Jekiseni jekiseni

Zvemukati

• Denosumab jekiseni (Prolia) inoshandiswa
• Denosumab jekiseni (Xgeva) inoshandiswa Denosumab jekiseni iri mukirasi yemishonga inonzi RANK ligand inhibitors. Inoshanda kudzivirira kurasikirwa kwefupa nekuvharira imwe receptor mumuviri kudzora kuputsika kwemapfupa. Inoshanda kurapa GCTB nekuvharira imwe receptor mumasero emota iyo inononoka kukura kwechirwere. Inoshanda kurapa yakakwira calcium mazinga nekuderedza kuputsika kwemapfupa sekuparara kwemapfupa kunoburitsa calcium.
• Usati wagamuchira jekiseni re denosumab,
• Jekiseni reDenosumab rinogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Denosumab jekiseni (Prolia) inoshandiswa

• kurapa osteoporosis (mamiriro ayo mapfupa anotetepa uye kupera simba nekutyoka zviri nyore) mumadzimai akaguma kuenda kumwedzi ('' shanduko yehupenyu; '' kupera kwekuenda kumwedzi) vane njodzi yakawandisa yekutyoka (mapfupa akavhunika) kana ndiani asingatore kana kupindura kumimwe mishonga yekurapa osteoporosis.
• kurapa varume vane njodzi yakawedzera yekutyoka (akavhunika mapfupa) kana vasingakwanise kutora kana kusapindura kumimwe mishonga yekurapa osteoporosis.
• kurapa osteoporosis iyo inokonzerwa nekorticosteroid mishonga mune varume nevakadzi vanozotora mishonga yecorticosteroid kweinenge mwedzi mitanhatu uye vane njodzi yakawedzera yekutyoka kana vasingakwanise kutora kana kusapindura kumimwe mishonga yekurapa yeosteoporosis.
• kurapa kurasikirwa kwemapfupa mune varume vari kurapwa kenza yeprostate nemimwe mishonga inokonzeresa kurasikirwa nefupa,
• kurapa kurasikirwa kwemabhonzo muvakadzi vane gomarara repazamu avo vari kugamuchira mimwe mishonga inowedzera njodzi yekutyoka.

Denosumab jekiseni (Xgeva) inoshandiswa Denosumab jekiseni iri mukirasi yemishonga inonzi RANK ligand inhibitors. Inoshanda kudzivirira kurasikirwa kwefupa nekuvharira imwe receptor mumuviri kudzora kuputsika kwemapfupa. Inoshanda kurapa GCTB nekuvharira imwe receptor mumasero emota iyo inononoka kukura kwechirwere. Inoshanda kurapa yakakwira calcium mazinga nekuderedza kuputsika kwemapfupa sekuparara kwemapfupa kunoburitsa calcium.

• kudzikisa njodzi yekutyoka muvanhu vane myeloma yakawanda (cancer inotangira mumasero eplasma uye inokonzeresa kukuvara kwemapfupa), uye mune vanhu vane mamwe marudzi ekenza yakatanga mune imwe nhengo yemuviri asi yakapararira kusvika kumapfupa.
• muvakuru uye vamwe vachiri kuyaruka kurapa hofori sero bundu repfupa (GCTB; rudzi rwechipfuva bundu) risingakwanise kurapwa nekuvhiya.
• kurapa yakakwira calcium mazinga ayo anokonzerwa nekenza mune vanhu vasina kupindura mimwe mishonga.

Jekiseni reDenosumab rinouya semhinduro (mvura) kujowa subcutaneously (pasi peganda) muruoko rwako rwekumusoro, chidya chepamusoro, kana mudumbu nzvimbo. Inowanzojowa nachiremba kana mukoti muhofisi yezvokurapa kana kukiriniki. Jekiseni reDenosumab (Prolia) rinowanzo kupihwa kamwe pamwedzi mitanhatu. Kana jekiseni yedenosumab (Xgeva) ichishandiswa kudzikisa njodzi yekutyoka kubva kune yakawanda myeloma, kana kenza yakapararira kusvika kumapfupa, inowanzo kupihwa kamwe chete pavhiki ina. Kana jekiseni redenosumab (Xgeva) richishandiswa kurapa hofori yesero bundu repfupa, kana yakakwira calcium mazinga anokonzerwa nekenza, inowanzo kupihwa mazuva ese manomwe kumatosi matatu ekutanga (pazuva 1, zuva 8, uye zuva regumi neshanu) uyezve kamwe chete pavhiki ina kutanga mavhiki maviri mushure mematanho matatu ekutanga.

