FAN bvunzo: chii icho, chii chairi uye mhedzisiro

Zvemukati

• Chii ichochi
• Maitirwo ebvunzo
• Kugadzirira kupi kunodiwa
• Zvinoreva mhedzisiro

Iyo ANA bvunzo rudzi rwemuyedzo unoshandiswa zvakanyanya kubatsira mukuongororwa kwezvirwere zvemuviri, kunyanya Systemic Lupus Erythematosus (SLE). Nekudaro, bvunzo iyi inovavarira kuona kuvepo kwema autoantibodies muropa, ayo ari masoja ekudzivirira anogadzirwa nemuviri uye anorwisa maseru nematukisi pachawo.

Iyi bvunzo inoenderana neiyo fluorescence pateni yemasoja ekudzivirira, ichiita kuti zvikwanise kuitarisa pasi peiyo microscope uye kubatsira mukuongororwa kwezvirwere zvakasiyana siyana. Kunyangwe zvakajairika kuve nemhedzisiro yakadzika pakuyedzwa kweANA, kana nhamba iyi yakanyanya kukwirira, zvinogona kureva kuti kune chirwere chemuviri, chinoda kuzivikanwa nekurapwa nekukurumidza sezvinobvira kubvisa zviratidzo.

Chii ichochi

Iyi FAN bvunzo inogona kubatsira kuongorora autoimmune hosha dzakadai se:

• Lupus, chinova chirwere che autoimmune chinozivikanwa ne inflation yejojo, ganda, maziso neitsvo, semuenzaniso;
• Rheumatoid arthritis, umo mune kurwadziwa, kutsvuka uye kuzvimba kwemajoini. Heano maitiro ekuziva rheumatoid arthritis;
• Wechidiki idiopathic arthritis, umo mune kuzvimba kweimwe kana kupfuura majoini muvana;
• Autoimmune hepatitis, umo kuvapo kwe autoantibodies kunokonzera kuzvimba muchiropa. Ziva izvo zvakakosha zviratidzo zve autoimmune hepatitis;
• Scleroderma, inova autoimmune chirwere chinoonekwa nekuwedzera kugadzirwa kwe collagen, ichikonzera ganda nemajoini kuomesa;
• Dermatomyositis, chinova chirwere chinoputira chinoonekwa nekushomeka kwemhasuru uye maronda edermatological. Dzidza zvakawanda nezve dermatomyositis;
• Sjogren's chirwere, iyo inoratidzirwa nekuzvimba kwezvipenga zvakasiyana mumuviri, zvichikonzera kuoma maziso nemuromo, semuenzaniso. Heano maitiro ekuziva zviratidzo zveSjogren's Syndrome.

Kazhinji, chiremba anogona kunyumwira zvirwere izvi kana munhu aine zviratidzo zvinotora nguva yakareba kuti zvitsakatike, senge nzvimbo dzvuku pamuviri, kuzvimba, kugara uchirwadziwa mumajoini, kuneta zvakanyanya kana kupisa fivhiri, semuenzaniso.

Maitirwo ebvunzo

Muedzo uyu uri nyore kwazvo, zvinongoda kuti chikamu chidiki cheropa chibviswe nenyanzvi yakadzidziswa, iyo inotumirwa kurabhoritari kunoongororwa.

Kuunganidzwa kweropa kunowanzoitwa kuchipatara, asi kunogona zvakare kuitwa kumakiriniki akakosha, ese evakuru nevana. Panyaya yevacheche, iko kuunganidzwa kunowanzoitwa nekamwe kadiki petsoka, pasina chikonzero chekushandisa tsono.

Murabhoritari, kuongororwa kunoitwa nekuwedzera dhayi ye fluorescent yakaratidzirwa nemasoja ekudzivirira muviri anoonekwa mumuenzaniso. Ipapo, iro ropa rine dhayi rakanyorwa rakaiswa mumudziyo une tsika yemasero emunhu anozivikanwa seHep-2 maseru, ayo anotendera iwo iwo maonero akajeka ezve akasiyana maseru maseru uye zvikamu zvechitokisi kutenderera. Nekudaro zvinokwanisika kuita kuongororwa, nekuti kunoitwa kubva kune iyo fluorescence pateni inoonekwa kuburikidza nemicroscope.

Kugadzirira kupi kunodiwa

Iko hakuna yakasarudzika mhando yekugadzirira iyo FAN bvunzo, zvinongokurudzirwa chete kuzivisa chiremba nezve mushonga uri kushandiswa uye zvinogona kuitika matambudziko ehutano.

Zvinoreva mhedzisiro

Muvanhu vane hutano, iyo FAN bvunzo inowanzo kuve isina kunaka kana isiri-inoshanda, ine hunhu senge 1/40, 1/80 kana 1/160. Zvisinei, izvi hazvirevi kuti pese pazvinenge zvisina kunaka, hapana chirwere chemuviri. Nekudaro, kunyangwe kana iri negative, uye zvinoenderana nezviratidzo zvinoratidzwa, chiremba anogona kuraira kumwe kuyedzwa kuti asimbise kuti hachisi chirwere chemuviri.

Kana mhedzisiro iri yakanaka, kana reagent, inowanzo kupa kukosha kwe 1/320, 1/640 kana 1/1280. Uye zvakare, kune zvakare positivity pateni iyo inoenderana ne fluorescence inoonekwa pasi pe microscope, iyo inobatsira kusiyanisa zvirinani mhando yechirwere uye iyo inogona kusanganisira:

• Nyukireya yakafanana: inogona kuratidza kuvepo kwe lupus, rheumatoid arthritis kana yevechidiki idiopathic arthritis, zvinoenderana nemutachiona anoonekwa. Kana kuvepo kweanti-DNA, anti-chromatin uye anti-histone antibodies ikazivikanwa, izvi zvinoratidza lupus;
• Nyukireya ine macentromeric: inowanzo kuratidza scleroderma;
• Nyukireya yakanaka yakavezwa: inowanzo kuratidza Sjögren's syndrome kana lupus, zvinoenderana neanorwisa utachiona anoonekwa;
• Nyukireya yakazara: lupus, rheumatoid arthritis kana systemic sclerosis maererano nema antibodies anozivikanwa;
• Yakanaka ine cytoplasmic: inogona kuva polymyositis kana dermatomyositis;
• Inoenderera membrane yenyukireya: inogona kuratidza autoimmune hepatitis kana lupus;
• Iine Nucleolar: inowanzo chiratidzo che systemic sclerosis.

Mhedzisiro iyi inofanira kugara ichidudzirwa uye kuongororwa nachiremba uye, mune zvese zviitiko, kumwe kuyedzwa kunodiwa usati wasimbisa kuongororwa.