzi BMS Access Support. Kuti uwane rumwe ruzivo uye kuti uzive kana iwe uchikodzera rutsigiro, fona 800-861-0048 kana shanyira iyo webhusaiti chirongwa.

Empliciti chipimo chemushonga

Iyo Empliciti muyero unorayirwa nachiremba wako inoenderana nezvakati wandei zvinhu. Izvi zvinosanganisira:

• mishonga ipi yauri kutora neEmpliciti
• uremu hwemuviri wako

Yako dosi inogona kugadziridzwa nekufamba kwenguva kuti usvike iyo iyo yakakunakira iwe. Chiremba wako anozopedzisira agadza dosi diki iyo inopa zvaunoda.

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda.

Mafomu emishonga uye simba

Empliciti inouya sehupfu hwakasanganiswa nemvura isina kuchena uye ikaitwa mhinduro. Inopihwa seinopinda (IV) infusion (jekiseni mumutsipa wako kwenguva yakati rebei). Mhinduro yacho inogadzirwa uye iyo IV infusion inopihwa iwe kunzvimbo yekuchengetedza hutano.

Empliciti inowanikwa musimba mbiri: 300 mg uye 400 mg.

Dosage yeakawanda myeloma

Muyero weEmpliciti uyo waunogamuchira zvinoenderana nehuremu hwemuviri wako uye nemishonga ipi yauri kutora neEmpliciti.

Kana iwe uri kutora Empliciti ine lenalidomide (Revlimid) uye dexamethasone:

• iyo yakajairwa muyero ndeye 10 mg yeEmpliciti yekirogiramu yega yega (anenge 2.2 mapaundi) ehuremu hwemuviri wako
• iwe unozowana madhidhi evhiki eEmpliciti kwemavhiki masere ekutanga, ayo anoonekwa seanotenderera maviri, ekurapwa
• mushure memaviri ako ekutanga marapirwo, Empliciti inopihwa kamwe pasvondo mbiri

Kana iwe uri kutora Empliciti ine pomalidomide (Pomalyst) uye dexamethasone:

• iyo yakajairwa muyero ndeye 10 mg yeEmpliciti yekirogiramu yega yega (anenge 2.2 mapaundi) ehuremu hwemuviri wako
• iwe unozowana madhidhi evhiki eEmpliciti kwemavhiki masere ekutanga, ayo anoonekwa seanotenderera maviri, ekurapwa
• mushure memaviri ako ekutanga marapirwo, muyero unowedzera kusvika ku20 mg yeEmpliciti yekirogiramu yega yemuviri wako, unopihwa kamwe chete pavhiki ina

Semuenzaniso weiyo kuverenga kuverenga, munhu mukuru anorema 70 kilograms (anenge 154 mapaundi) aigashira 700 mg dose yeEmpliciti. Izvi zvinoverengerwa semakirogiramu makumi manomwe akawedzeredzwa ne10 mg yemushonga, iyo yakaenzana 700 mg yeEmpliciti.

Uine chero muyero sarudzo, iwe unowanzo ramba uchitora Empliciti kudzamara myeloma yako yakawanda yanyanya kana iwe uine zvinokanganisa mhedzisiro kubva kuEmpliciti.

Ko kana ndikapotsa dosi?

Kana iwe ukarasikirwa musangano weEmpliciti yako infusion, ronga imwe musangano nekukurumidza sezvazvinogona. Taura nachiremba wako nezvenzira yakanakisa yekuronga yako madosi emangwana kuti iwe ugone kuzviita kune ako infusions.

Ive neshuwa yekutora yako dexamethasone dose sekurairwa nachiremba wako. Kana ukarasikirwa neiyo dexamethasone, udza chiremba wako kuti wakanganwa kuitora. Kukanganwa muyero wechirwere ichi kunogona kukukonzera kuti uve nemhinduro kune Empliciti. Izvi zvinogona dzimwe nguva kuve zvakakomba.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Dzimwe nguva kushandisa mishonga kunogona kuita kuti myeloma yako yakawanda igadzikane (isingawedzere kuipa) kwenguva yakareba. Kana iwe uri kutora Empliciti uye yako yakawanda myeloma isiri kuwedzera, chiremba wako anogona kukurudzira kuti iwe ugare paEmpliciti kurapwa kwenguva refu.

Mumakiriniki miedzo, inopfuura hafu yevanhu vanotora Empliciti havana kuve nekuwedzera kwevakawanda myeloma kwemwedzi inopfuura gumi. Iyo yakareba yenguva yauchazotora Empliciti zvinoenderana nekuti muviri wako unopindura sei kumushonga.

Dzimwe nzira dzeEmpliciti

Mimwe mishonga kana marapirwo aripo anogona kubata akawanda myeloma. Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira yeEmpliciti, taura nachiremba wako. Vanogona kukuudza nezvemimwe mishonga kana kurapwa kunogona kukushandira iwe.

Mienzaniso yemamwe madhiragi ayo anogona kushandiswa kurapa akawanda myeloma anosanganisira:

• bortezomib (Velcade)
• carfilzomib (Kyprolis)
• ixazomib (Ninlaro)
• daratumumab (Darzalex)
• thalidomide (Thalomid)
• lenalidomide (Revlimid)
• pomalidomide (Pomalyst)
• mamwe steroid, akadai se prednisone kana dexamethasone

Mimwe mishonga inogona kushandiswa kurapa akawanda myeloma anosanganisira:

• radiation (inoshandisa matanda esimba kuuraya cancer maseru)
• stem sero kuisazve

Empliciti (elotuzumab) vs. Darzalex (daratumumab)

Unogona kushamisika kuti Empliciti inofananidzwa sei nemimwe mishonga inorayirwa kuti ishandiswe zvakafanana. Pano tinotarisa kuti Empliciti neDarzalex zvakafanana uye zvakasiyana.

