Nicotinamide Riboside: Zvakanakira, Mativi Ekupedzisira uye Dosage

Zvemukati

• Chii chinonzi Nicotinamide Riboside?
• Zvinogona Kubatsira
• Yakashandurwa Nyore kuNAD +
• Inogonesa Enzymes Iyo Inogona Kukurudzira Hutano Kukwegura
• Inogona Kubatsira Kuchengetedza Maseru eBongo
• Inogona Kuderera Mwoyo Chirwere Njodzi
• Zvimwe Zvichabatsira
• Zvingangoitika Njodzi uye Side Migumisiro
• Chipimo chemushonga uye Zvinokurudzirwa
• Icho Chinokosha

Gore rega rega, maAmerican vanoshandisa mabhiriyoni emadhora kuzvinhu zvinopesana nekukwegura.

Nepo zvigadzirwa zvakawanda zvinopesana nekukwegura zvichizama kushandura zviratidzo zvekukwegura paganda rako, nicotinamide riboside - inonziwo niagen - inovavarira kudzoreredza zviratidzo zvekukwegura kubva mukati memuviri wako.

Mukati memuviri wako, nicotinamide riboside inoshandurwa kuita NAD +, mamorekuru anobatsira aripo mukati memumwe wemasero ako uye anotsigira akawanda maficha ekukwegura kune hutano.

Ichi chinyorwa chinotsanangura zvese zvaunoda kuti uzive nezve nicotinamide riboside, kusanganisira mabhenefiti ayo, mhedzisiro uye muyero.

Chii chinonzi Nicotinamide Riboside?

Nicotinamide riboside, kana niagen, ndeimwe nzira yevhitamini B3, inonziwo niacin.

Sedzimwe mhando dzevhitamini B3, nicotinamide riboside inoshandurwa nemuviri wako kuita nicotinamide adenine dinucleotide (NAD +), coenzyme kana mubatsiri wemorekuru.

NAD + inoshanda sehuni kune akawanda akakosha maitiro ehupenyu, akadai se (,):

• Kushandura chikafu kuita simba
• Kugadzirisa DNA yakakuvara
• Kusimbisa maseru ekudzivirira maseru
• Kugadzika wachi yemukati yemuviri wako kana circadian rhythm

Nekudaro, huwandu hweNAD + mumuviri wako zvinowira pasi nezera ().

Akaderera NAD + nhanho dzakabatanidzwa kune kunetsekana kwehutano sekukwegura uye chirwere chisingaperi, senge chirwere cheshuga, chirwere chemwoyo, chirwere cheAlzheimer uye kurasikirwa kwemaonero ().

Sezvineiwo, kutsvagurudzwa kwemhuka kwakawana kuti kukwidza mazinga eNAD + kunogona kubatsira kudzosera zviratidzo zvekukwegura uye kudzikisa njodzi yezvirwere zvakawanda zvisingaperi (,,).

Nicotinamide riboside inowedzera - senge niagen - yakakurumidza kuve inozivikanwa nekuti inoita kunge inonyanya kushanda mukusimudzira NAD + nhanho ().

Nicotinamide riboside inowanikwawo mumatanho emukaka wemombe, mbiriso uye doro ().

Nicotinamide riboside, kana niagen, ndeimwe nzira yevhitamini B3. Inokurudzirwa seye anti-kuchembera inowedzera nekuti inowedzera muviri wako mazinga eNAD +, ayo anoita sehuni kune akawanda akakosha maitiro ehupenyu.

Zvinogona Kubatsira

Nekuti kutsvagurudza kwakawanda pamusoro peicotinamide riboside neNAD + kunobva kuzvidzidzo zvemhuka, hapana mhedziso dzakajeka-dzingaitwe pamusoro pekushanda kwayo kuvanhu.

Izvo zvakati, heano mamwe mabhenefiti ehutano anogona nicotinamide riboside.

Yakashandurwa Nyore kuNAD +

NAD + inonzi coenzyme, kana mubatsiri wemorekuru, iyo inotora chikamu mune zvakawanda zvipenyu maitiro.

Kunyange zvichikosha pahutano hwakanaka, tsvagiridzo inoratidza kuti NAD + nhanho dzinoramba dzichidonha nezera. Low NAD + nhanho dzakabatana nehurombo kuchembera uye dzakasiyana siyana dzezvirwere zvinokuvadza (,).

