Ibrutinib

Zvemukati

• Ibrutinib inoshandiswa:
• Usati watora ibrutinib,
• Ibrutinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Ibrutinib inoshandiswa:

• kurapa vanhu vane mantle cell lymphoma (MCL; kenza inokura nekukurumidza iyo inotanga mumasero ezvirwere zvemuviri) avo vakatorapwa nechero imwe chemotherapy mishonga,
• kurapa vanhu vane chisingaperi lymphocytic leukemia (CLL; rudzi rwekenza inotanga mumasero machena eropa) uye diki lymphocytic lymphoma (SLL; rudzi rwekenza inotanga kunyanya mune node node),
• kurapa vanhu vane Waldenstrom's macroglobulinemia (WM; kenza inononoka kukura inotanga mune mamwe maseru machena eropa mumapfupa ako),
• kurapa vanhu vane marginal zone lymphoma (MZL; kenza inononoka kukura iyo inotanga mune imwe mhando yemasero machena eropa ayo anowanzo kurwisa hutachiona) avo vakatorapwa neimwe mhando yekemotherapy mishonga,
• uye kurapa vanhu vane chirwere chisingaperi chinomiririra chirwere (cGVHD; chinetso chehematopoietic stem-cell transplant [HSCT; maitiro anotsiva marora emapfupa ane mwongo wemapfupa ane hutano] anogona kutanga chinguva mushure mekuisirwa uye agare kwenguva yakareba ) mushure mekurapwa zvisina kubudirira ne1 kana yakawanda mishonga.

Ibrutinib iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito chepuroteni isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kumisa kupararira kwekenza masero.

Ibrutinib inouya se capsule uye piritsi yekutora nemuromo. Inowanzo kutorwa kamwe chete zuva nezuva. Tora ibrutinib panguva dzakatenderedza nguva imwechete mazuva ese. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora ibrutinib chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza iyo capsules yakazara negirazi remvura; usavhure, kana kuvhuna, kana kuzvitsenga. Medza iyo mahwendefa yakazara negirazi remvura; usacheke, usapwanya kana kutsenga.

Kana iwe uri kugamuchira obinutuzumab (Gazyva) jekiseni kana rituximab (Rituxan) jekiseni, chiremba wako anogona kukuudza iwe kuti utore yako dosi ye imbrutinib usati wagamuchira jekiseni rako.

Chiremba wako anogona kudzikisira muyero wako, kana kukanganisa kana kurega chirevo chako. Izvi zvinoenderana nekuti mushonga unoshanda sei kwauri uye nemhedzisiro iwe yaunosangana nayo. Taura nachiremba wako nezve manzwiro auri kuita panguva yekurapwa kwako. Ramba uchitora ibrutinib kunyangwe iwe uchinzwa zvakanaka. Usarega kutora ibrutinib usina kutaura nachiremba wako.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora ibrutinib,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune ibrutinib, chero mimwe mishonga, kana chero chipi chezvinhu zvinosanganiswa muibrutinib capsules kana mapiritsi. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemakwenzi yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: anticoagulants ('blood thinner') senge warfarin (Coumadin, Jantoven); antifungals senge fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), uye voriconazole (Vfend); antiplatelet mishonga yakadai seclopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), uye ticlopidine; aprepitant (Simbisa); carbamazepine (Carbatrol, Epitol, Tegretol, Teril); clarithromycin (Biaxin, Prevpac), digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nevamwe); erythromycin (EES, Erythrocin, vamwe), mimwe mishonga yekurapa hutachiona hwehutachiona hwehutachiona (HIV) kana kuwana immunodeficiency syndrome (AIDS) senge efavirenz (Sustiva, muAtripla), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, muKaletra), uye saquinavir (Invirase); methotrexate (Otrexup, Rasuvo, Trexall, Xatmep); nefazodone; phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rifamate, Rimactane, vamwe); verapamil (Calan, Covera, muTarka, vamwe); uye telithromycin (haichawanikwi muU.S.; Ketek). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's Wort.
• udza chiremba wako kana uine hutachiona kana kuti uchangobva kuvhiyiwa. Uyezve udza chiremba wako kana uchiputa kana uine kana wakambove nechirwere cheshuga, kurova kwemoyo zvisina kujairika, hypertension (yakakwira BP), cholesterol yakakwira, matambudziko ekubuda ropa, kana chirwere chemoyo, cheitsvo, kana chechiropa.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, uri kuyamwisa, kana kana iwe uchironga kubereka mwana. Iwe haufanire kuve nepamuviri iwe paunenge uchitora ibrutinib. Kana iwe uri munhukadzi, iwe uchafanirwa kutora nhumbu yekubata usati watanga kurapwa uye unofanirwa kushandisa kuberekwa kudzivirira kubata pamuviri panguva yekurapwa kwako nebrutinib uye kwemwedzi mumwe mushure mekumira kutora mushonga. Kana iwe uri murume, iwe nemukadzi wako mukadzi munofanira kushandisa kuberekwa panguva yekurapa kwako neibrutinib uye endererai kwemwedzi mumwe mushure mekupedzisira kwedosi. Kana iwe kana mumwe wako mukava nepamuviri muchitora ibrutinib, danai chiremba wako nekukurumidza. Ibrutinib inogona kukonzera kukuvara kwemucheche.
• kana uri kuvhiyiwa, kusanganisira kuvhiya mazino, udza chiremba kana chiremba wemazino kuti uri kutora ibrutinib. Chiremba wako anogona kukuudza kuti rega kutora ibrutinib mazuva matatu kusvika manomwe usati wavhiyiwa kana maitiro.