Zvishandiso

Ose maEmpliciti neDarzalex anotenderwa neKudya neDrug Administration (FDA) kurapa akawanda myeloma muvakuru avo:

• vatove vakaedza kanenge marapirwo maviri apfuura aisanganisira lenalidomide (Revlimid) uye proteasome inhibitor, senge bortezomib (Velcade) kana carfilzomib (Kyprolis). Kune vanhu ava, kana Empliciti kana Darzalex inoshandiswa ne pomalidomide (Pomalyst) uye dexamethasone.

Empliciti inorayirwawo kune vakuru vanoti:

• vanga vaine imwe kana matatu ekurapa munguva yakapfuura yevakawanda myeloma. Kune vanhu ava, Empliciti inoshandiswa mukubatana nelenalidomide (Revlimid) uye dexamethasone.

Darzalex zvakare FDA-inogamuchirwa kurapa akawanda myeloma muvanhu vakuru vakatora imwe kana akawanda ekurapa munguva yakapfuura. Inokurudzirwa kuti ishandiswe pachayo uye mukubatana nemamwe marapirwo, zvichibva pane nhoroondo yekurapa kwemumwe nemumwe.

Mafomu emishonga uye manejimendi

Empliciti inouya sehupfu. Yakagadzirwa kuva mhinduro uye ikapihwa kwauri seinishuwa (IV) infusion (jekiseni mumutsipa wako kwenguva yakati rebei). Empliciti inowanikwa musimba mbiri: 300 mg uye 400 mg.

Yako Empliciti dosage inopesana zvichienderana nehuremu hwako uye imwe mishonga yauri kutora neEmpliciti. Kuti uwane rumwe ruzivo nezve madheji, ona chikamu "Empliciti dosage" pamusoro.

Empliciti inowanzo kupihwa vhiki yega yega kwekutanga maviri macircuit (akazara mavhiki masere) ekurapwa. Mushure meizvi, iwe unowana Empliciti vhiki mbiri kusvika ina dzese, zvinoenderana nekuti ndeipi mishonga yauri kushandisa neEmpliciti. Kuti uwane rumwe ruzivo, ndapota ona chikamu "Empliciti dosage" pamusoro.

Darzalex inouya semhinduro yemvura. Inopihwa zvakare seyakaiswa intravenous (IV). Darzalex inowanikwa musimba mbiri: 100 mg / 5 mL uye 400 mg / 20 mL.

Yako Darzalex dosage inoenderanawo nemuviri wako uremu. Nekudaro, iyo purogiramu yedosi ichasiyana zvichienderana nemishonga ipi yauri kutora naDarzalex.

Darzalex inowanzo kupihwa vhiki nevhiki kwemavhiki matanhatu kusvika mapfumbamwe. Mushure meizvi, iwe unowana Darzalex kamwe chete pavhiki mbiri kana ina, zvichienderana nekuti wave nenguva yakareba sei uchiishandisa.

Side migumisiro uye njodzi

Empliciti uye Darzalex zvese zvine mishonga inotarisa yakawanda myeloma. Naizvozvo, ese ari maviri mishonga anogona kukonzera akafanana akafanana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Yako mhedzisiro inogona kusiyana zvichienderana nemishonga ipi yauri kutora neEmpliciti kana Darzalex. Chiremba wako anogona kutsanangura chaiwo mhedzisiro mhedzisiro iwe yaunogona kusangana nayo zvichienderana nemishonga ipi yauri kutora.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yezvinowanzoitika mhedzisiro mhedzisiro inogona kuitika neEmpliciti, neDarzalex, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika neEmpliciti:
  • cataract (kuchena mumaziso eziso rako)
  • kurwadziwa mumuromo mako kana pahuro
  • kurwadziwa kwepfupa
• Zvinogona kuitika neDarzalex:
  • kushaya simba
  • kusvotwa
  • kurwadziwa shure
  • dzungu
  • kushaya hope (kunetseka kurara)
  • kuwedzerwa kweropa
  • kurwadza kwemajoini
• Zvinogona kuitika neese Empliciti uye Darzalex:
  • kuneta (kushaya simba)
  • manyoka
  • kuvimbiswa
  • kuderera kwechido
  • kupindwa nechando
  • kukosora
  • kurutsa
  • kunetseka kufema
  • mhasuru
  • kuzvimba mumaoko ako kana makumbo
  • kuwedzerwa shuga yeropa
  • musoro

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yemigumisiro yakakomba inogona kuitika neEmpliciti, neDarzalex, kana nemishonga yose (kana inotorwa zvakasiyana).

• Zvinogona kuitika neEmpliciti:
  • matambudziko echiropa
  • kugadzira mamwe marudzi ekenza, akadai segomarara reganda
• Zvinogona kuitika neDarzalex:
  • neutropenia (yakachena chena masero eropa)
  • thrombocytopenia (yakaderera platelet level)
• Zvinogona kuitika neese Empliciti uye Darzalex:
  • infusion maitiro
  • peripheral nerve chirwere (kukuvara kune dzimwe tsinga dzako)
  • zvirwere, zvakadai semabayo

Kubudirira

Empliciti uye Darzalex zvese zvinogamuchirwa kurapa akawanda myeloma muvanhu vakuru.