Imwe nzira yekusimudza NAD + nhanho ndeyekushandisa NAD + vatangiri - iwo ekuvakisa NAD + - senge nicotinamide riboside.

Zvidzidzo zvezvipfuwo zvinoratidza kuti nicotinamide riboside inosimudza ropa NAD + nhanho dzinokwana kusvika ku2.7 nguva. Uyezve, zviri nyore kushandiswa nemuviri wako kupfuura mamwe maNAD + anotungamira ().

Inogonesa Enzymes Iyo Inogona Kukurudzira Hutano Kukwegura

Nicotinamide riboside inobatsira kuwedzera mazinga eNAD + mumuviri wako.

Mukupindura, NAD + inomutsa mamwe maenzyme anogona kusimudzira hutano hwakanaka.

Rimwe boka istutuins, inoita kunge inovandudza hupenyu uye hutano hwakazara mumhuka. Zvidzidzo zvinoratidza kuti sirtuin inogona kugadzirisa yakakuvara DNA, inowedzera kusagadzikana kusagadzikana, inoderedza kuzvimba uye inopa mamwe mabhenefiti anosimudzira hutano hwakanaka (,,).

Sirtuin zvakare vane basa rehupenyu-hunowedzera mabhenefiti ecalorion kurambidzwa ().

Rimwe boka i Poly (ADP-Ribose) polymerases (PARPs), iyo inogadzirisa yakakuvara DNA. Zvidzidzo zvinobatanidza yakakwira PARP chiitiko kune kushoma kukuvara kweDNA uye hupenyu hwakareba (,).

Inogona Kubatsira Kuchengetedza Maseru eBongo

NAD + inoita basa rakakosha mukubatsira ako maseru ehuropi zera zvakanaka.

Mukati memasero ehuropi, NAD + inobatsira kudzora kugadzirwa kwePGC-1-alpha, puroteni inoita senge inobatsira kuchengetedza maseru kurwisa oxidative kusagadzikana uye kukanganisika kwemitochondrial function ().

Vatsvagiri vanofunga kuti kushushikana kweiyo oxidative uye kukanganisika kwemitochondrial basa kwakabatana nehukama hune hukama nezera seAlzheimer's uye Parkinson's chirwere (,,).

Mumakonzo ane chirwere cheAlzheimer, nicotinamide riboside yakasimudza huropi NAD + nhanho uye PGC-1-alpha kugadzirwa neanosvika 70% uye 50%, zvichiteerana. Pakupera kwekudzidza, mbeva dzakaitwa zvirinani zvirinani mundangariro-based mabasa ().

Mune bvunzo-chubhu yekudzidza, nicotinamide riboside yakasimudza NAD + mazinga uye zvakanyanya kuvandudza mashandiro emitochondrial mumasero emidzi akatorwa kubva kuParkinson's chirwere murwere ().

Zvisinei, hazvisati zvichinyatsojeka kuti zvinobatsira sei kukwidziridza NAD + nhanho mune vanhu vane zera-zvine chekuita nehuropi zvinetso. Zvimwe zvidzidzo zvevanhu zvinodiwa.

Inogona Kuderera Mwoyo Chirwere Njodzi

Kukwegura chinhu chakakura chinokonzera chirwere chemoyo, chinova ndicho chikonzero chikuru cherufu ().

Inogona kukonzera tsinga dzeropa senge yako aorta kuti iwedzere, kuomarara uye kusapfava.

Shanduko dzakadai dzinogona kukwidza kuwedzera kweropa uye kuita kuti moyo wako ushande zvakanyanya.

Mune mhuka, kusimudza NAD + kwakabatsira kudzosera shanduko inoenderana nezera kune arteri ().

Muvanhu, nicotinamide riboside yakasimudza NAD + nhanho, yakabatsira kudzikamisa kuomarara muaorta uye kudzikisa systolic yeropa muvanhu vakuru vari panjodzi yekukwirisa kweropa (22).

Izvo zvakati, kumwe kutsvagurudza kwevanhu kunodiwa.

