Ilumya (tildrakizumab-asmn)

Zvemukati

• Chii chinonzi Ilumya?
• FDA tendero
• Ilumya generic
• Ilumya mutengo
• Mari uye inishuwarenzi rubatsiro
• Ilumya anoshandisa
• Ilumya yemucheka psoriasis
• Zvishandiso zvisina kubvumidzwa
• Ilumya chipimo chemushonga
• Mafomu emishonga uye simba
• Chipimo chemushonga psoriasis
• Ko kana ndikapotsa dosi?
• Ndichada here kushandisa mushonga uyu kwenguva refu?
• Ilumya mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Jekiseni saiti maitiro
• Manyoka
• Kuwedzera njodzi yehutachiona
• Immune reaction kuna Ilumya
• Dzimwe nzira kuna Ilumya
• Ilumya vs. Tremfya
• About
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Ilumya vs. mimwe mishonga
• Ilumya vs.Cosentyx
• Ilumya vs. Humira
• Ilumya vs. Enbrel
• Ilumya vs. methotrexate
• Ilumya shandisa nemamwe madhiragi
• Ilumya uye doro
• Ilumya kudyidzana
• Ilumya uye inorarama majekiseni
• Maitiro ekutora Ilumya
• Usati watanga Ilumya kurapwa
• Nguva
• Ilumya anoshanda sei
• Zvinotora nguva yakareba sei kuti zvishande?
• Ilumya uye nhumbu
• Ilumya uye kuyamwisa
• Mibvunzo yakajairika nezve Ilumya
• Ilumya inorapa plaque psoriasis here?
• Ndakagara ndichishandisa mafuta ekuzadza psoriasis yangu. Sei ndichifanira kutanga kugamuchira majekiseni?
• Ndichatora nguva yakareba sei kutora Ilumya?
• Chii chinonzi biologic drug?
• Ilumya inoshandiswa kurapa psoriatic arthritis?
• Sei ndichifanira kuongorora TB ndisati ndatanga kurapwa naIrumya?
• Chii chandingaite kudzivirira hutachiona ini ndichitora Ilumya?
• Ilumya yambiro
• Ruzivo rwehunyanzvi rweIlumya
• Nzira yekuita
• Pharmacokinetics uye metabolism
• Contraindications
• Mishonga
• Kufanotaura
• Kuchengetedza

Chii chinonzi Ilumya?

Ilumya (tildrakizumab-asmn) izita remazita remishonga yekurapa iro rinoshandiswa kurapa zvine mwero kusvika kune yakaoma plaque psoriasis. Inotarisirwa kune vanhu vakuru vanokodzera systemic therapy (zvinodhaka zvinopihwa jekiseni kana kutorwa nemuromo) kana phototherapy (light therapy).

Ilumya rudzi rwemushonga unonzi monoclonal antibody. Iyo monoclonal antibody yakasarudzika immune system mapuroteni akagadzirwa murabhoritari. Aya mapuroteni anonongedza chaiwo zvikamu zve immune immune yako. Ivo rudzi rwe biologic therapy (zvinodhaka zvakagadzirwa kubva kuzvinhu zvipenyu pachinzvimbo chemakemikari).

Ilumya anouya mune imwe-dhizaini yakasarudzwa sirinji. Anopa hutano muhofisi yechiremba wako anozvitungamira nekuzvibaya jekiseni pasi peganda rako (jekiseni rinotsvedza).

Mushure memadosi maviri ekutanga, ayo anopiwa mavhiki mana akaparadzaniswa, Ilumya anopihwa vhiki dzese gumi nembiri.

Mune zvidzidzo zvemakiriniki, pakati pe55 muzana uye 58 muzana yevanhu vakagamuchira Ilumya vaive neashoma kana kujekesa psoriasis zviratidzo mushure memasvondo gumi nemaviri. Vanopfuura zvikamu zviviri kubva muzvitatu zvevanhu vaive nemhedzisiro iyi vakavachengeta kwevhiki makumi matanhatu nemana.

FDA tendero

Ilumya yakagamuchirwa neKudya neDrug Administration (FDA) munaKurume 2018.

Ilumya generic

Ilumya inowanikwa chete sezita-zita remishonga. Haisi ikozvino inowanikwa mune generic fomu.

Ilumya ine chinodhaka tildrakizumab, icho chinonziwo tildrakizumab-asmn.

Ilumya mutengo

Sezvo nemishonga yese, mutengo weIlumya unogona kusiyana.

Mari yako chaiyo inoenderana neinishuwarenzi yako yekuvhara.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara iyo Ilumya, rubatsiro rwuripo.

Sun Pharma Global FZE, iyo inogadzira Ilumya, ichapa chirongwa chinonzi Ilumya Support Lighting the Way. Kuti uwane rumwe ruzivo, fona 855-4ILUMYA (855-445-8692) kana shanyira iyo Ilumya webhusaiti.

Ilumya anoshandisa

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai saIlumya kurapa mamwe mamiriro. Ilumya inogona zvakare kushandiswa kure-chitaridzi kune mamwe mamiriro.

Ilumya yemucheka psoriasis

Ilumya FDA-inogamuchirwa kurapa zvine mwero kusvika kune yakaoma plaque psoriasis muvakuru vanokodzera systemic kurapa kana phototherapy. Systemic therapy mishonga inotorwa nemuromo kana kuburikidza nejekiseni uye inoshanda mumuviri wese. Phototherapy (light therapy) kurapwa kunosanganisira kuburitsa ganda rakakanganiswa kune yakasikwa kana yekugadzirwa ultraviolet mwenje.

Vanhu vanokodzera kurapwa systemic kana phototherapy kazhinji ndivo avo:

• vane zvine mwero kusvika kwakasimba plaque psoriasis, kana
• vakaedza kurapwa kwemusoro asi vakaona kuti marapirwo aya haana kudzora kwavo psoriasis zviratidzo

Sekureva kweNational Psoriasis Foundation, plaque psoriasis inoonekwa seyakaenzana kusvika kune yakaoma kana mabheti akafukidza anopfuura matatu muzana yemuviri wako. Kuti uenzanise, ruoko rwako rwese runogadzira chikamu chimwe kubva muzana yemuviri wako.

Kana iwe uine mahwendefa enzvimbo dzakaomarara, senge maoko ako, tsoka, kumeso, kana sikarudzi, psoriasis yako inoonekwawo kunge ine mwero kusvika mukukutu.

Zvishandiso zvisina kubvumidzwa

Ilumya inogona kushandiswa kure-chitaridzi kune mamwe mamiriro. Kunze-chitambi kushandiswa ndiko kana mushonga unobvumidzwa kurapa imwechete mamiriro unorayirwa kurapa imwe mamiriro.

Psoriatic arthritis

Ilumya haina kubvumidzwa kurapa psoriatic arthritis, asi inogona kupihwa off-label kune ino mamiriro. Psoriatic arthritis inosanganisira psoriasis zviratidzo zveganda pamwe nekurwadziwa, kuzvimba majoini.

