Ponesimod

Zvemukati

• Ponesimod inoshandiswa kudzivirira zvikamu zvezviratidzo uye kunonoka kuwedzera kwekuremara kune vanhu vakuru vakadzokororazve mafomu eakawanda sclerosis (MS; chirwere umo tsinga dzisingashande nemazvo uye vanhu vanogona kuona kushaya simba, kupera simba, kurasikirwa kwekubatana kwemhasuru, uye matambudziko nekuona, kutaura, uye kudzora dundira), kusanganisira: Ponesimod iri mukirasi yemishonga inonzi sphingosine l-phosphate receptor modulators. Inoshanda nekudzora kuita kwema immune maseru anogona kukonzera kukuvara kwetsinga.
• Usati watora ponesimod,
• Ponesimod inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:
• Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

Ponesimod inoshandiswa kudzivirira zvikamu zvezviratidzo uye kunonoka kuwedzera kwekuremara kune vanhu vakuru vakadzokororazve mafomu eakawanda sclerosis (MS; chirwere umo tsinga dzisingashande nemazvo uye vanhu vanogona kuona kushaya simba, kupera simba, kurasikirwa kwekubatana kwemhasuru, uye matambudziko nekuona, kutaura, uye kudzora dundira), kusanganisira: Ponesimod iri mukirasi yemishonga inonzi sphingosine l-phosphate receptor modulators. Inoshanda nekudzora kuita kwema immune maseru anogona kukonzera kukuvara kwetsinga.

• kiriniki yakasarudzika syndrome (CIS; yekutanga nerve chiratidzo chiratidzo chinotora maawa angangoita makumi maviri nemana),
• kudzokerazve-kurerutsa chirwere (kosi yechirwere uko zviratidzo zvinoputika nguva nenguva),
• inoshanda yechipiri inofambira mberi chirwere (yekupedzisira nhanho yechirwere nekuenderera mberi kuwedzera zviratidzo.)

Ponesimod inouya sehwendefa kutora nemuromo. Inowanzo kutorwa kamwe chete pazuva kana pasina chikafu. Tora ponesimod kwakatenderedza nguva yakafanana zuva rega rega. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora ponesimod chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza mapiritsi akazara; usatsemure, kutsenga, kana kuvapwanya.

Chiremba wako angangotanga iwe padosi yakaderera yeponesimod uye zvishoma nezvishoma uwedzere dhosi rako kwemazuva gumi nemashanu ekutanga.

Ponesimod inogona kukonzera kurova kwemoyo kunonoka, kunyanya mukati maawa mana ekutanga mushure mekutora yako yekutanga dosi. Iwe unotora chako chekutanga chipimo cheponesimod muhofisi yechiremba wako kana imwe nzvimbo yekurapa. Iwe unozogashira iyo electrocardiogram (ECG; bvunzo iyo inorekodha mashandiro emagetsi emoyo) usati watora yako yekutanga dosi uye zvakare maawa mana mushure mekutora iwo muyero. Iwe unozofanirwa kugara kunzvimbo yekurapa kweinenge maawa mana mushure mekunwa mushonga kuti ugone kuongororwa. Iwe ungangoda kugara kunzvimbo yekurapa kwenguva yakareba kupfuura maawa mana kana husiku husiku kana uine mamwe mamiriro kana kutora mimwe mishonga inowedzera njodzi yekuti kurova kwemoyo wako kunonoka kana kana kurova kwemoyo wako kuchinonoka kupfuura zvaitarisirwa kana kuramba uchinonoka mushure mekutanga 4 maawa. Iwe unogona zvakare kuda kugara kunzvimbo yekurapa kweinenge maawa mana mushure mekutora yako yechipiri dosi kana kurova kwemoyo wako kuchinonoka zvakanyanya kana iwe uchitora yako yekutanga dosi. Udza chiremba wako kana iwe uchinzwa dzungu, kuneta, kurwadziwa pachipfuva, kana kunonoka kana kusagadzikana kwemoyo chero nguva panguva yekurapwa kwako.

Ponesimod inogona kubatsira kudzora multiple sclerosis asi haizopore. Usarega kutora ponesimod usina kutaura nachiremba wako.

