TP53 Genetic Bvunzo

Zvemukati

• Chii chinonzi TP53 genetic test?
• Chii chinoshandiswa?
• Nei ini ndichida TP53 genetic test?
• Chii chinoitika panguva yeTP53 genetic test?
• Ndichafanira here kuita chero chinhu kugadzirira bvunzo?
• Pane here njodzi kune bvunzo?
• Zvinorevei mhedzisiro yacho?
• Pane chimwe chinhu here chandinofanira kuziva nezve TP53 bvunzo?
• Zvinyorwa

Chii chinonzi TP53 genetic test?

A TP53 genetic test inotarisa shanduko, inozivikanwa sekuchinja, mune geni inonzi TP53 (tumor protein 53). Magene ndiwo akakosha mayuniti enhaka akapfuudzwa kubva kuna mai nababa vako.

TP53 geni rinobatsira kumisa kukura kwemamota. Inozivikanwa se bundu rinodzvinyirira. Bundu rinodzvinyirira geni rinoshanda semabhureki pamotokari. Inoisa "mabhureki" kumasero, saka haapatsanure nekukurumidza. Kana iwe uine TP53 mutation, iyo geni inogona kutadza kudzora kukura kwemasero ako. Kusadzora kukura kwemasero kunogona kukonzera kenza.

A TP53 shanduko inogona kugarwa nhaka kubva kuvabereki vako, kana kuwanikwa gare gare muhupenyu kubva kunharaunda kana kubva pakukanganisa kunoitika mumuviri wako panguva yesero kupatsanurwa.

• Iyo nhaka TP53 shanduko inozivikanwa seLi-Fraumeni syndrome.
• Li-Fraumeni urwere chinhu chisingawanzoitika magene anogona kuwedzera njodzi yako kune mamwe marudzi ekenza.
• Aya kanzura anosanganisira gomarara repazamu, gomarara repfupa, leukemia, uye kenza nyoro yetishu, inonziwo sarcomas.

Yakawanikwa (inozivikanwawo sekuti somatic) TP53 shanduko dzakajairika. Izvi zvinoshanduka zvakawanikwa munenge hafu yezviitiko zvese zvegomarara, uye nemhando dzakasiyana dzegomarara.

Mamwe mazita: TP53 mutation ongororo, TP53 yakazara gene ongororo, TP53 somatic mutation

Chii chinoshandiswa?

Muedzo unoshandiswa kutsvaga shanduko yeTP53. Haisi muyedzo wenguva dzose.Iyo inowanzo kupihwa kune vanhu zvichibva pane nhoroondo yemhuri, zviratidzo, kana zvekare kuongororwa kwecancer.

Nei ini ndichida TP53 genetic test?

Unogona kuda TP53 bvunzo kana:

• Wakaonekwa uine bhonzo repfupa kana rakapfava tisati tasvika makore makumi mana nemashanu
• Wakaonekwa uine, pre-menopausal kenza yemazamu, bundu rehuropi, leukemia, kana kenza yemapapu usati wasvika makore makumi mana nematanhatu.
• Wakave nerimwe kana mamwe mapundu asati asvika makore makumi mana nemasere
• Mumwe kana vamwe vemhuri yako vakaonekwa vaine Li-Fraumeni syndrome uye / kana kuve nekenza vasati vava nemakore makumi mana nemashanu

Izvi zviratidzo iwe unogona kunge uine nhaka yekuchinja kweTP53 geni.

Kana iwe uchinge waonekwa uine cancer uye usina nhoroondo yemhuri yechirwere, wako wekuchengetedza hutano anogona kuraira iyi bvunzo kuti aone kana TP53 mutation inogona kunge ichikonzera kenza yako. Kuziva kana iwe uine shanduko kunogona kubatsira wako mupi kuronga kurapwa uye kufungidzira zvingangoitika mhedzisiro yechirwere chako.

Chii chinoitika panguva yeTP53 genetic test?