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki. Asi zvakaparadzana zvidzidzo zvakawana zvese Empliciti uye Darzalex kuve inoshanda pakurapa akawanda myeloma.

Mariro

Empliciti uye Darzalex ese ari maviri zita-zita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Ose maEmpliciti neDarzalex anopiwa seinopinda (IV) infusions kuchipatara. Mari chaiyo yauchabhadhara chero mishonga inoenderana neinishuwarenzi yako, nzvimbo yauri, uye kiriniki kana chipatara kwaunogamuchira kurapwa kwako.

Empliciti vs. Ninlaro

Unogona kushamisika kuti Empliciti inofananidzwa sei nemimwe mishonga inorayirwa mashandisiro akafanana. Pano tinotarisa kuti Empliciti naNinlaro zvakafanana uye zvakasiyana.

Zvishandiso

Vaviri Empliciti naNinlaro vanobvumidzwa neKudya neDrug Administration (FDA) kurapa akawanda myeloma.

Empliciti inorayirwa vanhu vanopinda mune imwe yeaya maviri mamiriro ekurapa:

• Vakuru vane imwe kana matatu kurapwa munguva yakapfuura yavo yakawanda myeloma. Kune vanhu ava, Empliciti inoshandiswa mukubatana nelenalidomide (Revlimid) uye dexamethasone.
• Vakuru vane angangoita maviri apfuura akawanda myeloma mishonga yaisanganisira lenalidomide (Revlimid) uye proteasome inhibitor, senge bortezomib (Velcade) kana carfilzomib (Kyprolis). Kune vanhu ava, Empliciti inoshandiswa musanganiswa ne pomalidomide (Pomalyst) uye dexamethasone.

Ninlaro anotenderwa kurapa akawanda myeloma muvanhu vakuru vakaedza imwe kurapwa kamwechete munguva yakapfuura. Ninlaro inogamuchirwa kuti ishandiswe pamwe chete nelenalidomide (Revlimid) uye dexamethasone.

Mafomu emishonga uye manejimendi

Empliciti inouya sehupfu. Yakagadzirwa kuva mhinduro uye ndokupihwa seinopinda (IV) infusion (jekiseni mumutsipa wako kwenguva yakati rebei). Empliciti inowanikwa musimba mbiri: 300 mg uye 400 mg.

Yako Empliciti dosage inopesana zvichienderana nehuremu hwako uye imwe mishonga yauri kutora neEmpliciti. Kuti uwane rumwe ruzivo nezve madheji, ona chikamu "Empliciti dosage" pamusoro.

Empliciti inowanzo kupihwa vhiki yega yega kumatangi maviri ekutanga (ese masvondo masere) ekurapwa. Mushure meizvi, iwe unowana Empliciti vhiki mbiri kusvika ina dzese, zvinoenderana nekuti ndeipi mishonga yauri kushandisa neEmpliciti. Kuti uwane rumwe ruzivo, ndapota ona chikamu "Empliciti dosage" pamusoro.

Ninlaro inouya semacapsule anotorwa nemuromo kamwe chete pasvondo. Ninlaro inowanikwa mune matatu masimba:

• 2.3 mg
• 3 MG
• 4 MG

Side migumisiro uye njodzi

Empliciti neNinlaro zvese zvine mishonga inobatsira kubvisa akawanda masero eemaeloma. Naizvozvo, ese ari maviri mishonga anogona kukonzera akafanana akafanana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Ninlaro inogamuchirwa chete kuti ishandiswe nelenalidomide (Revlimid) uye dexamethasone. Muchikamu chino, tiri kufananidza mhedzisiro yeNinlaro yekurapa mubatanidzwa nemhedzisiro yeEmpliciti zvakare mukubatana nelenalidomide (Revlimid) uye dexamethasone.

Yako mhedzisiro inogona kusiyana zvichienderana nemishonga ipi yauri kutora neEmpliciti kana Ninlaro. Chiremba wako anogona kutsanangura chaiwo mhedzisiro mhedzisiro iwe yaunogona kusangana nayo zvichienderana nemishonga ipi yauri kutora.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yezvinowanzoitika mhedzisiro mhedzisiro inogona kuitika neEmpliciti, neNinlaro, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika neEmpliciti kurapwa kusanganisa:
  • kuneta (kushaya simba)
  • kupindwa nechando
  • kukosora
  • kuderera kwechido
  • musoro
  • cataract (kuchena mumaziso eziso rako)
  • kurwadziwa mumuromo mako
• Zvinogona kuitika neNinlaro kurapwa kusanganisa:
  • kusvotwa
  • kuchengetwa kwemvura, izvo zvinogona kukonzera kuzvimba
  • kurwadziwa shure
• Zvinogona kuitika pamwe neese Empliciti uye Ninlaro musanganiswa wekurapa:
  • manyoka
  • kuvimbiswa
  • kurutsa

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika neEmpliciti, neNinlaro, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika neEmpliciti kurapwa kusanganisa:
  • infusion maitiro
  • hutachiona hwakakomba
  • kugadzira mamwe marudzi ekenza
• Zvinogona kuitika neNinlaro kurapwa kusanganisa:
  • thrombocytopenia (yakaderera platelet level)
  • kuputika kwakakomba kweganda
• Zvinogona kuitika pamwe neese Empliciti neNinlaro musanganiswa wekurapa:
  • peripheral nerve chirwere (kukuvara kune dzimwe tsinga dzako)
  • matambudziko echiropa

Kubudirira

Empliciti naNinlaro vese vanobvumidzwa kurapa akawanda myeloma muvanhu vakuru.

