Munyori: Robert Simon
Zuva Rekusika: 24 Chikumi 2021
Gadziridza Zuva: 24 Kurume 2025
Anonim
Cinqair (reslizumab)- Asthma- by Saro Arakelians, PharmD- Episode # 123
Vhidhiyo: Cinqair (reslizumab)- Asthma- by Saro Arakelians, PharmD- Episode # 123

Zvemukati

Chii chinonzi Cinqair?

Cinqair izita rezita remishonga yekurapa. Iyo inoshandiswa kurapa zvakakomba eosinophilic asthma muvakuru. Nemhando iyi yeasthma yakaoma, une mazinga akakwirira emaosinophil (rudzi rwechena sero reropa). Iwe unotora Cinqair mukuwedzera kune yako mamwe maasifma zvinodhaka. Cinqair haina kushandiswa kurapa asthma flare-ups.

Cinqair ine reslizumab, inova mhando yemushonga unonzi biologic. Biologics inogadzirwa kubva kumasero uye kwete kubva kumakemikari.

Cinqair chikamu chekirasi yemishonga inonzi interleukin-5 antagonist monoclonal antibodies (IgG4 kappa). Kirasi yezvinodhaka iboka remishonga inoshanda nenzira yakafanana.

Anopa hutano anokupa iwe Cinqair seinopinda (IV) kumisikidzwa muhofisi yechiremba wako kana kukiriniki. Uyu jekiseni mutsinga yako inodonha zvishoma nezvishoma mukati menguva. Cinqair infusions inowanzo kutora maminetsi makumi maviri kusvika makumi mashanu.

Kubudirira

Cinqair yakawanikwa ichishanda pakurapa kwakanyanya eosinophilic asthma.


Muzvidzidzo zviviri zvemakiriniki, 62% uye 75% yevanhu vakagamuchira Cinqair yechirwere chakakomba eosinophilic asthma havana asthma flare-up. Asi chete 46% uye 55% yevanhu vakatora placebo (hapana kurapwa) havana asthma flare-up. Vanhu vese vakarapwa neCinqair kana placebo kwemasvondo makumi mashanu nemaviri. Zvakare, vazhinji vevanhu vaitora inhaled corticosteroids uye beta-agonists panguva yekudzidza.

Cinqair generic kana biosimilar

Cinqair inowanikwa chete sezita rezita remishonga. Iine chinodhaka chinoshanda reslizumab.

Cinqair haisi parizvino mune fomu biosimilar.

Biosimilar imishonga yakafanana neiyo zita-zita zvinodhaka. Mushonga wegeneral, kune rimwe divi, ikopi chaiyo yechiratidzo-zita remushonga. Biosimilars akavakirwa pane biologic mishonga, iyo inogadzirwa kubva kune zvikamu zvehupenyu zvipenyu. Mageneral akavakirwa pamishonga yenguva dzose inogadzirwa kubva kumakemikari.

Biosimilars uye generic zvese zviri zviviri zvakachengeteka uye zvinobudirira sezita rezita-zita ravanogadzirwa kutevedzera. Zvakare, ivo vanowanzo kudhura zvakaderera pane zita-zita mishonga.


Cinqair mutengo

Sezvo nemishonga yese, mutengo weCinqair unogona kusiyana. Mubatsiri wezvehutano anokupa iwe mushonga sekupinza (IV) kumisikidzwa kuhofisi yechiremba wako kana kukiriniki. Mari yaunobhadhara yako infusion inoenderana nehurongwa hweinishuwarenzi uye kwaunowana kurapwa kwako. Cinqair haiwanikwi kuti iwe utenge pane chemishonga yemuno.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara Cinqair, kana kana iwe uchida rubatsiro kuti unzwisise yako inishuwarenzi kufukidzwa, rubatsiro rwuripo.

Teva Respiratory, LLC, iyo inogadzira Cinqair, inopa Teva Support Solutions. Kuti uwane rumwe ruzivo uye kuti uzive kana iwe uchikodzera rutsigiro, fonera 844-838-2211 kana shanyira iyo webhusaiti chirongwa.