Chiyero cheTP53 chinowanzoitwa paropa kana mwongo wemapfupa.

Kana iwe uri kuongorora ropa, nyanzvi yehutano anotora muyero weropa kubva mutsinga iri muruoko rwako, achishandisa tsono diki. Mushure mekunge tsono yaiswa, kashoma reropa kanounganidzwa muthubhu yekuyedza kana muhombodo. Unogona kunzwa kakuruma kana tsono ichipinda kana kubuda. Izvi zvinowanzotora maminetsi asingasviki mashanu.

Kana iwe uri kuwana bvunzo yemongo, maitiro ako anogona kusanganisira anotevera matanho:

• Iwe ucharara pasi nedivi rako kana dumbu rako, zvichienderana nekuti ipfupa ripi rinoshandiswa kuyedzwa. Mazhinji mapfupa emongo bvunzo anotorwa kubva muchiuno bone.
• Muviri wako uchafukidzwa nemachira, zvekuti iyo chete nzvimbo yakatenderedza saiti yekuyedza iri kuratidza.
• Saiti iyi ichave yakacheneswa ne antiseptic.
• Iwe unowana jekiseni remhinduro inovhiringidza. Zvinogona kuruma.
• Kana nzvimbo yacho yangove chiveve, mutapi wezvehutano anotora muyenzaniso. Iwe unozofanirwa kunyepera kunyarara panguva dzekuyedzwa.
• Mutapi wezvehutano anoshandisa chakakosha chishandiso chinomonyoroka mupfupa kutora sampuli yemapfupa emwongo. Iwe unogona kunzwa kumanikidzwa pane ino saiti apo sampuro ichitorwa.
• Mushure mekuyedzwa, mupi wezvehutano anozovhara saiti nebhandeji.
• Ronga kuti mumwe munhu akutyaire kumba, nekuti unogona kupihwa sedative pamberi pebvunzo, izvo zvinogona kukuwisira.

Ndichafanira here kuita chero chinhu kugadzirira bvunzo?

Iwe kazhinji haudi chero yakakosha gadziriro yeropa kana yemafupa bvunzo.

Pane here njodzi kune bvunzo?

Pane njodzi shoma yekuongororwa ropa. Unogona kunge uine marwadzo mashoma kana kupwanya panzvimbo yakaiswa tsono, asi zviratidzo zvizhinji zvinokurumidza kupera.

Mushure mekuyedzwa kwemongo wemapfupa, unogona kunzwa kuomarara kana kurwadziwa panzvimbo yejekiseni. Izvi zvinowanzoenda mumazuva mashoma. Wako wekuchengeta hutano anogona kukurudzira kana kuraira anodzora marwadzo kuti abatsire.

Zvinorevei mhedzisiro yacho?

Kana iwe wakamboonekwa uine Li-Fraumeni syndrome, it hazviiti zvinoreva kuti une kenza, asi njodzi yako yakakwira kupfuura vanhu vazhinji. Asi kana iwe uine shanduko, iwe unogona kutora matanho ekuderedza njodzi yako, senge:

• Kakawanda kenza kuongororwa. Gomarara rinorapika kana rikawanikwa muzvikamu zvekutanga.
• Kuita mararamire shanduko, senge kuwana zvakanyanya kurovedza muviri uye kudya chikafu chine hutano
• Chemoprevention, kutora mimwe mishonga, mavitamini, kana zvimwe zvinhu kudzikisa njodzi kana kunonotsa kukura kwekenza.
• Kubvisa "panjodzi" tishu

Aya matanho anozosiyana zvichienderana nehutano hwako nhoroondo uye nhoroondo yemhuri.

Kana iwe uine gomarara uye zvawanikwa zvinoratidza kuti yakawanikwa TP53 mutation (shanduko yakawanikwa, asi hauna nhoroondo yemhuri yekenza kana Li-Fraumeni syndrome), mupi wako anogona kushandisa ruzivo kubatsira kufungidzira kuti chirwere chako chichava sei uye kutungamira yako kurapwa.

