Gigantism

Gigantism kukura zvisina kujairika nekuda kwekuwedzera kwekukura kwehomoni (GH) panguva yehucheche.

Gigantism ishoma kwazvo. Chikonzero chakajairika chekuburitswa kweGH kwakanyanya isingaite cancer (benign) bundu repituitary gland. Zvimwe zvikonzero zvinosanganisira:

• Chirwere cheGenetic chinokanganisa ruvara rweganda (pigmentation) uye chinokonzeresa mamota ane ganda, moyo, uye endocrine (hormone) system (Carney complex)
• Chirwere cheGenetic chinokanganisa mapfupa uye ganda pigmentation (McCune-Albright syndrome)
• Chirwere cheGenetic umo imwe kana dzakawanda zvee endocrine gland dzakanyanyisa kushanda kana kuumba bundu (akawanda endocrine neoplasia mhando 1 kana mhando 4)
• Chirwere cheGenetic chinogadzira pituitary tumors
• Chirwere umo mamota anoumba pamitsipa yeuropi uye musana (neurofibromatosis)

Kana GH yakawandisa ikaitika mushure mekukura kwefupa kwakamira (kupera kwekuyaruka), mamiriro acho anozivikanwa seacromegaly.

Mwana achakura pakukwirira, pamwe nemhasuru nenhengo. Uku kukura kwakanyanyisa kunoita kuti mwana akure zvakanyanya zera rake.

Zvimwe zviratidzo zvinosanganisira:

• Kunonoka kuyaruka
• Kuona kaviri kana kunetseka nerutivi (peripheral) kuona
• Yakakurumbira huma (yekumberi mabhosi) uye yakakurumbira shaya
• Makakatanwa pakati pemeno
• Kutemwa nemusoro
• Kuwedzera kudikitira
• Nguva dzisina kujairika (kuenda kumwedzi)
• Joint kurwadziwa
• Maoko makuru nemakumbo ane minwe yakakora nezvigunwe
• Kusunungurwa kwemukaka wemukaka
• Zvinetso zvekurara
• Kuwedzera kwechiso maficha
• Kushaya simba
• Izwi rinochinja

Anopa hutano anoita bvunzo dzepanyama uye obvunza nezve zviratidzo zvemwana.

Rabhoritari bvunzo dzinogona kurairwa dzinosanganisira:

• Cortisol
• Estradiol (vasikana)
• GH kudzvinyirira bvunzo
• Prolactin
• Insulini-senge kukura chinhu-ini
• Testosterone (vakomana)
• Uturu hwehomoni

Kufungidzira bvunzo, senge CT kana MRI scan yemusoro, zvakare inogona kurairwa kuti iongorore pituitary bundu.

Kune mapituitary tumors, kuvhiyiwa kunogona kuporesa akawanda kesi.

Kana kuvhiya kusingakwanise kubvisa zvachose bundu, mishonga inoshandiswa kuvharira kana kudzikisira kuburitswa kweGH kana kudzivirira GH kuti isvike pakatarisana nematuru.

Dzimwe nguva kurapwa kwemwaranzi kunoshandiswa kudzikisa saizi yebundu mushure mekuvhiyiwa.

Kuvhiyiwa kwepituitary kunowanzo kubudirira mukudzora kugadzirwa kweGH.

Kurapa kwekutanga kunogona kudzosera kwakawanda shanduko dzinokonzerwa neGH yakawandisa.

Kuvhiya uye kurapwa nemwaranzi kunogona kutungamira kumazinga akadzika emamwe mahormone epituitary. Izvi zvinogona kukonzera chero eanotevera mamiriro:

• Adrenal insufficiency (adrenal glands haigadziri yakakwana mahormone avo)
• Chirwere cheshuga insipidus (yakanyanya nyota uye kuwedzeredza weti; mune zvisingawanzoitika zviitiko)
• Hypogonadism (glands yemuviri mabonde inoburitsa mashoma kana asina mahormone)
• Hypothyroidism (thyroid shwanu haigadzi yakakwana utachiona kemikari)

Fonera waunopa kana mwana wako aine zviratidzo zvekukura zvakanyanya.

Gigantism haigone kudzivirirwa. Kurapa kwekutanga kunogona kudzivirira chirwere ichi kubva pakuwedzera uye kubatsira kudzivirira kunetseka.

Pituitary hofori; Kuwedzeredza kwekukura kwehomoni; Kukura kwehormone - yakawandisa kugadzirwa

• Endocrine masero

Katznelson L, Mitemo ER Jr, Melmed S, et al; Endocrine Sosaiti. Acromegaly: iyo endocrine nzanga yekiriniki yekudzidzira nhungamiro. J Clin Endocrinol Metab. 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Melmed S. Acromegaly. Muna: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Vakuru uye Chiremba. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits.