Tisagenlecleucel jekiseni

Zvemukati

• Usati wagamuchira jekiseni tisavalecleucel,
• Tisagenlecleucel jekiseni inogona kukonzeresa mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana izvo zvakanyorwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Tisagenlecleucel jekiseni inogona kukonzeresa zvakakomba kana kutyisidzira hupenyu maitiro anonzi cytokine release syndrome (CRS). Chiremba kana mukoti anozokutarisa zvakanyatsonaka panguva yako yekumukiswa uye kweanenge mavhiki mana mushure. Udza chiremba wako kana iwe uine chirwere chekuvhiringidza kana iwe uine kana uchifunga kuti iwe unogona kunge uine chero hutachiona hutachiona izvozvi. Iwe unozopihwa mishonga maminetsi makumi matatu kusvika makumi matanhatu usati wamukirwa kuti ubatsire kudzivirira maitiro kune tisagenlecleucel. Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge wamukoserwa, udza chiremba wako nekukurumidza: fivha, kutonhora, kuzunza, kukosora, kurasikirwa nechido, manyoka, mhasuru kana kurwadziwa kwemajoini, kuneta, kunetseka kufema, kufema kwekufema, kuvhiringidzika, kusvotwa , kurutsa, dzungu, kana musoro wakareruka.

Tisagenlecleucel jekiseni inogona kukonzeresa kana kutyisidzira hupenyu hutachiona maitiro. Kana ukasangana nechimwe chezviratidzo zvinotevera, udza chiremba wako nekukurumidza: kutemwa nemusoro, kusagadzikana, kuvhiringidzika, kushushikana, kunetseka kurara kana kuramba wakarara, kuzunza kusingadzoreki kwechikamu chemuviri, kurasikirwa kwekuziva, kuvhiringidzika, kushungurudzika, kugwinha, kurwadziwa kana chiveve muruoko kana gumbo, kurasikirwa nechiyero, kunetseka kunzwisisa, kana kunetseka kutaura.

Tisagenlecleucel jekiseni inongowanikwa chete kuburikidza neyakaganhurirwa kugovera chirongwa. Chirongwa chinonzi Kymriah REMS (Risk Evaluation uye Mitigation Strategic) chakagadzwa nekuda kwenjodzi dzeCRS uye neurological chepfu. Unogona chete kugamuchira mishonga kubva kuna chiremba uye nzvimbo yehutano inotora chikamu muchirongwa.Kumbira chiremba wako kana iwe uine chero mibvunzo nezvechirongwa ichi.

Chiremba wako kana wemishonga anokupa iro gadziriro yeruzivo yemurwere (Gwaro RezveMishonga) paunotanga kurapwa na tisagenlecleucel. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Tisagenlecleucel jekiseni rinoshandiswa kurapa mamwe acute lymphoblastic leukemia (ZVESE; inonziwo acute lymphoblastic leukemia uye acute lymphatic leukemia kumwe kurapwa (s). Iyo inoshandiswawo kurapa imwe mhando yeasina-Hodgkin's lymphoma (mhando yegomarara inotanga mune imwe mhando yemasero machena eropa ayo anowanzo kurwisa hutachiona) kune vanhu vakuru vakadzoka kana vasingateereri mushure mekurapwa neimwe mishonga miviri. Tisagenlecleucel jekiseni iri mukirasi yemishonga inonzi autologous cellular immunotherapy, mhando yemishonga yakagadzirirwa kushandisa maseru kubva muropa rega murwere. Inoshanda nekukonzeresa immune system (boka remasero, zvinyama, uye nhengo zvinodzivirira muviri kubva pakurwiswa nemabhakitiriya, mavairasi, cancer maseru, nezvimwe zvinhu zvinokonzeresa chirwere) kurwisa maseru egomarara.

Tisagenlecleucel jekiseni rinouya sekumisa (mvura) kuiswa jekiseni (kupinda mutsinga) nachiremba kana mukoti muhofisi yechiremba kana nzvimbo yekumukisa. Iyo inowanzo kupihwa pamusoro penguva inosvika pamaminetsi makumi matanhatu sedosi yenguva imwe. Usati wagamuchira yako tisagenlecleucel dose, chiremba wako kana mukoti achapa mimwe mishonga yemakemikari kugadzirira muviri wako tisagenlecleucel.

Anenge mavhiki matatu kusvika mana usati waiswa muyero wehusikugenlecleucel jekiseni, muyero wemasero machena eropa uchatorwa kunzvimbo yekuunganidza masero uchishandisa nzira inonzi leukapheresis (maitiro anobvisa masero machena eropa kubva mumuviri). Maitiro aya anotora maawa matatu kusvika matanhatu uye angangoda kudzokororwa. Nekuti mushonga uyu unogadzirwa kubva kumaseru ako wega, unofanirwa kupihwa iwe chete. Izvo zvakakosha kuti uve nenguva uye kuti usarasikirwe yako yakarongedzwa maseru ekuunganidzwa kusarudzwa (s) kana kugamuchira yako yekurapa dosi. Iwe unofanirwa kuronga kugara mukati memaawa maviri enzvimbo kwawakagamuchira yako tisagenlecleucel kurapwa kweinenge mavhiki mana mushure medosi yako. Anopa hutano hwako anotarisa kuti aone kana kurapwa kwako kuri kushanda uye nekukutarisa iwe kune chero zvingangoitika mhedzisiro. Taura nachiremba wako nezvekuti ungagadzirira sei leukapheresis uye zvaunotarisira panguva uye mushure mekuita.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati wagamuchira jekiseni tisavalecleucel,

• udza chiremba wako uye wemishonga kana uri weergoria kune tisagenlecleucel, chero mimwe mishonga, dimethyl sulfoxide (DMSO), dextran 40, kana chero zvimwe zvinoshandiswa mujekiseni tisagenlecleucel. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemakwenzi yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: steroid senge dexamethasone, methylprednisolone (Medrol), prednisolone, uye prednisone (Rayos). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• udza chiremba wako kana iwe wakambove nekuita kubva kumakemikari epamberi ekurapa senge matambudziko ekufema kana kusagadzikana kwemoyo. Uyezve, udza chiremba wako kana iwe wakambove nemapapu, itsvo, moyo, kana chirwere cheropa.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Iwe unozofanirwa kuve nemuedzo wepamuviri usati watanga tisagenlecleucel kurapwa. Kana iwe ukava nepamuviri iwe uchinge wagamuchira tisagenlecleucel jekiseni, fonera chiremba wako nekukasira. Tisagenlecleucel jekiseni inogona kukuvadza fetus.
• iwe unofanirwa kuziva kuti tisagenlecleucel jekiseni inogona kukutsira uye kukonzeresa kuvhiringidzika, kushaya simba, dzungu, uye pfari. Usatyaire mota kana kushandisa michina kweinokwana masvondo masere mushure mekunge yako tisagenlecleucel dose.
• usape ropa, nhengo, zvinyama, kana masero ekuisazve kana wagamuchira tisagenlecleucel jekiseni.
• bvunza nachiremba wako kuti uone kana iwe uchida kugamuchira chero majekiseni. Usave nemajekiseni pasina kutaura nachiremba wako kweanenge mavhiki maviri usati watanga chemotherapy, panguva yako yekurapa tisagenlecleucel, uye kudzamara chiremba wako akuudza kuti immune system yako yapora.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Ukatadza nguva yekutora masero ako, unofanirwa kufonera chiremba wako nenzvimbo yekuunganidza ipapo ipapo. Ukasuwa musangano wekutambira yako tisagenlecleucel dose, unofanira kufonera chiremba wako ipapo ipapo.

Tisagenlecleucel jekiseni inogona kukonzeresa mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• kuvimbiswa
• kurwadziwa nemudumbu
• kurwadziwa shure

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana izvo zvakanyorwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kubuda ropa zvisina kujairika kana kupwanya
• ropa mune weti
• yakaderera weti kuwanda kana huwandu
• kuzvimba kwemaziso, kumeso, miromo, rurimi, huro, maoko, maoko, tsoka, makumbo, kana makumbo ezasi
• kunetseka kumedza
• mapundu
• mikoko
• kuvava

Tisagenlecleucel jekiseni inogona kuwedzera njodzi yako yekuvandudza mamwe cancer. Taura nachiremba wako nezve njodzi dzekugamuchira uyu mushonga.

Tisagenlecleucel jekiseni inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika paunenge uchigamuchira mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza zvese zvakagadzwa nachiremba wako, nzvimbo yekuunganidzira masero, uye rabhoritari. Chiremba wako anogona kuraira kumwe kuongororwa kwelebhu kare, panguva, uye mushure mekurapwa kwako kuti utarise mhinduro yemuviri wako kune tisagenlecleucel jekiseni.

Usati waita chero bvunzo yerabhoritari, udza chiremba wako nevashandi ve murabhoritari kuti urikugamuchira jekiseni tisagenlecleucel. Mushonga uyu unogona kukanganisa mhedzisiro yemamwe miedzo yemarabhoritari.

Bvunza wako wemishonga chero mibvunzo iwe unayo nezve tisagenlecleucel jekiseni.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Kymriah^®