Dzidza zvakawanda nezve bvunzo dzemarabhoritari, mareferenzi masosi, uye mhinduro dzekunzwisisa

Pane chimwe chinhu here chandinofanira kuziva nezve TP53 bvunzo?

Kana iwe uchinge waonekwa uine kana kufungidzira kuti une Li-Fraumeni syndrome, zvinogona kubatsira kutaura kune wegeneral chipangamazano. A genetic chipangamazano inyanzvi yakadzidziswa mu genetics uye kuongororwa kwemajini. Kana usati waedzwa, chipangamazano anogona kukubatsira kuti unzwisise njodzi uye bhenefiti yekuyedzwa. Kana iwe wakaedzwa, mupi wezano anogona kukubatsira kuti unzwisise mhedzisiro uye nekukutungamira iwe kunotsigira masevhisi nezvimwe zviwanikwa.

Zvinyorwa

1. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Oncogenes uye bundu rinodzvinyirira magene; [yakagadziridzwa 2014 Jun 25; yakataurwa 2018 Jun 29]; [angangoita mana skrini. Inowanikwa kubva ku: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-suppressor-genes.html
2. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2020. Marapiro Akanangwa Anoshandiswa Sei Kurapa Cancer; [yakagadziridzwa 2019 Zvita 27; yakataurwa 2020 Chivabvu 13]; [angangoita mana skrini. Inowanikwa kubva ku: https://www.cancer.org/treatment/treatment-and-side-effects/treatment-types/targeted-therapy/what-is.html
3. Cancer.net [Internet]. Alexandria (VA): American Society yeKiriniki Oncology; c2005–2018. Li-Fraumeni Syndrome; 2017 Oct [yakataurwa 2018 Jun 29]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.cancer.net/cancer-types/li-fraumeni-syndrome
4. Cancer.net [Internet]. Alexandria (VA): American Society yeKiriniki Oncology; c2005-2020. Kunzwisisa Targeted Therapy; 2019 Jan 20 [yakataurwa 2020 Chivabvu 13]; [angangoita mana skrini. Inowanikwa kubva ku: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-targeted-therapy
5. Nzvimbo dzekudzivirira nekudzivirira hosha [Internet]. Atlanta: Dhipatimendi reUtano reU.S. Kenza Kudzivirira uye Kudzora: Kuongorora Kuyedza; [yakagadziridzwa 2018 May 2; yakataurwa 2018 Jun 29]; [angangoita matatu skrini. Inowanikwa kubva: https://www.cdc.gov/cancer/dcpc/prevention/screening.htm
6. Li-Fraumeni Syndrome: LFSA Sangano [Internet]. Holliston (MA): Li-Fraumeni Syndrome Association; c2018. Chii chinonzi LFS?: Li-Fraumeni Syndrome Association; [yakataurwa 2018 Jun 29]; [angangoita maviri skrini. Inowanikwa kubva: https://www.lfsassociation.org/what-is-lfs
7. Mayo Clinic [Indaneti]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1998–2018. Bone marrow biopsy uye kushuvira: Ongororo; 2018 Jan 12 [yataurwa 2018 Jun 29]; [angangoita mana skrini. Inowanikwa kubva: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
8. Mayo Clinic: Mayo Medical Laboratories [Internet]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1995–2018. Bvunzo ID: P53CA: Hematologic Neoplasms, TP53 Somatic Mutation, DNA Sequicing Exons 4-9: Clinical and Interpretive; [yakataurwa 2018 Jun 29]; [angangoita mana skrini. Inowanikwa kubva: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/62402
9. Mayo Clinic: Mayo Medical Laboratories [Internet]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1995–2018. Bvunzo ID: TP53Z: TP53 Gene, Yakazara Gene Kuongorora: Kliniki uye Dudziro; [yakataurwa 2018 Jun 29]; [angangoita mana skrini. Inowanika kubva: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35523
