Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) chirwere chemuviri. Muchirwere ichi, immune system yemuviri inokanganisa kurwisa nyama dzakanaka. Inogona kukanganisa ganda, majoini, itsvo, huropi uye dzimwe nhengo.

Chikonzero cheSLE hachizivikanwe zvakajeka. Inogona kuve yakabatana nezvinhu zvinotevera:

• Genetic
• Zvakatipoteredza
• Hormonal
• Mimwe mishonga

SLE inowanzoitika kune vakadzi kupfuura varume vangangoita gumi kusvika pa1. Zvinogona kuitika chero zera. Zvisinei, inowanzoonekwa mumadzimai madiki ari pakati pemakore gumi nemashanu kusvika makumi mana nemana. MuUS, chirwere ichi chinowanzoitika muAfrican America, Asia America, Africanaribbean, uye Hispanic America.

Zviratidzo zvinosiyana kubva pamunhu kumunhu, uye zvinogona kuuya nekuenda. Wese munhu ane SLE ane marwadzo akabatana uye kuzvimba pane imwe nguva. Vamwe vanoita arthritis. SLE inowanzo bata majoini eminwe, maoko, mawoko, nemabvi.

Zvimwe zviratidzo zvakajairika zvinosanganisira:

• Kurwadziwa pachifuva kana uchitora kufema kwakanyanya.
• Kuneta.
• Fivha isina chimwe chikonzero.
• Kazhinji kusagadzikana, kusagadzikana, kana kurwadziwa (malaise).
• Bvudzi kurasikirwa.
• Kuonda.
• Maronda emuromo.
• Kunzwisisa kune zuva.
• Kuputika kweganda - Rino "butterfly" rash rinotanga mukati mehafu yevanhu vane SLE. Iwo mapundu anowanzoonekwa pamusoro pematama uye zambuko remhino. Inogona kunge yakapararira. Zvinotowedzera pakuvhenekerwa nezuva.
• Kuzvimba lymph node.

Zvimwe zviratidzo nezviratidzo zvinoenderana nechero chikamu chemuviri chakakanganiswa:

• Ubongo uye huta hurongwa - Kutemwa nemusoro, kushaya simba, kuveveve, kurira, kubatwa, matambudziko ekuona, ndangariro uye hunhu shanduko
• Dumbu rekugaya - Dumbu rekurwadziwa, kuda kurutsa, uye kurutsa
• Mwoyo - Matambudziko eValve, kuzvimba kwemhasuru yemoyo kana lining yemoyo (pericardium)
• Lung - Kuumbika kwemvura munzvimbo yekuteterera, kunetseka kufema, kukosora ropa
• Ganda - Maronda mumuromo
• Itsvo - Kuzvimba mumakumbo
• Kutenderera - Kuvhara mutsinga kana tsinga, kuzvimba kwemitsipa yeropa, kudzikamisa tsinga dzeropa mukupindura kutonhora (Raynaud phenomenon)
• Ropa kusanzwisisika kusanganisira kupererwa neropa, yakachena chena ropa masero kana platelet kuverenga

Vamwe vanhu vane zviratidzo zveganda chete. Izvi zvinonzi discoid lupus.

Kuti uonekwe uine lupus, unofanirwa kuve nezvina kubva gumi nembiri zviratidzo zvechirwere. Vanenge vese vanhu vane lupus vane bvunzo yakanaka yeantinuclear antibody (ANA). Zvisinei, kuva neAAA yakanaka chete hazvireve kuti une lupus.

Anopa hutano anozoongorora bvunzo. Iwe unogona kunge uine kuputika, arthritis, kana edema mumakumbo. Panogona kunge paine kurira kusingaite kunodaidzwa kunzi kupesana kwemoyo kana kukwikwidza kukwikwidza rub. Wako mupi achaitawo bvunzo dzetsinga.

Miedzo inoshandiswa kuongorora SLE inogona kusanganisira:

• Antinuclear nyowani (ANA)
• CBC ine mutsauko
• Chest x-ray
• Serum creatinine
• Kuongorora urinal

Iwe unogona zvakare kuve nemimwe bvunzo kuti udzidze zvakawanda nezve mamiriro ako. Mimwe yacho ndeiyi:

• Antinuclear nyukiliya (ANA) pani
• Zadzisa zvikamu (C3 neC4)
• Maantibodies kune DNA-yakapetwa kaviri
• Coombs bvunzo - tungamira
• Cryoglobulins
• ESR uye CRP
• Itsvo inoshanda ropa bvunzo
• Chiropa chinoshanda kuongororwa kweropa
• Rheumatoid chinhu
• Antiphospholipid antibodies uye lupus anticoagulant bvunzo
• Itsvo biopsy
• Kufungidzira kuyedza kwemoyo, huropi, mapapu, majoini, mhasuru kana ura

Hakuna mushonga we SLE. Chinangwa chekurapa ndechekudzora zviratidzo. Zviratidzo zvakakomba zvinosanganisira moyo, mapapu, itsvo, uye dzimwe nhengo dzinowanzoda kurapwa nenyanzvi. Munhu wega wega ane SLE anoda kuongororwa maererano:

• Kurwara kuri kuita sei
• Ndeipi chikamu chemuviri chinokanganiswa
• Ndeapi maitiro ekurapa anodikanwa

Mafomu akapfava echirwere anogona kurapwa ne:

• NSAID dzezviratidzo zvekubatana uye pleurisy. Taura nemupi wako usati watora iyi mishonga.
• Low doses ye corticosteroids, senge prednisone, yeganda uye arthritis zviratidzo.
• Corticosteroid makirimu ekuputika kweganda.
• Hydroxychloroquine, mushonga unoshandiswawo kurapa malaria.
• Methotrexate inogona kushandiswa kudzikisa chiyero checorticosteroids
  
• Belimumab, mushonga webiologic, unogona kubatsira kune vamwe vanhu.

