Muchero Wemazambiringa Yambiro: Iyo Inogona Kuwirirana neyakajairika Mishonga

Zvemukati

• Inobatana sei nemishonga?
• 1-3: Mimwe mishonga yecholesterol
• 4-7: Imwe mishonga yeropa
• 8-9: Mishonga mishoma yemwoyo mutinhimira
• 10-13: Mimwe mishonga yekurwisa hutachiona
• 14-20: Mimwe mishonga yemafungiro
• 21–24: Vamwe vanoonda ropa
• 25–27: Mishonga yekurwadziwa yakati wandei
• 28-31: Mashoma erectile kudzvinyirira uye mishonga yeprostate
• Unofanira here kusiya chibereko?
• Chinokosha

Grapefruit chibereko chinonaka checitrus chine mabhenefiti mazhinji ehutano. Nekudaro, inogona kusangana nemimwe mishonga yakajairika, ichichinja mhedzisiro yavo pamuviri wako.

Kana iwe uchida kuziva nezve yambiro yemuzambiringa pamishonga yakawanda, chinyorwa ichi chinokubatsira kuti unzwisise kuti nei chiripo uye kuti ndezvipi zvaunogona kusarudza.

Heino kunyatso tarisa makumi matatu nematatu madhiragi anogona kuve nekudyidzana kune njodzi ne grapefruit, pamwe nedzimwe nzira.

Ongorora: Chinyorwa ichi chine ruzivo rwevose - kwete chairo zano rekurapa. Taura nachiremba wako usati wachinja kushandisa kwako chero mushonga.

Inobatana sei nemishonga?

Mishonga inogadziriswa muchiropa chako uye mudumbu ura neboka rakasarudzika remapuroteni anonzi cytochrome P450 (CYPs).

CYPs inoputsa mishonga, ichideredza huwandu hweropa hwakawanda hwayo.

Muchero wemazambiringa uye vashoma vehama dzayo dzepedyo, seSeville orenji, tangelos, pomelos, uye Minneolas, zvine kirasi yemakemikari anonzi furanocoumarins.

Furanocoumarins anovhiringidza zvakajairika mashandiro eCYPs. Muchokwadi, ongororo dzinoratidza kuti ivo vanowedzera huwandu hweropa hunopfuura 85 mishonga (1).

Nekudzora nzira iyo maCYP anowanzo kupaza mishonga muura hwako uye chiropa, grapefruit inogona kuwedzera mhedzisiro yemishonga iyi (1).

Pane zvinhu zvitatu zvekuziva kuti unzwisise kuti uye sei uye nekugona kuti ungadya zvakadii grapefruit nemishonga iyi.

1. Hazvitore zvakawanda. Rimwe bharanzi kana rimwe girazi remuto wemazambiringa rinokwana kushandura kuti mishonga iyi inokukanganisa sei.
2. Migumisiro yaro inopedza mazuva akawanda. Kukwanisa kweGrapefruit kukanganisa mishonga kunogara kwemazuva 1-3. Kutora mishonga yako maawa mashoma kunze kwekuishandisa haina kukwana zvakakwana.
3. Zvakakosha. Kune chiverengero chidiki chemishonga, mhedzisiro yemhedzisiro inogona kuve yakakomba.

Uine izvo mupfungwa, heino ruzivo rwakadzama nezve makumi matatu nemaviri mishonga inowirirana iyo inogona kudyidzana ne grapefruit, yakakamurwa nekushandiswa.

1-3: Mimwe mishonga yecholesterol

Mimwe mishonga yecholesterol inonzi statins inobatwa ne grapefruit.

Statins inoshanda nekudzivirira kugadzirwa kwechisikigo kwecholesterol. Izvi zvinovandudza chimiro che lipoprotein muropa uye zvinoderedza kufa kubva kuchirwere chemwoyo kune varwere vari panjodzi yacho ().

Statins dzinogona kukonzera rhabdomyolysis, kana kuparara kwemhasuru nyama. Izvi zvinotungamira kukundikana kwemhasuru, kurwadziwa, uye dzimwe nguva kukuvara kweitsvo ().

Muchero wemichero unowedzera huwandu hweropa hwezvitatu zvakajairika statins zvakanyanya, zvichiwedzera njodzi ye rhabdomyolysis ():

1. Atorvastatin (Lipitor)
2. Lovastatin (Mevacor)
3. Simvastatin (Zocor)

Imwe ongororo yakaratidza kuti kunwa girazi remuzivi wemuzambiringa ne simvastatin kana lovastatin kwakawedzera huwandu hweropa hweaya masisitendi ne 260% ().

