Aplastic kupererwa neropa

Aplastic anemia mamiriro ezvinhu umo mwongo wepfupa hauite akakwana masero eropa. Bone mwongo ndiyo yakapfava, munyama uri pakati pemabhonzo unoitisa kuburitsa masero eropa nemaplatelet.

Aplastic anemia inokonzerwa nekukuvara kune eropa maseru masero. Masero emadzinde maseru asina kukura mumongo wemapfupa ayo anopa mhando dzese dzeropa maseru (masero matsvuku eropa, machena masero eropa, uye maplatelet). Kukuvadza kune masero maseru kunotungamira mukudzikira kwehuwandu hweaya maseru eropa mhando.

Aplastic anemia inogona kukonzerwa ne:

• Kushandiswa kwemamwe madhiragi kana kuratidzwa kumakemikari ane chepfu (senge chloramphenicol, benzene)
• Kuratidzirwa kune radiation kana chemotherapy
• Autoimmune kusagadzikana
• Kubata pamuviri
• Utachiona

Dzimwe nguva, chikonzero hachizivikanwe. Muchiitiko ichi, kusagadzikana kunonzi idiopathic aplastic anemia.

Zviratidzo zvinokonzerwa nekushomeka kwemasero matsvuku, machena maseru, uye maplatelet. Zviratidzo zvinogona kunge zvakanyanya kubva pakutanga kana zvishoma nezvishoma zvichinyanyisa nekufamba kwenguva sezvo chirwere ichi chichienderera mberi.

Yakadzika tsvuku masero kuverenga (anemia) inogona kukonzera:

• Kuneta
• Pallor (kuchena)
• Kukurumidza kurova kwemoyo
• Kufema nekufema
• Kushaya simba
• Musoro wakareruka pakumira

Yakadzika chena masero kuverenga (leukopenia) inokonzera kuwedzera njodzi yehutachiona.

Low platelet count (thrombocytopenia) inogona kukonzera kubuda ropa. Zviratidzo zvinosanganisira:

• Kubuda ropa mazino
• Kupwanya kuri nyore
• Mhuno inobuda ropa
• Rash, madiki madiki anonongedza matsvuku paganda (petechiae)
• Kazhinji kana zvakakomba hutachiona (husingawanzo kujairika)

Kuongororwa kweropa kucharatidza:

• Low red red cell cell kuverenga (kupererwa neropa)
• Yakadzika chena yeropa masero kuverenga (leukopenia)
• Low reticulocyte count (reticulocytes ndiwo madiki masero matsvuku eropa)
• Yakadzika platelet kuverenga (thrombocytopenia)

A bone marrow biopsy inoratidza mashoma-kupfuura-akajairwa maseru eropa uye huwandu hwakawedzera hwemafuta.

Zviitiko zvakapfava zveaplastic anemia izvo zvisina zviratidzo zvingangoda kurapwa.

Sezvo huwandu hwesero reropa hunowedzera kudzikira uye zviratidzo zvinokura, ropa nemaplatelet zvinopihwa kuburikidza nekuisirwa. Nekufamba kwenguva, kuwedzerwa kunogona kumira kushanda, zvichikonzera kushomeka kwemasero eropa kuwanda. Ichi chiitiko chinotyisidzira hupenyu.

Bone marora, kana stem cell transplant inogona kukurudzirwa kune vechidiki. Izvo zvinowanzo kuve zvinokurudzirwa kune avo makumi mashanu emakore uye vadiki, asi vanhu vanopfuura makumi mashanu vanogona kugashirwa kana vaine hutano zvakakwana. Uku kurapa kunoshanda zvakanyanya kana mupi ari hama kana hanzvadzi inonyatsoenderana. Izvi zvinodaidzwa kuti zvinoenderana hama yemupi ..

Vakwegura uye avo vasina akaenzana mukoma mupi vanopihwa mushonga wekudzvinyirira immune system. Iyi mishonga inogona kubvumira kuti mwongo wemapfupa uite zvakare kuita masero eropa ane hutano. Asi chirwere chinogona kudzoka (kudzokazve). Kuiswa kwemongo wepfupa pamwe nemupi asina hukama kunogona kuyedzwa kana mishonga iyi isingabatsire kana chirwere chikadzoka mushure mekupora.

Kusarapwa, kwakanyanya aplastic anemia kunotungamira kukurumidza kufa. Bone marrow kuisirwa inogona kubudirira kwazvo muvechidiki. Kuisazve chinhu chinoshandiswa muvanhu vakura kana kana chirwere ichi chadzoka mushure mekunge mishonga yamira kushanda.

Zvinetso zvinogona kusanganisira:

• Zvirwere zvakanyanya kana kubuda ropa
• Matambudziko emapfupa ekutsvaira
• Zviitiko kumishonga
• Hemochromatosis (kuvaka kwesimbi yakawandisa mumatumbu emuviri kubva kuwedzerwa kuwedzerwa maseru matsvuku)

Fonera wako mupi wezvehutano kana kuenda kukamuri yekukurumidzira kana kubuda ropa kuchiitika pasina chikonzero, kana kana kubuda ropa kwakaoma kumira. Fona kana iwe ukaona kazhinji hutachiona kana husina kujairika kuneta.

Hypoplastic kupererwa neropa; Bone marora kutadza - aplastic anemia

• Bone marrow kuisirwa - kubuda

• Bone marora kushuvira

Bagby GC. Aplastic anemia uye inoenderana nemapfupa emongo kukundikana nyika. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chap 156.

Culligan D, Watson HG. Ropa nemapfupa. Mu: Muchinjikwa SS, ed. Underwood's Pathology. 7th ed. Philadelphia, PA: Elsevier; 2019: chitsiko 23.

Wechidiki NS, Maciejewski JP. Aplastic kupererwa neropa. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits.