Nexium vs. Prilosec: Kurapa kweGERD mairi

Zvemukati

• Nei maPPI achishanda
• Nei vachinyorerwa
• Misiyano
• Kubudirira
• Mutengo wekuregererwa
• Zvimwe zvinokanganisa
• Yambiro nekudyidzana
• Njodzi zvinhu
• Kubatana kwezvinodhaka
• Kutora

Isu tinosanganisira zvigadzirwa zvatinofunga zvinobatsira kuvaverengi vedu. Kana iwe ukatenga kuburikidza nehukama pane ino peji, isu tinogona kuwana diki komisheni. Heano maitiro edu.

Kunzwisisa zvaunogona kuita

Kushungurudzika kunonetsa zvakakwana. Kuita nzwisiso yesarudzo yako yemushonga yegastroesophageal Reflux chirwere (GERD) inogona kuita kuti zvinyanye kuoma.

Maviri eanonyanya kutaurwa proton pump inhibitors (PPIs) ndeye omeprazole (Prilosec) uye esomeprazole (Nexium). Ose ari maviri ave kuwanikwa se over-the-counter (OTC) zvinodhaka.

Nyatso tarisa pane ese maviri kuti uone kuti ndeapi mabhenefiti ayo mumwe mushonga anogona kupa pamusoro peumwe.

Nei maPPI achishanda

Pombi dzeProton ma enzymes anowanikwa mumasero eparietal emudumbu mako. Ivo vanoita hydrochloric acid, iyo hombodo huru yemudumbu acid.

Muviri wako unoda mudumbu acid yekugaya. Nekudaro, kana mhasuru iri pakati pemudumbu wako uye yegurokuru isina kuvhara zvakanaka, iyi acid inogona kupedzisira yaenda mugurokuro rako. Izvi zvinokonzera kunzwa kupisa mubhokisi rako nehuro kwakabatana neGERD.

Inogona zvakare kukonzera:

• asima
• kukosora
• chirwere chemabayo

PPIs inoderedza huwandu hweacid iyo inogadzirwa nemaproton pumps. Vanoshanda zvakanyanya kana iwe ukavatora awa kusvika pamaminitsi makumi matatu usati wadya. Iwe unozoda kuvatora kwemazuva akati wandei vasati vanyatso shanda.

PPIs dzave dzichishandiswa kubvira 1981. Ivo vanoonekwa semushonga unoshanda kwazvo wekudzora dumbu acid.

Nei vachinyorerwa

PPIs senge Nexium ne Prilosec anoshandiswa kurapa gastric acid zvine hukama, kusanganisira:

• GERD
• chirungurira
• esophagitis, kunova kuzvimba kana kuputika kweiyo esophagus
• mudumbu uye duodenal ulcers, izvo zvinokonzerwa ne Helicobacter pylori (H. pylori) hutachiona kana nonsteroidal anti-kupisa zvinodhaka (NSAIDs)
• Zollinger-Ellison syndrome, chiri chirwere umo mamota anokonzeresa kugadzirwa kweakanyanya dumbu acid

Misiyano

Omeprazole (Prilosec) uye esomeprazole (Nexium) mishonga yakafanana. Nekudaro, pane misiyano midiki mukugadzirwa kwavo kwemakemikari.

Prilosec ine maisomers maviri emushonga omeprazole, nepo Nexium iine chete isomer

Isomer izwi rinoreva mamorekuru ayo anosanganisira iwo mamwe makemikari, asi akarongwa neimwe nzira.Nekudaro, iwe unogona kuti omeprazole uye esomeprazole zvakagadzirwa nematombo akafanana, asi akaiswa pamwechete zvakasiyana.

Nepo misiyano yemasomers ingaite senge diki, inogona kukonzera mutsauko mashandisiro anoita zvinodhaka.

Semuenzaniso, iyo isomer iri muNexium inogadziriswa zvishoma nezvishoma kupfuura Prilosec mumuviri wako. Izvi zvinoreva kuti mazinga emushonga ari pamusoro muropa rako, uye kuti esomeprazole inogona kudzikisa kugadzirwa kweasidhi kwenguva yakareba.

Inogona zvakare kushanda zvishoma nekukurumidza kurapa zviratidzo zvako zvichienzaniswa ne omeprazole. Esomeprazole zvakare yakaputsika zvakasiyana nechiropa chako, saka zvinogona kutungamira mukudyidzana kwemushonga pane omeprazole.

