Munyori: Clyde Lopez
Zuva Rekusika: 20 Chikunguru 2021
Gadziridza Zuva: 1 Kubvumbi 2025
Anonim
Leflunomide (DMARD) pharmacology - mechanism of action, adverse effects and cholestyramine
Vhidhiyo: Leflunomide (DMARD) pharmacology - mechanism of action, adverse effects and cholestyramine

Zvemukati

Usatore leflunomide kana iwe uri nepamuviri kana kuronga kuve nepamuviri. Leflunomide inogona kukuvadza fetus. Iwe haufanire kutanga kutora leflunomide kusvikira iwe watora bvunzo yepamuviri nemhedzisiro yakaipa uye chiremba wako anokuudza kuti hauna nhumbu. Iwe unofanirwa kushandisa nzira inoshanda yekudzivirira kuberekwa usati watanga kutora leflunomide, panguva yekurapa kwako ne leflunomide, uye kwemakore maviri mushure mekurapwa. Kana nguva yako yakanonoka kana iwe ukarasikirwa nenguva panguva yekurapwa ne leflunomide, danaidza chiremba wako nekukasira. Taura nachiremba wako kana uchironga kubata pamuviri mukati memakore maviri mushure mekumisa kurapwa neeflunomide. Chiremba wako anogona kupa mushonga unobatsira kubvisa mushonga uyu nekukurumidza kubva mumuviri wako.

Leflunomide inogona kukonzera kukuvara kwechiropa kunogona kutyisidzira hupenyu uye kutokonzeresa kufa. Ngozi yekukuvara kwechiropa yakanyanya muvanhu vanotora mimwe mishonga inozivikanwa kukonzera kukuvara kwechiropa, uye nevanhu vane chirwere chechiropa. Udza chiremba wako kana iwe wakambove kana uine hepatitis kana chero imwe mhando yechirwere chechiropa uye kana iwe ukanwa kana kumbonwa doro rakawanda. Udza chiremba wako uye wemishonga kana iwe uri kutora acetaminophen (Tylenol, mune zvimwe zvinopfuura-the-counter zvigadzirwa), aspirin uye mamwe nonsteroidal anti-inflammatory mishonga (NSAIDs senge ibuprofen [Advil, Motrin] uye naproxen [Aleve, Naprosyn], cholesterol -kuderedza mishonga (statins), hydroxychloroquine, zvigadzirwa zvesimbi, isoniazid (Laniazid, muRifamate, muRifater), methotrexate (Trexall), niacin (nicotinic acid), kana rifampin (Rifadin, Rimactane, muRifamate, muRifater). unzwe chero cheanotevera zviratidzo, dana chiremba wako nekukurumidza: kusvotwa, kuneta zvakanyanya, kujairika kubuda ropa kana kupwanya, kushomeka kwesimba, kurasikirwa nenzara, kurwadziwa munzvimbo yepamusoro yekurudyi yemudumbu, yero yeganda kana maziso, nerima-ruvara weti, kana zviratidzo zvakaita sefuru.


Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako anozoraira mimwe bvunzo kuti atarise mhinduro yemuviri wako kune leflunomide.

Taura nachiremba wako nezve njodzi dzekutora leflunomide.

Leflunomide inoshandiswa yoga kana musanganiswa nemimwe mishonga kurapa rheumatoid arthritis (mamiriro umo muviri unorwisa majoini ayo, zvichikonzera kurwadziwa, kuzvimba, uye kurasikirwa nebasa). Leflunomide ari mukirasi yemishonga inonzi chirwere-kugadzirisa antirheumatic zvinodhaka (DMARDs). Inoshanda nekuderedza kuzvimba uye kunonoka kufambira mberi kwechimiro, icho chinogona kubatsira kuvandudza chiitiko chemuviri chevanhu vane rheumatoid arthritis.

Leflunomide inouya sehwendefa kutora nemuromo. Inowanzotorwa kamwe chete pazuva. Chiremba wako anogona kukuudza iwe kuti utore muhombe muhombe we leflunomide kwemazuva matatu ekutanga ekurapwa. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora leflunomide chaizvo sekurairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.


Chiremba wako angangoda kudzikisa dosi yako kana kumisa kurapwa kana iwe ukawana mamwe akanyanya mhedzisiro. Ive neshuwa yekuudza chiremba wako kuti unonzwa sei panguva yekurapwa kwako.