Dzimwe nzira: Pravastatin (Pravachol), rosuvastatin (Crestor), uye fluvastatin (Lescol) haibatanidze nemuzambiringa (1).

Grapefruit inogona kuwedzera iyo mhedzisiro yemamwe statin cholesterol mishonga, ichikonzera kukuvara kwemhasuru.

4-7: Imwe mishonga yeropa

Mazhinji mhando dzemishonga yekumanikidza kweropa haina kukanganiswa ne grapefruit.

Nekudaro, inotevera ina ropa reropa mishonga inofanira kushandiswa zvine hungwaru:

1. Felodipine
2. Nifedipine (Procardia)
3. Losartan (Cozaar)
4. Eplerenone (Inspra)

Mishonga miviri yekutanga mune ino chinyorwa inozivikanwa se calcium chiteshi blockers. Ivo vanoshanda nekushandura mashandisiro anoita tsinga dzako dzeropa calcium, kuzorodza iyo midziyo, uye kurerutsa BP.

Mishonga miviri yekupedzisira mune ino runyorwa inoshanda nekuderedza chiitiko chehomoni inonzi angiotensin 2, iyo inowanzo wedzera kuwedzera kweropa.

Imwe ongororo yakawana huwandu hweropa re nifedipine hwakawedzera zvakanyanya kana ichitorwa pamwe nemikombe miviri (500 mL) yemuto wemazambiringa, zvichienzaniswa isina muto. Izvi zvakakonzera kudonha nekukurumidza kweropa, izvo zvinogona kuve nenjodzi kana zvisina kuchengetedzwa ().

Losartan haina kujairika nekuti chibereko chinoderedza zvainoita, zvichikanganisa kugona kwayo kudzora BP ().

Eplerenone inoshanda zvakafanana kune losartan, asi ayo mwero anowedzera kana atorwa ne grapefruit. Kuwedzeredza eplerenone mazinga kunogona kukonzera potassium yakawandisa muropa, iyo inogona kukanganisa moyo mutinhimira (1).

Dzimwe nzira: Spironolactone (Aldactone), mushonga wakafanana kune losartan uye eplerenone, haibatanidze nemuzambiringa. Amlodipine (Norvasc) ndeye calcium chiteshi blocker senge felodipine uye nifedipine, iyo zvakare isingadyidzane ne grapefruit (,).

Kunyangwe chibereko chemuzambiringa chisingapindire nemishonga yakawanda yeropa, zvinogona kukonzera mishoma mishonga yekuwedzeredza BP.

8-9: Mishonga mishoma yemwoyo mutinhimira

Muchero wemazambiringa unokanganisa mishoma mishonga iyo inobata zvisina kujairika moyo zvitaira.

Uku kudyidzana kunogona kuve nenjodzi uye kunosanganisira:

1. Amiodarone
2. Dronedarone (Multaq)

Chidzidzo chakapa varume gumi nevaviri vaitora amiodarone girazi remuto wemazambiringa (anenge mazana matatu mL). Matanho emishonga akawedzera kusvika pa84%, zvichienzaniswa nevaya vasinganwe jisi ().

Iyi mishonga miviri inoita basa rakakomba mukugadzirisa hutano hwevarwere vane moyo mutserendende kusagadzikana. Shanduko dzakanangana nemichero yemichero, mumatanho emishonga iyi dzimwe nguva yakakonzera shanduko yemoyo kurira ().

Kunyangwe paine mashoma moyo Rhythm mishonga inowirirana ne grapefruit, iyo mhedzisiro inogona kuve nenjodzi.

10-13: Mimwe mishonga yekurwisa hutachiona

Pamwechete inonzi antimicrobials, iyi inorwisa hutachiona mishonga inosiyana zvakanyanya mukuita kwavo uye kuparara mumuviri.

Kunyangwe maantimicrobials ari mamwe emhando dzakasiyana dzemishonga, pane mishonga mishoma chete ine mukurumbira wekudyidzana kwemazambiringa.

1. Erythromycin
2. Rilpivirine uye zvine hukama nemishonga yeHIV
3. Primaquine uye zvine hukama nemishonga yemalaria
4. Albendazole

Erythromycin inoshandiswa kurapa akati wandei marudzi ehutachiona hutachiona. Chidzidzo chakafananidza jusi remuzambiringa nemvura muvarwere vanotora erythromycin zvakaratidza kuti muto wakawedzera huwandu hweropa remushonga ne84% ().