10. MD Anderson Cancer Center [Indaneti]. Yunivhesiti yeTexas MD Anderson Cancer Center; c2018. TP53 Kuchinja Ongororo; [yakataurwa 2018 Jun 29]; [angangoita matatu skrini. Inowanikwa kubva: https://www.mdanderson.org/research/research-resource/core-facilities/molecular-diagnostics-lab/services/tp53-mutation-analysis.html
11. Merck Chinyorwa Chevatengi Vhezheni [Internet]. Kenilworth (NJ): Merck & Co, Inc .; c2018. Bone Marrow Kuongorora; [yakataurwa 2018 Jun 29]; [angangoita maviri skrini. Inowanikwa kubva: http://www.merckmanuals.com/home/blood-disorders/symptoms-and-diagnosis-of-blood-disorders/bone-marrow-examination
12. National Cancer Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. NCI Duramazwi reMitemo yeCancer: chemoprevention; [yakataurwa 2018 Jul 11]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=chemoprevention
13. National Cancer Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Kuongorora kweGenetic kweHereditary Cancer Syndromes; [yakataurwa 2018 Jun 29]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
14. National Cancer Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. NCI Duramazwi reMitemo yeCancer: geni; [yakataurwa 2018 Jun 29]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
15. NeoGenomics [Indaneti]. Fort Myers (FL): NeoGenomics Laboratories; c2018. TP53 Kuchinja Ongororo; [yakataurwa 2018 Jun 29]; [angangoita matatu skrini. Inowanikwa kubva: https://neogenomics.com/test-menu/tp53-mutation-analysis
16. NIH U.S. National Raibhurari yeMishonga: Genetics Kumba Referensi [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. TP53 geni; 2018 Jun 26 [yataurwa 2018 Jun 29]; [angangoita maviri skrini. Inowanikwa kubva: https://ghr.nlm.nih.gov/gene/TP53
17. NIH U.S. National Raibhurari yeMishonga: Genetics Kumba Referensi [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Chii chinonzi gene mutation uye shanduko dzinoitika sei ?; 2018 Jun 26 [yataurwa 2018 Jun 29]; [angangoita maviri skrini. Inowanikwa kubva: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation
18. Parrales A, Iwakuma T. Targeting Oncogenic Mutant p53 yeCancer Therapy. Kumberi Oncol [Internet]. 2015 Dec 21 [yakataurwa 2020 Chivabvu 13]; 5: 288. Inowanikwa kubva: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685147
19. Yunivhesiti yeRochester Medical Center [Internet]. Rochester (NY): Yunivhesiti yeRochester Medical Center; c2018. Health Encyclopedia: Gomarara repazamu: Kuongorora Genetic; [yakataurwa 2018 Jun 29]; [angangoita maviri skrini. Inowanikwa kubva: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=16421-1
20. Kutsvaga Kuongorora [Internet]. Quest Diagnostics; c2000–2017. Kwayedza Center: TP53 Somatic Mutation, Prognostic; [yakataurwa 2018 Jun 29]; [angangoita matatu skrini. Inowanikwa kubva: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=16515
21. UW Hutano [Internet]. Madison (WI): Yunivhesiti yeWisconsin Zvipatara uye Makiriniki Chiremera; c2017. Ruzivo rwehutano: Bone Marrow Aspiration uye Biopsy: Maitiro Anoitwa; [yakagadziridzwa 2017 May 3; yakataurwa 2018 Jul 17]; [angangoita mashanu skrini. Inowanikwa kubva: https://www.uwhealth.org/health/topic/medicaltest/biopsy-bone-marrow/hw200221.html#hw200245

Ruzivo ruri pane ino saiti harufanire kushandiswa sekutsiva kwehunyanzvi kurapwa kana kurairwa. Bata mupi wehutano kana iwe uine mibvunzo nezve hutano hwako.