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki. Asi zvakaparadzana zvidzidzo zvakawana ese Empliciti naNinlaro kuti vabudirire pakurapa akawanda myeloma.

Mariro

Empliciti naNinlaro ese ari maviri zita-zita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Empliciti inopihwa seinopinda mutsinga (IV) kumisikidzwa kuchipatara. Ninlaro capsules inoparidzirwa nehunyanzvi hwemishonga. Mari chaiyo yauchabhadhara chero mishonga inoenderana neinishuwarenzi yako, nzvimbo yako, uye kuti unogamuchira kurapwa kwako kukiriniki kana chipatara.

Empliciti yeakawanda myeloma

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai seEmpliciti kurapa akawanda myeloma. Iyi mamiriro imhando yekenza inobata yako masero eplasma. Aya maseru rudzi rweye chena yeropa sero iyo inobatsira muviri wako kurwisa utachiona uye hutachiona.

Uine akawanda myeloma, muviri wako unoita zvisina kujairika plasma masero. Masero eplasma asina kujairika, anonzi myeloma maseru, anokanganisa masero ako ane plasma akanaka. Izvi zvinoreva kuti une mashoma masero eplasma ane hutano anokwanisa kurwisa utachiona. Myeloma masero anogadzirawo protein inonzi M protein. Iyi protein inogona kuvaka mumuviri wako uye nekukuvadza dzimwe nhengo dzako.

Empliciti inorayirwa vanhu vanopinda mune imwe yeaya maviri mamiriro ekurapa:

• Vakuru vane imwe kana matatu kurapwa munguva yakapfuura yavo yakawanda myeloma. Kune vanhu ava, Empliciti inoshandiswa mukubatana nelenalidomide (Revlimid) uye dexamethasone.
• Vakuru vane angangoita maviri apfuura akawanda myeloma mishonga yaisanganisira lenalidomide (Revlimid) uye proteasome inhibitor, senge bortezomib (Velcade) kana carfilzomib (Kyprolis). Kune vanhu ava, Empliciti inoshandiswa musanganiswa ne pomalidomide (Pomalyst) uye dexamethasone.

Kubudirira kurapa akawanda myeloma

Zvidzidzo zvekuchipatara zvakaratidza kuti Empliciti inoshanda pakumisa kufambira mberi (kuwedzera) kweakawanda myeloma. Mhedzisiro yezvimwe zvezvidzidzo izvi zvinotsanangurwa pazasi.

Empliciti ine lenalidomide (Revlimid) uye dexamethasone

Mumakiriniki ekuedzwa, vanhu vane myeloma yakawanda vakapihwa Empliciti ine lenalidomide uye dexamethasone, kana lenalidomide uye dexamethasone chete.

Zvidzidzo zvakaratidza kuti vanhu vanotora musanganiswa weEmpliciti vaive nenjodzi yakaderera yekuti chirwere chavo chifambire mberi. Kwemakore anopfuura maviri, avo vanotora Empliciti nelenalidomide uye dexamethasone vaive ne30% njodzi yakaderera pane vanhu vaitora iyo mishonga vasina Empliciti.

Mune kumwe kuongorora kwakatora makore mashanu, vanhu vaitora mubatanidzwa weEmpliciti vaive ne 27% panjodzi yakaderera yechirwere chavo ichiwedzera kupfuura vanhu vanotora lenalidomide uye dexamethasone voga.

Empliciti ine pomalidomide (Pomalyst) uye dexamethasone

Mumakiriniki ekuedzwa, vanhu vane myeloma yakawanda vakapihwa Empliciti ine pomalidomide uye dexamethasone, kana pomalidomide uye dexamethasone chete.

Vanhu vanotora mubatanidzwa weEmpliciti vaive ne46% panjodzi yakaderera yechirwere chavo ichiwedzera kuwedzera mushure memwedzi mipfumbamwe yekurapwa, zvichienzaniswa nevanhu vanotora pomalidomide uye dexamethasone voga.

Empliciti shandisa nemamwe madhiragi

Empliciti inopihwa nemimwe mishonga kana ichishandiswa kurapa myeloma yakawanda.

Multiple myeloma mishonga inoshandiswa neEmpliciti

Empliciti inogara ichishandiswa musanganiswa nesteroid inonzi dexamethasone. Iyo inogara ichishandiswa pamwe chete nelenalidomide (Revlimid) kana pomalidomide (Pomalyst). Kushandisa iyi mishonga neEmpliciti kunobatsira mushonga kuti ubudirire pakurapa myeloma yakawanda.

Pre-infusion mishonga inoshandiswa neEmpliciti

Usati wawana yako intravenous (IV) infusion yeEmpliciti, unotora mimwe mishonga inonzi pre-infusion mishonga. Iyi mishonga inoshandiswa kubatsira kudzivirira mhedzisiro (kusanganisira infusion reaction) inokonzerwa neEmpliciti kurapwa.

Iwe uchagamuchira inotevera pre-infusion mishonga ingangoita maminetsi makumi mashanu kusvika makumi mapfumbamwe pamberi pekurapwa kwako kweEmpliciti:

• Dexamethasone. Iwe uchagamuchira 8 mg ye dexamethasone ne IV jekiseni.
• Diphenhydramine (Benadryl). Iwe unotora 25 mg kusvika 50 mg yediphenhydramine pamberi peiyo Empliciti infusion. Diphenhydramine inogona kupihwa nemutsinga (IV) jekiseni kana sehwendefa inotorwa nemuromo.
• Acetaminophen (Tylenol). Iwe zvakare uchatora 650 mg kusvika ku1,000 mg yeacetaminophen nemuromo.