Mune imwe diki kiriniki yekudzidza, Ilumya haana kunyanya kugadzirisa psoriatic arthritis zviratidzo kana kurwadziwa painoshandiswa kwemasvondo gumi nematanhatu, zvichienzaniswa ne placebo (hapana kurapwa).

Nekudaro, zvimwe zvidzidzo zviri kuitiwa kuyedza kana Ilumya inobatsira pakurapa psoriatic arthritis. Imwe yenguva refu yekiriniki yekudzidza irikuenderera mberi.

Ankylosing spondylitis

Ilumya haina kubvumidzwa kurapwa kwe ankylosing spondylitis (arthritis iyo inokanganisa musana wako). Zvisinei, kune kuenderera mberi kwechipatara kuongorora kuti inoshanda here kune ino mamiriro.

Ilumya chipimo chemushonga

Iyi inotevera ruzivo inotsanangura yakajairwa muyero weIlumya. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda.

Mafomu emishonga uye simba

Ilumya anouya mune imwechete-dhizaini yakasarudzwa sirinji. Sirinji yega yega ine 100 mg yetildrakizumab mu1 mL yemhinduro.

Ilumya inopihwa sejekiseni pasi peganda rako (subcutaneous).

Chipimo chemushonga psoriasis

Iyo yakakurudzirwa dhizaini yeIlumya ye plaque psoriasis imwe 100-mg subcutaneous jekiseni.

Iwe uchagamuchira yekutanga neyechipiri jekiseni vhiki ina dzakaparadzana. Mushure meyero yechipiri, iwe unozogamuchira ese mamwe madosi masvondo gumi nemaviri. Anopa hutano kuhofisi yechiremba wako achapa jekiseni rega rega.

Ko kana ndikapotsa dosi?

Kana iwe ukakanganwa kuenda kuhofisi yechiremba wako kune imwe dose, danaidza kuti ugadzirise kusarudzwa kwako nekukurumidza sezvaunoyeuka. Mushure meizvozvo, tangazve yakajairwa chirongwa chakakurudzirwa.

Semuenzaniso, kana iwe watogashira iyo yekutanga miviri doses, iwe waizoronga inotevera dhivhisi kwemasvondo gumi nemaviri mushure mekuita kwako dhizaini.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Izvi zvinoenderana nekuti iwe nachiremba wako moona here kuti Ilumya yakachengeteka uye inoshanda pakurapa psoriasis yako. Kana ukadaro, unogona kushandisa mushonga kwenguva refu kudzora ako psoriasis zviratidzo.

Ilumya mhedzisiro

Ilumya inogona kukonzera manyoro kana zvakakomba mhedzisiro. Iyi inotevera rondedzero ine mamwe eakakosha mhedzisiro mhedzisiro inogona kuitika uchitora Ilumya. Rondedzero iyi haisanganisi mhedzisiro inogona kuitika.

Kuti uwane rumwe ruzivo nezve zvingangoitika mhedzisiro yeIlumya kana matipi ekuti ungagadzirise sei zvinoshungurudza mhedzisiro, taura nachiremba wako kana wemishonga.

Zvimwe zvakajairika mhedzisiro

Iyo yakajairika mhedzisiro mhedzisiro yeIlumya inogona kusanganisira:

• zvirwere zvepamusoro zvekufema
• jekiseni saiti maitiro
• manyoka

Mazhinji emhedzisiro iyi anogona kuenda mukati memazuva mashoma kana vhiki dzinoverengeka. Kana vakanyanya kuomarara kana vasingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Yakakomba mhedzisiro kubva kuIlumya haina kujairika, asi inogona kuitika. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Yakakomba mhedzisiro mhedzisiro inogona kusanganisira iyo yeergic reaction kuna Ilumya. Zviratidzo zvinosanganisira:

• kuputika kweganda
• kuvava
• kuzvimba kwehuro, muromo, kana rurimi, izvo zvinogona kukonzera kutambudzika kufema
• angioedema (kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka)

Jekiseni saiti maitiro

Mune zvidzidzo zvemakiriniki, jekiseni saiti yekuitika yakaitika mu3 muzana yevanhu vakagamuchira Ilumya. Zviratidzo panzvimbo yejojo ​​zvinogona kusanganisira:

• kutsvuka
• ganda rinonhuwa
• kurwadziwa kunzvimbo yejekiseni
• kukuvadza
• kuzvimba
• kuzvimba
• kubuda ropa

Injection saiti saiti kazhinji haina kunyanyisa uye inofanirwa kuenda mukati memazuva mashoma. Kana vakanyanya kana kuti vasingaendi, taura nachiremba wako.

Manyoka

Manyoka akaitika mu2 muzana yevanhu vakagamuchira Ilumya muzvidzidzo zvekuchipatara. Iyi divi mhedzisiro inogona kuenda nekuenderera mberi nekushandisa kwechirwere. Kana manyoka ako akakomba kana kutora kwenguva yakareba kupfuura mazuva akati wandei, taura nachiremba wako.

Kuwedzera njodzi yehutachiona

Mune zvidzidzo zvemakiriniki, zvikamu makumi maviri nezviviri zvevanhu vakagamuchira Ilumya vakatapukirwa. Zvakakosha kucherechedza, zvakadaro, kuti huwandu hwakaenzana hwehutachiona hwakaitika muvanhu vakagamuchira placebo (hapana kurapwa).

Zvirwere zvakajairika muvanhu vaitora Ilumya zvaive zvepamusoro zvekufema, senge dzihwa. Kusvika pagumi nemana kubva muzana yevanhu vari muchidzidzo vaive nehutachiona hwekufema. Nekudaro, angangoita ese hutachiona hwaive hunyoro kana husina kunyanya kukomba. Asingasviki 0.3 muzana yehutachiona akaonekwa seakakomba.

Ilumya inowedzera mukana wako wehutachiona nekuti inoderedza mashandiro ezvimwe zvikamu zvemuviri wako. Immune system yako ndiyo inodzivirira muviri wako kuhutachiona.

Usati watanga kurapwa naIlumya, chiremba wako anozokutarisa kuti watapukirwa hutachiona, kusanganisira tibhii (TB). Kana iwe uine nhoroondo yeTB kana uine TB inoshanda, iwe uchafanirwa kugamuchira kurapwa kwechimiro icho usati watanga kutora Ilumya.

Munguva yako yese yekurapa Ilumya, zvakakosha kuti ubate chiremba wako ipapo kana uine zviratidzo zveTB. Izvi zvinosanganisira fivhiri, tsandanyama aches, kuonda, kukosora, kana ropa mune yako mamasi.

Immune reaction kuna Ilumya

Mune zvidzidzo zvemakiriniki, isingasviki 7 muzana yevanhu vanotora Ilumya vaive nemabatirwo akaitwa immune system yavo neIlumya.

Maantibodies mapuroteni anorwisa zvinhu zvekunze mumuviri wako sevapambi. Muviri unogona kugadzira ma antibodies kune chero chinhu chekunze, kusanganisira monoclonal antibodies senge Ilumya.

