Felty chirwere

Felty syndrome chirwere chinosanganisira rheumatoid arthritis, chiropa chakazvimba, kuderera kwechena masero eropa kuverenga, uye kudzokorora hutachiona. Kashoma.

Chikonzero cheFelty syndrome hachizivikanwe. Inowanzoitika kune vanhu vane rheumatoid arthritis (RA) kwenguva yakareba. Vanhu vane chirwere ichi vari panjodzi yekutapukirwa nekuti vane yakaderera chena masero eropa kuverenga.

Zviratidzo zvinosanganisira:

• Kazhinji kunzwa kwekusagadzikana (malaise)
• Kuneta
• Kushaya simba mugumbo kana ruoko
• Kupererwa nechido
• Kurasikirwa kwekurema kwemaune
• Maronda paganda
• Kubatana kwakabatana, kuomarara, kurwadziwa, uye hurema
• Zvirwere zvinowanzoitika
• Ziso dzvuku nekupisa kana kubuda

Kuongorora kwepanyama kucharatidza:

• Dzimba yekuzvimba
• Majoini anoratidza zviratidzo zveRA
• Zvichida kuzvimba chiropa uye lymph node

Kuverengera kwakazara kweropa (CBC) nemusiyano kunoratidza yakaderera nhamba masero eropa machena anonzi neutrophils. Vanenge vese vanhu vane Felty syndrome vane bvunzo yakanaka yerheumatoid factor.

Dumbu ultrasound inogona kusimbisa pena yekuzvimba.

Muzviitiko zvakawanda, vanhu vane iyi syndrome havasi kuwana kurumbidzwa kurapwa kweRA. Ivo vangangoda mimwe mishonga yekudzvinyirira immune system yavo uye kudzikisira zviitiko zveRA yavo.

Methotrexate inogona kusimudzira yakaderera neutrophil kuverenga. Iyo drug rituximab yakabudirira mune vanhu vasingapindure kune methotrexate.

Granulocyte-koloni inosimudzira chinhu (G-CSF) inogona kukwidziridza iyo neutrophil kuverenga.

Vamwe vanhu vanobatsirwa nekubviswa kwepleen (splenectomy).

Pasina kurapwa, hutachiona hunogona kuramba huchiitika.

RA inogona kuwedzera.

Kurapa RA, zvakadaro, kunofanirwa kunatsiridza Felty syndrome.

Unogona kuva nezvirwere zvinoramba zvichidzoka.

Vamwe vanhu vane Felty syndrome vakawedzera huwandu hwemakemikari ane granular, anonziwo LGL leukemia. Izvi zvicharapwa ne methotrexate muzviitiko zvakawanda.

Fonera wako mupi wezvehutano kana iwe ukaita zviratidzo zvechirwere ichi.

Kukurumidza kurapwa kweRA nemishonga parizvino yakakurudzirwa zvakanyanya kunoderedza njodzi yekuvandudza Felty syndrome.

Seropositive rheumatoid arthritis (RA); Felty's chirwere

• Antibodies

Bellistri JP, Muscarella P. Splenectomy yezvinetso zvehematologic. Mune: Cameron JL, Cameron AM, eds. Parizvino Kuvhiya Therapy. 12th ed. Philadelphia, PA: Elsevier; 2017: 603-610.

Erickson AR, Cannella AC, Mikuls TR. Clinical maficha erheumatoid arthritis. Mune: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley uye Firestein's Bhuku reRheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017: chits. 70.

Gazitt T, Loughran TP Jr. Chisingaperi neutropenia muLGL leukemia uye rheumatoid arthritis. Hematology Am Soc Hematol Dzidza Chirongwa. 2017; 2017 (1): 181-186. PMID: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254.

Myasoedova E, Turesson C, Matteson EL. Zvimwe zvikamu zve rheumatoid arthritis. Mu: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2019: chitsiko 95.

Savola P, Brück O, Olson T, et al. Somatic STAT3 shanduko muFelty syndrome: chirevo chepathogenesis yakajairika ine hombe granular lymphocyte leukemia. Haematologica. 2018; 103 (2): 304-312. PMID: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

Wang CR, Chiu YC, Chen YC. Kubudirira kurapwa kweanokanganisa neutropenia muFelty's syndrome ine rituximab. Scand J Rheumatol. 2018; 47 (4): 340-341. PMID: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.