Usadye grapefruit kana orenji maSeville (dzimwe nguva anoshandiswa mumarmalade), kana kunwa muto wemazambiringa paunenge uchitora mushonga uyu.

Ita shuwa kuti unonwa mvura yakawanda kana zvimwe zvinwiwa zuva rega rega iwe paunenge uchitora ibrutinib.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira iro zuva. Nekudaro, kana iwe ukasarangarira kusvika zuva rinotevera, ruka iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Ibrutinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• manyoka
• kusvotwa
• kuvimbiswa
• kurutsa
• kurwadziwa nemudumbu
• chirungurira kana kuzvimbaradza
• kuderera kwechido
• kuneta zvakanyanya kana kushaya simba
• mhasuru, bhonzo, uye kurwadziwa kwemajoini
• mhasuru
• kuzvimba kwemaoko, tsoka, makumbo, kana makumbo ezasi
• mapundu
• kuvava
• maronda mumuromo nehuro
• kushushikana
• kunetseka kurara kana kuramba wakarara
• kukosora, kumhanya kana kuputira mhino
• kusaona zvakanaka
• maziso akaoma kana mvura
• ziso repingi

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kuzvimba kwechiso, huro, rurimi, miromo, uye maziso
• kunetseka kumedza kana kufema
• mikoko
• kupwanya kusingawanzo kana kubuda ropa
• pink, tsvuku, kana yakasviba weti
• Ropa kana dema, zvigaro zvekugara
• mhino kubuda ropa
• kurutsa kweropa; kana kurutsa ropa kana shava zvinhu zvakafanana nekofi nzvimbo
• pfari
• nekukurumidza kana zvisina kujairika kurova kwemoyo
• mweya wekufema
• chipfuva kusagadzikana
• dzungu, musoro wakareruka kana kunzwa kupera simba
• maonero anochinja
• kurwadziwa nemusoro (kunotora nguva yakareba)
• fivha, kutonhora, kukosora, kutsvuka, ganda rinodziya, kana zvimwe zviratidzo zvehutachiona
• kuvhiringidzika
• shanduko mukutaura kwako
• kuderera kwekuita weti
• zvinorwadza, kazhinji, kana kukurumidza kuita weti

Ibrutinib inogona kuwedzera njodzi yako yekuvandudza mamwe marudzi ekenza kusanganisira kenza yeganda kana dzimwe nhengo. Taura nachiremba wako nezve njodzi dzekutora ibrutinib.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nechiedza, kupisa kwakanyanya uye hunyoro kwete muchimbuzi.

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe uye kusvika kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakavharira makapu ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye kubva kwavari uye kusvika. http://www.upandaway.org

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako anogona kuraira kumwe kuongorora kwerabhoritari uye kuongorora yako BP kuti utarise mhinduro yemuviri wako kune ibrutinib.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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