Hepatitis C Genotype 2: Chii Chaunotarisira

Zvemukati

• Nei zvichikosha kuti ndine genotype 2?
• Hepatitis C genotype 2 inorapwa sei?
• Glecaprevir uye pibrentasvir (Mavyret)
• Sofosbuvir uye velpatasvir (Epclusa)
• Daclatasvir (Daklinza) uye sofosbuvir (Sovaldi)
• Maitirwo mamwe magenotypes
• Ndeapi matambudziko angangoitika?
• Outlook

Mhedziso

Paunenge uchinge wagamuchira hepatitis C kuongororwa, uye usati watanga kurapwa, iwe uchazoda kumwe kuongorora kweropa kuti uone genotype yehutachiona. Iko kune matanhatu akasimbiswa-genotypes (maronda) ehepatitis C, uyezve anopfuura makumi manomwe neshanu madiki.

Kuongororwa kweropa kunopa ruzivo chairwo nezve huwandu hwoutachiona huripo muropa rako.

Muedzo uyu haufanire kudzokororwa nekuti genotype haichinje. Kunyangwe zvisingawanzoitika, zvinokwanisika kutapukirwa neanopfuura rimwe genotype. Izvi zvinonzi hutachiona hukuru.

MuUnited States, dzinenge gumi neshanu kusvika gumi neshanu muzana muzana dzevanhu vane hepatitis C vane genotype 2. Genotype 1 ndiyo uye inobata kusvika pa75 muzana yevanhu vane hepatitis C.

Kuziva yako genotype kunokanganisa kurapa kwako kurudziro.

Nei zvichikosha kuti ndine genotype 2?

Kuziva kuti iwe une genotype 2 inopa ruzivo rwakakosha pamusoro pesarudzo dzako dzekurapa uye kuti zvingangobudirira sei.

Kubva pane genotype, vanachiremba vanogona kudzikisira pasi kuti ndeapi marapirwo angangoshanda uye kuti unofanira kutora nguva yakareba sei. Izvi zvinogona kukutadzisa kubva pakutambisa nguva pane isiriyo kurapwa kana kutora mishonga kwenguva yakareba kupfuura zvaunofanirwa kuita.

Mimwe genotypes inopindura zvakasiyana pakurapwa kupfuura vamwe. Uye inguvai yaunoda kutora mushonga inogona kusiyanisa zvichienderana ne genotype yako.

Zvisinei, genotype haigone kutaurira vanachiremba kuti mamiriro acho achakurumidza sei kukura, kuti zviratidzo zvako zvingave zvakakomba sei, kana kuti hutachiona hwakanyanya huchave husingaperi.

Hepatitis C genotype 2 inorapwa sei?

Hazvizivikanwe kuti sei, asi zvevanhu vanobvisa hutachiona hweH hepatitis C pasina kurapwa. Sezvo pasina nzira yekuziva kuti ndiani anowira muchikamu ichi, muhutachiona hwakanyanya, chiremba wako achakurudzira kumirira kwemwedzi mitanhatu kuti ubate hutachiona, nekuti hunogona kujekesa zvoga.

Hepatitis C inorapwa nemishonga inorwisa hutachiona inojekesa muviri wako hutachiona uye inodzivirira kana kuderedza kukuvara kwechiropa chako. Kazhinji, iwe unotora musanganiswa wemaviri antiviral madhiragi kwemavhiki masere kana kupfuura.

Pane mukana wakanaka wekuti uve neyakaenderera virologic mhinduro (SVR) kune yemumuromo mishonga yekurapa. Mune mamwe mazwi, inopora zvikuru. Iyo SVR mwero wezhinji yeiyo nyowani hepatitis C zvinodhaka zvinosanganiswa zvakakwirira kusvika 99 muzana.

Paunenge uchisarudza zvinodhaka uye uchifunga kuti unofanira kutora nguva yakareba sei, chiremba wako anowanzo funga zvinotevera zvinhu:

• hutano hwako hwese
• huwandu hwehutachiwana huripo mune yako system (viral load)
• kunyangwe kana usati uine cirrhosis kana kumwe kukuvara kuchiropa chako
• kunyangwe iwe watove kurapwa chirwere chehepatitis C, uye nemarapirwo awanga uine

Glecaprevir uye pibrentasvir (Mavyret)

Iwe unogona kunyorerwa mubatanidzwa uyu kana iwe uri mutsva pakurapwa kana iwe wakarapwa ne peginterferon plus ribavirin kana sofosbuvir plus ribavirin (RibaPack) uye haina kukurapa. Muyero wacho mapiritsi matatu, kamwe chete pazuva.

Inguva yakadii iwe kutora mushonga:

• kana iwe usina cirrhosis: masvondo masere
• kana iwe uine cirrhosis: vhiki gumi nembiri

Sofosbuvir uye velpatasvir (Epclusa)

Musanganiswa uyu ndeimwe sarudzo kune vanhu vatsva pakurapwa, kana avo vakamborapwa kare. Iwe unotora piritsi rimwe chete pazuva kwevhiki gumi nembiri. Iyo dosi yakafanana, kunyangwe kana iwe uine cirrhosis.

