Infliximab, Injodzi Mhinduro

Zvemukati

• Yambiro dzakakosha
• FDA yambiro:
  
• Dzimwe yambiro
• Chii chinonzi infliximab?
• Nei zvichishandiswa
• Inoshanda sei
• Infliximab mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Infliximab inogona kudyidzana nemimwe mishonga
• Infliximab yambiro
• Allergy yambiro
• Yambiro kune vanhu vane mamwe mamiriro ehutano
• Yambiro kune mamwe mapoka
• Maitiro ekutora infliximab
• Tora sekurairwa
• Zvakakosha kufunga kwekutora infliximab
• Kufamba
• Clinical bvunzo uye kuongorora
• Pamberi pemvumo

Zvakanakisa zve infliximab

1. Infliximab jekiseni mhinduro inowanikwa sezita-zita zvinodhaka. Izvo hazviwanikwe mune generic vhezheni. Mazita ezita: Remicade, Inflectra, Renflexis.
2. Infliximab inouya mune isina jekiseni mhinduro yekushandisa seyakafasirwa infusion.
3. Infliximab injectable solution inoshandiswa kurapa chirwere cheCrohn, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, uye plaque psoriasis.

Yambiro dzakakosha

FDA yambiro:

• Mushonga uyu une nhema bhokisi yambiro. Idzi ndidzo yambiro dzakanyanya kubva kuFood and Drug Administration (FDA). Nyevero bhokisi dema rinonyevera vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.
• Ngozi yehutachiona hwakakomba yambiro: Infliximab inogona kudzora immune system yako kurwisa hutachiona. Vamwe vanhu vanoita hutachiona hwakakomba vachitora mushonga uyu. Izvi zvinogona kusanganisira tibhii (TB) kana zvimwe hutachiona zvinokonzerwa nehutachiona, hutachiona, kana fungi. Usatore infliximab kana iwe uine chero hutachiona hutachiona usati wataura nachiremba wako kutanga. Chiremba wako anogona kukutarisa iwe nezviratidzo zvehutachiona usati, panguva, uye mushure mekurapwa kwako ne infliximab. Chiremba wako anogona zvakare kukuyedza iwe TB usati watanga infliximab.
• Ngozi yekenza yambiro: Uyu mushonga unowedzera njodzi ye lymphoma, gomarara remuromo wechibereko, uye mamwe marudzi ekenza. Vanhu vane makore ari pasi pegumi nemasere, vakuru vechirume, uye avo vane chirwere cheCrohn kana ulcerative colitis vanogona kuve nekenza. Taura nachiremba wako kana iwe uine chero mhando yekenza. Chiremba wako angangoda kugadzirisa yako mishonga.

Dzimwe yambiro

• Chiropa chekukuvara yambiro: Infliximab inogona kukuvadza chiropa chako. Udza chiremba wako kana iwe uine zviratidzo zvekukuvara kwechiropa, senge:
  • kuita yero kweganda rako kana kuchena kwemeso ako
  • weti yakasviba
  • kurwadziwa kudivi rerudyi renzvimbo yako yemudumbu
  • kupindwa nechando
  • kuneta zvakanyanya
• Lupus-kunge chiratidzo chengozi. Lupus chirwere chinobata immune system yako. Zviratidzo zvinogona kusanganisira kurwadziwa kwepfupa kusingaendi, kupfupika kwemweya, kurwadza kwemajoini, uye kuputika pamatama ako kana maoko zvinowedzera muzuva. Iwe chiremba ungasarudza kumira infliximab kana iwe ukaita izvi zviratidzo.
• Yambiro yejekiseni: Usatore mushonga wekurarama uchitora infliximab. Mirira kwemwedzi mitatu mushure mekumira infliximab kuti ugamuchire mushonga mupenyu. Mienzaniso yejekiseni mhenyu inosanganisira yemumhino yekudzivirira furuwenza jekiseni, gwirikwiti, mamota, uye rubella wekudzivirira, uye chickenpox kana shingles jekiseni. Mushonga mhenyu haugone kukudzivirira kubva kuchirwere iwe uchinwa mushonga uyu. Kana iwe uri pasi pezera remakore gumi nemasere, ita shuwa kuti majekiseni ese kusvika nhasi usati watanga infliximab.
• Kuita kwakakomba mushure mekuyambirwa yambiro. Kuita kwakakomba kunokanganisa moyo wako, moyo mutinhimira, uye tsinga dzeropa zvinogona kuitika mukati maawa makumi maviri nemana ekutanga kweimwe infusion yechirwere ichi. Izvi zvinogona kusanganisira kurwiswa kwemoyo, uko kunogona kuuraya. Kana iwe uine zviratidzo zvakaita sedzungu, kurwadziwa pachipfuva, kana kurohwa mukati meawa makumi maviri nemana ekuderedzwa kwako, fonera chiremba wako ipapo ipapo.

Chii chinonzi infliximab?

Infliximab imishonga inonyorwa. Inowanikwa seyakagadziriswa jekiseni.

Infliximab inowanikwa sezita rezita remishonga Remicade, Inflectra, uye Renflexis. (Inflectra naRenflexis mabhiosimilars. * * Infliximab haiwanikwe mune ye generic vhezheni.

Infliximab inogona kusanganiswa ne methotrexate painenge ichishandiswa kurapa rheumatoid arthritis.

Biosimilar imhando yeiyo biologic drug. Biologics inogadzirwa kubva kune yakasikwa sosi, senge masero mapenyu. Biosimilar yakafanana neye brand-zita biologic drug, asi haisi iyo chaiyo kopi. (Chigadzirwa chakajairika, kune rumwe rutivi, ikopi chaiyo yechinodhaka chakagadzirwa kubva kumakemikari. Mazhinji mishonga inogadzirwa nemakemikari.)

Biosimilar inogona kupihwa mushonga wekurapa mamwe kana ese mamiriro ezvinhu ayo maratidziro ezita zvinodhaka, uye anotarisirwa kuve nemhedzisiro kumurwere. Mune ino kesi, Inflectra naRenflexis mabhiosimilar vhezheni yeRemicade.

Nei zvichishandiswa

Infliximab inoshandiswa kurapa:

• Chirwere cheCrohn (kana usati wapindura kune mamwe madhiragi)
• ulcerative colitis (kana usati wapindura kune mimwe mishonga)
• rheumatoid arthritis (inoshandiswa ne methotrexate)
• ankylosing spondylitis
• psoriatic arthritis
• yenguva refu uye yakaoma plaque psoriasis (inoshandiswa kana iwe uchida kurapa muviri wako wese kana kana mamwe marapirwo asina kukodzera iwe)

Inoshanda sei

Mushonga uyu unoshanda nekudzivirira kuita kweprotein mumuviri wako unonzi tumor necrosis factor-alpha (TNF-alpha). TNF-alpha inogadzirwa ne immune system yako. Vanhu vane mamwe mamiriro vane yakawandisa TNF-alpha. Izvi zvinogona kukonzera kuti immune system irwise zvikamu zvine hutano zvemuviri. Infliximab inogona kuvhara kukuvara kunokonzerwa neakawanda TNF-alpha.

Infliximab mhedzisiro

Infliximab injectable solution haikonzeri kutsimwaira, asi inogona kukonzeresa mimwe mhedzisiro.

Zvimwe zvakajairika mhedzisiro

Iyo yakajairika mhedzisiro mhedzisiro iyo inogona kuitika ne infliximab inosanganisira:

• kufema, sekutapukirwa nesinus uye huro
• kutemwa nemusoro
• kukosora
• kurwadziwa nemudumbu

Hunyoro mhedzisiro mhedzisiro inogona kuenda mukati memazuva mashoma kana mashoma mavhiki. Taura nachiremba wako kana wemishonga kana vakanyanya kuomarara kana vasingaendi nenzira.

Yakakomba mhedzisiro

Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira. Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

• Kutadza kwemoyo. Zviratidzo zvinogona kusanganisira:
  • kunetseka kufema
  • kuzvimba kwemakumbo ako kana tsoka
  • kukurumidza kuwedzera uremu
• Matambudziko eropa. Zviratidzo zvinogona kusanganisira:
  • kupwanya kana kubuda ropa zviri nyore
  • fivha iyo isingaendi
  • kutaridzika chaizvo
• Zvinotyisa system matambudziko. Zviratidzo zvinogona kusanganisira:
  • maonero anochinja
  • kushaya simba kwemaoko ako kana makumbo
  • chiveve kana kugwinha kwemuviri wako
  • pfari
• Allergic reaction / infusion maitiro. Zvinogona kuitika kusvika maawa maviri mushure mekuiswa infliximab. Zviratidzo zvinogona kusanganisira:
  • kuputika kweganda
  • kuvava
  • mikoko
  • kuzvimba kwechiso chako, miromo, kana rurimi
  • kupisa kana kutonhora
  • matambudziko kufema
  • kurwadziwa pachipfuva
  • yakakwira kana yakaderera BP (dzungu kana kunzwa kupera simba)
• Kunonoka kusagadzikana. Zviratidzo zvinogona kusanganisira:
  • mhasuru kana kurwadziwa kwemajoini
  • kupindwa nechando
  • mapundu
  • musoro
  • huro inorwadza
  • kuzvimba kwechiso kana maoko
  • kunetseka kumedza
• Psoriasis. Zviratidzo zvinogona kusanganisira:
  • kutsvuka, zvigamba kana kukwidza mapundu paganda
• Utachiona. Zviratidzo zvinogona kusanganisira:
  • kupisa kana kutonhora
  • kukosora
  • huro inorwadza
  • kurwadziwa kana kunetseka kupfuura weti
  • kunzwa kuneta zvakanyanya
  • inodziya, tsvuku, kana inorwadza ganda

Disiki: Chinangwa chedu ndechekukupa iwe neruzivo rwakanyanya uye rwazvino ruzivo. Nekudaro, nekuti zvinodhaka zvinokanganisa munhu wega wega, hatigone kuvimbisa kuti ruzivo urwu runosanganisira mhedzisiro inogona kuitika. Ruzivo urwu harusi rwekutsiva yezano rekurapa. Gara uchikurukura zvinogona kuitika mhedzisiro nemubatsiri wehutano anoziva nhoroondo yako yekurapa.

Infliximab inogona kudyidzana nemimwe mishonga

Infliximab jekiseni remhinduro inogona kusangana nemimwe mishonga, mahebhu, kana mavitamini aungave uchitora. Anopa hutano hwako anotarisa kunze kwekudyidzana nemishonga yako yazvino. Gara uine chokwadi chekuudza chiremba wako nezvese mishonga, mahebhu, kana mavitamini auri kutora.

Disiki: Chinangwa chedu ndechekukupa iwe neruzivo rwakanyanya uye rwazvino ruzivo. Nekudaro, nekuti zvinodhaka zvinopindirana zvakasiyana mumunhu mumwe nemumwe, hatigone kuvimbisa kuti ruzivo urwu runosanganisira kusangana kwese kunogona kuitika. Ruzivo urwu harusi rwekutsiva yezano rekurapa. Gara uchitaura nemupi wako wezvehutano nezve zvingangoita kudyidzana nezvose zvinodhaka zvinodhaka, mavitamini, mahebhu uye zvinowedzerwa, uye pamusoro-pe-pikisi zvinodhaka zvauri kutora.

Infliximab yambiro

Mushonga uyu unouya neyambiro zhinji.

Allergy yambiro

Infliximab inogona kukonzeresa kukonzeresa. Izvi zvinogona kuitika paunenge uchirapwa kana kusvika maawa maviri mushure. Zviratidzo zvinogona kusanganisira:

• mikoko (tsvuku, yakasimudzwa, inocheka makanda eganda)
• kunetseka kufema
• kurwadziwa pachipfuva
• yakakwira kana yakaderera BP. Zviratidzo zvekuderera kweropa zvinosanganisira:
  • dzungu
  • kunzwa kupera simba
  • kunetseka kufema
  • fivha uye kutonhora

Dzimwe nguva infliximab inogona kukonzera kunonoka kweyeergic reaction. Reaction inogona kuitika mazuva matatu kusvika gumi nemaviri mushure mekugamuchira yako jekiseni. Udza chiremba wako ipapo kana iwe uine chimwe chezviratidzo izvi zvekunonoka kugarisana neyakaitika:

• kupindwa nechando
• mapundu
• musoro
• huro inorwadza
• mhasuru kana kurwadziwa kwemajoini
• kuzvimba kwechiso chako nemaoko
• dambudziko kumedza

Yambiro kune vanhu vane mamwe mamiriro ehutano

Kune vanhu vane hutachiona: Udza chiremba wako kana iwe uine chero hutachiona, kunyangwe iri diki, senge rakavhurika rakacheka kana chironda chinotaridzika hutachiona. Muviri wako unogona kuva nenguva yakaoma yekurwisa hutachiona iwe paunenge uchitora infliximab.