Kuwedzera kwehuwandu hwemushonga uyu kunogona kukanganisa moyo mutinhimira ().

Muchero wemazambiringa unowedzerawo mazinga emishonga yeHIV rilpivirine uye maraviroc, kuwedzera kune primaquine-inosangana nemishonga yemalaria. Izvi zvinogona kukanganisa moyo mutinhimira kana basa (1).

Nekuti mishonga inorwisa mabhakitiriya inowanzo kutorwa kwenguva yakati rebei, pamwe zviri nyore kungodzivirira grapefruit uchinwa mishonga iyi.

Dzimwe nzira: Clarithromycin imishonga mukirasi imwechete seyrythromycin isingawirirane ne grapefruit. Doxycycline ese ari maviri maantibioti uye antimalarial mushonga uyo zvakare haufambidzane nawo (1).

Mimwe mishonga yekurwisa hutachiona haifanirwe kushandiswa ne grapefruit, nekuti inogona kutungamira mukukanganisa mutinhimira wemoyo kana basa.

14-20: Mimwe mishonga yemafungiro

Mazhinji mishonga yekudzvinyirira uye inorwisa-kushushikana mishonga yakachengeteka kushandisa neye grapefruit.

Zvisinei, mishonga yakawanda yemafungiro inosangana nayo, kusanganisira:

1. Quetiapine (Seroquel)
2. Lurasidone (Latuda)
3. Ziprasidone (Geodon)
4. Buspirone (Buspar)
5. Diazepam (Valium)
6. Midazolam (Ndima)
7. Triazolam (Halcion)

Zvinodhaka senge quetiapine uye lurasidone zvinoshandiswa kurapa kusagadzikana uye kusagadzikana kwehunhu. Kuwedzera kwehuwandu hwemishonga iyi kunogona kukonzera shanduko yemoyo kana kurara (1).

Zvakare, diazepam, midazolam, uye triazolam ndiwo mamwe madhiragi ayo dzimwe nguva anoshandiswa kutyisidzira kana dzimwe nzira dzekushushikana.

Imwe ongororo yakafananidza mimwe yemishonga iyi muvarwere vapfumbamwe, vamwe vacho vaidya grapefruit. Yakaratidza kuti grapefruit inogona kuwedzera izvi zvinodhaka 'mhedzisiro, zvichikonzera kukotsira kwakanyanya ().

Kudya grapefruit uchitora mishonga inoenderana nemanzwiro pamusoro inogona kukonzeresa kushanduka kwemoyo, kurara zvakanyanya, uye zvimwe zvinokanganisa zvinodhaka.

21–24: Vamwe vanoonda ropa

Ropa rakapfava rinoshandiswa kurapa kana kudzivirira kuwanda kweropa. Mimwe yacho inobatwa ne grapefruit, inosanganisira:

1. Apixaban (Eliquis)
2. Rivaroxaban powder (Xarelto)
3. Clopidogrel (Plavix)
4. Ticagrelor (Brilinta)

Clopidogrel inoenderana nemaCYPs - mapuroteni anonamira grapefruit - kushanda. Nekudaro, inova isingashande painosanganiswa ne grapefruit.

Chidzidzo chevarwere vanomwe vanotora clopidogrel ne200 mL yeiyo bhuratifuru muto kana mvura yakaratidza kudzikisira kumisikidza kwechirwere nemuto wacho. Nekudaro, kugona kwayo kurapa kugwamba kweropa hakuna kukanganiswa ().

Zvakajairika, grapefruit inowedzera huwandu hweropa yemimwe mishonga pane ino runyorwa, izvo zvinogona kukonzera kubuda ropa ().

Dzimwe nzira: Warfarin (Coumadin) inoshandiswa kune zvinangwa zvakafanana neizvo zveapixaban uye rivaroxaban powder. Nepo warfarin ichinzwira chikafu chine vitamini K, kumisikidza kwayo hakukanganiswi ne grapefruit ().

Vazhinji vanoonda ropa vanobatwa ne grapefruit. Izvi zvinogona kutungamira mukubuda ropa kana kudzivirirwa kushoma kweropa.