Chiremba wako kana wemishonga anokupa iro gadziriro yeruzivo yemurwere (Medication Guide) paunotanga kurapwa neponesimod uye pese paunozadza mushonga wako. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora ponesimod,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune ponesimod, chero mimwe mishonga, kana chero chipi zvacho chemapiritsi eponesimod. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemiti yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero yeanotevera: alemtuzumab (Campath, Lemtrada); amiodarone (Nexterone, Pacerone); beta-blockers senge atenolol (Tenormin, muTenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, muDutoprol, muLopressor HCT), nadolol (Corgard, muCorzide), nebivolol (Bystolic, muByvalson ), propranolol (Inderal LA, Innopran XL), sotalol (Betapace, Sorine, Sotylize) uye timolol; carbamazepine (Carbatrol, Equetro, Tegretol, vamwe); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nevamwe); modafinil (Provigil); phenytoin (Dilantin); procainamide; quinidine (muNuedexta); rifampin (Rifadin, Rimactane, muRifamate, vamwe); uye verapamil (Calan, Verelan, muTarka). Uyezve udza chiremba wako kana uri kutora chero ipi yemishonga inotevera, kana kana iwe wakambotora kare: corticosteroids yakadai se dexamethasone, methylprednisolone (Medrol), uye prednisone (Rayos); mishonga yekenza; uye mishonga yekushayisa simba kana kudzora immune system se glatiramer acetate (Copaxone, Glatopa) uye interferon beta (Betaseron, Extavia, Plegridy). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kubatana neponesimod, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isingaonekwe pane ino runyorwa.
• udza chiremba wako kana iwe wakambove kana nechero cheaya mamiriro mumwedzi mitanhatu yapfuura: chirwere chemwoyo, angina (kurwadziwa pachipfuva), sitiroko kana mini-stroke, kana kukundikana kwemoyo. Uyezve udza chiremba wako kana iwe uine irregular moyo mutinhimira kana mamwe marudzi emoyo block, kunze kwekunge iwe uine pacemaker. Chiremba wako anogona kukuudza kuti usatora ponesimod.
• udza chiremba wako kana uine fivhiri kana hutachiona kana kana uine hutachiona hunouya nekuenda kana husingaendi. Zvakare, udza chiremba wako kana iwe kana wakambove nekurwadziwa kwemoyo, kurohwa, mini-sitiroko, chirwere cheshuga, kurara kufema (mamiriro maunomira muchidimbu kufema kakawanda mukati mehusiku) kana zvimwe zvinetso zvekufema, BP, uveitis (kuzvimba kweziso) kana mamwe matambudziko eziso, gomarara reganda, kana chirwere chemoyo kana chechiropa. Uyezve udza chiremba wako kana uine refu QT syndrome (mamiriro anowedzera mukana wekukura kweasina kujairika kurova kwemoyo, uko kunogona kukonzera kupera simba kana kufa kamwe kamwe), irregular heart rhythm, kana kana uchangobva kugamuchira mushonga.
• udza chiremba wako kana iwe uri nepamuviri kana kuronga kuva nepamuviri, kana uri kuyamwisa.Iwe unofanirwa kushandisa kuberekwa kudzivirira kubata pamuviri panguva yekurapa kwako uye kweinenge 1 vhiki mushure meyako yekupedzisira dosi. Kana iwe ukava nepamuviri uchitora ponesimod kana mukati mevhiki rimwe mushure mekupedzisira kwako, dana chiremba wako. Ponesimod inogona kukuvadza fetus.
• hauna majekiseni emwedzi mumwe usati watanga kurapwa kwako ne ponesimod, panguva yekurapwa kwako, uye kwe1 kusvika 2 mavhiki mushure mekuita kwako kwekupedzisira usingataure nachiremba wako. Taura nachiremba wako nezve majekiseni aungangoda kugamuchira usati watanga kurapwa kwako ne ponesimod.
• udza chiremba wako kana usati wambobata chepfu uye usati wawana mushonga wekurapa. Chiremba wako anogona kuraira kuongororwa kweropa kuti aone kana iwe wakambosangana nehuku hwehuku. Iwe ungangoda kugamuchira mushonga wekurwara wehuku wozomirira vhiki ina usati watanga kurapwa kwako ne ponesimod.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Ukasuwa 1 kusvika kumazuva matatu eponesimod panguva yekutora nguva (14-day starter pack), tora piritsi rakarasika nekukurumidza kana uchinge uchirangarira uye kuenderera mberi nekurapwa kwako nekutora piritsi rimwe chete pazuva mu starter pack sezvakarongwa. Ukatadza kutora mazuva mana kana anopfuura mumutsara weponesimod panguva yekutora nguva (14-day starter pack), fonera chiremba wako sezvo iwe uchizoda kutangazve kurapwa neyekutsva-14-zuva Starter pack. Kana iwe uine mamwe mamiriro emoyo, ungangoda kuongororwa nachiremba wako kweanenge maawa mana paunotora dosi rako rinotevera.