Kana muviri wako ukaita ma antibodies kuna Ilumya, zvinokwanisika kuti mushonga wacho hauchazove unoshanda pakurapa psoriasis yako. Izvo zvakakosha kuti uzive, zvisinei, kuti Ilumya yakaitwa isingashande mune chete nezve 3 muzana yevanhu vakaigamuchira.

Dzimwe nzira kuna Ilumya

Mimwe mishonga iripo inogona kurapa zvine mwero kusvika kune yakaoma plaque psoriasis. Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira yeIlumya, taura nachiremba wako kuti udzidze zvakawanda nezvemimwe mishonga inogona kukushandira zvakanaka.

Mienzaniso yemamwe madhiragi ayo anogona kushandiswa kurapa zvine mwero kusvika kune yakaoma plaque psoriasis inosanganisira:

• methotrexate (Otrexup, Rasuvo, Trexall)
• adalimumab (Humira)
• etanercept (Enbrel)
• secukinumab (Cosentyx)
• ustekinumab (Stelara)
• guselkumab (Tremfya)

Ilumya vs. Tremfya

Unogona kushamisika kuti Ilumya inofananidzwa sei nemimwe mishonga yakatemwa kushandiswa kwakafanana. Pano tinotarisa kuti Ilumya neTremfya zvakafanana uye zvakasiyana.

About

Ilumya ine tildrakizumab, inova mhando yemushonga unonzi monoclonal antibody. Tildrakizumab inhibits (block) chiitiko cheprotein inonzi iyo interleukin-23 (IL-23) molecule. Mune plaque psoriasis, iyi molecule inobatanidzwa mune yeganda sero buildup iyo inotungamira kune mabara.

Tremfya zvakare monoclonal antibody inovhara chiitiko cheI IL-23. Iine mushonga guselkumab.

Ilumya naTremfya ese ari maviri biologic zvinodhaka izvo zvinoderedza kuzvimba uye zvinobatsira kudzivirira mabwe ekuumbwa kune vanhu vane psoriasis. Biologics mishonga inogadzirwa kubva kune zvipenyu kwete makemikari.

Zvishandiso

Ilumya naTremfya vese vari vaviri-vanobvumidzwa FDA kurapa zvine mwero kune zvakanyanya plaque psoriasis muvakuru vanokodzera systemic kurapa kana phototherapy.

Systemic therapy ine mishonga inotorwa nemuromo kana kuburikidza nemajekiseni anoshanda mumuviri wese. Phototherapy inosanganisira kuburitsa iro rakakanganiswa ganda kune yakasikwa kana yekugadzirwa ultraviolet mwenje.

Aya marudzi ekurapa anowanzo shandiswa zvine mwero kusvika kune yakaoma plaque psoriasis kana kune vanhu vasingapindure kune ekurapa ayo ari epamusoro (anoshandiswa kuganda).

Mafomu emishonga uye manejimendi

Ilumya anouya mune imwe-dosi yakasarudzwa sirinji iyo ine 100 mg ye tildrakizumab. Ilumya inopihwa sejekiseni pasi peganda (subcutaneous) kuhofisi yechiremba. Majekiseni maviri ekutanga anopiwa vhiki ina dzakaparadzana. Mushure meaya majekiseni, madosi anopiwa vhiki dzese gumi nembiri.

SaIlumya, Tremfya inouya mune imwe-dosi yakasarudzwa sirinji, asi iine 100 mg ye guselkumab. Inopihwawo sejekiseni rinotsvedza. Uye sekuna Ilumya, majekiseni maviri ekutanga anopiwa mavhiki mana akapatsanurwa. Zvisinei, mishonga yose mushure mezvo inopiwa masvondo masere ega ega.

Tremfya inogona kupihwa kuhofisi yechiremba wako, kana kuzvibaya-majekiseni kumba mushure mekunge wawana kudzidziswa kwakakodzera kubva kune wako mupi wezvehutano.

Side migumisiro uye njodzi

Ilumya naTremfya vane zvimwe zvakafanana mhedzisiro uye zvimwe zvakasiyana. Mienzaniso yakanyorwa pazasi.

Kubudirira

Ilumya naTremfya havana kuenzaniswa muzvidzidzo zvekiriniki, asi zvese zviri zviviri zvinoshanda pakurapa zvine mwero kune zvakanyanya plaque psoriasis.

Kufananidza zvisina kunangana kweplate psoriasis zvinodhaka zvakawana kuti Tremfya inogona kushanda zvakanyanya pakuvandudza zviratidzo kupfuura Ilumya. Muchidzidzo ichi, vanhu vakatora Tremfya vaive nemazana gumi nemana nemazana mana ezviuru mukana wekuve nezvikamu makumi manomwe nezvishanu kubva muzana zvezviratidzo, zvichienzaniswa nevanhu vakatora nzvimbo (pasina kurapwa).

Muchidzidzo chimwe chete ichocho, vanhu vakatora Ilumya vaive nemakumi gumi nemaviri mikana yekuwana mhedzisiro yakafanana kana ichienzaniswa nenzvimbo inogara nzvimbo.

Mariro

Ilumya naTremfya zvese zvinodhaka-zita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Ilumya neTremfya kazhinji zvinodhura zvakafanana. Iko chaiko mutengo waunobhadharira chero chinodhaka unoenderana nehurongwa hweinishuwarenzi.

Ilumya vs. mimwe mishonga

Pamusoro peTremfya, kune mimwe mimwe mishonga inoshandiswa kurapa plaque psoriasis. Pazasi pane fananidzo pakati peIlumya uye mimwe yemishonga iyi.

Ilumya vs.Cosentyx

Ilumya ine tildrakizumab, inova mhando yemushonga unonzi monoclonal antibody. Tildrakizumab inhibits (block) chiitiko cheprotein inonzi iyo interleukin-23 (IL-23) molecule. Mune plaque psoriasis, iyi molecule inobatanidzwa mune yeganda sero buildup iyo inotungamira kune mabara.

Cosentyx iriwo monoclonal antibody. Iine mushonga secukinumab uye unodzivirira interleukin-17A (IL-17A). Kunge IL-23, IL-17A inobatanidzwa mune yeganda sero buildup iyo inotungamira kune mabara.

Kunyangwe Ilumya neCosentyx ese ari maviri biologic zvinodhaka, zvinoshanda munzira dzakasiyana.

Biologics mishonga inogadzirwa kubva kune zvipenyu kwete makemikari.

Zvishandiso

Ilumya naCosentyx vese vari vaviri-vanobvumidzwa FDA kurapa zvine mwero kune yakaoma plaque psoriasis muvanhu vakuru vari kukwikwidza systemic kurapa kana phototherapy. Systemic therapy mishonga inotorwa nemuromo kana kuburikidza nejekiseni uye inoshanda mumuviri wese. Phototherapy inosanganisira kuburitsa iro rakakanganiswa ganda kune ultraviolet mwenje.

