Acromegaly

Acromegaly mamiriro mune huwandu hwakawanda hwekukura kwehomoni (GH) mumuviri.

Acromegaly chiitiko chisingawanzo. Izvo zvinokonzereswa kana iyo pituitary gland ichiita yakawandisa kukura mahormone. Iyo pituitary gland idiki diki endocrine gland yakasungirirwa pazasi pehuropi. Iyo inodzora, inogadzira, uye inoburitsa mahormone akati wandei, kusanganisira kukura mahormone.

Kazhinji noncancerous (benign) bundu repituitary gland rinoburitsa yakawandisa kukura mahormone. Mune zvisingawanzoitika zviitiko, pituitary tumors inogona kugarwa nhaka.

Muvana, yakawandisa GH inokonzeresa gigantism pane acromegaly.

Zviratidzo zveacromegaly zvinogona kusanganisira chero yeanotevera:

• Kunhuwa kwemuviri
• Ropa muzvigaro
• Carpal tunnel chirwere
• Yakadzikira mhasuru simba (kushaya simba)
• Kupera kwemaonero ekunze
• Kuneta kuri nyore
• Kureba kwakanyanya (kana yakawandisa GH kugadzirwa kunotanga muhudiki)
• Kuwedzera kudikitira
• Kutemwa nemusoro
• Kuwedzera kwemoyo, izvo zvinogona kukonzera kupera simba
• Kuchema
• Shaya kurwadziwa
• Marwadzo akabatana, mashoma akabatana kufamba, kuzvimba kwenzvimbo dzemabhonzo dzakakomberedza mubatanidzwa
• Mapfupa mahombe echiso, shaya hombe nerurimi, mazino akapararira kwazvo
• Makumbo marefu (shanduko mukukura kweshangu), mawoko mahombe (shandura mhete kana saizi yegurovhusi)
• Zvipembenene zvakakura muganda (zvinyoronyoro) zvinokonzeresa ganda rine mafuta, kuomarara kweganda, ma tag eganda (kukura)
• Kurara kufema
• Yakawedzera minwe kana zvigunwe, nekuzvimba, kutsvuka, uye kurwadziwa

Zvimwe zviratidzo zvinogona kuitika nechirwere ichi:

• Colon polyps
• Bvudzi rakawandisa kukura muvakadzi (hirsutism)
• Kuwedzera kweropa
• Nyora 2 chirwere cheshuga
• Kuwedzera kwehutachiona
• Kurera huremu

Anopa hutano anoita bvunzo dzepanyama uye obvunza nezve zviratidzo zvako.

Iyi bvunzo inotevera inogona kurairwa kuti isimbise kuongororwa kweacromegaly uye kutarisa matambudziko.

• Ropa glucose
• Kukura kwehomoni uye kukura kwehomoni kudzvinyirira bvunzo
• Insulin-senge kukura chinhu 1 (IGF-1)
• Prolactin
• Mutsara x-ray
• MRI yeuropi, kusanganisira iyo pituitary gland
• Echocardiogram
• Colonoscopy
• Kurara kudzidza

Mimwe miedzo inogona kurairwa kuti itarise kana iyo yakasara yepituitary gland iri kushanda zvakajairika.

Kuvhiya kubvisa pituitary bundu riri kukonzera iyi mamiriro kunowanzo gadzirisa isina kujairika GH. Dzimwe nguva, bundu rakakura kwazvo kuti ribviswe zvachose uye acromegaly haina kurapwa. Mune ino kesi, mishonga uye radiation (radiotherapy) inogona kushandiswa kurapa acromegaly.

Vamwe vanhu vane mamota anonyanya kuoma kubvisa nekuvhiya vanorapwa nemishonga pane kuvhiyiwa. Iyi mishonga inogona kuvhara kugadzirwa kweGH kubva kune pituitary gland kana kudzivirira kuita kweGH mune mamwe mativi emuviri.

Mushure mekurapwa, iwe uchafanirwa kuona mupi wako nguva dzose kuti uve nechokwadi chekuti gland repituitary riri kushanda zvakajairika uye kuti acromegaly haidzoke. Kuongororwa kwegore rega kunokurudzirwa.

Izvi zviwanikwa zvinogona kupa rumwe ruzivo nezve acromegaly:

• National Institute of Diabetes uye Digestive uye Kidney Zvirwere - www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly
• National Sangano reRare Dambudziko - rarediseases.org/rare-diseases/acromegaly

Kuvhiyiwa kwepituitary kunobudirira muvanhu vazhinji, zvinoenderana nesaizi yebundu uye neruzivo rweeurosurgeon ine pituitary tumors.

Pasina kurapwa, zviratidzo zvichawedzera. Mamiriro ezvinhu akadai seBP, chirwere cheshuga, uye chirwere chemwoyo zvinogona kukonzeresa.

Fonera mupiki wako kana:

• Iwe une zviratidzo zveacromegaly
• Zviratidzo zvako hazviite nekurapwa

Acromegaly haigone kudzivirirwa. Kurapa kwekutanga kunogona kudzivirira chirwere ichi kubva pakuwedzera uye kubatsira kudzivirira kunetseka.

Somatotroph adenoma; Kukura kwehomoni kuwandisa; Kukura kwehomoni kunovharira pituitary adenoma; Pituitary hofori (muhucheche)

• Endocrine masero

Katznelson L, Mitemo ER Jr, Melmed S, et al. Acromegaly: iyo endocrine nzanga yekiriniki yekudzidzira nhungamiro. J Clin Endocrinol Metab. 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Klein I. Endocrine kusagadzikana uye chirwere chemwoyo. Mune: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Chirwere Chemwoyo cheBraunwald: A Chinyorwa cheCardiovascular Medicine. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015: chits. 81.

Melmed S. Acromegaly. Muna: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Vakuru uye Chiremba. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits.