Cholesterol Kudzora: PCSK9 Inhibitors vs. Statins

Zvemukati

• Nezve statins
• Mashandiro avo
• Mhando
• Nezve PCSK9 inhibitors
• Kana zvatemwa
• Mashandiro avo
• Zvimwe zvinokanganisa
• Kubudirira
• Mutengo
• Taura nachiremba wako
• Taura nachiremba wako

Nhanganyaya

Vanenge mamirioni makumi manomwe nemana emamamerica vane cholesterol yakawanda, sekureva kwe. Nekudaro, vashoma pane hafu varikuwana kurapwa kwayo. Izvi zvinovaisa panjodzi yakakwira yekurwara kwemwoyo uye sitiroko. Nepo kurovedza muviri uye kudya kunovaka muviri kazhinji kuchizobatsira kudzora mwero wecholesterol, dzimwe nguva mishonga inodiwa.

Mhando mbiri dzemishonga inorayirwa kurapa cholesterol yakawanda inosanganisira ma statins uye PCSK9 inhibitors. Statins ndiwo mukurumbira kurapwa kwave kuripo kubvira ma1980. PCSK9 inhibitors, kune rimwe divi, rudzi rutsva rwecholesterol zvinodhaka. Ivo vakagamuchirwa neKudya neDrug Administration muna 2015.

Kana iwe nachiremba wako muchisarudzira chemushonga wecholesterol iwe, unogona kufunga nezvezvinhu zvakadai semhedzisiro, mutengo, uye kushanda. Verenga pamusoro kuti udzidze zvakawanda nezve aya madhiragi uye nemhando mbiri idzi dzinofananidza

Nezve statins

Statins ndeimwe yemhando dzakajairika dzemishonga inoshandiswa kubatsira kudzikisa cholesterol. Kana iwe uine cholesterol yakakura kana imwe njodzi yemoyo, chiremba wako anogona kukuudza kuti utange kutora statin. Ivo anowanzo shandiswa sekutanga-mutsara kurapwa kweiyo cholesterol yakawanda. Izvi zvinoreva kuti ndiwo marapiro ekutanga anogona kuratidzwa nachiremba wako.

Mashandiro avo

Statins inoshanda nekuvhara chinhu chinonzi HMG-CoA reductase. Ichi chidimbu chiropa chako chinoda kugadzira cholesterol. Kuvhara chinhu ichi kunoderedza huwandu hwecholesterol inogadzirwa nechiropa chako. Statins inoshandawo nekubatsira muviri wako kudzoreredza chero cholesterol yakaungana pamadziro emidziyo yako yeropa. Kuti udzidze zvakawanda, verenga nezve mashandiro mashandiro.

Mhando

Statins inouya muchimiro chemapiritsi kana macapsule aunotora nemuromo. Kune akawanda marudzi ematemu anowanikwa muUnited States nhasi. Zvinosanganisira:

• atorvastatin (Lipitor)
• fluvastatin (Lescol)
• lovastatin (Altoprev)
• pravastatin (Pravachol)
• rosuvastatin (Crestor)
• simvastatin (Zocor)
• pitavastatin (Livalo)

Nezve PCSK9 inhibitors

Statins inogona kupihwa vanhu vazhinji vane cholesterol yakawanda, asi PCSK9 inhibitors inowanzo gadzirirwa chete mamwe marudzi evanhu. Nekuti ma statins anga aripo kwenguva yakareba, tinoziva zvakawanda nezvekuti anoshanda sei. PCSK9 inhibitors inyowani uye nekudaro vane shoma-refu-refu data rekuchengetedza.

Zvakare, PCSK9 inhibitors inodhura zvakanyanya kana ichienzaniswa nema statins.

PCSK9 inhibitors inopihwa jekiseni chete. Kune maviri chete PCSK9 Inhibitors anowanikwa nhasi muUnited States: Anokosha (alirocumab) uye Repatha (evolocumab).

Kana zvatemwa

IAmerican College yeCardiology inokurudzira kuti iwe nachiremba wako mufunge nezvePCSK9 inhibitor chete kana:

• iwe unofungidzirwa kunge wakanyanya njodzi kune dambudziko remwoyo uye cholesterol yako haina kudzorwa nema statins kana mamwe cholesterol-anoderedza madhiragi
• une hutachiona hunodaidzwa kuti hwemhuri hypercholesterolemia, iyo inosanganisira zvakanyanya mwero wecholesterol

Mune imwe yezviitiko izvi, PCSK9 inhibitors inowanzo gadzirirwa mushure memhando mbiri dzemishonga dzisina kubatsira kudzikisa cholesterol yako mazinga. Semuenzaniso, chiremba wako anogona kutanga kupa chirevo.Kana izvo zvikasadzikisa cholesterol yako zvakakwana, chiremba wako anogona kukurudzira ezetimibe (Zetia) kana zvinodhaka zvinonzi bile acid resins. Mienzaniso yeiyi inosanganisira cholestyramine (Locholest), colesevelam (Welchol), kana colestipol (Colestid).