25–27: Mishonga yekurwadziwa yakati wandei

Mishonga yakawanda yekurwadziwa inobatwa ne grapefruit:

1. Fentanyl
2. Oxycodone
3. Colchicine

Fentanyl uye oxycodone marwadzo ekudzora marwadzo. Kunyangwe huwandu hwavo hweropa hunokanganiswa zvishoma nezvidiki zvechibereko, zvinogona kuchinja urefu hwenguva yavanogara mumuviri (,).

Colchicine mushonga wekare unoshandiswa kurapa gout. Iyo inogadziriswa neCYP uye inogona kuwirirana ne grapefruit. Zvakangodaro, ongororo ya2012 yakaratidza kuti kunwa mazana maviri emamirimita emuto wemuzambiringa wemazambiringa kwaingova nemhedzisiro pamatanho ayo ().

Dzimwe nzira: Morphine uye Dilaudid marwadzo ekudzora marwadzo asina kukanganiswa ne grapefruit (1).

Mamwe marwadzo ekunyaradza anodzora anoramba achireba muropa kana achitorwa ne grapefruit.

28-31: Mashoma erectile kudzvinyirira uye mishonga yeprostate

Mamwe mashoma erectile kudzvinyirira uye mishonga yeprostate inofanirwa kutariswa maererano nekudyidzana kwemazambiringa.

1. Sildenafil (Viagra)
2. Tadalafil (Cialis)
3. Tamsulosin (Flomax)
4. Silodosin (Rapaflo)

Erectile dysfunction mishonga se sildenafil uye tadalafil inoshanda nekuzorodza tsinga dzeropa, izvo zvinowedzera kuyerera kweropa kune erection.

Nekuti mimwe mitsipa yeropa inozorora nemishonga iyi futi, kuwanda kweropa kwemishonga iyi inokonzerwa ne grapefruit kunogona kudzikisa BP ().

Zvakare, mishonga yekuwedzera yeprostate senge tamsulosin inogona zvakare kukonzeresa dzungu uye kuderera kweropa paunotorwa ne grapefruit ().

Dzimwe nzira: Imwe kirasi yemishonga yekuwedzera yeprostate, inosanganisira finasteride uye dutasteride, haina kukanganiswa zvakanyanya ne grapefruit ().

Muchero wemazambiringa haufanire kudyiwa nemishonga yekusagadzikana kweiyo erectile kana mimwe mishonga yekuwedzera yeprostate.

Unofanira here kusiya chibereko?

Nepo chinyorwa ichi chichinyora 31 inowanzo mishonga inowirirana ne grapefruit, haisi runyorwa ruzere.

Drugs.com inopa yekudyidzana kusangana cheki iwe yaunogona kushandisa kutarisa yako mishonga yekudyidzana.

Pamusoro pezvo, Rxlist.com inonyora mimwe mishoma mishonga isingawanzoitika inobatana ne grapefruit.

Zvakakosha kuyeuka kuti girifusi rimwe chete rakazara kana rimwe girazi hombe remuto inokwana kushandura mwero weropa wemishonga yakawanda. Uye mimwe yemishonga iyi inogona kuve nemhedzisiro yakaipa kana ikabatana ne grapefruit.

Kana iwe parizvino urikutora mishonga nekudyidzana kwemazambiringa, chinja kune mumwe mushonga kana kurega kudya grapefruit.

Kana usina kukahadzika, svikira kuna chiremba wako kana wemishonga kuti uwane rairo yakasarudzika.

Kunyangwe zvidiki zvemuzambiringa zvinogona kudyidzana nemimwe mishonga uye zvichikonzera zvakakomba mhedzisiro.

Chinokosha

Muchero wemazambiringa unopindira nemapuroteni ari mudumbu ura uye chiropa izvo zvinowanzo kupaza akawanda mishonga.

Kudya grapefruit kana kunwa muto wemazambiringa paunenge uchitora iyi mishonga kunogona kutungamira kune akakwirisa emazinga avo muropa rako - uye yakawanda mhedzisiro.

Nemamwe madhiragi, aine kana zvidiki zvidiki zvemuzambiringa zvinogona kukonzera mhedzisiro. Naizvozvo, iko kusanganisa kunofanirwa kudzivirirwa.

Kemufesi yako inogona kutara mishonga iyi neyeyambiro yekudyidzana nemazambiringa.

Ita shuwa kuti chiremba wako uye wemishonga vanoziva kana iwe uchigara uchidya grapefruit. Ivo vanogona kukubatsira iwe kusarudza kana zvakachengeteka kuishandisa iwe uri pane imwe mishonga.