Cosentyx iri zvakare FDA-inogamuchirwa kurapa psoriatic arthritis (psoriasis ine joint arthritis) uye ankylosing spondylitis (arthritis muzongoza).

Mafomu emishonga uye manejimendi

Ilumya neCosentyx zvese zvinopihwa sejekiseni pasi peganda (subcutaneous).

Ilumya inopihwa muhofisi yechiremba nemupi wezvehutano. Majekiseni maviri ekutanga anopiwa vhiki ina dzakaparadzana. Mushure meaya majekiseni maviri, madosi anopiwa vhiki gumi nembiri dzese. Yese dosi ndeye 100 mg.

Iyo yekutanga dosi yeCosentyx inowanzo kupihwa muhofisi yechiremba. Mushure meizvozvo, mushonga uyu unogona kunge uri wega-kujowa kumba mushure mekudzidziswa kwakakodzera nemupi mupi wezvehutano.

ZveCosentyx, majekiseni maviri e150 mg (kweanosvika 300 mg pa dose) anopiwa vhiki nevhiki kwevhiki shanu. Mushure meizvozvo, jekiseni rimwe rinopihwa mwedzi wega wega. Imwe yeaya madhizaini anowanzoita 300 mg, kunyangwe vamwe vanhu vangangoda 150 mg pagedhi.

Side migumisiro uye njodzi

Ilumya neCosentyx vane zvimwe zvakafanana mhedzisiro uye zvimwe zvakasiyana. Mienzaniso yemhedzisiro yemhedzisiro zvinodhaka zvakanyorwa pazasi.

Kubudirira

Ilumya neCosentyx havana kuenzaniswa muzvidzidzo zvekiriniki, asi ese ari maviri anoshanda pakurapa zvine mwero kune zvakakomba plaque psoriasis.

Kufananidza zvisina kunangana kweplate psoriasis zvinodhaka zvakawana kuti Cosentyx inogona kushanda zvakanyanya kupfuura Ilumya pakuvandudza zviratidzo. Muchidzidzo ichi, vanhu vakatora 300 mg yeCosentyx vaive ka17.5 zvakapetwa mukana wekuve ne75-muzana kuvandudza muzviratidzo zvichienzaniswa nevanhu vakatora placebo (vasina kurapwa).

Muchidzidzo chimwe chete ichocho, vanhu vakatora Ilumya vaive nemakumi gumi neshanu mukana wekuti vawane mhedzisiro yakafanana, zvichienzaniswa ne placebo.

Mariro

Ilumya neCosentyx ese ari maviri mazita ezita zvinodhaka. Ikozvino hapana mafomu akajairika anowanikwa chero emushonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Ilumya neCosentyx kazhinji zvinodhura zvakafanana. Iko chaiko mutengo waunobhadharira chero chinodhaka unoenderana nehurongwa hweinishuwarenzi.

Ilumya vs. Humira

Ilumya ine tildrakizumab, inova mhando yemushonga unonzi monoclonal antibody. Tildrakizumab inhibits (block) chiitiko cheprotein inonzi iyo interleukin-23 (IL-23) molecule. Mune plaque psoriasis, iyi molecule inobatanidzwa mune yeganda sero buildup iyo inotungamira kune mabara.

Humira ine chinodhaka adalimumab. Ichowo monoclonal antibody uye inovhara chiitiko cheprotein inonzi tumor necrosis factor-alpha (TNF-alpha). TNF-alpha ikemikari mutumwa iyo inokonzeresa kukurumidza ganda sero kukura mu plaque psoriasis.

Kunyangwe Ilumya naHumira ese ari maviri biologic zvinodhaka anovhara immune immune, anoshanda nenzira dzakasiyana. Biologics mishonga inogadzirwa kubva kune zvipenyu kwete makemikari.

Zvishandiso

Ilumya naHumira vese vari vaviri FDA-inogamuchirwa kurapa zvine mwero kune yakaoma plaque psoriasis muvanhu vakuru vari kukwikwidza systemic kurapa kana phototherapy. Systemic therapy mishonga inotorwa nemuromo kana kuburikidza nejekiseni uye inoshanda pane muviri wese. Phototherapy inosanganisira kurapa iro rakakanganiswa ganda ne ultraviolet mwenje kuratidzwa.

Humira ine akati wandei mamwe mashandisiro anotenderwa FDA, mamwe acho anosanganisira:

• rheumatoid arthritis
• psoriatic arthritis
• Chirwere cheCrohn
• ankylosing spondylitis
• urikanwi colitis

Mafomu emishonga uye manejimendi

Ilumya naHumira vese vanopihwa majekiseni pasi peganda (subcutaneous).

Ilumya inopihwa muhofisi yechiremba nemupi wezvehutano. Majekiseni maviri ekutanga anopiwa vhiki ina dzakaparadzana. Mushure meaya majekiseni maviri, madosi anopiwa vhiki gumi nembiri dzese. Yese dosi ndeye 100 mg.

Humira anopiwawo muhofisi yechiremba, kana seyangu-yekuzvidzivirira kumba mushure mekudzidziswa kwakakodzera kubva kune anopa hutano. Iyo yekutanga dhizeti ndeye 80 mg, inoteverwa ne40-mg dosi vhiki imwe chete gare gare. Mushure meizvozvo, 40-mg dose inopihwa vhiki mbiri dzese.

Side migumisiro uye njodzi

Ilumya naHumira vanoshanda nenzira dzakasiyana asi vane mamwe mhedzisiro. Mienzaniso yezvakajairika uye zvakakomba mhedzisiro yemushonga wega wega zvakanyorwa pazasi.

Humira ane mabhokisi akanyeverwa kubva kuDFA. Nyevero yebhokisi ndiyo yakasimba nzira yekunyevera iyo FDA inoda. Nyevero dzinotaura kuti Humira inowedzera njodzi yehutachiona hwakakomba uye mamwe kanzira.

Kubudirira

Ilumya naHumira havana kuenzaniswa muzvidzidzo zvekiriniki, asi zvese zviri zviviri zvinoshanda pakurapa zvine mwero kune zvakanyanya plaque psoriasis.

Kumwe kuenzanisa kusinga tsanangurike kwakawana kuti Ilumya akashanda pamwe naHumira semubato psoriasis kurapwa. Muchidzidzo ichi, vanhu vakatora chero chinodhaka vaive nemakumi gumi neshanu mukana wekuti vave nechiratidzo chekuvandudza pane vanhu vakatora placebo (vasina kurapwa).

Zvisinei, zvichibva pakuongorora kwayo mamwe madhiragi, chidzidzo ichi chakaratidza kuti mishonga inotarisa IL-23, senge Ilumya, inoita kunge inoshanda pakurapa plaque psoriasis kupfuura TNF-blockers, senge Humira. Zvimwe zvidzidzo zvinodiwa.