Mashandiro anoita Empliciti

Multiple myeloma imhando yekenza inobata mamwe machena masero eropa anonzi plasma masero. Aya maseru anobatsira muviri wako kurwisa utachiona uye hutachiona. Plasma masero anokanganiswa neakawanda myeloma anoita cancer uye anonzi myeloma masero.

Empliciti inoshanda pane imwe mhando yerudzi rweropa chena inonzi yakasikwa mhondi (NK) cell. NK maseru anoshanda mumuviri wako kuuraya masero asina kujairika, senge cancer maseru kana maseru ane utachiona.

Empliciti inoshanda nekumisikidza (kubatidza) yako maNK maseru. Izvi zvinobatsira maNK masero ako kuwana asina kujairika plasma maseru ayo anokanganiswa neakawanda myeloma. Iyo NK maseru anobva aparadza iwo asina kujairika maseru. Empliciti inoshandawo nekutsvaga iyo myeloma maseru eako masero eNK.

Empliciti inonzi immunotherapy drug. Iyi mishonga inoshanda nema immune system kubatsira muviri wako kurwisa mamwe mamiriro.

Zvinotora nguva yakareba sei kuti zvishande?

Empliciti inotanga kushanda mumuviri wako mushure mekunge wagamuchira yako infusion yekutanga. Nekudaro, iwe ungangodaro usingaone kana Empliciti inotanga kushanda. Chiremba wako achakwanisa kutarisa kana chiri kushanda nekuita imwe bvunzo. Kana iwe uine mibvunzo nezve kuti sei Empliciti iri kukushandira iwe, taura nachiremba wako.

Empliciti uye doro

Iko hakuna kumwe kuzivikanwa kuwirirana pakati peEmpliciti nedoro. Nekudaro, Empliciti inogona kukonzera matambudziko echiropa. Kunwa doro kunogona zvakare kuwedzera chiropa chako basa.

Taura nachiremba wako usati wanwa doro paunenge uchitora Empliciti. Vanogona kukuraira kana zvakachengeteka kuti iwe unwe doro paunenge uchishandisa mushonga uyu.

Kubatana kweEmpliciti

Empliciti haiwanzo kudyidzana nemimwe mishonga. Nekudaro, mishonga inoshandiswa neEmpliciti inozivikanwa kuwirirana nemimwe mishonga.

Kukurukurirana kwakasiyana kunogona kukonzera mhedzisiro. Semuenzaniso, kumwe kudyidzana kunogona kukanganisa mashandiro anoita mushonga. Kumwe kudyidzana kunogona kuwedzera mhedzisiro kana kuita kuti ive yakaoma.

Empliciti kurapwa kunogona zvakare kukanganisa mhedzisiro yeimwe bvunzo bvunzo.

Empliciti uye bvunzo dzemarabhoritari

Empliciti inogona kukanganisa mhedzisiro yemamwe bvunzo ayo anoshandiswa kutarisa M protein mumuviri wako. M protein inogadzirwa neakawanda myeloma maseru. Chikamu chepamusoro cheM protein chinoreva kuti gomarara rako rakawedzera.

Chiremba wako acharaira bvunzo kuti atarise M protein mumuviri wako panguva yeEmpliciti kurapwa. Izvi zvinoita kuti chiremba wako aone kuti muviri wako uri kupindura sei mushonga.

Nekudaro, Empliciti inogona kuchinja mhedzisiro yeM M protein yeropa bvunzo. Izvi zvinogona kuita kuti zviomere chiremba wako kuziva kana yako yakawanda myeloma iri kuvandudza kana kwete. Empliciti inogona kuita kuti iratidzike senge une yakawanda M protein kupfuura zvaunoita chaizvo. Kuti ushande uchitenderedza izvi, chiremba wako anogona kuraira bvunzo bvunzo dzisina kukanganiswa neEmpliciti kuti utarise kurapwa kwako.

Kumwe kudyidzana kwemishonga

Empliciti inogara ichitorwa ne dexamethasone uye kana pomalidomide (Pomalyst) kana lenalidomide (Revlimid). Kunyangwe paine pasina kuzivikanwa kwekudyidzana kwemishonga neEmpliciti, kune zvinozivikanwa kudyidzana kwemishonga iyo yaanoshandisa nayo.

Ive neshuwa yekukurukura nachiremba wako kana wemishonga chero zvingaite kudyidzana kwekusanganiswa kwemishonga iwe yauri kutora.

Iyo Empliciti inopihwa sei

Iwe unofanirwa kutora Empliciti zvinoenderana nachiremba wako kana rairo yemupi wezvehutano. Empliciti inopihwa nemutsinga (IV) kumisikidzwa, kazhinji kuburikidza netsinga iri muruoko rwako. Zvinodhaka zvinopihwa neIN infusion zvinopihwa zvishoma nezvishoma kwenguva yakati. Zvinogona kutora awa kana kupfuura kuti ugamuchire yako yakazara dosi yeEmpliciti.