Cinqair mhedzisiro

Cinqair inogona kukonzera zvinyoro kana zvakakomba mhedzisiro. Aya anotevera mazita ane mamwe akakosha mhedzisiro mhedzisiro anogona kuitika panguva yekugamuchira Cinqair. Aya mazita haabatanidzi zvese zvinokanganisa mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvingangoitika mhedzisiro yeCinqair, taura nachiremba wako kana wemishonga. Ivo vanogona kukupa iwe matipi ekuti ungatarise sei nechero mhedzisiro mhedzisiro inogona kunetsa.


Zvimwe zvakajairika mhedzisiro

Rutivi rwakanyanya kuitika rweCinqair marwadzo oropharyngeal. Uku kurwadziwa muchikamu chehuro chako chiri kuseri kwemuromo wako. Mune zvidzidzo zvemakiriniki, 2.6% yevanhu vakatora Cinqair vaive nemarwadzo oropharyngeal. Izvi zvakafananidzwa ne2.2% yevanhu vakatora placebo (pasina kurapwa).

Kurwadziwa kweOropharyngeal kunogona kuenda mukati memazuva mashoma kana mavhiki mashoma. Kana kurwadziwa kwakanyanya kana kusingaendi, taura nachiremba wako kana wemishonga. Vanogona kupa mazano ekukubatsira kuti unzwe zvirinani.

Yakakomba mhedzisiro

Yakakomba mhedzisiro kubva kuCinqair haina kujairika, asi inogona kuitika. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

  • Anaphylaxis * (rudzi rweakanyanya kukanganiswa nemagetsi). Zviratidzo zvinogona kusanganisira:
    • kunetseka kufema, kusanganisira kukosora uye kufema
    • dambudziko kumedza
    • kuzvimba kumeso kwako, muromo, kana huro
    • inononoka kurova
    • anaphylactic kuvhunduka (kamwe kamwe kudonha kweropa uye kunetseka kufema)
    • mapundu
    • ganda rinonhuwa
    • kutaura kwakashata
    • dumbu (dumbu) kurwadziwa
    • kusvotwa
    • kuvhiringidzika
    • kushushikana
  • Gomarara. Zviratidzo zvinogona kusanganisira:
    • shanduko mumuviri wako (rakasiyana ruvara, kugadzirwa, kuzvimba, kana mapundu muzamu rako, dundira, ura, kana ganda)
    • kutemwa nemusoro
    • pfari
    • kuona kana kunetseka kwekunzwa
    • dhonza kune rumwe rutivi rwechiso chako
    • kubuda ropa kana kupwanya
    • kukosora
    • kuchinja mukudya
    • kuneta (kushaya simba)
    • kupindwa nechando
    • kuzvimba kana mapundu
    • kurema kana kuonda

Rutivi mhedzisiro mhedzisiro

Unogona kushamisika kuti kangani mamwe maratidziro anoitika nemushonga uyu. Heano mamwe marondedzero pane mashoma emhedzisiro mhedzisiro iyi inogona kukonzerwa nemushonga.

Allergic reaction

Sezvazvakaita nemishonga yakawanda, vamwe vanhu vanogona kusangana neanogamuchira mushure mekugamuchira Cinqair. Zviratidzo zvehunhu husina kugadzikana hunogona kusanganisira:

  • kuputika kweganda
  • kuvava
  • kuburitsa (kudziya uye kutsvuka mukati meganda rako)

Hazvizivikanwe kuti vanhu vangani vakagadzira zvinyoro nyoro mushure mekugamuchira Cinqair.

Imwe yakanyanya kukonzeresa kusagadzikana isingawanzo asi inogoneka. Inonzi anaphylaxis (ona pazasi).

Anaphylaxis

Ndichiri kugamuchira Cinqair, vamwe vanhu vanogona kukudziridza zvisingawanzoitika allergic reaction inonzi anaphylaxis. Kuita uku kwakanyanya uye kunogona kutyisidzira hupenyu. Mune zvidzidzo zvemakiriniki, 0.3% yevanhu vakagamuchira Cinqair vakagadzira anaphylaxis.

Ma immune system ako anobatsira kudzivirira muviri wako pazvinhu zvinogona kukonzera chirwere. Asi dzimwe nguva muviri wako unovhiringidzika uye uchirwa nezvinhu zvisingakonzere chirwere. Kune vamwe vanhu, immune system yavo inorwisa zvigadzirwa muCinqair. Izvi zvinogona kutungamira kune anaphylaxis.