Ukasuwa 1 kusvika kumazuva matatu eponesimod mushure menguva yekutora (dosi yekuchengetedza) tora piritsi rakarasika nekukurumidza paunenge uchirangarira uye kuenderera mberi nekurapwa kwako. Ukatadza kutora mazuva mana kana anopfuura mumutsara weponesimod mushure menguva yekutora (dosi yekuchengetedza), fonera chiremba wako sezvo iwe uchizoda kutangazve kurapwa neyekutsva-14-zuva Starter pack. Kana iwe uine mamwe mamiriro emoyo, ungangoda kuongororwa nachiremba wako kweanenge maawa mana paunotora dosi rako rinotevera.

Ponesimod inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• dzungu
• kukosora
• kurwadziwa nemaoko kana tsoka

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kunonoka kurova kwemoyo
• kurwadziwa pahuro, kupfupika kwekufema, kurwadziwa nemuviri, kupisa muviri, kupisa nekuita weti, kutonhora, kukosora, uye zvimwe zviratidzo zvehutachiona panguva yekurapwa uye kweanosvika mavhiki maviri kana maviri mushure mekurapwa kwako.
• kushaya simba kune rumwe rutivi rwemuviri kana kusindimara kwemaoko kana makumbo izvo zvinowedzera kuwedzera nekufamba kwenguva; shanduko mukufunga kwako, ndangariro, kana kuenzanisa; kuvhiringidzika kana kuchinja hunhu; kana kupera simba
• kusvibiswa, mimvuri, kana bofu nzvimbo pakati pechiratidzo chako; kunzwisisika kuchiedza; isina kujairika ruvara kune chiono chako kana mamwe matambudziko ekuona
• kusvotwa, kurutsa, kurasikirwa nehavi, kurwadziwa mudumbu, kuita yero kweganda kana maziso, kana weti yakasviba
• nyowani kana kuwedzera kupfupika kwekufema

Ponesimod inogona kuwedzera njodzi yekuva nekenza yeganda. Udza chiremba wako kana iwe uine chero shanduko kune iripo mole; nzvimbo nyowani yakasviba paganda; maronda asingapore; kukura paganda rako senge bundu rinogona kupenya, rakacheneruka chena, rine ruvara rweganda, kana pingi, kana chero shanduko paganda rako. Chiremba wako anofanira kutarisa ganda rako chero shanduko panguva yekurapwa ne ponesimod. Deredza nguva yaunoshandisa muchiedza chezuva uye ultraviolet (UV) mwenje. Pfeka mbatya dzekudzivirira uye ushandise sunscreen ine yakakwirira zuva kudzivirira chinhu. Taura nachiremba wako nezve njodzi dzekutora mushonga uyu.

Ponesimod inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi). Kana mushonga wako ukauya ne desiccant packet (kadiki kapaketi kaine chinhu chinotora mwando kuti mishonga iome), siya pakiti iri muhombodo asi chenjera kuti usamedze.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

• kunonoka kana kusagadzikana kwemoyo

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira kumwe kuongorora kwelebhu uye bvunzo dzemaziso, uye anozotarisa kuwedzerwa kweropa rako usati uye panguva yekurapwa kwako kuve nechokwadi kuti zvakachengeteka kuti utange kutora kana kuramba uchitora ponesimod.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Ponvory^®