Kusarudzika kwekusarudza kweIgA

Kusarudzika kwekusarudzika kweIg ndiyo yakajairika kushomeka kusagadzikana kusagadzikana. Vanhu vane chirwere ichi vane mwero wakaderera kana usipo weprotein yeropa inonzi immunoglobulin A.

Kushaya kweIgA kunowanzo gara nhaka, zvinoreva kuti inopfuudzwa kuburikidza nemhuri. Nekudaro, kune zvekare zviitiko zvekushomeka kwezvinodhaka-zvinokonzerwa neIgA.

Iyo inogona kugarwa senhengo ye autosomal yakanyanya kana autosomal hunhu hwakawanda. Inowanzo kuwanikwa muvanhu vanobva kuEurope. Izvo hazvisi zvakajairika muvanhu vemamwe madzinza.

Vanhu vazhinji vane yakasarudzika IgA kushomeka havana zviratidzo.

Kana munhu aine zviratidzo, zvinogona kusanganisira kazhinji zvikamu zve:

• Bronchitis (hutachiona hwemhepo)
• Chirwere chisingaperi
• Conjunctivitis (hutachiona hwemaziso)
• Kuzvimba kwepamuviri, kusanganisira ulcerative colitis, chirwere cheCrohn, uye chirwere chakaita sechirwere
• Mukanwa hutachiona
• Otitis media (yepakati nzeve hutachiona)
• Pneumonia (chirwere chemapapu)
• Sinusitis (sinus chirwere)
• Zvirwere zveganda
• Epamusoro mweya wekufema

Zvimwe zviratidzo zvinosanganisira:

• Bronchiectasis (chirwere umo mweya masaga mudiki mumapapu anokuvara uye kuwedzerwa)
• Chirwere pasina chikonzero chinozivikanwa

Panogona kunge paine nhoroondo yemhuri yekushaya kweIgA. Miedzo inogona kuitwa inosanganisira:

• IgG subclass zviyero
• Kuwanda kwema immunoglobulins
• Serum immunoelectrophoresis

Hapana kurapwa chaiko kunowanikwa. Vamwe vanhu zvishoma nezvishoma vanokura zvakajairika mazinga eIg pasina kurapwa.

Kurapa kunosanganisira kutora matanho ekuderedza huwandu uye kuomarara kwezvirwere. Mishonga inorwisa mabhakitiriya inowanzo dikanwa kurapa hutachiona.

Immunoglobulins inopihwa kuburikidza netsinga kana jekiseni kusimudzira immune system.

Autoimmune chirwere chekurapa chakavakirwa padambudziko chairo.

Ongorora: Vanhu vane kukwana kwakakwana kweIg vanogona kugadzira anti-IgA antibodies kana vakapihwa zvigadzirwa zveropa uye maemonoglobulins. Izvi zvinogona kutungamira kune allergies kana kutyisidzira hupenyu anaphylactic kuvhunduka. Nekudaro, ivo vanogona kupihwa zvakachengeteka IgA-yakapedzwa immunoglobulins.

Kusarudzika kweIga kushomeka hakukuvadzi kupfuura mamwe akawanda zvirwere zvekudzivirira muviri.

Vamwe vanhu vane IgA kushomeka vanozopora vega uye vogadzira IgA muhukuru hwakawanda mukati menguva yemakore.

Autoimmune kusagadzikana senge rheumatoid arthritis, systemic lupus erythematosus, uye celiac sprue inogona kukura.

Vanhu vane kushomeka kweIg vanogona kugadzira antibodies kuIgA. Nekuda kweizvozvo, vanogona kuve neakakomba, nyangwe kutyisidzira hupenyu mukuisirwa kweropa uye zvigadzirwa zveropa.

Kana iwe uine kushomeka kweIgA, ita shuwa yekutaura nezvako kumubatsiri wako wehutano kana immunoglobulin kana zvimwe zvinowedzerwa ropa-zvinowedzerwa senzira yekurapa chero mamiriro.

Genetic kuraira kunogona kuve kwakakosha kune vangangove vabereki vane nhoroondo yemhuri yekusarudzika IgA kushomeka.

Kushaya kweIgA; Immunodepressed - IgA kushomeka; Immunosuppressed - IgA kushomeka; Hypogammaglobulinemia - IgA kushomeka; Agammaglobulinemia - IgA kushomeka

• Antibodies

Cunningham-Rundles C. Zvirwere zvekutanga zvekudzivirira muviri. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chitsiko 236.

Sullivan KE, Buckley RH. Kukanganisa kwekutanga kwekugadzira antibody. Mune: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Chinyorwa chePediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020: chitsiko 150.