Zvamunoda Kuziva Nezve MTHFR Gene

Zvemukati

• Zvimwe zvekuchinja kweMTHFR
• Zviratidzo zvekuchinja kweMTHFR
• Kuedzwa kweMTHFR shanduko
• Kurapa kwehukama hwakanangana nehutano
• Matambudziko mukuzvitakura
• Inogona kuwedzera
• Kudya kufunga
• Kutora

Isu tinosanganisira zvigadzirwa zvatinofunga zvinobatsira kuvaverengi vedu. Kana iwe ukatenga kuburikidza nehukama pane ino peji, isu tinogona kuwana diki komisheni. Heano maitiro edu.

Chii chinonzi MTHFR?

Iwe unogona kunge wakaona chidimbu "MTHFR" chichiwedzera mune dzazvino nhau dzehutano. Inogona kutaridzika seshoko rekutuka pakutanga kuona, asi inongoreva kune yakajairika geni shanduko.

MTHFR inomirira methylenetetrahydrofolate reductase. Iri kuwana kutariswa nekuda kwekuchinja kwemajini kunogona kutungamira kumatunhu akakwirira muropa uye nemazinga akaderera e folate nemamwe mavitamini.

Pakave nekufunganya kwekuti dzimwe nyaya dzehutano dzakabatana nekuchinja kweMTHFR, saka kuyedza kwave kunyanya kuitika mukati memakore.

Zvimwe zvekuchinja kweMTHFR

Iwe unogona kuve neumwe kana maviri shanduko - kana kwete - pane iyo MTHFR geni. Shanduko idzi dzinowanzo danwa kuti dzakasiyana. Musiyano chikamu cheDNA regene iro rinowanzosiyana, kana kusiyana, kubva pamunhu kuenda kumunhu.

Kuve nemusiyano mumwe - heterozygous - kashoma kupa kune hutano. Vamwe vanhu vanotenda kuve nekaviri shanduko - homozygous - zvinogona kutungamira kumatambudziko akakomba. Kune maviri akasiyana, kana mafomu, ekuchinja anogona kuitika paMTHFR gene.

Mhando dzakasiyana ndedze:

• C677T. Vanenge makumi matatu kusvika makumi mana muzana yevagari vemuAmerica vanogona kuve neshanduko pachimiro chemajini C677T. Vanoda kusvika makumi maviri neshanu muzana yevanhu vekwaMasipanishi, uye gumi kusvika gumi neshanu muzana yezana reCaucasus, vane homozygous kune izvi zvakasiyana.
• A1298C. Iko kune kushomeka kutsvagisa nezve izvi zvakasiyana. Zvidzidzo zviripo zvinowanzo kuve nenzvimbo kana dzinza. Semuenzaniso, ongororo ya2004 yakanangana nevane zana nemakumi maviri vanopa ropa reIrish nhaka. Pakati pevaipa, 56, kana 46.7 muzana, vaive heterozygous yeiyi misiyano, uye 11, kana 14.2 muzana, vaive homozygous.
• Izvo zvakare zvinokwanisika kuwana ese ari maviri C677T uye A1298C shanduko, inova imwe kopi yeimwe neimwe.

Gene shanduko dzinogarwa nhaka, zvinoreva kuti unozviwana kubva kuvabereki vako. Pakubata pamuviri, unogamuchira kopi imwe yeMTHFR gene kubva kumubereki wega wega. Kana vese vakaita shanduko, njodzi yako yekuchinja homozygous yakakwira.

Zviratidzo zvekuchinja kweMTHFR

Zviratidzo zvinosiyana kubva pamunhu kusvika pamunhu uye kubva pamusiyano kuenda mukusiyana. Kana iwe ukakurumidza kutsvaga internet, iwe ungangowana akawanda mawebhusaiti anoti MTHFR inokonzeresa mamiriro akati wandei.

Ramba uchifunga kuti kutsvagisa kwakatenderedza MTHFR nemhedzisiro yayo kuchiri kuchinja. Uchapupu hunobatanidza hwakawanda hweaya mamiriro ehutano kuMTHFR parizvino hausi kana kuti hauna kubvumidzwa.

Kupfuura zvingangoitika, kunze kwekunge uine matambudziko kana kuyedzwa kwaitwa, haufe wakaziva nezve yako MTHFR mutation chinzvimbo.

Mamiriro ezvinhu akafananidzirwa kuti abatanidzwe neMTHFR anosanganisira:

• chirwere chemwoyo uye thromboembolic (kunyanya kuwanda kweropa, kurohwa, embolism, uye kurwiswa kwemoyo)
• kuora mwoyo
• kushushikana
• bipolar kusagadzikana
• schizophrenia
• gomarara rekoloni
• acute leukemia
• kurwadziwa kusingaperi uye kuneta
• kurwadziwa kwemutsipa
• migraines
• kudzokorora kudzokorodza mumadzimai ezera rekubereka vana
• nhumbu ine neural tube zvikanganiso, senge musana bifida uye anencephaly

Dzidza zvakawanda nezvekuva nepamuviri wakabudirira neMTHFR.

Iyo njodzi inogona kuwedzerwa kana munhu aine maviri majini akasiyana kana ari homozygous yekuchinja kweMTHFR.

Kuedzwa kweMTHFR shanduko

Masangano akasiyana siyana ezvehutano - anosanganisira American College of Obstetricians uye Gynecologists, Koreji yeAmerican Pathologists, American College yeMedical Genetics, uye American Heart Association - usakurudzire kuyedzwa kwemisiyano kunze kwekunge munhu anewo zvakanyanya mwero wehomocysteine ​​kana zvimwe zviratidzo zvehutano.

Zvakadaro, iwe ungangoda kuziva kuti uwane yako yega MTHFR chinzvimbo. Funga kushanyira chiremba wako uye nekukurukura zvayakanakira nezvayakaipira zvekuedzwa.

Ramba uchifunga kuti kuongororwa kwemajini hakugone kuvharwa neinishuwarenzi yako. Fonera anotakura ako kana iwe uchifunga kuyedzwa kubvunza nezve mari.

Dzimwe dzimba dzekumba dzekuyedza dzinopa kuongororwa kweMTHFR futi. Mienzaniso inosanganisira:

• 23ndeNdosarudzo yakakurumbira inopa ruzivo rwemadzinza uye ruzivo rwehutano. Inotengawo isingadhuri ($ 200). Kuti uite iyi bvunzo, unoisa mate muhubhu uye wotumira kuburikidza netsamba kune lab. Mhedzisiro inotora mavhiki matanhatu kusvika masere.
• Imba Yangu MTHFR ($ 150) ndeimwe sarudzo inonyanya kutarisisa shanduko. Muedzo unoitwa nekutora DNA kubva mukati medama rako nemasabs. Mushure mekutumira iyo specimen, mhedzisiro inotora vhiki imwe chete kana maviri.

Kurapa kwehukama hwakanangana nehutano

Kuva neMTHFR musiyano hazvireve kuti unoda kurapwa. Zvinogona kungoreva iwe unofanirwa kutora vhitamini B yekuwedzera.

Kurapa kunowanzo fanirwa kana iwe uine yakanyanya yakanyanya homocysteine ​​mazinga, kazhinji nguva dzose pamusoro peiyo nhanho inofungidzirwa kune mazhinji MTHFR akasiyana. Chiremba wako anofanira kutonga zvimwe zvinokonzeresa zvekuwedzera homocysteine, izvo zvinogona kuitika kana kana pasina MTHFR akasiyana.

Zvimwe zvikonzero zvepamusoro homocysteine ​​zvinosanganisira:

• hypothyroidism
• mamiriro akaita seshuga, cholesterol yakawanda, uye neBP
• kufutisa uye kusaita basa
• mimwe mishonga, yakadai seatorvastatin, fenofibrate, methotrexate, uye nicotinic acid

Kubva ipapo, kurapwa kunoenderana nechikonzero uye hazvireve kuti unofunga nezve MTHFR. Kunze kwekunge uri pawakaonekwa uine ese eanotevera mamiriro panguva imwe chete.

• yakakwira homocysteine ​​mazinga
• yakasimbiswa MTHFR shanduko
• vhitamini kushomeka mu folate, choline, kana mavitamini B-12, B-6, kana riboflavin

Muzviitiko izvi, chiremba wako anogona kukurudzira kukwidziridzwa kugadzirisa kushomeka pamwe nemishonga kana kurapwa kugadzirisa mamiriro ehutano chaiwo.

Vanhu vane MTHFR shanduko vangangodawo kutora matanho ekudzivirira kudzikisa yavo homocysteine ​​mazinga. Imwe nzira yekudzivirira iri kuchinja mamwe mararamire sarudzo, ayo anogona kubatsira pasina kushandisa mishonga. Mienzaniso inosanganisira:

• kurega kusvuta, kana uchisvuta
• kuwana muviri zvakakwana
• kudya chikafu chine hutano, chakaringana

Matambudziko mukuzvitakura

Kudzokororwazve kwepamuviri uye neural chubhu zvikanganiso zvinogona kunge zvakabatana neMTHFR. Genetic and Rare Diseases Information Center inoti zvidzidzo zvinoratidza kuti vakadzi vane maC677T akasiyana vari pangozi yekuve nemwana ane neural tube chirema.

Chidzidzo che2006 chakatarisa vakadzi vane nhoroondo yekudzokororwa kwepashure. Yakawana kuti makumi mashanu neshanu muzana avo vaive neakawanda homozygous magene, kusanganisira MTHFR, inosanganisirwa nekugwamba kweropa, zvichipesana ne10 muzana chete yevakadzi vari muchikamu chekutonga.

Taura nachiremba wako nezve kuyedza kana chero cheanotevera mamiriro anoshanda kwauri:

• Iwe wakasangana nezvakawanda zvisina tsananguro miscarriage.
• Wakave nemwana ane neural tube chirema.
• Iwe unoziva iwe une MTHFR mutation, uye iwe une nhumbu.

Kunyangwe paine humbowo hushoma hwekutsigira, vamwe vanachiremba vanokurudzira kutora mishonga yekuvhara ropa. Yakawedzera folate yekuwedzera inogona zvakare kukurudzirwa.

Inogona kuwedzera

Iyo MTHFR geni mutation inodzivirira nzira iyo muviri unogadzira folic acid uye mamwe akakosha mavitamini B. Kuchinja kuwedzerwa kweichi chinovaka chinhu chingangotarisisa kupokana nemhedzisiro yacho.

Folic acid ndeyechokwadi inogadzirwa nevanhu folate, chinhu chinowanzoitika chinowanikwa muzvikafu. Kutora iyo bioavailable fomu ye folate - methylated folate - zvinogona kubatsira muviri wako kuutora zviri nyore.

Vanhu vazhinji vanokurudzirwa kutora multivitamin iyo inove neinosvika 0.4 milligrams efolic acid zuva rega rega.

Vakadzi vane nhumbu havakurudzirwe kushandura mavitamini epamuviri kana kutarisirwa zvichienderana nemamiriro avo eMTHFR chete. Izvi zvinoreva kutora muyero wakaenzana we0,6 mamigiramu efolic acid zuva nezuva.

Vakadzi vane nhoroondo yeiyo neural tube kuremara vanofanirwa kutaura nachiremba wavo kune mamwe marongero.

Multivitamini ine methylated folate inosanganisira:

• Thorne Basic Nutrients 2 / Zuva
• Smarty bhurukwa Adult Yakazara
• Amai Shiri Kusununguka Mavitamini

Taura nachiremba wako usati wachinja mavitamini uye zvinowedzera. Vamwe vanogona kukanganisa mimwe mishonga kana kurapwa kwauri kugamuchira.

Chiremba wako anogona zvakare kuratidza kunyorerwa mavitamini ane folate maringe nefolic acid. Zvichienderana neinishuwarenzi yako, mitengo yesarudzo idzi inogona kusiyanisa kana ichienzaniswa nemhando dzakasiyana-siyana.

Kudya kufunga

Kudya chikafu chakapfuma mu folate kunogona kubatsira zvakasikwa kutsigira ako mazinga eiyi yakakosha vhitamini. Zvisinei, kuwedzera kunogona kunge kuchiri kudikanwa.

Sarudzo dzakanaka dzekudya dzinosanganisira:

• mapuroteni akaita bhinzi yakabikwa, pizi, uye nyemba
• veggies senge sipinashi, asparagus, lettuce, beet, broccoli, chibage, zvinomera zveBrussels, uye bok choy
• michero yakaita secantaloupe, honeydew, banana, raspberries, grapefruit, uye strawberries
• majusi akaita seorenji, chinanazi chinamanzi, mazambiringa, matomatisi, kana mumwe muto wemuriwo
• nzungu ruomba
• mbeu yezuva

Vanhu vane shanduko yeMTHFR vangangoda kudzivirira chikafu chine fomu yekugadzira, folic acid - asi humbowo hahuna kujeka kuti hunokosha kana hunobatsira.

Ive neshuwa yekutarisa zvinyorwa, sezvo ichi vhitamini ichiwedzerwa kune akawanda akafumiswa zviyo, senge pasta, zviyo, chingwa, uye hupfumi hunotengeswa.

Dzidza zvakawanda nezve musiyano uripo pakati pe folate uye folic acid.

Kutora

Mamiriro ako eMTHFR anogona kana kuti angave asiri kukanganisa hutano hwako. Kumwe kutsvagurudza kunodiwa kuti uone iko kwechokwadi kukanganisa, kana kuripo, kwakabatana nemisiyano.

Zvakare, mazhinji anoremekedzwa masangano ehutano haakurudzire kuyedzwa kweiyi shanduko, kunyanya pasina zvimwe zvinoratidza zvechiremba. Taura nachiremba wako nezvezvakanakira uye njodzi dzekuyedza, pamwe nezvimwe zvinonetsa zvaungave nazvo.

Ramba uchidya zvakanaka, kurovedza muviri, uye kudzidzira mamwe mararamiro ane hutano kutsigira hupenyu hwako hwese.