Mariro

Ilumya naHumira vese vari vaviri-zita remishonga zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Nekudaro, kune akati wandei biosimilar mafomu eadalimumab (mushonga muHumira) uyo anotenderwa kurapa psoriasis. Izvi zvinosanganisira Hyrimoz, Cyltezo, uye Amjevita. Biosimilar zvinodhaka zvakafanana neiyo biologic drug iyo yakavakirwa pariri, asi haisi iwo chaiwo chaiwo. Biosimilar zvinodhaka zvinogona kuita ingangoita makumi matatu muzana muzana pane yepakutanga mushonga.

Ilumya naHumira kazhinji vanodhura zvakafanana. Iko chaiko mutengo waunobhadharira chero chinodhaka unoenderana nehurongwa hweinishuwarenzi.

Ilumya vs. Enbrel

Ilumya ine tildrakizumab, inova mhando yemushonga unonzi monoclonal antibody. Tildrakizumab inhibits (block) chiitiko cheprotein inonzi iyo interleukin-23 (IL-23) molecule. Mune plaque psoriasis, iyi molecule inobatanidzwa mune yeganda sero buildup iyo inotungamira kune mabara.

Enbrel zvakare iri monoclonal antibody. Iine iyo drug etanercept, iyo inovhara chiitiko cheprotein inonzi tumor necrosis factor-alpha (TNF-alpha). TNF-alpha ikemikari mutumwa iyo inokonzeresa kukurumidza ganda sero kukura mu plaque psoriasis.

Ose Ilumya naEnbrel mishonga yebiologic inoderedza kuumbika, asi vanozviita nenzira dzakasiyana. Biologics mishonga inogadzirwa kubva kune zvipenyu kwete makemikari.

Zvishandiso

Ilumya naEnbrel vese vari vaviri-vanobvumidzwa FDA kurapa zvine mwero kune yakaoma plaque psoriasis muvanhu vakuru vari kukwikwidza systemic kurapa kana phototherapy. Systemic therapy mishonga inotorwa nemuromo kana kuburikidza nejekiseni uye inoshanda pane muviri wese. Phototherapy inosanganisira kurapa iro rakakanganiswa ganda ne ultraviolet mwenje kuratidzwa.

Enbrel inobvumidzwawo kurapa zvine mwero kusvika kune yakaoma plaque psoriasis muvana vane makore mana makore uye zvichikwira, pamwe ne:

• rheumatoid arthritis
• polyarticular vechidiki idiopathic arthritis
• psoriatic arthritis
• ankylosing spondylitis

Mafomu emishonga uye manejimendi

Ilumya neEnbrel vese vanopihwa majekiseni pasi peganda (subcutaneous).

Ilumya anouya mune imwechete-dhizaini yakasarudzwa sirinji. Inopihwa muhofisi yechiremba nemupi wako wezvehutano. Majekiseni maviri ekutanga anopiwa vhiki ina dzakaparadzana. Mushure meaya majekiseni maviri, madosi anopiwa vhiki gumi nembiri dzese. Jekiseni rega rega riri 100 mg.

Enbrel inopihwawo muhofisi yechiremba kana seyako-yekuzvidzivirira kumba mushure mekudzidziswa kwakakodzera kubva kune anopa hutano. Kwemwedzi mitatu yekutanga, Enbrel inopihwa kaviri pasvondo. Mushure meizvozvo, muyero wekuchengetedza unopihwa kamwe chete pasvondo. Yese dosi ndeye 50 mg.

Enbrel inowanikwa mune akawanda mafomu, kusanganisira imwechete-dhizaini yakasarudzwa sirinji uye autoinjector.

Side migumisiro uye njodzi

Ilumya naEnbrel vanoshanda munzira dzakasiyana asi vane mimwe mitezo yakafanana. Mienzaniso yezvakajairika uye zvakakomba mhedzisiro yemushonga wega wega zvakanyorwa pazasi.

Enbrel ane mabhokisi akanyeverwa kubva kuDFA. Nyevero yebhokisi ndiyo yakasimba nzira yekunyevera iyo FDA inoda. Yambiro dzinoti Enbrel inowedzera mukana wehutachiona hwakakomba uye mamwe kanzura.

Kubudirira

Ilumya naEnbrel vese vanoshanda pakurapa plaque psoriasis, asi Ilumya inogona kunge ichinyanya kushanda pakuderedza maratidziro echiratidzo.

Mune imwe kiriniki yekudzidza, 61 muzana yevanhu vakagamuchira Ilumya vaive nechiratidzo chekuvandudza chinosvika makumi manomwe neshanu muzana. Kune rimwe divi, makumi mana neshanu muzana yevanhu vakagamuchira Enbrel vaive nekuvandudzwa kwakafanana.

Mariro

Ilumya naEnbrel vese vane zita rezita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Enbrel inodhura zvishoma pane Ilumya. Iko chaiko mutengo waunobhadharira chero chinodhaka unoenderana nehurongwa hweinishuwarenzi.

Ilumya vs. methotrexate

Ilumya ine tildrakizumab, inova mhando yemushonga unonzi monoclonal antibody. Tildrakizumab inhibits (block) chiitiko cheprotein inonzi iyo interleukin-23 (IL-23) molecule. Iyi mamorekuru inobatanidzwa mune yeganda maseru anovaka ayo anotungamira kumatare.

Methotrexate (Otrexup, Trexall, Rasuvo) rudzi rwemushonga unonzi antimetabolite, kana folic acid anopikisa (blocker). Methotrexate inoshanda nekuvhara chiitiko cheiyo enzyme iyo inobatanidzwa mukukura kwemasero eganda uye kugadzirwa kwedombo.

Ilumya mushonga webiologic, nepo methotrexate iri yakajairika systemic kurapwa.Systemic therapy inoreva mishonga inotorwa nemuromo kana kuburikidza nejekiseni uye inoshanda mukati memuviri wese. Biologics mishonga inogadzirwa kubva kune zvipenyu kwete makemikari.

Ose madhiragi anobatsira kuvandudza psoriasis zviratidzo nekudzikisa matombo ekuumbwa.

Zvishandiso

Ilumya uye methotrexate ese ari maviri FDA-anotenderwa kurapa rakasimba plaque psoriasis. Ilumya inobvumidzwawo kurapa zvine mwero plaque psoriasis. Methotrexate inoitirwa kushandiswa chete kana munhu psoriasis zviratidzo zvakakomba kana kuremadza uye usinga pindure kune mimwe mishonga.

Methotrexate inobvumidzwawo kurapa mamwe marudzi ekenza uye rheumatoid arthritis.

Mafomu emishonga uye manejimendi

Ilumya inopihwa sejekiseni pasi peganda (subcutaneous) kuhofisi yechiremba nemupi wezvehutano. Majekiseni maviri ekutanga anopiwa vhiki ina dzakaparadzana. Mushure meaya majekiseni, madosi anopiwa vhiki dzese gumi nembiri. Jekiseni rega rega riri 100 mg.

Methotrexate inouya sehwendefa remuromo, mhinduro yemvura, kana jekiseni. Nekurapa kweplate psoriasis, inowanzo kutorwa nemuromo. Inogona kutorwa seyero imwechete kamwe pavhiki, kana semitero mitatu yakapihwa maawa gumi nemaviri akaparadzaniswa kamwe pasvondo.