Daclatasvir (Daklinza) uye sofosbuvir (Sovaldi)

Iyi regimen inogamuchirwa yehepatitis C genotype 3. Haibvumirwe kurapa genotype 2, asi vanachiremba vanogona kuishandisa kure-chitaridzi kune vamwe vanhu vane genotype iyi.

Iyo dosi ndiyo imwe daclatasvir piritsi uye imwe sofosbuvir piritsi kamwe pazuva.

Inguva yakadii iwe kutora mushonga:

• kana iwe usina cirrhosis: masvondo gumi nemaviri
• kana iwe uine cirrhosis: 16 kusvika 24 mavhiki

Kutevera-kuongororwa kweropa kucharatidza kuti uri kupindura sei kurapwa.

Ongorora: Off-label kushandisa zvinodhaka zvinoreva kuti mushonga wakabvumidzwa neDFA nechinangwa chimwe unoshandiswa nechinangwa chakasiyana chisina kubvumidzwa. Nekudaro, chiremba achiri kugona kushandisa mushonga wechinangwa icho. Izvi zvinodaro nekuti iyo FDA inodzora kuyedzwa uye kubvumidzwa kwemishonga, asi kwete mashandisiro anoita vanachiremba mishonga yekurapa varwere vavo. Nekudaro, chiremba wako anokwanisa kukunyorera mushonga asi ivo vanofunga zvakanakira iwe. Dzidza zvakawanda nezve off-label tsamba yekushandisa zvinodhaka.

Maitirwo mamwe magenotypes

Kurapa kwemagenotypes 1, 3, 4, 5, uye 6 zvakare kunoenderana nezvinhu zvakasiyana zvakaita sehutachiona uye huwandu hwekukuvara kwechiropa. Genotypes 4 ne6 hazvina kujairika, uye genotypes 5 ne6 hazviwanzo muUnited States.

Mishonga yeAntiviral inogona kusanganisira iyi mishonga kana musanganiswa wayo:

• daclatasvir (Daklinza)
• elbasvir / grazoprevir (Zepatier)
• glecaprevir / pibrentasvir (Mavyret)
• ledipasvir / sofosbuvir (Harvoni)
• ombitasvir / paritaprevir / ritonavir (Technivie)
• ombitasvir / paritaprevir / ritonavir uye dasabuvir (Viekira Pak)
• simeprevir (Olysio)
• sofosbuvir (Sovaldi)
• sofosbuvir / velpatasvir (Epclusa)
• sofosbuvir / velpatasvir / voxilaprevir (Vosevi)
• ribavirin

Kureba kwekurapa kunogona kusiyana negenotype.

Kana kukuvara kwechiropa kwakakomba zvakakwana, kuisirwa chiropa kunogona kukurudzirwa.

Ndeapi matambudziko angangoitika?

Hepatitis C genotype 2 inowanzo kurapwa. Asi chirwere chisingaperi chinogona kutungamira kumatambudziko akakomba.

Vazhinji vanhu vane hepatitis C havana kana zviratidzo kana zviratidzo zvinyoro, kunyangwe chiropa chiri kukuvara.

Mwedzi mitanhatu yekutanga mushure mehutachiona inotsanangurwa seacute hepatitis C hutachiona. Izvi ndezvechokwadi kunyangwe iwe uine zviratidzo kana kwete. Nokurapwa, uye dzimwe nguva pasina kurapwa, vanhu vazhinji vanojekesa hutachiona panguva ino.

Iwe haugone kuve nekukuvara kwakakomba kwechiropa panguva yechikamu chakakomba, asi mune zvisingawanzoitika zviitiko zvinokwanisika kuve nekuzara kwechiropa kutadza.

Kana iwe uchine hutachiona muhurongwa hwako mushure memwedzi mitanhatu, une chirwere chisingaperi chehepatitis C. Kunyangwe zvakadaro, chirwere ichi chinowanzotora makore mazhinji kuti chifambire mberi. Zvinetso zvakakomba zvinogona kusanganisira cirrhosis, kenza yechiropa, uye kutadza kwechiropa.

Statistics yezvinetso zve genotype 2 pachayo iri kushomeka.

Kune ese marudzi ehepatitis C muUnited States, fungidziro yekuti:

• 75 kusvika 85 kubva zana vanhu vane hutachiona vanoenderera mberi nekukura hutachiona husingaperi
• 10 kusvika 20 ichaita cirrhosis yechiropa mukati memakore makumi maviri kusvika makumi matatu

Pane imwe nguva vanhu vanogadzira cirrhosis, ivo vanomhanya yekutora kenza yechiropa gore rega.

Outlook

Pakutanga iwe unowana kurapwa, zvirinani mikana yako yekudzivirira zvakakomba chiropa kukuvara. Pamusoro pekurapwa kwezvinodhaka, iwe uchazoda yekutevera-kuongororwa kweropa kuti uone kuti iri kushanda zvakadii.

Maonero ehepatitis C genotype 2 akanaka kwazvo. Izvi zvinonyanya kuitika kana iwe ukatanga kurapwa nekukurumidza, hutachiona usati hwave nemukana wekukuvadza chiropa chako.

Kana iwe ukabudirira kubvisa hepatitis C genotype 2 kubva kune yako system, unowana ma antibodies ekubatsira kukudzivirira kubva pakurwiswa mune ramangwana. Asi iwe unogona kutapukirwa neimwe mhando yehepatitis kana imwe genotype yehepatitis C.