Empliciti inongopihwa kuhofisi yechiremba kana kukiriniki yehutano. Paunenge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge wakanganisa

Nguva yekutora

Empliciti inopihwa pamazuva makumi maviri nemasere ekurapa kutenderera. Iwe kangani iwe waunotora mushonga kunoenderana nemimwe mishonga yauri kutora neEmpliciti. Iyo yakajairwa nguva yekuti iwe paunotora Empliciti ndeinotevera:

• Kana iwe uri kutora Empliciti ine lenalidomide (Revlimid) uye dexamethasone, iwe unozogamuchira Empliciti kamwe vhiki imwe neimwe kune maviri ekutanga macircuit (akazara evhiki sere) ekurapwa. Mushure meizvozvo, iwe uchagamuchira Empliciti kamwe chete pasvondo.
• Kana iwe uri kutora Empliciti ine pomalidomide (Pomalyst) uye dexamethasone, iwe unogashirawo Empliciti kamwe vhiki imwe neimwe kumatambudziko maviri ekutanga (anoverengeka evhiki sere) ekurapwa. Mushure meizvozvo, iwe uchagamuchira Empliciti kamwe chete kutenderera, inova imwe dhivhisi masvondo mana.

Chiremba wako anoongorora kurapa kwako uye otarisa kuti mangani macircuit eEmpliciti auchazoda.

Empliciti uye nhumbu

Ikoko hakuna kumbove nezvidzidzo zveEmpliciti mune vakadzi vane nhumbu. Zvidzidzo zvezvipfuwo mukuzvitakura hazvisati zvaitwa zvekare zvemushonga uyu.

Nekudaro, lenalidomide (Revlimid) uye pomalidomide (Pomalyst), ayo ese anoshandiswa neEmpliciti, anogona kukonzera kukuvadza kwakanyanya kune fetus iri kukura. Iyi mishonga haifanirwe kushandiswa panguva yekuzvitakura. Kushandisa iyi mishonga panguva yekuzvitakura kunogona kukonzera kuremara kukuru kwekuberekwa kana kupererwa nepamuviri.

Nekuti Empliciti inongogamuchirwa kuti ishandiswe nelenalidomide (Revlimid) kana pomalidomide (Pomalyst), Empliciti inofanirwawo kudzivirirwa panguva yekuzvitakura. Vanhu vanotora Empliciti vanofanirwa kushandisa kubata pamuviri kana zvichidikanwa. Ona chikamu chinotevera, "Empliciti uye kudzora kubereka," kune rumwe ruzivo.

Kana iwe uine mibvunzo nezve kushandisa Empliciti panguva yekuzvitakura, taura nachiremba wako.

Empliciti uye kudzora kuberekwa

Hazvizivikanwe kana Empliciti yakachengeteka kutora panguva yekuzvitakura.

Nekudaro, lenalidomide (Revlimid) uye pomalidomide (Pomalyst), ayo ese anoshandiswa neEmpliciti, anogona kukonzera kukuvadza kwakakomba kumucheche ari kukura. Iyi mishonga haifanirwe kushandiswa panguva yekuzvitakura. Nekuti Empliciti inogamuchirwa chete kuti ishandiswe nelenalomide kana pomalidomide, Empliciti inofanirwawo kudzivirirwa panguva yekuzvitakura.

Nekuda kweizvi, chirongwa chakakosha chakagadzirwa kubatsira kudzivirira kubata pamuviri kune vanhu vanoshandisa mishonga iyi. Chirongwa ichi chinonzi chirongwa cheRisk Evaluation uye Mitigation Strategy (REMS) chirongwa.

Vese vakadzi nevanhurume vanoshandisa Empliciti vanofanirwa kubvumirana nekutevera mirairo yeiyo Revlimid REMS kana Pomalyst REMS. Iwe unozoteedzera chirongwa cheREMS chero mishonga yauri kutora neEmpliciti. Chirongwa chega chega chine zvimwe zvinodiwa zvinofanirwa kutevedzwa kuti urambe uchitora lenalidomide kana pomalidomide.

Pamusoro pekuda vanhu vanotora Empliciti kuti vashandise mabhaisikopo, chirongwa cheREMS chinodawo kuti iwe:

• kugara uchiongorora nhumbu, kana uri munhukadzi uchishandisa mushonga
• bvuma kusapa chero ropa kana urume paunenge uchishandisa mushonga

Kudzora kuberekwa kwevakadzi

Kana iwe uri vakadzi vanokwanisa kuve nepamuviri, iwe uchafanirwa kuve nemaviri mitezo yakaipa yekuzvitakura usati watanga kushandisa ingave lenalidomide kana pomalidomide.

Paunenge uchitora chero imwe yemishonga iyi, iwe unofanirwa kushandisa maviri mafomu ekudzivirira kuberekwa kana kurega bonde panguva yekurapa. Iwe unofanirwa kuenderera kushandisa kushandisa kuberekwa kana kurega bonde kweanopfuura mavhiki mana mushure mekumira kurapwa.

Kudzora kubereka kwevarume

Kana iwe uri murume anotora Empliciti pamwe neleneralomide kana pomalidomide, uye iwe uchiita zvepabonde nemadzimai anokwanisa kuve nepamuviri, uchafanirwa kushandisa kuberekwa (semakondomu) panguva yekurapa. Izvi zvakakosha kuti uite kunyangwe mumwe wako achishandisa mabhaisikopo. Iwe unofanirwa kuenderera uchishandisa kushandisa kuberekwa kweanopfuura mavhiki mana mushure mekumira kurapwa.

Empliciti uye kuyamwisa

Iko hakuna chero zvidzidzo zvinoratidza kana Empliciti inopfuura mumukaka wemukaka wevanhu kana kana ichikonzera chero migumisiro mumwana anoyamwa.