Side migumisiro uye njodzi

Ilumya uye methotrexate zvinokonzeresa zvakasiyana uye zvakakomba mhedzisiro. Mhedzisiro inowanzoitika uye yakakomba inoonekwa muvanhu vane psoriasis yakanyorwa pazasi. Rondedzero iyi haisanganisi zvese zvinokanganisa mhedzisiro yemushonga.

Methotrexate ine yambiro yakati wandei yetsiva kubva kuDAA inotsanangura njodzi yeimwe yemhedzisiro yakakomba inoratidzwa pamusoro. Nyevero yebhokisi ndiyo yambiro yakasimba iyo FDA inoda. Inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

Kubudirira

Ilumya uye methotrexate hazvina kuenzaniswa zvakananga muzvidzidzo zvekiriniki, asi zvese zviri zviviri zvinobatsira pakurapa plaque psoriasis.

Kumwe kuenzanisa kusinga tsanangurike kwakawana kuti Ilumya akashanda nezvazvo pamwe ne methotrexate yekuvandudza plaque psoriasis zviratidzo. Nekudaro, methotrexate yainyanya kukonzeresa zvakakomba mhedzisiro kana ichienzaniswa naIlumya.

Mariro

Ilumya inongowanikwa chete sezita-zita zvinodhaka. Ikozvino hapana mafomu akajairwa eIlumya. Methotrexate inowanikwa seyakajairika mushonga pamwe nemazita ezita zvinodhaka Trexall, Otrexup, uye Rasuvo. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Ilumya inodhura zvakanyanya kupfuura akajairwa uye mazita ezita mafomu e methotrexate. Iko chaiyo yaunobhadhara iwe yemhando ipi neipi yechinodhaka inoenderana nehurongwa hweinishuwarenzi.

Ilumya shandisa nemamwe madhiragi

Ilumya inoshanda mukuvandudza plaque psoriasis pachayo, asi inogona zvakare kushandiswa nemimwe mishonga yekuwedzera kubatsirwa. Kushandisa inopfuura imwechete nzira yekurapa psoriasis kunogona kubatsira kujekesa mabara nekukurumidza uye kujekesa chikamu chakakura chemapaque.

Musanganiswa wekusanganisa unogona zvakare kudzikisa muyero waunoda wemamwe psoriasis mishonga, iyo inoderedza njodzi yako yemhedzisiro. Uye zvakare, kurapa kwekubatanidza kunogona kudzora njodzi yako yekukunda kuramba Ilumya (kana mushonga wacho usisashandi kwauri).

Mienzaniso yemamwe marapirwo ayo anogona kushandiswa zvakachengeteka neIlumya anosanganisira:

• topical corticosteroids, senge betamethasone
• yemusoro vhitamini D makirimu uye mafuta (akadai seDovonex uye Vectical)
• methotrexate (Trexall, Otrexup, uye Rasuvo)
• phototherapy (light therapy)

Ilumya uye doro

Iko hakuna kuzivikanwa kuwirirana pakati pewaini neIlumya panguva ino. Nekudaro, manyoka ndomhedzisiro yeIlumya kune vamwe vanhu. Kunwa doro kunogona kukonzera manyoka. Naizvozvo, kunwa doro iwe uchigashira Ilumya kurapwa kunogona kuwedzera njodzi yako kune ino mhedzisiro.

Doro rinogona zvakare kuita kuti yako Ilumya kurapwa isanyanya kushanda. Izvi zvinokonzerwa nedoro mhedzisiro pane iyo psoriasis pachayo, uye ayo anogona mhedzisiro pamaitiro aunoteedzera yako yekurapa chirongwa. Kunwa doro kunogona:

• kuwedzera kuzvimba kunogona kutungamira kune ganda sero kuvaka
• kuderedza immune system yako kugona kurwisa hutachiona uye nezvinetso zveganda
• kukonzera kuti ukanganwe kutora mishonga yako kana kumira kutevera chirongwa chako chekurapa

Kana iwe ukatora Ilumya uye uchinetseka kudzivirira doro, taura nachiremba wako nezvenzira dzekudzivirira hutachiona uye nekuvandudza mikana yako yekubudirira kurapwa naIlumya.

Ilumya kudyidzana

Ilumya ane mashoma ekudyidzana kwemishonga. Izvi zvinodaro nekuti Ilumya uye mamwe ma monoclonal antibodies anogadziriswa, kana kuputswa, nemuviri neimwe nzira kupfuura mishonga yakawanda iri. (Monoclonal antibodies mishonga inogadzirwa mubhu kubva kumasero emunodzivirira.)

Mazhinji madhiragi, mahebhu, uye zvinowedzerwa zvinogadziriswa nema enzymes muchiropa chako. Ilumya, kune rimwe divi, inogadziriswa nenzira imwecheteyo kune maseru anodzivirira uye mapuroteni mumuviri. Muchidimbu, yakaputsika mukati memasero mumuviri wako wese. Nekuti Ilumya haina kuputswa pasi muchiropa chako nemimwe mishonga, kazhinji haina kubatana navo.

Ilumya uye inorarama majekiseni

Kumwe kubatana kwakakosha kweIlumya majekiseni ehupenyu. Urarame majekiseni ekudzivirira anofanirwa kudzivirirwa panguva yekurapwa naIlumya.

Mishonga inorarama ine hutachiona hushoma. Nekuti Ilumya inovharira immune system mhinduro yakajairika yekurwisa chirwere, muviri wako unogona kutadza kurwisa hutachiona mumushonga wekurarama paunenge uchinwa mushonga.

Mienzaniso yeanorarama majekiseni ekudzivirira panguva yekurapwa kweIlumya anosanganisira majekiseni e:

• gwirikwiti, mamota, uye rubella (MMR)
• chibhokisi
• yero fever
• chikeni pokisi
• rotavirus

Usati watanga kurapwa naIlumya, taura nachiremba wako nezvekuti ungangoda chero ei majekiseni aya. Iwe nachiremba wako mungasarudza kunonoka kurapwa naIlumya kudzamara mushure mekubaiwa jekiseni nechero majekiseni mhenyu amungade.

Maitiro ekutora Ilumya

Ilumya inopihwa sejekiseni pasi peganda (subcutaneous) nemubatsiri wezvehutano muhofisi yechiremba. Yakajowa mudumbu mako, zvidya, kana maoko ekumusoro. Majekiseni mudumbu mako anofanirwa kuve anove akaenzana masendimita maviri kubva padumbu rako.

Ilumya haifanire kujekiwa munzvimbo dzezvitsvuku, mamaki, kana mitsipa yeropa. Iyo haifanire zvakare kupihwa mukati memabhuru, mavanga, kana nzvimbo dzvuku kana nyoro.