Kune vanhu vane tibhii (TB): Infliximab inokanganisa immune system yako uye inogona kuita kuti zvive nyore kwauri kuti uwane TB. Chiremba wako anogona kukuyedza TB usati watanga mushonga.

Kune vanhu vane hepatitis B: Kana iwe ukatakura hutachiona hwehepatitis B, inogona kuita basa paunenge uchishandisa infliximab. Kana hutachiona hukatanga kushanda zvakare, unofanirwa kurega kutora mushonga uye kurapa hutachiona. Chiremba wako anogona kuita kuongororwa kweropa usati watanga kurapwa, panguva yekurapwa, uye kwemwedzi yakati wandei uchitevera kurapwa ne infliximab.

Kune vanhu vane matambudziko eropa: Infliximab inogona kukanganisa masero ako eropa. Udza chiremba wako nezve chero matambudziko aunenge uine neropa rako usati watanga kutora infliximab.

Kune vanhu vane matambudziko etsinga: Infliximab inogona kuita kuti zvimwe zviratidzo zvehurongwa hwemitsipa zviwedzere. Iishandise nekuchenjerera kana uine multiple sclerosis kana Guillain-Barre syndrome.

Kune vanhu vane moyo kutadza: Mushonga uyu unogona kuita kuti moyo utadze zvakanyanya. Fonera chiremba wako ipapo ipapo kana iwe ukawana zviratidzo zvekuwedzera kwemoyo kukundikana. Zviratidzo zvinogona kusanganisira kupfupika kwemweya wekufema, kuzvimba kwemakumbo ako kana tsoka, uye nekukasira kuwedzera uremu. Iwe unofanirwa kurega kutora infliximab kana moyo wako ukakundikana ukawedzera kuipa.

Yambiro kune mamwe mapoka

Kune vakadzi vane pamuviri: Infliximab chikamu chepamuviri B chinodhaka. Izvi zvinoreva zvinhu zviviri:

1. Zvidzidzo zvemushonga mumhuka dzine nhumbu hazvina kuratidza njodzi kumucheche.
2. Iko hakuna zvakakwana zvidzidzo zvinoitwa mumadzimai akazvitakura kuratidza kana mushonga uyu uchiisa njodzi kumucheche.

Udza chiremba wako kana iwe uine pamuviri kana kuronga kuva nepamuviri. Infliximab inofanirwa kushandiswa panguva yekuzvitakura chete kana iyo ingangove bhenefiti inopembedza iyo inogona kuve njodzi kune iyo fetus.

Dana chiremba wako kana iwe ukava nepamuviri paunenge uchitora ichi chinodhaka.

Kune vakadzi vari kuyamwa: Hazvizivikanwe kana mushonga uyu uchipinda mumukaka wemuzamu. Kana infliximab ikapfuudzwa kumwana wako kuburikidza nemukaka wako wepamu, zvinogona kukonzera zvakakomba mhedzisiro.

Iwe nachiremba wako mungangoda kusarudza kana muchizotora infliximab kana kuyamwisa.

Kune vakuru: Iwe unogona kunge uri pangozi yakanyanya yehutachiona hwakakomba uchitora infliximab kana iwe uri pamusoro pemakore makumi matanhatu nemashanu.

Zvevana: Infliximab haina kuratidzirwa kuve yakachengeteka uye inoshanda kune chirwere cheCrohn kana ulcerative colitis muvanhu vadiki pane makore matanhatu.

Kuchengetedzwa uye kushanda kwe infliximab yemamwe mamiriro hazvina kusimbiswa muvanhu vadiki pane makore gumi nemasere.

Maitiro ekutora infliximab

Chiremba wako anoona chipimo chemushonga icho chakanakira iwe zvichienderana nemamiriro ako uye huremu. Hutano hwako hwese hungakanganisa dhayeti yako. Udza chiremba wako nezvese mamiriro ehutano aunazvo chiremba wako kana mukoti asati akupa mushonga. Iwe unozopihwa infliximab kuburikidza netsono yakaiswa mutsinga (IV kana intravenous infusion) paruoko rwako.