Izvo hazvizivikanwe kana lenalidomide (Revlimid) uye pomalidomide (Pomalyst) inogona kukonzera chero mhedzisiro muvana. Nekudaro, nekuda kwenjodzi yemhedzisiro yakakomba muvana, kuyamwisa kunofanirwa kudzivirirwa uchitora Empliciti.

Mibvunzo yakajairika nezve Empliciti

Heano mhinduro kumimwe mibvunzo inowanzo bvunzwa nezve Empliciti.

Icho Empliciti chemotherapy?

Kwete, Empliciti haina kunzi chemotherapy (echinyakare mishonga inoshandiswa kurapa cancer). Chemotherapy inoshanda nekuuraya maseru mumuviri wako ari kukurumidza kuwanda (kugadzira mamwe maseru). Kunyangwe izvi zvichiuraya maseru ekenza, zvinogona zvakare kuuraya mamwe maseru ane hutano.

Kusiyana neyakajairwa chemotherapy, Empliciti chirwere chakanangwa. Rudzi urwu rwemushonga runoshanda pane mamwe maseru (anonzi chaiwo maseru anouraya), kunanga maseru ekenza. Nekuti Empliciti inovavarira rakakosha boka remasero, haina kukanganisa maseru ako ane hutano zvakanyanya. Izvi zvinoreva kuti zvinogona kukonzera mashoma mhedzisiro pane yakajairwa chemotherapy.

Chii chichaitika pakurapwa kwangu kweEmpliciti?

Empliciti inopihwa seinopinda (IV) infusion (jekiseni mumutsipa wako kwenguva yakati rebei). IV inowanzoiswa muruoko rwako.

Iwe unowanzo gashira dhosi imwe yeEmpliciti svondo rega rega pamatanho maviri ekutanga ekurapa. (Kutenderera kwega kwega mazuva makumi maviri nemasere.) Ipapo, iwe unogona kuwana kumisikidzwa kamwe chete pasvondo mbiri kana kamwe kamwe pavhiki ina. Iyi chikamu cheyako dosing purogiramu inoenderana nemishonga ipi yauri kutora neEmpliciti.

Iyo yakareba yenguva yekumanikidza kwese inotora zvinoenderana nehuremu hwemuviri wako uye kuti mangani madosi eEmpliciti iwe watogamuchira.

Mushure meyero yako yechipiri yeEmpliciti, yako infusion haifanire kutora nguva inopfuura awa rimwe. Zvinogona kubatsira kuunza chimwe chinhu chekuita panguva yako infusions kuita kuti nguva ipfuure nekukurumidza. Semuenzaniso, unogona kuuya nebhuku kana magazini kuti uverenge kana mimhanzi yekuterera.

Usati wawana yako Empliciti infusion, iwe unowana mamwe mimwe mishonga yekubatsira kudzivirira mamwe mhedzisiro, kusanganisira infusion reaction. Iyi mishonga inonzi pre-infusion mishonga.

Iyo pre-infusion mishonga iwe yauchazopihwa pamberi peEmpliciti infusion yako ndeiyi:

• diphenhydramine (Benadryl)
• dexamethasone
• acetaminophen (Tylenol)

Ndichaziva sei kana Empliciti iri kundishandira?

Empliciti inoshanda nekubatsira immune system yako kurwisa akawanda masero eemaeloma. Chiremba wako anokwanisa kuona kuti immune system yako iri kupindura sei pakurapwa nekuraira muyedzo kuti utarise mapuroteni eM.

M mapuroteni anogadzirwa nemasero akawanda emyeloma. Aya mapuroteni anogona kuvaka mumuviri wako uye kukonzera kukuvara kune dzimwe nhengo dzako. Chikamu chepamusoro cheM protein chinoonekwa muvanhu vane yakawanda yepamusoro myeloma.

Chiremba wako anogona kutarisa ako M mapuroteni mazinga kuti aone kuti uri kupindura sei kurapwa. M mapuroteni mazinga anogona kuyedzwa nekutarisa ropa kana weti sampuro.

Chiremba wako anogona zvakare kuongorora mhinduro yako pakurapwa nekuraira mapfupa anowoneka. Aya scans anoratidza kana iwe uine mamwe mapfupa ekuchinja anokonzerwa neakawanda myeloma.

Kushandisa Empliciti kunogona kundikonzera kuva nemamwe marudzi ekenza here?

Zvinogona kudaro. Kushandisa Empliciti kurapa akawanda myeloma kunogona kuwedzera njodzi yako yekuve nemamwe marudzi ekenza.

Mumakiriniki ekuedzwa, 9% yevanhu vanotora Empliciti ine lenalidomide (Revlimid) uye dexamethasone yakagadzira imwe mhando yekenza. Kune vanhu vanotora chete lenalidomide uye dexamethasone, 6% yakave nemhedzisiro yakafanana. Mhando dzekenza yakavapo yaive kenza yeganda uye mamota akaomarara, senge kenza yemuzamu kana yeprostate.

Zvakare mumakiriniki ekuedzwa, 1.8% yevanhu vanotora Empliciti ine pomalidomide (Pomalyst) uye dexamethasone yakagadzira imwe mhando yekenza. Pakati pevanhu vanotora pomalidomide uye dexamethasone voga, hapana akagadzira imwe mhando yekenza.

Panguva yekurapwa neEmpliciti, chiremba wako anogona kuraira kuwedzerwa kuongororwa kweropa kana kuongororwa kuti akuteerere kune chero kenza nyowani dzichiri kukura.