Chiremba wako anokuudza iwe kuti utore zvinowedzera zvecalcium uye vhitamini D iwe uchirapwa nejekiseni yedenosumab. Tora izvi zvinowedzera sezvakarairwa.

Kana jekiseni redenosumab (Prolia) richishandiswa kurapa osteoporosis kana kurasikirwa nefupa, chiremba wako kana wemishonga achakupa iro gadziriro yeruzivo yemurwere (Mishonga Inotungamira) paunotanga kurapwa nejekiseni yedenosumab uye nguva imwe neimwe yaunozadza mushonga wako. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati wagamuchira jekiseni re denosumab,

• udza chiremba wako uye wemishonga kana uri weergoria kune denosumab (Prolia, Xgeva), chero mimwe mishonga, latex, kana chero chimwe chezvinhu zvinosanganiswa mujekiseni re denosumab. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
• iwe unofanirwa kuziva kuti jekiseni yedenosumab inowanikwa pasi pemazita ezita Prolia naXgeva Iwe haufanire kugamuchira zvinopfuura chimwe chigadzirwa chine denosumab panguva imwe chete. Ive neshuwa yekuudza chiremba wako kana iwe uchirapwa neimwe yeiyi mishonga.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemiti yauri kutora kana kuronga kutora.Ive neshuwa yekutaura chero eanotevera: angiogenesis inhibitors senge axitinib (Inlyta), bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), kana sunitinib (Sutent); bisphosphonates senge alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), zoledronic acid (Reclast); kenza chemotherapy mishonga; mishonga inodzvinyirira immune system seazathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), uye tacrolimus (Astagraf XL, Envarsus, Prograf) ; steroids senge dexamethasone, methylprednisolone (A-Methapred, Depo-Medrol, Medrol, Solu-Medrol), uye prednisone (Rayos); kana mishonga inoshandiswa kudzikisa yako calcium mazinga, senge cinacalcet (Sensipar). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• udza chiremba wako kana iwe wakambove kana wakambove uine yakaderera mwero wecalcium muropa rako. Chiremba wako angangotarisa huwandu hwecalcium muropa rako usati watanga kurapwa uye angango kukuudza kuti usatore jekiseni re denosumab kana iyo nhanho yakanyanya kuderera.
• udza chiremba wako kana iwe uri kugamuchira dialysis kurapwa kana kana iwe uine kana wakambove uine anemia (mamiriro umo masero matsvuku eropa asingaunze oxygen yakakwana kunhengo dzese dzemuviri); gomarara; chero mhando yehutachiona, kunyanya mumuromo mako; matambudziko nemuromo wako, mazino, matadza, kana meno ekugezesa; mazino kana kuvhiyiwa mukanwa (mazino abviswa, mazino anodyara); chero mamiriro anomisa ropa rako kubva pakuvhara kazhinji; chero mamiriro ezvinhu anoderedza mashandiro e immune system yako; kuvhiya pane yako yegland gland kana parathyroid gland (diki gland mumutsipa); kuvhiya kuti ubvise chikamu chemuviri wako mudiki; matambudziko nedumbu rako kana ura zvinoita kuti zviomere muviri wako kutora zvinovaka muviri; polymyalgia rheumatica (kusagadzikana kunokonzera kurwadziwa kwemhasuru uye kushaya simba); chirwere cheshuga, kana chirwere cheparathyroid kana cheitsvo.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Iwe unozofanirwa kuve neyakaipa nhumbu bvunzo usati watanga kurapwa neinosumab jekiseni. Iwe haufanire kuve nepamuviri iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchiri kugamuchira jekiseni re denosumab Iwe unofanirwa kushandisa nzira yakavimbika yekudzivirira kuberekwa kudzivirira nhumbu iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchirapa Kana iwe ukava nepamuviri uchigamuchira jekiseni re denosumab, kana mukati memwedzi mishanu yekurapa kwako, dana chiremba wako nekukasika Denosumab inogona kukuvadza fetus.
• iwe unofanirwa kuziva kuti jekiseni reDenosumab rinogona kukonzera osteonecrosis yeshaya (ONJ, yakakomba mamiriro ejaya pfupa), kunyanya kana iwe ukavhiyiwa mazino kana kurapwa paunenge uchigamuchira uyu mushonga. Chiremba wemazino anofanira kuongorora mazino ako uye aite chero marapirwo anodikanwa, kusanganisira kuchenesa kana kugadzirisa mazino asina kukodzera, usati watanga kugamuchira jekiseni redenosumab. Ive neshuwa yekugeza mazino nekuchenesa muromo wako zvakanaka paunenge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchitsvaga Taura nachiremba wako usati wawana chero kurapwa kwemazino iwe uchinge uchigamuchira mushonga uyu.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Kana iwe ukarasikirwa musangano wekutambira jekiseni redhinosabu, unofanirwa kufonera mupi wako wezvehutano nekukurumidza sezvazvinogona. Muyero wakarasika unofanirwa kupihwa nekukasira pazvinogona kuchinjwazve. Kana jekiseni reDenosumab (Prolia) richishandiswa osteoporosis kana kurasikirwa nefupa, mushure mekutambira iro rakarasika, jekiseni rako rinotevera rinofanira kurongwa mwedzi mitanhatu kubva pazuva rekubayiwa kwako kwekupedzisira.