Usati watanga Ilumya kurapwa

Nekuti Ilumya inonetesa immune system yako, chiremba wako anozokutarisa tibhii (TB) usati watanga kurapwa. Kana iwe uine TB inoshanda, unozogamuchira kurapwa kweTB usati watanga Ilumya. Uye kana iwe uine TB munguva yakapfuura, ungangoda kurapwa usati watanga Ilumya.

Asi kunyangwe iwe usina zviratidzo zveTB, unogona kunge uine fomu isingashandi yeTB, iyo inonzi latent TB. Kana uine TB yakahwanda uye uchitora Ilumya, TB yako inogona kutanga kushanda. Kana kuyedzwa kuchiratidza kuti une TB yakahwanda, ungangoda kurapwa kweTB usati kana panguva yekurapwa kwako naIlumya.

Nguva

Yekutanga neyechipiri majekiseni eIlumya anopiwa vhiki ina dzakaparadzana. Mushure meiyi miviri yekutanga, iwe unozodzokera kuhofisi yechiremba vhiki dzese gumi nembiri kune imwe dosi. Kana iwe ukarasikirwa musangano kana dosi, ita imwe musangano nekukurumidza sezvazvinogona.

Ilumya anoshanda sei

Plaque psoriasis chirwere che autoimmune, chinova chiitiko chinokonzeresa kuti immune system inyanye kushanda. Plaque psoriasis inokonzeresa machena masero eropa, ayo anobatsira muviri kurwisa hosha, nekukanganisa kurwisa masero eganda emunhu. Izvi zvinokonzera kuti maseru eganda apatsanuke nekukura nekukurumidza.

Maseru eganda anogadzirwa nekukurumidza zvekuti maseru akura haana nguva yekudonha uye anoita nzvimbo yemasero matsva. Uku kuwanda uye kuwanda kwemasero eganda kunokonzeresa, kupwanya, kunorwadza ganda zvigamba zvinonzi mabara.

Ilumya inorwisa monoclonal antibody, iri mhando yemushonga unogadzirwa kubva kumasero emumuviri murabhoritari. MaMonoclonal antibodies anotarisa chaiwo zvikamu zve immune immune.

Ilumya anovharira chiitiko cheprotein immune system inonzi interleukin-23 (IL-23). Ine plaque psoriasis, IL-23 inogonesa makemikari anokonzera immune system kurwisa maseru eganda. Nekudzivirira IL-23, Ilumya inobatsira kudzikisa kuwanda kwemasero eganda uye mabara.

Nekuti Ilumya anovharira chiitiko cheI IL-23, inonzi inonzi interleukin inhibitor.

Zvinotora nguva yakareba sei kuti zvishande?

Ilumya ichatanga kushanda nekukurumidza iwe paunotanga kuitora. Nekudaro, zvinotora nguva kuvaka mune yako sisitimu uye kutora kushanda kwakazara, saka zvinogona kuve mavhiki akati wandei usati waona chero mhedzisiro.

Mune zvidzidzo zvemakiriniki, mushure mevhiki rimwe chete rekurapwa, vashoma pane makumi maviri muzana yevanhu vanotora Ilumya vakaona kuvandudzwa kwemapareti. Nekudaro, mushure memasvondo gumi nemaviri, inopfuura hafu yevanhu vakagashira Ilumya vakaona shanduko yakakura muzviratidzo zvavo zvepsoriasis. Huwandu hwevanhu vane zviratidzo zvakavandudzwa zvakaramba zvichiwedzera kuburikidza nemavhiki makumi maviri nemasere ekurapwa.

Ilumya uye nhumbu

Hazvizivikanwe kana Ilumya yakachengeteka kushandisa panguva yepamuviri. Dzidzo yemhuka yakaratidza imwe njodzi kumucheche kana Ilumya ikapihwa kune mukadzi ane nhumbu. Zvisinei, zvidzidzo zvemhuka hazviwanzo kufanotaura zvichaitika nevanhu.

Kana iwe uri nepamuviri kana kuronga kuve nepamuviri, taura nachiremba wako nezve mabhenefiti uye njodzi dzeiyo Ilumya kurapwa panguva yekuzvitakura.

Ilumya uye kuyamwisa

Hazvizivikanwe kana Ilumya achipfuura mumukaka wemukaka wemunhu. Muzvidzidzo zvemhuka, Ilumya akapinda mumukaka wemukaka, achifumura kuyamwisa mudiki kune mushonga. Zvisinei, zvidzidzo zvemhuka hazviwanzo kufanotaura zvichaitika muvanhu.

Kana iwe uri kufunga nezve Ilumya kurapwa paunenge uchiyamwa, taura nachiremba wako nezve mabhenefiti uye njodzi.

Mibvunzo yakajairika nezve Ilumya

Heano mhinduro kumimwe inowanzo bvunzwa mibvunzo nezve Ilumya.

Ilumya inorapa plaque psoriasis here?

Kwete, Ilumya hairape plaque psoriasis. Parizvino hapana mushonga wechirwere ichi. Nekudaro, kurapwa naIlumya kunogona kubatsira kuvandudza ako psoriasis zviratidzo.

Ndakagara ndichishandisa mafuta ekuzadza psoriasis yangu. Sei ndichifanira kutanga kugamuchira majekiseni?

Chiremba wako anogona kunge akafunga kuti systemic kurapwa kunogona kuita zvakawanda kugadzirisa zviratidzo zvako kupfuura ako makirimu. Zvirongwa zvemushonga zvinopihwa jekiseni kana kutorwa nemuromo uye zvinoshanda mumuviri wese.

Maitiro ekurapa akadai saIlumya anowanzo shanda zvakanyanya pakuvandudza psoriasis zviratidzo pane kurapa kwemusoro (zvinodhaka zvinoshandiswa kuganda). Izvi zvinodaro nekuti vanoshanda kubva mukati nekunze. Vanotarisa immune system pachayo, iyo inokonzeresa yako psoriasis plaque. Izvi zvinogona kubatsira zvese kujekesa uye kudzivirira psoriasis mabara.

Misoro yekurapa, kune rumwe rutivi, kazhinji inobata mabhenekeri mushure mekuumbwa kwawo.

Zvirongwa zvehurongwa dzimwe nguva zvinoshandiswa mukubatana pamwe, kana panzvimbo pe, kurapwa kwemusoro. Dzinogona kushandiswa kana:

• mishonga yemusoro haivandudze yako plaque psoriasis zviratidzo zvakakwana, kana
• mahwendefa anofukidza chikamu chikuru cheganda rako (kazhinji 3 muzana kana kupfuura), zvichiita kuti kurapa kwemisoro kusabatsire. Izvi zvinofungidzirwa zvine mwero kune zvakanyanya psoriasis.

Ndichatora nguva yakareba sei kutora Ilumya?

Unogona kutora Ilumya kwenguva yakareba kana iwe nachiremba wako mukafunga kuti Ilumya yakachengeteka uye inoshanda kwauri.

Chii chinonzi biologic drug?