Empliciti matanho

Usati watora Empliciti, taura nachiremba wako nezve nhoroondo yako yehutano. Empliciti inogona kunge isingave yakakunakira iwe kana uine mamwe marapirwo. Izvi zvinosanganisira:

• Kubata. Hazvizivikanwe kana Empliciti inokuvadza kune mwana ari kukura. Nekudaro, Empliciti inoshandiswa neine lenalidomide (Revlimid) kana pomalidomide (Pomalyst). Ose madhiragi aya anozivikanwa kuti anokonzera kuremara kwekuberekwa. Nekuda kweizvi, vanhu vanotora chero lenalidomide kana pomalidomide vanofanirwa kushandisa kubata pamuviri kudzivirira kubata pamuviri pavanenge vachishandisa mishonga iyi. Kuti uwane rumwe ruzivo, ndapota ona chikamu "Empliciti uye nhumbu" pamusoro.
• Kuyamwisa. Hazvizivikanwe kana Empliciti ichipfuura muchipfuva chemunhu. Nekudaro, nekuda kwenjodzi yemhedzisiro yakakomba muvana, kuyamwisa kunofanirwa kudzivirirwa uchitora Empliciti. Kuti uwane rumwe ruzivo, ndapota ona chikamu "Empliciti uye kuyamwisa" pamusoro.
• Zvirwere zvazvino. Iwe haufanire kutanga kutora Empliciti kana uine hutachiona hwehutachiona. Izvi zvinosanganisira furuu yakajairika, furuwenza, kana zvimwe hutachiona uye hutachiona hutachiona. Chiremba wako anogona kukurudzira kuti utange Empliciti mushure mekunge warapwa chero hutachiona. Izvi zvinodaro nekuti Empliciti inogona kushomeka immune system yako, izvo zvinoita kuti zvive zvakaoma kurwisa hutachiona.

Ongorora: Kuti uwane rumwe ruzivo nezve zvingangoitika zvakaipa zveEmpliciti, ona iyo "Empliciti mhedzisiro" chikamu pamusoro.

Ruzivo rwehunyanzvi rweEmpliciti

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Zviratidzo

Empliciti inoratidzirwa kurapa akawanda myeloma muvanhu vanopinda mune imwe yeaya maviri mamiriro ekurapa:

• Vakuru avo vakambogamuchira imwe kusvika kumatatu ekurapwa. Mune vanhu ava, Empliciti inoshandiswa nelenalidomide (Revlimid) uye dexamethasone.
• Vakuru vakatogamuchira kanopfuura maviri marapirwo aisanganisira lenalidomide (Revlimid) uye chero proteasome inhibitor. Mune vanhu ava, Empliciti inoshandiswa ne pomalidomide (Pomalyst) uye dexamethasone.

Empliciti haina kuratidzwa kuti ishandiswe mune vanhu vari pasi pemakore gumi nemasere ekuberekwa.

Nzira yekuita

Empliciti ndeye IgG1 monoclonal antibody iri immunostimulatory. Empliciti inoshanda nekutarisa iyo Signaling Lymphocytic Activation Molecule Mhuri yemhuri 7 (SLAMF7).

SLAMF7 inoratidzirwa kwete chete pane chaiwo mhondi (NK) masero uye masero eplasma muropa, asiwo pane akawanda myeloma maseru. Empliciti inoshanda nekufambisa kuparadzwa kwemasero emyeloma kuburikidza neanorwisa-inotenderera maseru cytotoxicity (ADCC). Iyi michina inoshanda nekuda kwekudyidzana pakati peNK masero uye masero ane hutachiona hwemyeloma. Zvimwe zvidzidzo zvinoratidza kuti Empliciti inogona zvakare kubatsira kumisikidza NK maseru, ayo anobva atsvaga nekuparadza masero emyeloma.

Pharmacokinetics uye metabolism

Empliciti clearance inowedzera sezvo huremu hwemuviri huchiwedzera. Empliciti yakaratidza nonlinear pharmacokinetics, uko kuwedzera kwedosi kwakakonzera kuratidzwa kukuru kune mushonga kupfuura zvakafanotaurwa.

Contraindications

Empliciti haina chaiyo inopesana. Zvisinei, inofanira kudzivirirwa mumadzimai ane pamuviri kana inotorwa sezvakaratidzwa, iyo inosanganisira kushandiswa kwepomalidomide kana lenalidomide.

Kuchengetedza

Empliciti inowanikwa seiri 300 mg kana 400 mg yeiyo lyphilized poda mune imwechete-yekushandisa vial. Iyo poda inofanirwa kugadziriswazve uye kusanganiswa isati yagadziriswa.

Empliciti poda inofanirwa kuchengetwa mufiriji (pane tembiricha ye36 ° F kusvika 46 ° F / 2 ° C kusvika 8 ° C) uye inodzivirirwa kubva pachiedza. Usagwamba kana kuzunza hombodo.

Kana poda yacho yagadziriswa, mhinduro yacho inofanirwa kuiswa mukati maawa makumi maviri nemana. Mushure mekusanganisa, kana iyo infusion ikasashandiswa ipapo ipapo, inofanira zvakare kuve firiji yakachengetedzwa kubva pachiedza. Mhinduro yeEmpliciti inofanirwa kuchengetwa kwemaawa masere (emaawa makumi maviri nemana ese) pane tembiricha yemukati uye mwenje wemukati.

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.