Iwe uchagamuchira yako yechipiri dhivhisi mavhiki maviri mushure medosi yako yekutanga. Maitiro anogona kutonyanya kupararira mushure meizvozvo.

Disiki: Chinangwa chedu ndechekukupa iwe neruzivo rwakanyanya uye rwazvino ruzivo. Nekudaro, nekuti zvinodhaka zvinokanganisa munhu wega wega, hatigone kuvimbisa kuti urwu runyorwa runosanganisira madosi anowanikwa. Ruzivo urwu harusi rwekutsiva yezano rekurapa. Gara uchitaura nachiremba wako kana wemishonga nezve madheji akakukodzera.

Tora sekurairwa

Infliximab inoshandiswa pakurapa kwenguva refu. Iyo inouya nenjodzi dzakakomba kana iwe ukasazvitora sezvakarairwa.

Kana iwe usingazvitore zvachose: Kana iwe ukasatora infliximab, mamiriro ako anogona kusanatsiridza uye anogona kuwedzera kuipa.

Kana iwe ukarega kuitora: Mamiriro ako anogona kuwedzera kana iwe ukamira kutora infliximab.

Kana iwe ukatora zvakawandisa: Mubatsiri wezvehutano chete ndiye anofanira kugadzirira mishonga uye ndokupa iwe. Kutora zvakawandisa zvemushonga hazviite. Nekudaro, ita shuwa yekukurukura dosi yako nachiremba wako pakushanya kumwe nekumwe.

Chii chaunofanira kuita kana ukarasikirwa nedosi: Izvo zvakakosha kuti usarasikirwe nedosi yako. Dana chiremba wako kana iwe usingakwanise kuchengeta musangano wako.

Maitiro ekuudza kana mushonga uri kushanda: Zviratidzo zvako zvinofanirwa kuve nani. Zvechirwere cheCrohn uye ulcerative colitis, unogona kunge uine mashoma zviratidzo flare-ups. Kune arthritis, unogona kukwanisa kufamba famba uye kuita mabasa zviri nyore.

Zvakakosha kufunga kwekutora infliximab

Chengetedza izvi kufunga mupfungwa kana chiremba wako akaraira infliximab kwauri.

Kufamba

Kufamba kunogona kukanganisa yako dosing purogiramu. Infliximab inopihwa neyehutano mutapi muchipatara kana pakiriniki. Kana iwe ukaronga kufamba, taura nachiremba wako pamusoro pezvirongwa zvako zvekufamba uye uone kana zvichizokanganisa yako dosing purogiramu.

Clinical bvunzo uye kuongorora

Usati uye panguva yekurapa kwako nemushonga uyu, chiremba wako anogona kuita bvunzo kuti atarise hutano hwako. Iyi bvunzo inogona kusanganisira:

• Tuberculosis (TB) bvunzo: Chiremba wako anogona kukuedza TB usati watanga infliximab uye kukutarisisa zvakanyanya zviratidzo nezviratidzo paunenge uchizvitora.
• Hepatitis B hutachiona hutachiona bvunzo: Chiremba wako anogona kuita kuongororwa kweropa kuti akutarise hutachiona hwehepatitis B usati watanga kurapwa uye paunenge uchigamuchira infliximab. Kana iwe uine hutachiona hwehepatitis B, chiremba wako achaita kuongororwa kweropa panguva yekurapwa uye kwemwedzi yakati wandei uchitevera kurapwa.
• Mimwe bvunzo: Iyi bvunzo inogona kusanganisira:
  • kuongororwa ropa kuongorora hutachiona
  • chiropa chinoshanda bvunzo

Pamberi pemvumo

Makambani mazhinji einishuwarenzi anoda kupihwa mvumo yekutanga kwechirwere ichi. Izvi zvinoreva kuti chiremba wako achazoda kupihwa mvumo kubva kukambani yeinishuwarenzi kambani yako yeinishuwarenzi isati yabhadharira mushonga.

Disiki: Healthline yaedza nepese painogona kuti ive nechokwadi chekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro.Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.