Mishonga yeSLE yakanyanya inogona kusanganisira:

• Yakakwira-dose corticosteroids.
• Immunosuppressive mishonga (iyi mishonga inodzvinyirira immune system). Iyi mishonga inoshandiswa kana iwe uine lupus yakakomba iyo iri kukanganisa system yemitsipa, itsvo kana dzimwe nhengo. Inogona zvakare kushandiswa kana iwe ukasaita zvirinani necorticosteroids, kana kana zviratidzo zvako zvichinyanya kuoma paunomira kutora corticosteroids.
• Mishonga inowanzo shandiswa inosanganisira mycophenolate, azathioprine uye cyclophosphamide. Nekuda kwehusimbe hwayo, cyclophosphamide inogumira kune ipfupi kosi yemwedzi mitatu kusvika kumitanhatu. Rituximab (Rituxan) inoshandiswa mune zvimwe zviitiko futi.
• Ropa rakapfava, senge warfarin (Coumadin), yekuvhara kwekupokana senge antiphospholipid syndrome.

Kana uine SLE, zvakakoshawo kuti:

• Pfeka mbatya dzekudzivirira, magirazi ezuva uye sunscreen kana uri muzuva.
• Wana kudzivirira mwoyo kutarisirwa.
• Gara up-to-date nemajekiseni.
• Iva nemiedzo yekuongorora kutetepa kwemapfupa (osteoporosis).
• Dzivisa fodya uye unwe doro shoma.

Kupa mazano uye mapoka ekutsigira anogona kubatsira nenyaya dzekunetseka dzakanangana nechirwere ichi.

Mhedzisiro yevanhu vane SLE yakavandudzwa mumakore apfuura. Vanhu vazhinji vane SLE vane zviratidzo zvishoma. Kunyatsoita kwako kunoenderana nekuti chirwere chakanyanya sei. Vanhu vazhinji vane SLE vanozoda mishonga kwenguva yakareba. Zvinenge zvese zvinoda hydroxychloroquine nekusingaperi. Zvisinei, muUS, SLE ndechimwe chepamusoro makumi maviri chinokonzera kufa kwevanhukadzi vari pakati pemakore mashanu ne64.Mishonga mitsva yakawanda iri kuongororwa kusimudzira mhedzisiro yevakadzi vane SLE.

Chirwere chinowanzo kuve chinoshanda zvakanyanya:

• Mumakore ekutanga mushure mekuongororwa
• Mune vanhu vari pasi pemakore makumi mana

Vakadzi vazhinji vane SLE vanogona kubata pamuviri uye kuendesa mwana ane hutano. Mhedzisiro yakanaka inowanzoitika kune vakadzi vanowana kurapwa kwakaringana uye vasina matambudziko akakomba emoyo kana itsvo. Zvisinei, kuvapo kwezvimwe zvirwere zveSLE kana antiphospholipid antibodies zvinomutsa njodzi yekuparara.

LUPUS NEPHRITIS

Vamwe vanhu vane SLE vane zvisizvo zvisina kujairika zvekuchengetedza immune mumasero eitsvo. Izvi zvinotungamira kune inonzi mamiriro lupus nephritis. Vanhu vane dambudziko iri vanogona kukundikana itsvo. Ivo vangangoda dialysis kana itsvo kuisirwa.

Tsvo biopsy inoitwa kuti uone huwandu hwekukuvara kune itsvo uye kubatsira kutungamira kurapwa. Kana inoshanda nephritis iripo, kurapwa nemishonga yekudzivirira muviri inosanganisira yakakwira doses yecorticosteroids pamwe necyclophosphamide kana mycophenolate inodiwa.

ZVIMWE ZVIKAMU ZVOMUDZIMU

SLE inogona kukonzera kukuvara munzvimbo dzakasiyana dzemuviri, kusanganisira:

• Ropa rinovhara mune tsinga dzetsinga dzemakumbo, mapapu, huropi, kana ura
• Kuparadzwa kwemasero matsvuku eropa kana kupererwa neropa kwechirwere chenguva refu (chisingaperi)
• Fluid yakatenderedza moyo (pericarditis), kana kuzvimba kwemoyo (myocarditis kana endocarditis)
• Fluid yakatenderedza mapapu uye kukuvara kwemapapu tishu
• Matambudziko epamuviri, kusanganisira kusununguka
• Kurohwa
• Uturu hunokanganisa nemarwadzo emudumbu uye mhingaidzo
• Kuzvimba mumatumbu
• Yakanyanya yakaderera ropa platelet kuverenga (maplatelet anodiwa kumisa chero kubuda ropa)
• Kuzvimba kwemitsipa yeropa

Kurara uye Pamuviri

Ose maSLE uye mimwe yemishonga inoshandiswa SLE inogona kukuvadza mwana asati azvarwa. Taura nemupi wako usati wava nepamuviri. Kana iwe ukava nepamuviri, tsvaga mupi uyo ane ruzivo ne lupus uye nepamuviri.

Fonera mupiki wako kana iwe uine zviratidzo zveSLE. Zvakare daidza kana iwe uine chirwere ichi uye zviratidzo zvako zvichitowedzera kana chiratidzo chitsva chikaitika.

Yakaparadzirwa lupus erythematosus; SLE; Lupus; Lupus erythematosus; Butterfly mapundu - SLE; Discoid lupus

• Systemic lupus erythematosus
• Lupus, discoid - maonero ezve maronda pachifuva
• Lupus - discoid pachiso chemwana
• Systemic lupus erythematosus kuputika kumeso
• Antibodies

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