Kubudirira

Zvimwe zvidzidzo zvinoratidza kuti mutsauko uripo pakati pe omeprazole uye esomeprazole inogona kupa zvakanakira vanhu vane mamwe mamiriro.

Chidzidzo chekare kubva muna 2002 chakawana kuti esomeprazole yakapa kudzora kwakabudirira kweGERD kupfuura omeprazole panguva imwe chete.

Sekureva kwekudzidza kwakazotevera muna2009, esomeprazole yakapa runyararo nekukurumidza kupfuura omeprazole muvhiki yekutanga yekushandisa. Mushure mevhiki rimwe, kusunungurwa kwechiratidzo kwaive kwakafanana.

Zvisinei, mune chinyorwa cha2007 muAmerican Family Physician, vanachiremba vakabvunza izvi nezvimwe zvidzidzo zvePPIs. Vakataura zvinonetsa zvakadai se:

• mutsauko muhuwandu hwezvinhu zvinoshandiswa zvinopihwa muzvidzidzo
• kukura kwezvidzidzo
• nzira dzekuchipatara dzinoshandiswa kuyera kushanda

Vanyori vakaongorora 41 zvidzidzo pamusoro pekubudirira kwePPIs. Vakagumisa kuti pane mutsauko mushoma mukubudirira kwePPIs.

Nekudaro, nepo paine imwe dhata inoratidza kuti esomeprazole inoshanda zvakanyanya pakubvisa zviratidzo, nyanzvi zhinji dzinobvumirana kuti maPPI ane zvakafanana mhedzisiro.

IAmerican College yeGastroenterology inotaura kuti hapana misiyano mikuru mukuti maPPI akasiyana sei pakurapa GERD.

Mutengo wekuregererwa

Musiyano mukuru pakati pePrilosec neNexium yaive mutengo kana uchiongororwa.

Kusvikira Kurume 2014, Nexium yaiwanikwa chete nemushonga uye nemutengo wakakwira zvakanyanya. Nexium ikozvino inopa yakawandisa-iyo-counter (OTC) chigadzirwa icho chakatengwa nemakwikwi nePrisosec OTC. Zvisinei, generic omeprazole inogona kunge isingadhuri pane Prilosec OTC.

Pachivanhu, makambani einishuwarenzi haana kuvhara zvigadzirwa zveOTC. Nekudaro, iwo musika wePPI watungamira vazhinji kuti vadzokorore kufukidza kwavo Prilosec OTC neNexium OTC. Kana inishuwarenzi yako ikasafukidza OTC PPIs, mushonga wegeneric omeprazole kana esomeprazole inogona kunge iri yako sarudzo yakanaka.

Nexium dzimwe nguva inonzi "neniwo" mishonga nokuti yakafanana zvikuru naPrisosec, mushonga uripo. Vamwe vanhu vanofunga kuti "neniwo" zvinodhaka inongova nzira yemakambani emishonga kuti aite mari nekuteedzera madhiragi atovepo. Asi vamwe vakapokana kuti "neniwo" zvinodhaka zvinogona kudzikisira mutengo wemishonga, nekuti zvinokurudzira kukwikwidzana pakati pemakambani emishonga.

Shanda nachiremba wako kana wemishonga kuti usarudze kuti PPI yakakunakira iwe. Pamusoro pemutengo, funga zvinhu zvakaita se:

• mhedzisiro
• mamwe marapirwo
• mimwe mishonga yauri kutora

Zvimwe zvinokanganisa

Vanhu vazhinji havana mhedzisiro kubva kuPPIs. Kazhinji, vanhu vanogona kusangana:

• manyoka
• kusvotwa
• kurutsa
• musoro

Iyi mhedzisiro mhedzisiro inogona kuve yakanyanya kuve ne esomeprazole kupfuura omeprazole.

Zvinotendwa zvakare kuti ese maPPI anogona kuwedzera njodzi ye:

• musana uye kutsemuka kwechiuno mumadzimai ekumashure ekumwedzi, kunyanya kana mishonga ikatorwa kwegore kana kupfuura kana pamadhora epamusoro
• hutachiona kuzvimba kwekoloni, kunyanya mushure mekuchengetwa muchipatara
• chirwere chemabayo
• kushomeka kwehutano, kusanganisira vhitamini B-12 uye kushomeka kwemagesium

Chinongedzo cheinogona kuve dementia njodzi yakataurwa muna 2016, asi chidzidzo chakakura chekusimbisa muna 2017 chakaratidza kuti pakanga pasina njodzi yakawedzera yeundangariro kubva pakushandisa PPIs.

