Spironolactone (Aldactone)

Zvemukati

• Chii ichochi
• Sei kutora
• 1. Zvakakosha neBP
• 2. Kukundikana Kwemwoyo Kukundikana
• 3. Chiropa cirrhosis
• 4. Nephrotic Syndrome
• 5. Edema
• 6. Hypokalemia / hypomagnesaemia
• 7. Preoperative kurapwa kwePrimary Hyperaldosteronism
• 8. Hutachiona hweBP
• Nzira yekuita
• Zvinogona kuitika mhedzisiro
• Contraindications

Spironolactone, inozivikanwa nekutengesa seAldactone, inoshanda sedhiraivhu, ichiwedzera kubviswa kwemvura kuburikidza neweti, uye seyakawandisa, uye inogona kushandiswa pakurapa kweBP, kuzvimba kwakanangana nezvinetso mukushanda kwemoyo kana zvirwere. muchiropa neitsvo, hypokalemia kana pakurapa hyperaldosteronism, semuenzaniso.

Mune zvimwe zviitiko, uyu mushonga unogona kupihwa kurapwa kweacne uye kudzivirira kurasikirwa nevhudzi, zvisinei izvi zvinoshandiswa hazvisi chikamu chezvakakosha zvinoratidza spironolactone, uye hazvitaurwe mupakeji yekuisa.

Spironolactone inogona kutengwa muma pharmacies, nemutengo unosvika gumi nemana kusvika makumi mana nemashanu reais, zvinoenderana nekuti munhu anosarudza iyo kani kana iyo generic, inoda kuratidzwa kwemushonga.

Chii ichochi

Spironolactone inoratidzirwa ye:

• Yakakosha hypertension;
• Edema inokonzerwa nemoyo, itsvo kana chiropa matambudziko;
• Ediopathic edema;
• Rubatsiro rwekubatsira muhutachiona hwehutachiona;
• Hypokalemia apo mamwe matanho anoonekwa seasina kukodzera kana kukwana;
• Kudzivirira kwe hypokalemia uye hypomagnesaemia muvanhu vanotora diuretics;
• Kuongororwa uye kurapwa kweiyo hyperaldosteronism.

Dzidza nezve mamwe marudzi e diuretics uye dzidza mashandiro avo.

Sei kutora

Muyero unoenderana nedambudziko rekurapwa:

1. Zvakakosha neBP

Iyo yakajairwa dosi ndeye 50 mg / zuva kusvika 100 mg / zuva, iyo mune isingagadzike kana yakaoma kesi inogona kuwedzerwa zvishoma nezvishoma, mukati mevhiki mbiri, kusvika ku200 mg / zuva. Kurapa kunofanirwa kuenderera kweinenge vhiki mbiri kuti uve nemhinduro yakakwana pakurapwa. Iyo dose inofanirwa kugadziriswa pazvinenge zvichidikanwa.

2. Kukundikana Kwemwoyo Kukundikana

Iyo yakakurudzirwa kutanga zuva rega rega ndeye 100 mg mune imwe chete kana yakakamurwa dosi, iyo inogona kusiyana pakati pe25 mg ne200 mg zuva nezuva. Iyo yakajairwa yekuchengetedza dosi inofanirwa kutemerwa munhu wega wega.

3. Chiropa cirrhosis

Kana iyo urinary sodium / urinary potasiamu chiyero chakakura kudarika 1, iyo yakajairwa dhiyo ndeye 100 mg / zuva. Kana ichi chiyero chiri pasi pe1, iyo inokurudzirwa dosi ndeye 200 mg / zuva kusvika 400 mg / zuva. Iyo yakajairwa yekuchengetedza dosi inofanirwa kutemerwa munhu wega wega.

4. Nephrotic Syndrome

Iyo yakajairwa muyero muvakuru ndeye 100 mg / zuva kusvika 200 mg / zuva.

5. Edema

Iyo yakajairwa dhosi ndeye 100 mg pazuva kune vanhu vakuru uye ingangoita 3.3 mg pa kg yehuremu inoitiswa muchikamu chepakati. Muyero unofanirwa kugadziriswa zvichienderana nemhinduro uye kushivirira kwemunhu wega wega.

6. Hypokalemia / hypomagnesaemia

Muyero we25 mg / zuva kusvika 100 mg / zuva inokurudzirwa pakurapa hypopotassemia uye / kana hypomagnesemia inokonzerwa ne diuretics, apo muromo we potassium uye / kana magnesium zvinowedzera zvisina kukwana.

7. Preoperative kurapwa kwePrimary Hyperaldosteronism

Kana kuongororwa kwe hyperaldosteronism kwakanyatsogadziriswa nemimwe miedzo yakajeka, spironolactone inogona kupihwa muyero yezuva nezuva ye100 mg kusvika 400 mg mukugadzirira kuvhiya.

8. Hutachiona hweBP

Inofanirwa chete kushandiswa seyekurapa kwekubatsira uye kana paine zvakawandisa secretion yealdosterone, hypokalemia uye metabolic alkalosis. Iyo yekutanga dhizeti ndeye 100 mg / zuva, iyo inogona kuwedzerwa, kana zvichidikanwa, panguva dzevhiki mbiri, kusvika ku400 mg / zuva.

Nzira yekuita

Spironolactone yakasarudzika aldosterone antagonist, inoshanda zvakanyanya pane aldosterone-inotsamira sodiamu uye potasium ion nzvimbo yekutsinhana, iri mune yakasarudzika yakatsanangurwa tubule yeitsvo, zvichikonzera kuwedzera sodium uye mvura kubviswa uye kuwedzera potasium chengetedzo.

Zvinogona kuitika mhedzisiro

Mimwe mhedzisiro yespironolactone inogona kusanganisira benign zamu neoplasm, leukopenia, thrombocytopenia, kukanganisika kwemagetsi, shanduko mu libido, kuvhiringidzika, dzungu, kusagadzikana kwepamuviri uye kusvotwa, chisina kujairika chiropa basa, Steve-Johnson syndrome, chepfu epidermal necrolysis, kuputika kwemishonga, bvudzi kurasikirwa, hypertrichosis, kuvaviwa, mikoko, makumbo makumbo, chakakomba itsvo kutadza, kurwadziwa nemuzamu, kuenda kumwedzi, gynecomastia uye malaise.

Contraindications

Spironolactone haifanire kushandiswa nevanhu vane hypersensitive kune izvo zvinoumba fomula, vanhu vane chakakomba itsvo kutadza, kukanganisika kukuru kweitsvo basa, anuria, chirwere cheAdisonison, hyperkalaemia kana vari kushandisa mushonga unonzi eplerenone.