Leflunomide inogona kubatsira kudzora zviratidzo zve rheumatoid arthritis asi isingarape. Ramba uchitora leflunomide kunyangwe iwe uchinzwa zvakanaka. Usarega kutora leflunomide usina kutaura nachiremba wako.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora leflunomide,

  • udza chiremba wako uye wemishonga kana uri weergisi kune leflunomide, teriflunomide (Aubagio), chero mimwe mishonga, kana chero chinhu chinowanikwa mumafiritsi eeflunomide Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
  • udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemiti yauri kutora kana kuronga kutora. Ive neshuwa yekutaura mishonga yakanyorwa muchikamu CHINOKOSHA CHENYENZO uye chero ipi yeanotevera: anticoagulants ('blood thinner') senge warfarin (Coumadin Jantoven); cholestyramine (Prevalite); makemikari egoridhe akadai seauranofin (Ridaura); mishonga yekurapa kenza; mimwe mishonga inodzvinyirira immune system yakadai saazathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), uye tacrolimus (Astagraf, Prograf); penicillamine (Cuprimine, Depen), uye tolbutamide. Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
  • udza chiremba wako kana wakambobatwa nezvirwere zvakakomba kana kuti uchiwanzobatwa nezvirwere, gomarara kana zvimwe zvinokanganisa mwongo wemapfupa kana immune system (kusanganisira hutachiona hwehutachiona hweHIV] uye yawana immunodeficiency syndrome [AIDS]), chirwere cheshuga, kana chirwere cheitsvo.
  • udza chiremba wako kana iwe uchiyamwisa. Usamwisa mwana paunenge uchitora leflunomide.
  • kana iwe urikuronga kubereka mwana, iwe unofanirwa kutaura nachiremba wako nezve kumisa leflunomide uye kugamuchira kurapwa kunobatsira kubvisa uyu mushonga kubva mumuviri wako nekukurumidza.
  • bvunza chiremba wako nezve kushandiswa kwakachengeteka kwezvinwiwa zvinodhaka paunenge uchitora leflunomide.
  • Kutora leflunomide kunogona kudzora kugona kwako kurwisa hutachiona. Udza chiremba wako kana iwe uine hutachiona izvozvi kana kana iwe uine chero zviratidzo zvehutachiona senge fivhiri, chikosoro, kana zviratidzo zvakaita sefuru. Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchirapwa ne leflunomide, fonera chiremba wako: fever; huro inorwadza; kukosora; flu-kunge zviratidzo; nzvimbo yeganda rinodziya, tsvuku, rakazvimba, kana rinorwadza; zvinorwadza, zvakaoma, kana kazhinji weti; kana zvimwe zviratidzo zvehutachiona. Kurapa kwako ne leflunomide kunogona kuda kukanganiswa kana uine chirwere.
  • Unogona kunge uine hutachiona (TB; chirwere chakakomba chemapapu) asi usina zviratidzo zvechirwere. Mune ino kesi, leflunomide inogona kuita kuti hutachiona hwako huwedzere uye ikukonzere iwe kukudziridza zviratidzo. Udza chiremba wako kana wakambove neTB kana kuti wakambove neTB, kana wakambogara kana kushanyira nyika ine TB yakajairika, kana kuti kana wakambove pedyo nemunhu ane kana akamborwara neTB. Usati watanga kurapwa kwako ne leflunomide, chiremba wako anoita bvunzo yeganda kuti aone kana une TB. Kana iwe uine TB, chiremba wako acharapa hutachiona nemishonga inorwisa mabhakitiriya usati watanga kutora leflunomide.
  • hauna majekiseni pasina kutaura nachiremba wako.
  • iwe unofanirwa kuziva kuti leflunomide inogona kukonzera kukwira kweropa. Iwe unofanirwa kuve nekuongororwa kweropa rako usati watanga kurapwa uye nguva zhinji paunenge uchitora mushonga uyu.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira. Zvisinei, kana yava nguva yenguva yako inotevera, svetuka chirwere chakarasika uye ramba uchiita purogiramu yako yenguva dzose. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.


Leflunomide inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

  • manyoka
  • kurutsa
  • chirungurira
  • musoro
  • dzungu
  • kuonda
  • kurwadziwa shure
  • kurwadziwa kwemhasuru kana kushaya simba
  • kurwadziwa, kupisa, chiveve, kana kugwinha mumaoko kana tsoka
  • kurasikirwa nevhudzi
  • makumbo makumbo
  • ganda rakaoma

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo zvinotevera kana izvo zvakanyorwa muchikamu CHINOKOSHA CHENYENZO kana CHAKANYANYA, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

  • mapundu ane kana asina fever
  • mikoko
  • blister kana kubvisa ganda
  • maronda emuromo
  • kuvava
  • kunetseka kufema
  • chitsva kana kuwedzera kukosora
  • kurwadziwa pachipfuva
  • ganda rakachenuruka

Kugamuchira mishonga inodzvinyirira immune system inogona kuwedzera njodzi yekuvandudza mamwe marudzi ekenza. Kuwedzera kwekenza hakuna kutaurwa muzvidzidzo zvekiriniki ne leflunomide kusvika zvino. Taura nachiremba wako nezve njodzi dzekugamuchira leflunomide.

Leflunomide inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi) uye mwenje.

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira zvinotevera:

  • manyoka
  • kurwadziwa nemudumbu
  • kuneta zvakanyanya
  • kushaya simba
  • ganda rakachenuruka
  • kukurumidza kurova kwemoyo
  • mweya wekufema

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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