Mushonga webiologic mushonga unogadzirwa kubva kumapuroteni emunhu kana emhuka. Biologic zvinodhaka zvinoshandiswa kurapa autoimmune hosha, senge plaque psoriasis, inoshanda nekubatana neyemuviri immune system. Ivo vanoita izvi munzira dzakanangwa dzekudzora kuzvimba uye zvimwe zviratidzo zveanonyanya kushanda immune system.

Nekuti ivo vanofambidzana neakanyanya chaiwo maseru ezvirwere uye mapuroteni, biologics inofungidzirwa kuve nemhedzisiro mhedzisiro kana ichienzaniswa nemishonga inokanganisa huwandu hwakawanda hwesisitimu yemuviri, sezvinoita mishonga yakawanda.

Kana ichishandiswa kurapa psoriasis, biologic zvinodhaka zvinowanzo shandiswa kune vanhu vane zvine mwero kusvika kune yakaoma plaque psoriasis vasingapindure kune kumwe kurapwa (senge kurapa kwemusoro).

Ilumya inoshandiswa kurapa psoriatic arthritis?

Ilumya haisi FDA-inogamuchirwa kurapa psoriatic arthritis, asi inogona kushandiswa kure-chitaridzi nekuda kwechinangwa icho.

Mune imwe diki kiriniki yekudzidza, Ilumya haana kunyanya kugadzirisa psoriatic arthritis zviratidzo kana kurwadziwa, asi zvimwe zvidzidzo zviri kuitiswa kuyedza kuti zvinobatsira here kune ino mamiriro. Imwe yenguva refu yekiriniki yekudzidza irikuenderera mberi.

Sei ndichifanira kuongorora TB ndisati ndatanga kurapwa naIrumya?

Chiremba wako achakuedza kuti ushande kana kuti unonamira tibhii (TB) usati watanga kurapwa naIrumya. Vanhu vane TB isingazivikanwe vangasaziva kuti vane hutachiona nekuti kazhinji hapana zviratidzo. Kuongororwa ropa ndiyo nzira chete yekuziva kana munhu ane TB yakahwanda akabatwa.

Kuongororwa TB usati warapwa neIlumya kwakakosha nekuti Ilumya inoderedza immune system. Kana immune system ikashaiswa simba, haigone kurwisa hutachiona, uye TB yakahwanda inogona kushanda. Zviratidzo zveTB inoshanda zvinosanganisira fivha, kuneta, kuonda, kukosora ropa, uye kurwadziwa pachipfuva.

Kana ukaongororwa uine TB, ungangoda kurapwa TB usati watanga Ilumya.

Chii chandingaite kudzivirira hutachiona ini ndichitora Ilumya?

Ilumya kurapwa kunoderedza immune yako uye kunowedzera mukana wako wehutachiona. Mienzaniso yehutachiona hwakadai inosanganisira tibhii, shingles, hutachiona hutachiona, uye hutachiona hwekufema.

Zvisinei, pane zvinhu zvakati wandei zvaunogona kuita kubatsira kudzivirira hutachiona:

• Gara up-to-date pane majekiseni, kusanganisira echirwere (furuwenza).
• Dzivisa kusvuta.
• Shamba maoko ako nesipo kazhinji.
• Tevera kudya kunovaka muviri.
• Wana nguva yakakwana yokurara.
• Dzivisa kuva pedyo nevanhu vanorwara, kana zvichibvira.

Ilumya yambiro

Usati watora Ilumya, taura nachiremba wako nezve nhoroondo yako yehutano. Ilumya inogona kunge isingave yakakunakira iwe kana uine mamwe marapirwo. Izvi zvinosanganisira:

• Nhoroondo yeakakomba hypersensitivity reaction kuna Ilumya kana chero chemidziyo yayo. Kana iwe wakambove neakanyanya kuita kuna Ilumya munguva yakapfuura, haufanire kurapwa nemushonga uyu. Kuita kwakanyanya kunosanganisira kuzvimba kwechiso kana rurimi uye kunetseka kufema.
• Zvirwere zvinoshanda kana nhoroondo yekudzokororwa hutachiona. Ilumya haifanire kutanga nevanhu vane hutachiona hwazvino kana nhoroondo yekudzokororwa hutachiona. Kana iwe ukava nehutachiona uchitora Ilumya, udza chiremba wako ipapo ipapo. Ivo vanozokutarisa zvakanyanya uye vangasarudza kumisa yako Ilumya kurapwa kudzamara hutachiona hwaporeswa.
• Tiibhii. Kana iwe uine TB yakavanzika kana TB inoshanda, ungangoda kurapwa kweTB usati watanga Ilumya. Iwe haufanire kutanga Ilumya kana uine TB inoshanda. (Kana uine TB yakavanzika, chiremba wako anogona kunge uchitanga kutora Ilumya panguva yekurapwa kwako TB.)

Ruzivo rwehunyanzvi rweIlumya

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Nzira yekuita

Ilumya ine yemunhu monoclonal antibody tildrakizumab. Iyo inosunga kune iyo p19 subunit yeiyo interleukin-23 (IL-23) cytokine uye inodzivirira kubva mukusunga kune iyo IL-23 receptor. Kuvhara IL-23 chiitiko kunodzivirira kumisikidza kweproinfigueatory T-anobatsira cell 17 (Th17) nzira.

Pharmacokinetics uye metabolism

Absolute bioavailability inosvika pamakumi masere muzana zvichitevera subcutaneous jekiseni. Peak yekumanikidza inosvika mumazuva matanhatu. Kudzikama-kwenyika kusungwa kunosvika nevhiki 16.

Ilumya yakashatiswa kuita madiki peptides uye amino acids kuburikidza nekatabolism. Kubvisa hafu-hupenyu ingangoita mazuva makumi maviri nematatu.

Contraindications

Ilumya inopesana nevarwere vane nhoroondo yeakakomba hypersensitivity reaction kumushonga kana chero yeanowana.

Mishonga

Dzivisa mhenyu majekiseni evarwere vanogamuchira Ilumya.

Kufanotaura

Vese varwere vanofanirwa kuongororwa kuti yakavanzika kana inoshanda tibhii isati yarapwa naIlumya. Usapa Ilumya kune varwere vane TB inoshanda. Varwere vane TB isingazivikanwe vanofanira kutanga kurapwa kweTB vasati vatanga kurapwa naIlumya.

Kuchengetedza

Ilumya inofanirwa kuchengetwa mufiriji pa36⁰F kusvika 46⁰F (2⁰C kusvika 8⁰C). Chengetedza mumudziyo wepakutanga kudzivirira kubva pachiedza. Ilumya inogona kuchengetwa mukamuri tembiricha - inosvika 77⁰F (25⁰C) - kusvika mazuva makumi matatu. Kana uchinge wakachengetwa pakushambidzika kwemukati, usadzosera mufiriji. Usagwamba kana kuzunza. Regai Ilumya agare pakamuri tembiricha kwemaminitsi makumi matatu pamberi pehutongi.

Disiki: MedicalNewsToday yaedza nepese painogona kuti ive nechokwadi chekuti ruzivo rwese nderwechokwadi, rwakakwana, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.