Zviratidzo zveanaphylaxis zvinogona kusanganisira:

  • kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka
  • kuzvimba kwerurimi rwako, muromo, kana huro
  • kunetseka kufema

Anaphylaxis inogona kuitika chaipo mushure meyadhi yako yechipiri yeCinqair, saka zvakakosha kuti maitiro acho agadziriswe kamwechete.

Ichi chikonzero nei mupi wako wezvehutano achikutarisa kwemaawa akati wandei mushure mekunge wagamuchira Cinqair. Kana iwe ukaita zviratidzo zveanaphylaxis, wako mupi wezvehutano anozokubata ipapo ipapo. Vachaitawo kuti chiremba wako azive.

Kana chiremba wako achida kuti umire kushandisa Cinqair, vanogona kukurudzira mumwe mushonga wakasiyana.

Anaphylactic maitiro anogona dzimwe nguva kukonzera biphasic anaphylaxis. Uku kurwisa kwechipiri kweanaphylaxis. Biphasic anaphylaxis inogona kuitika maawa kusvika mazuva akati wandei mushure mekutanga kurwisa. Kana iwe uine anaphylactic reaction, wako wekuchengeta hutano mupi angangoda kukutarisisa iwe kumberi. Vachada kuve nechokwadi kuti iwe hauna kukura biphasic anaphylaxis.

Zviratidzo zvebiphasic anaphylaxis zvinogona kusanganisira:

  • ganda rinotsva, tsvuku, kana rine mikoko (itchy welts)
  • kumeso kwakazvimba uye rurimi
  • kunetseka kufema
  • dumbu (dumbu) kurwadziwa
  • kurutsa
  • manyoka
  • yakaderera BP
  • kurasikirwa kwekuziva (kufenda)
  • anaphylactic kuvhunduka (kamwe kamwe kudonha kweropa uye kunetseka kufema)

Kana usiri panzvimbo yekuchengetedza hutano uye iwe uchifunga kuti une anaphylactic kana biphasic reaction kuCinqair, fonera 911 ipapo ipapo. Mushure mokunge maitiro acho arapwa, rega chiremba wako azive. Vanogona kukurudzira mumwe mushonga weasthma.

Gomarara

Mimwe mishonga inogona kukonzera kuti maseru ako arambe achikura muhukuru kana nhamba uye ozoita gomarara. Dzimwe nguva aya maseru ane gomarara anoenda kumatishu munzvimbo dzakasiyana dzemuviri wako. Aya mazamu ematissue anonzi mamota.

Mune zvidzidzo zvemakiriniki, 0.6% yevanhu vakagamuchira Cinqair vakagadzira mamota akaumbwa munzvimbo dzakasiyana dzemuviri. Vazhinji vevanhu vakaonekwa kuti vane mamota mukati memwedzi mitanhatu yedosi yavo yekutanga yeCinqair. Izvi zvakafananidzwa ne0,3% yevanhu vakatora placebo (pasina kurapwa).

Kana iwe ukacherekedza chero zviratidzo zvemamota izvo zvisingaendi, udza chiremba wako. (Ona iyo "Yakakomba mhedzisiro mhedzisiro" chikamu pamusoro pane runyorwa rwezviratidzo.) Iwe ungangoda bvunzo kubatsira chiremba wako kuti azive zvakawanda nezve mamota. Chiremba wako anogonawo kukurudzira mumwe mushonga weasthma.

Cinqair muyero

Iyo Cinqair muyero unorayirwa nachiremba wako zvinoenderana nehuremu hwako.

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, wako mupi wezvehutano anogona kukupa iwe wakasiyana kana ukarairwa nachiremba wako kuti adaro. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda.

Mafomu emishonga uye simba

Cinqair inouya mune 10-mL vial. Imwe vial ine 100 mg ye reslizumab. Mubatsiri wako wezvehutano anokupa mhinduro iyi seyomukati (IV) infusion. Uyu jekiseni mutsinga yako inodonha zvishoma nezvishoma mukati menguva. Cinqair infusions inowanzo kutora maminetsi makumi maviri kusvika makumi mashanu.

