Bone mwongo (stem cell) mupiro

Mongo wefupa ndiwo munyoro, une mafuta mukati memapfupa ako. Bhongo remongo rine masero emadzinde, ayo ari maseru asina kukura anova masero eropa.

Vanhu vane chirwere chinotyisidzira hupenyu, senge leukemia, lymphoma, uye myeloma vanogona kurapwa nekupfupa kwemongo. Izvi zvave kunzi kazhinji zvinonzi stem cell transplant. Kune urwu rudzi rwekurapa, mwongo wemapfupa unounganidzwa kubva kune anopa. Dzimwe nguva, vanhu vanogona kupa yavo pfupa mwongo.

Kupiwa kwemongo wemapfupa kunogona kuitwa kana nekuunganidza mwongo wemupfupa nekuvhiya, kana nekubvisa masero emidzi kubva muropa remupi.

Kune mhando mbiri dzekupiwa kwemongo wemapfupa:

• Autologous mapfupa emongo ndipo apo vanhu vanopa yavo yega mongo. "Auto" zvinoreva wega.
• Allogenic bone marrow kuisirwa ndipo apo mumwe munhu anopa mongo wemabhonzo. "Allo" zvinoreva zvimwe.

Nechekuisa allogenic, magene emupi wemupi anofanirwa kunge achifananidza magene emubatsiri. Mukoma kana hanzvadzi anogona kunge ari mutambo wakanaka. Dzimwe nguva vabereki, vana, uye dzimwe hama mitambo yakanaka. Asi chete vangangoita makumi matatu muzana vevanhu vanoda kupfekwa kwemongo wemapfupa vanogona kuwana mupi akaenzana mumhuri yavo.

Ivo 70% yevanhu vasina hama inoenderana nemutambo vanogona kukwanisa kuwana imwe kuburikidza nerejista yemongo wemapfupa. Chikuru pane icho chinonzi Be the Match (bethematch.org). Iyo inonyora vanhu vangave vachida kupa mupfupa wemapfupa uye vanochengeta ruzivo rwavo mudura. Vanachiremba vanogona kushandisa registry kuti vawane inoenderana mupi wemunhu anoda pfupa remongo.

Maitiro Ekujoinha Bone Marrow Registry

Kuti uverengerwe murejista yemupiro wemongo wemapfupa, munhu anofanira kuve:

• Pakati pemakore gumi nemasere kusvika makumi matanhatu
• Hutano uye hauna nhumbu

Vanhu vanogona kunyoresa pamhepo kana kune yemunharaunda vanopa registry drive. Ivo vari pakati pemazera e45 kusvika 60 vanofanirwa kujoina online. Iwo emuno, ari-mumunhu anotyaira anongogamuchira vanopa avo vari vadiki pane makore makumi masere nemashanu. Masero avo emidziyo anowanzo batsira varwere kupfuura maseru emadzinde kubva kuvanhu vakuru.

Vanhu vanonyoresa vanofanira kana:

• Shandisa swab yedonje kutora sampuro yemasero kubva mukati medama ravo
• Ipa chidiki cheropa sampu (inenge 1 kiyipuni kana mamirilita gumi nemashanu)

Masero kana ropa rinozoongororwa mapuroteni akasarudzika, anonzi mavanhu leukocytes antigen (HLA). HLAs inobatsira hutachiona-kurwisa system (immune system) taura musiyano uripo pakati penyama yemuviri nezvinhu zvisiri zvemuviri wako.

Bone marrow transplants anoshanda zvakanyanya kana iyo HLAs kubva kune iye mupi uye murwere vari pedyo mutambo. Kana maHLA emupi anowirirana zvakanaka nemunhu anoda kuisirwa, mupi anofanira kupa mutsva weropa sosi yekusimbisa mutambo. Ipapo, chipangamazano anosangana nemupi kuti vakurukure nezvehurongwa hwekupa mari yemongo.

Masero ekupa anokwanisa anogona kuunganidzwa munzira mbiri.

Peripheral ropa stem maseru ekuunganidza. Mazhinji maseru ekupa maseru anounganidzwa kuburikidza nenzira inonzi leukapheresis.

• Kutanga, mupiro anopiwa mazuva mashanu ekupfura kuti abatsire maseru maseru kufamba kubva mumongo wepfupa kuenda muropa.
• Munguva yekuunganidza, ropa rinobviswa kubva kune anenge apa kuburikidza netambo iri mutsinga (IV). Chikamu chemasero machena eropa chine masero enhengo anobva apatsanurwa mumushini ndokubviswa kunozopihwa kumugashiri.
• Masero matsvuku eropa anodzoserwa kumupi kuburikidza neIV mune rumwe ruoko.

Maitiro aya anotora anenge maawa matatu. Zvimwe zvinokanganisa zvinosanganisira:

• Kutemwa nemusoro
• Sora mapfupa
• Kusagadzikana kubva kune tsono dziri mumaoko

Kukohwa mwongo wemapfupa. Uku kuvhiyiwa kudiki kunoitwa pasi peanesthesia. Izvi zvinoreva kuti mupi achave akarara uye asingarwadziwe panguva yekuita. Mongo wemapfupa unobviswa kubva kumashure kwemapfupa ako epamuviri. Maitiro acho anotora ingangoita awa.

Mushure mekukohwa kwemongo wemapfupa, mupiro anogara muchipatara kudzamara vanyatsomuka uye vagogona kudya nekunwa. Zvimwe zvinokanganisa zvinosanganisira:

• Nausea
• Kutemwa nemusoro
• Kuneta
• Kupwanya kana kusagadzikana muzasi kumashure

Unogona kutangazve chiitiko chakajairika mune rinenge vhiki.

Kune mashoma mashoma njodzi kune anenge apa uye hapana hunogara hutano mhedzisiro. Mumuviri wako unozotsiva rakapihwa mwongo wemapfupa muanenge mavhiki mana kusvika matanhatu.

Stem cell transplant - mupiro; Allogeneic mupiro; Leukemia - mupiro wemongo wemapfupa; Lymphoma - mupiro wemongo wemapfupa; Myeloma - pfupa remongo wemupiro

American Cancer Society webhusaiti. Stem cell kuisirwa kenza. www.cancer.org/treatment/treatments-and-side-effects/treatment-types/stem-cell-transplant.html. Yakasvika munaNovember 3, 2020.

Fuchs E. Haploidentical hematopoietic cell kuisirwa. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds.Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits. 106.

National Cancer Institute webhusaiti. Ropa-rinogadzira masero masero anochinja. www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. Yakagadziridzwa Nyamavhuvhu 12, 2013. Yakasvika munaNovember 3, 2020.

• Bone Marrow Kudyara
• Masero emadzinde