Kana cholesterol yako ichiri yakanyanya kukwirisa mushure meiyi yechipiri mhando yemishonga, ipapo chiremba wako anogona kupa zano PCSK9 inhibitor.

Mashandiro avo

PCSK9 inhibitors inogona kushandiswa mukuwedzera kune kana pachinzvimbo chema statins. Iyi mishonga inoshanda zvakasiyana. PCSK9 inhibitors inotarisa protein muchiropa inonzi proprotein convertase subtilisin kexin 9, kana PCSK9. Nokuderedza huwandu hwePCSK9 mumuviri wako, PCSK9 inhibitors inobvumidza muviri wako kubvisa cholesterol zvakanyanya.

Zvimwe zvinokanganisa

Statins uye PCSK9 inhibitors imwe neimwe inokonzeresa zvinyoro uye zvakanyanya zvakakomba mhedzisiro, uye mhedzisiro yacho yakasiyana pakati pemishonga.

Kubudirira

Statins dzakaratidzirwa kudzikisa cholesterol muvanhu vazhinji. Iwo ave achishandiswa kubvira ma1980s uye mhedzisiro yavo yakave ichiongororwa muzviuru zvevanhu vanotora masitinamu kudzivirira kurwisa kwemoyo uye sitiroko.

Mukupesana, PCSK9 inhibitors dzakabvumidzwa munguva pfupi yapfuura, saka iyo yenguva refu-data rekuchengetedza haina kunaka. Asi PCSK9 inhibitors inoshanda zvakanyanya kune vamwe vanhu.Imwe ongororo yakaratidza kuti alirocumab yakaderedza cholesterol mazinga ne61 muzana. Izvo zvakare zvakadzora mukana wezviitiko zvemoyo zvakaita sekurwadziwa kwemoyo uye sitiroko. Chimwe chidzidzo chakawana mhedzisiro yakafanana neevolocumab.

Mutengo

Statins inowanikwa mu brand-zita uye generic mafomu. Mageneral anowanzo dhura zvishoma pane shanduro mhando, saka ma statins anogona kunge asingadhuri.

PCSK9 inhibitors itsva, saka havana generic vhezheni zviripo. Neichi chikonzero, ivo vanodhura kupfuura statins. Mari yePCSK9 inhibitors inogona kudarika $ 14,000 pagore. Uye zvakare, kuti mutengo uyu ufukidzwe neinishuwarenzi, unofanirwa kuwira mune chimwe chezvikamu zviviri zvinokurudzirwa kushandisa PCSK9 inhibitors. Kana iwe usingakwanise mune chimwe chezvikamu izvi, ungangodaro uchifanira kubhadhara PCSK9 inhibitor iwe pachako.

Taura nachiremba wako

Statins uye PCSK9 inhibitors dzakakosha sarudzo dzedhiragi mukurapa kwakawanda cholesterol mazinga. Kunyange mhando mbiri dzemishonga dzinobatsira kudzikisa cholesterol, pane mamwe misiyano yakakosha. Tafura iri pazasi inoratidzira iyi misiyano nekukasira.

Taura nachiremba wako

Kana iwe uine cholesterol yakawanda uye uchifunga kuti imwe yemhando idzi yemishonga inogona kunge yakakunakira iwe, danho rako rekutanga rinofanira kunge riri rekutaura nachiremba wako. Vanogona kukuudza zvakawanda pamusoro pemishonga iyi uye dzimwe nzira dzekurapa. Mimwe mibvunzo yekukurukura nachiremba wako inogona kunge iri:

• Mishonga idanho rinotevera kwandiri mukugadzirisa cholesterol yangu yakawanda here?
• Ini ndinosangana nenzira mbiri dzevanhu vanogona kupihwa PCSK9 inhibitors?
• Ini ndinofanira kutaura neane lipid nyanzvi?
• Ini ndinofanira kutanga chirongwa chekurovedza muviri kubatsira kubata cholesterol yangu?
• Iwe unogona kundirevera kune akanyoreswa dietitian kuti andibatsire kubata dhayeti yangu?