Vanhu vazhinji vanoona yakawandisa acid kugadzirwa pavanomira kushandisa PPIs. Zvisinei, nei izvi zvichiitika hazvinzwisisike zvachose.

Kune mazhinji dumbu asidi nyaya, zvinokurudzirwa kuti utore maPPI kweasingapfuuri mana kana masere masvondo kunze kwekunge chiremba wako aona kuti inguva yakareba yekurapa inodiwa.

Pakupera kwenguva yekurapa yakakurudzirwa, iwe unofanirwa kubvisa mushonga zvishoma nezvishoma. Shanda nachiremba wako kuti uite kudaro.

Yambiro nekudyidzana

Usati watora chero mushonga, taura nachiremba wako kuti udzidze nezve njodzi njodzi uye kudyidzana kwezvinodhaka zvinosangana nazvo.

Njodzi zvinhu

• ndezvedzinza reAsia, sezvo muviri wako ungatora nguva yakareba kugadzirisa maPPIs uye ungangoda imwe dosi
• vane chirwere chechiropa
• ave nemazinga mashoma emagesium
• vane pamuviri kana kuronga kuva nepamuviri
• vari kuyamwisa

Kubatana kwezvinodhaka

Nguva dzose udza chiremba wako nezvese zvinodhaka, mahebhu, uye mavitamini aunotora. Prilosec neNexium vanogona kusangana nemimwe mishonga yaungave uchitora.

US Food and Drug Administration (FDA) yakaburitsa yambiro yekuti mushonga muPrilosec unoderedza kushanda kweropa rakatetepa clopidogrel (Plavix).

Iwe haufanire kutora mishonga miviri pamwechete. Dzimwe PPI hadzina kuverengerwa muyambiro nekuti hadzina kuyedzwa kuita uku.

Iyi mishonga haifanirwe kutorwa pamwe neNexium kana Prilosec:

• clopidogrel
• delavirdine
• nelfinavir
• rifampin
• rilpivirine
• risedronate
• Wort St.

Mimwe mishonga inogona kusangana neNexium kana Prilosec, asi inogona kutorwa nemushonga. Udza chiremba wako kana iwe ukatora chero yemishonga iyi kuti vagone kuongorora njodzi yako:

• amphetamine
• aripiprazole
• atazanavir
• bisphosphonates
• bosentan
• carvedilol
• cilostazol
• kwevanatram
• clozapine
• cyclosporine
• dextroamphetamine
• esvitalopram
• antifungal zvinodhaka
• fosphenytoin
• iron
• hydrocodone
• mesalamine
• methotrexate
• methylphenidate
• phenytoin
• raltegravir
• saquinavir
• tacrolimus
• warfarin kana vamwe vanopikisa vhitamini K
• voriconazole

Kutora

Kazhinji, iwe unogona kusarudza iyo PPI inowanikwa nyore uye inodhura zvishoma. Asi ramba uchifunga kuti PPIs inobata chete zviratidzo zveGERD uye zvimwe zvinetswa. Izvo hazvirape iyo chikonzero uye zvinongoratidzirwa chete kwenguva pfupi kushandisa kunze kwekunge chiremba wako afunga neimwe nzira.

Maitiro ehupenyu anofanirwa kuve ako ekutanga matanho mukudzora GERD uye nekurwadziwa pahuro. Ungangoda kuedza:

• kurema manejimendi
• kudzivisa kudya kukuru usati warara
• kurega kana kurega kushandisa fodya, kana ukashandisa

Nekufamba kwenguva, GERD yenguva refu inogona kutungamira kukenza esophageal. Kunyangwe vashoma vanhu vane GERD vanowana kenza yekusophageal, zvakakosha kuti uzive njodzi yacho.

PPIs inotanga kushanda zvishoma nezvishoma, saka dzinogona kunge dzisiri mhinduro yeimwe nguva yekuchema kana reflux.

Dzimwe nzira dzinogona kupa ruyamuro rwekushandisa pano neapo, senge:

• chewable calcium calcium carbonate mahwendefa
• mvura yakaita sealuminium hydroxide uye magnesium hydroxide (Maalox) kana aluminium / magnesium / simethicone (Mylanta)
• asidhi-inoderedza zvinodhaka senge famotidine (Pepcid) kana cimetidine (Tagamet)

Zvese izvi zvinowanikwa seOTC zvinodhaka.