Zvimwe Zvichabatsira

Uye zvakare, nicotinamide riboside inogona kupa mamwe akawanda mabhenefiti:

• Inogona kubatsira kurasikirwa uremu: Nicotinamide riboside yakabatsira kumhanyisa metabolism yemakonzo. Zvisinei, hazvina kujeka kana zvaizove nemhedzisiro imwechete muvanhu uye kuti yakasimba sei mhedzisiro iyi ().
• Dai kudzikisa kenza njodzi: Yakakwira NAD + nhanho dzinobatsira kudzivirira kubva kukuvara kweDNA uye kushushikana kweiyo oxidative, iyo inosangana nekenza kukura (,).
• Inogona kubatsira kubata jet lag: NAD + inobatsira kudzora wachi yemukati yemuviri wako, saka kutora niagen kunogona kubatsira kurapa jet lag kana imwe circadian rhythm kusagadzikana nekugadzirisa muviri wako wemukati wachi ().
• Inogona kusimudzira hutano hwakasimba hwemhasuru: Kurera NAD + nhanho kwakabatsira kugadzirisa mhasuru mashandiro, simba uye kutsungirira mumakonzo ekare (,).

Nicotinamide riboside inokwidziridza mazinga eNAD +, ayo akabatana neanogona kuve marubatsiro ehutano maererano nekukwegura, hutano hwehuropi, chirwere chemwoyo njodzi uye nezvimwe.

Zvingangoitika Njodzi uye Side Migumisiro

Nicotinamide riboside inogona kunge yakachengeteka iine mashoma - kana paine - mhedzisiro.

Muzvidzidzo zvevanhu, kutora 1,000-2,000 mg pazuva hakuna zvakakuvadza (,).

Zvisinei, zvidzidzo zvevanhu zvipfupi mukureba uye zvine vashoma kwazvo vatori vechikamu. Kuti uwane yakajeka pfungwa yekuchengetedza kwayo, zvakawandisa zvidzidzo zvevanhu zvinodiwa.

Vamwe vanhu vakataura zvinyoro kusvika kune zvine mwero mhedzisiro, senge kusvotwa, kuneta, kutemwa nemusoro, manyoka, kusagadzikana kwemudumbu uye kugaya ().

Mhuka, kutora 300 mg pa kg yehuremu hwemuviri (136 mg paundi) zuva nezuva kwemazuva makumi mapfumbamwe pakanga pasina zvinokuvadza ().

Uyezve, kusiyana nemavhitamini B3 (niacin) zvinowedzera, nicotinamide riboside haifanire kukonzera kumeso kumeso ().

Nicotinamide riboside inoita kunge yakachengeteka ine mashoma mhedzisiro. Nekudaro, mhedzisiro yayo yenguva refu muvanhu ichiri isingazivikanwe.

Chipimo chemushonga uye Zvinokurudzirwa

Nicotinamide riboside inowanikwa mune yepiritsi kana capsule fomu uye inowanzonzi niagen.

Inowanikwa munzvimbo dzakasarudzwa dzehutano-chikafu, paAmazon kana kuburikidza nevatengesi vepamhepo.

Niagen inowedzera inowanzo iine nicotinamide riboside, asi vamwe vagadziri vanozvisanganisa pamwe nezvimwe zvinoshandiswa sePterostilbene, inova polyphenol - antioxidant inoenderana nemakemikari akafanana ne resveratrol ().

Mazhinji maNiagen ekuwedzera mabhureki anokurudzira kutora 250-300 mg pazuva, yakaenzana ne2-2 makapisizi pazuva zvichienderana nechiratidzo.

Vazhinji vagadziri venagen vanokurudzira kutora 250-300 mg yeNicotinamide riboside pazuva.

Icho Chinokosha

Nicotinamide riboside ndeimwe nzira yevhitamini B3 ine mashoma mhedzisiro. Inowanzo shambadzirwa seye anti-kuchembera chigadzirwa.

Muviri wako unoishandura kuita NAD +, iyo inotsvaira ese maseru ako. Nepo NAD + nhanho dzichidonha zvakasarudzika nezera, kuwedzera maNAD + nhanho dzinogona kudzosera akati wandei zviratidzo zvekukwegura.

Nekudaro, yakanyanya kutsvagisa nezve nicotinamide riboside neNAD + iri mumhuka. Zvimwe zvepamusoro-soro zvidzidzo zvevanhu zvinodiwa usati waikurudzira sekurapa.