Carcinoid chirwere

Carcinoid syndrome iboka rezviratidzo zvinosanganisirwa necarcinoid tumors. Aya ndiwo mamota emukati ura, colon, appendix, uye bronchial machubhu mumapapu.

Carcinoid syndrome ndiyo nzira yezviratidzo dzimwe nguva inoonekwa muvanhu vane mamota ecarcinoid. Aya mamota haana kujairika, uye kazhinji anononoka kukura. Mazhinji mamota ane carcinoid anowanikwa mune yemudumbu uye mapapu.

Carcinoid syndrome inowanikwa mune vanhu vashoma kwazvo vane marcinoid tumors, mushure mekunge bundu rapararira kuchiropa kana mapapu.

Aya mamota anosunungura akawandisa mahormone serotonin, pamwe nemamwe makemikari akati wandei. Mahormone acho anoita kuti tsinga dzeropa dzivhurike (dzakasununguka) Izvi zvinokonzera carcinoid syndrome.

Iyo carcinoid syndrome inoumbwa nezviratidzo zvina zvikuru zvinosanganisira:

• Kuputika (kumeso, mutsipa, kana kumusoro kwepamusoro), senge yakawedzera tsinga dzeropa dzinoonekwa paganda (telangiectasias)
• Kunetseka kufema, sekufema
• Manyoka
• Zvinetso zvemwoyo, zvakadai sekudonhedza mavharuvhu emwoyo, kurova kwemoyo kunononoka, yakaderera kana yakakwira BP

Zviratidzo dzimwe nguva zvinounzwa nekuedza kwemuviri, kana kudya kana kunwa zvinhu senge yebhuruu chizi, chokoreti, kana waini tsvuku.

Mazhinji emamota aya anowanikwa kana bvunzo kana maitiro akaitwa kune zvimwe zvikonzero, senge panguva yekuvhiyiwa mudumbu.

Kana kuongorora kwepanyama kwaitwa, mupi wehutano anogona kuwana zviratidzo zve:

• Matambudziko emagetsi emoyo, sekugunun'una
• Niacin-kushomeka kwechirwere (pellagra)

Miedzo inogona kuitwa inosanganisira:

• 5-HIAA mazinga mumuti
• Ropa bvunzo (kusanganisira serotonin uye chromogranin yeropa bvunzo)
• CT uye MRI scan yechifuva kana dumbu
• Echocardiogram
• Octreotide radiolabeled scan

Kuvhiya kubvisa bundu kazhinji ndiko kurapwa kwekutanga. Inogona kurapa zvachose mamiriro acho kana bundu rikabviswa zvachose.

Kana bundu rakapararira kuchiropa, kurapwa kunosanganisira chimwe cheanotevera:

• Kubvisa nzvimbo dzechiropa dzine tumarara maseru
• Kutumira (kupinza) mushonga zvakananga muchiropa kuti uparadze mamota

Kana bundu rose risingakwanise kubviswa, kubvisa zvikamu zvakakura zvebundu ("debulking") zvinogona kubatsira kubvisa zviratidzo.

Octreotide (Sandostatin) kana lanreotide (Somatuline) majekiseni anopiwa kune vanhu vane advanced carcinoid tumors isingakwanise kubviswa nekuvhiya.

Vanhu vane carcinoid syndrome vanofanirwa kunwa doro, kudya kukuru, uye chikafu chakakwira mu tyramine (chezi dzakakwegura, avocado, zvakawanda zvakagadziriswa chikafu), nekuti zvinogona kukonzera zviratidzo.

Mimwe mishonga yakajairika, senge inosarudza serotonin reuptake inhibitors (SSRIs), senge paroxetine (Paxil) uye fluoxetine (Prozac), inogona kuita kuti zviratidzo zviwedzere nekuwedzera huwandu hweserotonin. Zvisinei, Usarega kutora mishonga iyi kunze kwekunge mupi wako akakuudza kuti uite saizvozvo.

Dzidza zvakawanda nezve carcinoid syndrome uye uwane rubatsiro kubva:

• Iyo Carcinoid Cancer Foundation - www.carcinoid.org/resource/support-groups/directory/
• Neuroendocrine Tumor Research Foundation - netrf.org/for-patients/

Iko kutaridzika kwevanhu vane carcinoid syndrome dzimwe nguva kwakasiyana nemaonero mune vanhu vane tumota twemacarcinoid vasina chirwere.

Kufungidzira kunoenderanawo nenzvimbo yebundu. Mune vanhu vane chirwere, bundu rinowanzo pararira kuchiropa. Izvi zvinoderedza mwero wekupona. Vanhu vane carcinoid syndrome vari zvakare mukana wekuve nekenza yakaparadzana (yechipiri yekutanga bundu) panguva imwe chete. Pakazara, kufungidzira kunowanzo kuve kwakanakisa.

Zvinetso zvecarcinoid syndrome zvinogona kusanganisira:

• Kuwedzera kwenjodzi yekudonha nekukuvara (kubva pakadzika kweropa)
• Kuvhiringidzika kwematumbo (kubva pabundu)
• Kubuda ropa mudumbu
• Kukanganisa kwevhavha yemoyo

Fomu inouraya yecarcinoid syndrome, dambudziko recarcinoid, inogona kuitika seimwe divi mhedzisiro yekuvhiya, anesthesia kana chemotherapy.

Bata mupi wako kune musangano kana iwe uine zviratidzo zvecarcinoid syndrome.

Kurapa bundu kunoderedza njodzi yecarcinoid syndrome.

Flush chirwere; Argentaffinoma chirwere

• Serotonin inotora

National Cancer Institute webhusaiti. Gastrointestinal carcinoid tumors kurapwa (Adult) (PDQ) - hutano nyanzvi vhezheni. www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq. Yakagadziridzwa Nyamavhuvhu 16, 2020. Yakasvika Gumiguru 14, 2020.

Öberg K. Neuroendocrine mamota uye zvinetso zvinoenderana. Mune: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Chinyorwa cheEndocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020: chitsama 45.

Wolin EM, Jensen RT. Neuroendocrine mamota. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chitsiko 219.