Ivermectin: ndeyei uye kuti ungashandise sei

Zvemukati

• Chii ichochi
• Kushandisa sei
• 1. Strongyloidiasis, filariasis, inda uye nemaputi
• 2. Onchocerciasis
• Zvinogona kuitika mhedzisiro
• Ndiani asingafanire kutora
• Ivermectin uye COVID-19
• Mukurapa kwe COVID-19
• Mukudzivirira kwe COVID-19

Ivermectin mushonga unorwisa utachiona unokwanisa kuomesa nekusimudzira kubviswa kwezvirwere zvakawanda, zvichinyanya kuratidzwa nachiremba pakurapa onchocerciasis, elephantiasis, pediculosis, ascariasis uye mapere.

Mushonga uyu unoratidzwa kune vanhu vakuru uye vana pamusoro pemakore mashanu uye unogona kuwanikwa mumafarmacy, zvakakosha kuti ubvunze chiremba maererano nekushandiswa kwawo, sezvo muyero wacho ungasiyana zvichienderana neanotapukira anorapwa uye huremu hwemunhu abatwa. .

Chii ichochi

Ivermectin mushonga unorwisa utachiona unoratidzwa zvakanyanya pakurapa kwezvirwere zvakati, se:

• Utumbo hwakasimba;
• Filariasis, inozivikanwa seye elephantiasis;
• Maputi, anonziwo makudo;
• Ascariasis, inova hutachiona nehutachiona Ascaris lumbricoides;
• Pediculosis, inova infestation neinda;
• Onchocerciasis, inozivikanwa se "rwizi upofu".

Izvo zvakakosha kuti kushandiswa kwe ivermectin kunoitwa zvinoenderana nekutungamira kwachiremba, sezvo zvichikwanisika kudzivirira kuoneka kwemhedzisiro senge manyoka, kuneta, kurwadziwa mudumbu, kuonda, kuora uye kurutsa. Mune zvimwe zviitiko, dzungu, kukotsira, dzungu, kudedera uye mikoko inogona kuoneka paganda.

Kushandisa sei

Ivermectin inowanzoshandiswa mune imwe chete dhizaini maererano nechirwere chinotapukira chinofanira kubviswa. Mushonga unofanirwa kutorwa usina chinhu mudumbu, awa rimwe chete usati wadya kwekutanga kwezuva. Iyo haifanire kunwiswa nemishonga yebarbiturate, benzodiazepine kana valproic acid kirasi.

1. Strongyloidiasis, filariasis, inda uye nemaputi

Kurapa strongyloidiasis, filariasis, inda infestation kana scabies, iyo inokurudzirwa dosi inofanirwa kuchinjiswa kuyerwa kwako, seinotevera:

2. Onchocerciasis

Kurapa onchocerciasis, iyo inokurudzirwa dosi, zvinoenderana nehuremu, ndeinotevera:

Zvinogona kuitika mhedzisiro

Mimwe yemhedzisiro inowanzoitika panguva yekurapwa ne ivermectin manyoka, kusvotwa, kurutsa, kushaya simba kwakazara uye kushaya simba, kurwadziwa mumimba, kurasikirwa nechido kana kupatira. Aya maitiro anowanzo nyoro uye anoderera.

Uye zvakare, allergic reaction inogona zvakare kuitika, kunyanya kana uchitora ivermectin ye onchocerciasis, iyo inogona kuratidza nemarwadzo emimba, fivha, muviri unoruma, mavara matsvuku paganda, kuzvimba mumaziso kana maziso. Kana zviratidzo izvi zvikaonekwa, zvinokurudzirwa kurega kushandisa mushonga uye utsvage rubatsiro kuchipatara nekukasira kana kune iri padyo nenjodzi.

Ndiani asingafanire kutora

Mushonga uyu unopikiswa kune vakadzi vane nhumbu, vakadzi vari kuyamwisa, vana vari pasi pemakore mashanu kana gumi nemashanu kg nevarwere vane meningitis kana asthma. Uye zvakare, haifanire kushandiswa kune vanhu vane hypersensitivity kune ivermectin kana chimwe chezvimwe zvinhu zviripo mufomula.

Ivermectin uye COVID-19

Iko kushandiswa kwe ivermectin kurwisa COVID-19 kwakakurukurwa zvakanyanya munharaunda yesainzi, izvi nekuti ichi antiparasitic ine antiviral chiito kurwisa hutachiona hunokonzera yellow fever, ZIKA nedengue uye, nekudaro, zvaifungidzirwa kuti zvaizove nemhedzisiro SARS- CoV-2.

Mukurapa kwe COVID-19

Ivermectin yakaedzwa nevanoongorora muAustralia mune yetsika tsika in vitro, iyo yakaratidza kuti chinhu ichi chinoshanda mukubvisa hutachiona hweSARS-CoV-2 mumaawa makumi mana nemasere chete ^[1] . Nekudaro, mhedzisiro iyi yanga isingakwani kuratidza kushanda kwayo muvanhu, uye kuyedzwa kwekiriniki kunodiwa kuti uone kushanda kwayo chaiko. mu vivo, uyezve kuona kana iyo yekurapa dhizaini yakachengeteka muvanhu.

Chidzidzo chevarwere vari muchipatara muBangladesh^[2] yakanangana nekuona kana kushandiswa kwe ivermectin kwaizochengetedzeka kune ava varwere uye kuti paizove nemhedzisiro inopesana neSARS-CoV-2. Nekudaro, varwere ava vakaendeswa kune mashanu-mazuva ekurapa protocol ine ivermectin chete (12 mg) kana imwe chete muyero we ivermectin (12 mg) pamwe chete nemimwe mishonga kwemazuva mana, uye mhedzisiro yacho yakaenzaniswa neboka re placebo rine 72 varwere. Nekuda kweizvozvo, vaongorori vakaona kuti kushandiswa kweivermectin chete kwaive kwakachengeteka uye kuti kwaive kushanda pakurapa zvakapfava COVID-19 muvakuru varwere, zvisinei zvimwe zvidzidzo zvaizodiwa kuratidza izvi mhedzisiro.

Imwe ongororo yakaitwa muIndia yakanangana nekuona kana iko kushandiswa kwe ivermectin nekufemera mukati kungave neanopokana-nekukanganisa mheni kurwisa COVID-19 ^[3], sezvo mushonga uyu uine mukana wekukanganisa kutakurwa kwechimiro cheSARS-CoV-2 kuenda kuchikamu chemaseru emunhu, zvichikonzera antiviral athari. Nekudaro, izvi zvinogona kungogoneka neiyo mizinga yakakura ye ivermectin (yakakwira kupfuura iyo dosi inokurudzirwa yekurapa zvipembenene), izvo zvinogona kukonzera chiropa chepfu mhedzisiro Nekudaro, seimwe nzira kune yakakwira madosi e ivermectin, vatsvaguriri vakakurudzira kushandiswa kwechirwere ichi nekufemera, izvo zvinogona kuita chiito chiri nani kurwisa SARS-CoV-2, zvisinei iyi nzira yekutungamira ichiri kuda kunyatso dzidzwa.

Dzidza zvakawanda pamusoro pemishonga yekurapa hutachiona neiyo nyowani coronavirus.

Mukudzivirira kwe COVID-19

Pamusoro pe ivermectin ichidzidzwa senzira yekurapa yeCOVID-19, zvimwe zvidzidzo zvakaitwa nechinangwa chekuona kana kushandiswa kwechirwere ichi kuchizobatsira kudzivirira hutachiona.

Chidzidzo chevatsvagiri muUnited States chakanangana nekuongorora kuti nei COVID-19 iine zviitiko zvakasiyana munyika dzinoverengeka ^[5]. Nekuda kwekuferefeta uku, vakaona kuti nyika dzemu Africa dzine hudzamu hwakaderera nekuda kwekushandisa kwemishonga yakawanda, kunyanya mishonga inorwisa kupatsanurwa, kusanganisira ivermectin, nekuda kwenjodzi yakawedzera yezvipembenene munyika idzi.

Nekudaro, ivo vaongorori vanodavira kuti kushandiswa kweIvermectin kunogona kudzora mwero wekudzokororazve hutachiona uye kudzivirira kukura kwechirwere, zvisinei mhedzisiro iyi inongotarisana nekubatana, uye hapana kwayedzo yemakiriniki yakaitwa.

Imwe ongororo yakaratidza kuti kushandiswa kwemaanoparticles anosangana ne ivermectin kunogona kudzikisira kutaura kweanogamuchira aripo mumasero emunhu, ACE2, inosunga hutachiona, uye neproteinisi iripo pamusoro pehutachiona, ichideredza njodzi yekutapukirwa ^[6]. Nekudaro, zvimwe muzvidzidzo zvevivo zvinodikanwa kuratidza mhedzisiro yacho, pamwe nezvidzidzo zvehupfu kuona kuti kushandiswa kweivermectin nanoparticles kwakachengeteka.

Nezve kushandiswa kwe ivermectin zvinodzivirira, hapana zviyero zvinogutsa parizvino. Nekudaro, kuitira kuti ivermectin ishande nekudzivirira kana kudzikisa kupinda kwemavhairasi mumasero, zvinodikanwa kuti paine hutachiona, nekuti nekudaro zvinokwanisika kuve nehutachiona chiito chemushonga.