Anti-glomerular yepasi membrane chirwere

Anti-glomerular basement membrane zvirwere (anti-GBM zvirwere) chirwere chisingawanzo chinogona kusanganisira kukurumidza kuwedzera kutadza kweitsvo uye chirwere chemapapu.

Dzimwe mhando dzechirwere dzinosanganisira chete mapapu kana itsvo. Chirwere cheAnti-GBM chaimbozivikanwa seGoodpasture syndrome.

Anti-GBM chirwere chiri autoimmune kusagadzikana. Izvo zvinoitika kana immune system ikarwisa zvisirizvo nekuparadza hutano hwenyama. Vanhu vane chirwere ichi vanogadzira zvinhu zvinorwisa protein inonzi collagen mune zvidiki zvemweya masaga mumapapu uye zvikamu zvekusefa (glomeruli) zveitsvo.

Izvi zvinhu zvinonzi antiglomerular basement membrane antibodies. Iyo glomerular yepasi membrane inhengo yeitsvo iyo inobatsira kusefa marara uye nekuwedzera mvura kubva muropa. Antiglomerular yepasi membrane membrane antibodies maantibodies anorwisa iyi membrane. Vanogona kukuvadza chepasi membrane, izvo zvinogona kutungamira kukuvara kweitsvo.

Dzimwe nguva, kusagadzikana uku kunokonzerwa nehutachiona hwekupemha hutachiona kana nekufema mune hydrocarbon solvents. Mumamiriro ezvinhu akadaro, immune system inogona kurwisa nhengo kana nyama nekuti inodzikanganisa neaya mavhairasi kana makemikari ekunze.

Iyo immune system yekukanganisa mhinduro inokonzeresa kubuda ropa mumhepo masaga emapapu uye kuzvimba mune itsvo yekutsikisa zvikamu.

Zviratidzo zvinogona kuitika zvishoma nezvishoma pamusoro pemwedzi kana kunyangwe makore, asi zvinowanzo kukura nekukurumidza kupfuura mazuva kusvika mavhiki.

Kurasikirwa nechido, kuneta, uye kushaya simba ndizvo zvakajairika zviratidzo zvekutanga.

Zviratidzo zvemapapu zvinogona kusanganisira:

• Kukosora ropa
• Kuoma kukosora
• Kufema kwekufema

Itsvo uye zvimwe zviratidzo zvinosanganisira:

• Uropa weti
• Kupisa kunzwa kana uchiita weti
• Kusvotwa uye kurutsa
• Ganda rakachenuruka
• Kuzvimba (edema) mune chero nzvimbo yemuviri, kunyanya mumakumbo

Kuongorora kwepanyama kunogona kuratidza zviratidzo zvekukwira kweropa uye kuwanda kwemvura. Mutapi wezvehutano anogona kunzwa zvisina kujairika moyo nemapapu kurira kana achiteerera chipfuva ne stethoscope.

Urinalysis mhedzisiro inowanzo kuve isina kujairika, uye inoratidza ropa uye mapuroteni mune weti. Masero matsvuku eropa angaonekwa.

Iyi bvunzo inotevera inogona kuitwawo:

• Antiglomerular yepasi membrane membrane bvunzo
• Arterial ropa gasi
• BUN
• Chest x-ray
• Creatinine (serum)
• Lung biopsy
• Itsvo biopsy

Chinangwa chikuru kubvisa ma antibodies anokuvadza muropa. Kurapa kunogona kusanganisira:

• Plasmapheresis, iyo inobvisa ma antibodies anokuvadza kubatsira kudzikisa kuzvimba muitsvo nemapapu.
• Corticosteroid mishonga (senge prednisone) nemimwe mishonga, iyo inodzvinyirira kana kudzikamisa immune system.
• Mishonga yakadai seangiotensin-inoshandura enzyme (ACE) inhibitors uye angiotensin receptor blockers (ARBs), ayo anobatsira kudzora BP.
• Dialysis, iyo inogona kuitwa kana itsvo kukundikana isingakwanise kurapwa.
• Kuisa itsvo, kunogona kuitwa kana itsvo dzako dzisingachashandi.

Iwe unogona kutaurwa kudzikamisa kunwa kwako munyu uye zvinwiwa kudzora kuzvimba. Mune zvimwe zviitiko, yakaderera-kusvika-zvine mwero mapuroteni chikafu chinogona kukurudzirwa.

Izvi zviwanikwa zvinogona kupa rumwe ruzivo nezve anti-GBM chirwere:

• National Institute of Diabetes uye Digestive uye Kidney Zvirwere - www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases/anti-gbm-goodpastures-disease
• National Kidney Foundation - www.kidney.org/atoz/content/goodpasture
• National Sangano reRare Dambudziko - rarediseases.org/rare-diseases/goodpasture-syndrome

Kuongororwa kwekutanga kwakakosha. Maonero acho akanyanya kuipa kana itsvo dzakatokuvara zvakanyanya apo kurapwa kunotanga. Kukanganiswa kwemapapu kunogona kubva pane zvinyoro kusvika kune zvakanyanya.

Vanhu vazhinji vachada dialysis kana itsvo kuisirwa.

Isina kurapwa, mamiriro aya anogona kutungamira kune chero eanotevera:

• Chirwere chetsvo chisingaperi
• End-danho chirwere cheitsvo
• Kukundikana kwemapapu
• Inokurumidza kufambira mberi glomerulonephritis
• Yakanyanya pulmonary hemorrhage (kubuda ropa mumapapu)

Sheedza musangano pamwe nemupi wako kana iwe urikugadzira weti shoma, kana iwe uine zvimwe zviratidzo zveanorwisa-GBM chirwere.

Usambofa wakasveta glue kana siphon peturu nemuromo wako, izvo zvinoisa pachena mapapu kune hydrocarbon solvents uye anogona kukonzera chirwere.

Goodpasture chirwere; Inokurumidza kufambira mberi glomerulonephritis ine pulmonary hemorrhage; Pulmonary renal syndrome; Glomerulonephritis - pulmonary hemorrhage

• Itsvo kupa ropa
• Glomerulus uye nephron

Collard HR, King TE, Schwarz MI. Alveolar hemorrhage uye zvisingawanzo infiltrative hosha. Mune: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray naNadel Chinyorwa cheKufema Kwemishonga. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits 67.

Phelps RG, Turner AN. Anti-glomerular basement membrane chirwere uye chirwere cheGoodpasture. Muna: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Yakakwana Kliniki Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019: chitsiko 24.

Radhakrishnan J, Appel GB, D'Agati VD. Sekondari glomerular chirwere. Mune: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner uye Rector Iyo Itsvo. 11th ed. Philadelphia, PA: Elsevier; 2020: chits. 32.