Stage 4 Renal Cell Carcinoma: Metastasis, Kupona Mitengo, uye Kurapa

Zvemukati

• Chii chinonzi renal cell carcinoma?
• Inopararira sei?
• TNM staging uye nhanho dzegomarara reitsvo
• Ndeapi maonero?
• Ndedzipi nzira dzekurapa?
• Kutora

Chii chinonzi renal cell carcinoma?

Renal cell carcinoma (RCC), inonziwo renal cell cancer kana renal cell adenocarcinoma, rudzi rwakajairika kenza yeitsvo. Renal cell carcinomas account yeinenge 90 muzana yetsvo dzese dzeitsvo.

RCC inowanzotanga sebundu rinokura mune imwe yeitsvo dzako. Inogona zvakare kukura mune mbiri itsvo.Chirwere ichi chinowanzoonekwa nevarume kupfuura vakadzi.

Inopararira sei?

Kana bundu rine gomarara rikawanikwa mune imwe yeitsvo dzako, kurapa kwakajairwa kubvisa chikamu kana itsvo dzese dzakakuvara.

Kana bundu racho risina kubviswa, zvinowanzoitika kuti kenza inopararira kune yako lymph node kana dzimwe nhengo. Kupararira kwegomarara kunonzi metastasis.

Panyaya yeRCC, bundu rinogona kupinda mutsinga huru inobuda kunze kweitsvo. Inogona zvakare kupararira kune iyo lymph system uye dzimwe nhengo. Mapapu anonyanya kutapurika.

TNM staging uye nhanho dzegomarara reitsvo

Kenza yeitsvo inotsanangurwa mumatanho akagadziriswa neAmerican Joint Committee yeCancer. Iyo system inozivikanwa zviri nani seTNM system.

• "T" zvinoreva bundu. Vanachiremba vanopa "T" ine nhamba inoenderana nesaizi uye kukura kwethumba.
• "N" inotsanangura kana kenza yapararira kune chero node mune iyo lymph system.
• "M" zvinoreva kuti kenza yakagadziriswa.

Zvichienderana nehunhu hwataurwa pamusoro, vanachiremba vanopa RCC danho. Chikamu chacho chakavakirwa pahukuru hwebundu uye kupararira kwegomarara.

Pane matanho mana:

• Matanho 1 ne2 tsanangura kanzura umo bundu racho richiri muitsvo. Chikamu chechipiri zvinoreva kuti bundu rakakura kudarika masendimita manomwe kuyambuka.
• Matanho 3 ne4 zvinoreva kuti kenza inogona kunge yakapararira kuita mutsinga huru kana munyama uri padyo kana kune lymph node.
• Chikamu 4 ndiyo fomu yepamusoro yechirwere. Chikamu chechina chinoreva kuti gomarara rapararira kune adrenal gland kana rapararira kune lymph node dziri kure kana dzimwe nhengo. Nekuti iyo adrenal gland yakasungirirwa kune itsvo, gomarara rinowanzopararira ipapo kutanga.

Ndeapi maonero?

Makore mashanu ekupona kwecancer yeitsvo yakavakirwa pahuwandu hwevanhu vanogara makore angangoita mashanu nechirwere mushure mekunge yaonekwa.

IAmerican Cancer Society (ACS) inoshuma huwandu hwevanhu vanogara makore mashanu kana kupfuura mushure mekuongororwa maererano nematanho matatu zvichienderana nedata kubva kuNational Cancer Institute.

Aya matanho ndeaya:

• inowanikwa munharaunda (kenza haina kupararira kupfuura itsvo)
• dunhu (kenza yapararira padyo)
• kure (kenza yakapararira kunzvimbo dziri kure dzomuviri)

Zvinoenderana neACS, iyo RCC yekupona mitengo inoenderana nematatu aya ndeaya:

• localized: 93 muzana
• dunhu: 70 muzana
• kure: 12 muzana

Ndedzipi nzira dzekurapa?

Mhando yekurapwa iwe yaunogashira zvakanyanya zvinoenderana nedanho rekenza yako. Stage 1 RCC inogona kurapwa nekuvhiyiwa.

Nekudaro, panguva iyo kenza yapfuura kuenda padanho rechina, kuvhiyiwa kunogona kunge kusiri sarudzo.

Kana bundu uye metastasis zvichigona kusarudzika, kubviswa kwekuvhiya kwechirwere chegomarara uye / kana kurapwa kwetumastastatic tumor nekubvisa kana mamwe maitiro senge stereotactic muviri radiation radiation kana kupisa kweablation kunogona kunge kuchikwanisika.

Kana iwe uine danho rechina RCC, chiremba wako anozotarisa nzvimbo uye kupararira kwekenza yako uye hutano hwako hwese kuti uone kukodzera kwako kuvhiyiwa.

Kana kuvhiya isiriyo chaiyo sarudzo yekurapa nhanho 4 RCC, chiremba wako anogona kukurudzira marongero ehurongwa uchishandisa musanganiswa wemishonga.

Muenzaniso webundu rako, unonzi biopsy, unogona kuwanikwa kuti ubatsire kugona kurapa kwakanyanya kwerudzi rwako rwekenza. Kurapa kunogona kuvimba nekuti uine yakajeka sero kana isiri-yakajeka sero RCC.

Targeted therapy uye immunotherapy, kusanganisira tyrosine kinase inhibitors uye anti-PD-1 monoclonal antibodies, inogona kushandiswa kurapa nhanho 4 RCC. Mumwe mushonga unogona kupihwa wega kana musanganiswa nemumwe mushonga.

Mishonga inogona kusanganisira:

• axitinib + pembrolizumab
• pazopanib
• sunitinib
• ipilimumab + nivolumab
• cabozantinib

Mishonga mitsva inogona kuwanikwa kuburikidza nemakiriniki ekuedzwa. Unogona kukurukura nezve sarudzo yekunyoresa mukati nachiremba wako.

Chiremba wako anogona zvakare kukurudzira marapiro ekutsigira kuti abatsire nechero mhedzisiro kana zviratidzo.

Kutora

Kana iwe wakamboonekwa uine nhanho 4 RCC, yeuka kuti yakaburitswa manhamba ekupona fungidziro.

Kufungidzira kwako pachako kunoenderana neyako mhando yekenza uye nekureba kwayakaita, kupindura kurapwa, uye hutano hwako hwese.

Chinokosha ndechekuti:

• tevera kuraira kwachiremba wako
• enda kumahofisi ako
• tora mishonga yako

Zvakare, ive shuwa yekutevera kuburikidza nechero yekurapa mazano kana mararamiro marongero ekugadzirisa chero mhedzisiro uye zviratidzo. Izvi zvinogona kubatsira kutsigira hutano hwako hwese uye hutano paunenge uchirapwa.