Jekiseni reDenosumab rinogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• yakatsvuka, yakaoma, kana inocheka ganda
• kubuda kana kuputika kwemabhuru paganda
• kubvisa ganda
• kurwadziwa shure
• kurwadziwa mumaoko ako
• kuzvimba kwemaoko kana makumbo
• mhasuru kana kurwadziwa kwemajoini
• kusvotwa
• manyoka
• kuvimbiswa
• marwadzo emudumbu
• musoro

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kuomarara kwemhasuru, kumonyoroka, kupwanya, kana kupaza
• chiveve kana kugwinha nezvigunwe, zvigunwe, kana kutenderedza muromo wako
• mikoko, mapundu, kuruma, kunetseka kufema kana kumedza, kuzvimba kwechiso, maziso, huro, rurimi kana miromo,
• kupisa kana kutonhora
• kutsvuka, unyoro, kuzvimba kana kudziya kwenzvimbo yeganda
• fivha, kukosora, kufema kwekufema
• nzeve yemvura kana kurwadziwa kwakanyanya nzeve
• kazhinji kana kuda kukurumidza kuita weti, kupisa kunzwa kana iwe uchiita weti
• kurwadziwa kwakanyanya mudumbu
• marwadzo anorwadza kana kuzvimba, kusunungura mazino, chiveve kana kunzwa kunorema mushaya, kupora kwakashata kwesaya
• kubuda ropa zvisina kujairika kana kupwanya
• kusvotwa, kurutsa, kurwadziwa nemusoro, uye kudzika kwekusvinura mushure mekumisa denosumab uye kwegore rimwe chete mumashure

Jekiseni reDenosumab rinogona kuwedzera njodzi yekuti iwe uchatyora chidya chako bone (s) Unogona kunzwa kurwadziwa muhudyu mako, kugomera, kana zvidya kwemavhiki akati wandei kana mwedzi pfupa (kana) risati ratyoka, uye iwe unogona kuona kuti rimwe kana ese maviri mapfupa ako ezvidya akavhunika kunyangwe iwe usina kudonha kana kusangana nekumwe kushungurudzika. Hazvishamise kuti pfupa rehudyu riputse muvanhu vane hutano, asi vanhu vane osteoporosis vanogona kutyora pfupa iri kunyangwe vasingagamuchire jekiseni redenosumab. Jekiseni reDenosumab rinogona kukonzeresa mapfupa akavhuniwa kupora zvishoma nezvishoma uye zvinogona kukanganisa kukura kwemapfupa uye kudzivirira mazino kuti asapinde zvakanaka muvana. Taura nachiremba wako nezve njodzi dzekugamuchira jekiseni re denosumab.

Jekiseni reDenosumab rinogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika paunenge uchigamuchira mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Usazungunusa jekiseni re denosumab. Chengetedze mufiriji uye chengetedza kubva pachiedza. Usagwamba. Jekiseni reDenosumab rinogona kuchengetwa pane tembiricha yemukati kwemazuva gumi nemana.

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira mimwe bvunzo kuti uve nechokwadi chekuti yakachengeteka iwe kuti ugamuchire jekiseni re denosumab uye kutarisa mhinduro yemuviri wako kujekiseni re denosumab.

Usarega mumwe munhu achishandisa mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Prolia^®
• Xgeva^®