Chipimo chemushonga asima

Cinqair inowanzo gadzirirwa mumadhosi e3 mg / kg, kamwe chete pavhiki ina.

Huwandu hweCinqair hwaunogashira hunoenderana nekuti unorema zvakadii. Semuenzaniso, 150-lb. murume anorema anenge 68 kg. Kana chiremba wake akaraira 3 mg / kg yeCinqair kamwe chete pavhiki ina, muyero weCinqair unenge uri 204 mg pakuzadzwa (68 x 3 = 204).

Ko kana ndikapotsa dosi?

Ukatadza kusangana nenguva yekugamuchira Cinqair, fonera mupi wezvehutano nekukurumidza. Ivo vanogona kuronga musangano mutsva uye kugadzirisa nguva yekumwe kushanya kana zvichidikanwa.

Iyo pfungwa yakangwara kunyora yako chirongwa chekurapa pakarenda. Iwe unogona zvakare kuseta chiyeuchidzo pafoni yako kuitira kuti usapotsa musangano.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Cinqair inofanirwa kushandiswa seyakareba kurapwa kweakanyanya eosinophilic asthma. Kana iwe nachiremba wako mukaona kuti Cinqair yakachengeteka uye inoshanda kwauri, ungangoishandisa kwenguva yakareba.

Cinqair yeasthma

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai seCinqair kurapa mamwe mamiriro. Cinqair inobvumidzwa kurapwa zvakanyanya eosinophilic asthma muvakuru. Mushonga haubvumirwe kurapa mamwe marudzi easthma. Zvakare, Cinqair haina kubvumidzwa kurapa asthma flare-ups.

Iwe unotora Cinqair mukuwedzera kune yako yazvino kurapwa asthma.

Mune kiriniki yekudzidza, Cinqair yakapihwa vanhu mazana maviri nemakumi mashanu nevashanu vane chirwere chakakomba eosinophilic asthma kwemavhiki makumi mashanu nemaviri. Muboka iri, 62% yevanhu vanga vasina asthma flare-up panguva iyoyo. Izvi zvakafananidzwa ne46% yevanhu vakagamuchira placebo (pasina kurapwa). Kune avo vane asthma flare-up:

  • Vanhu vakagamuchira Cinqair vaive ne50% yakaderera mwero wekuparara mugore rimwe chete kupfuura vanhu vakagamuchira placebo.
  • Vanhu vakagamuchira Cinqair vaive ne55% chiyero chepasi chemafere-ups chaida kushandiswa kwecorticosteroids kupfuura vanhu vakagamuchira placebo.
  • Vanhu vakagamuchira Cinqair vaive ne34% yakaderera mwero wemafereji-izvo zvakatungamira kuchipatara kugara kupfuura vanhu vakagamuchira placebo.

Mune kumwe kuongorora kwekiriniki, Cinqair yakapihwa vanhu mazana maviri nemakumi maviri nevaviri vane chirwere chakakomba cheasthophilia kwemasvondo makumi mashanu nemaviri. Muboka iri, 75% yevanhu vanga vasina asthma flare-up panguva iyoyo. Izvi zvakafananidzwa ne55% yevanhu vakagamuchira placebo (pasina kurapwa). Kune avo vane asthma flare-up:

  • Vanhu vakagashira Cinqair vaive ne 59% yakaderera mwero wekuputika kupfuura vanhu vakagamuchira placebo.
  • Vanhu vakagashira Cinqair vaive ne 61% yakaderera mwero wemapere-ups yaida corticosteroids kupfuura vanhu vakagamuchira placebo.
  • Vanhu vakagamuchira Cinqair vaive ne31% yakaderera mwero wemafereji-izvo zvakatungamira kuchipatara kugara kupfuura vanhu vakagamuchira placebo.

Cinqair shandisa nemimwe mishonga

Iwe unoitirwa kushandisa Cinqair pamwe neyako yazvino mishonga yeasima. Mienzaniso yemishonga inogona kushandiswa neCinqair kurapa zvakakomba eosinophilic asthma inosanganisira:

  • Inhaled uye yemumuromo corticosteroids. Iyo inonyanyo shandiswa yeakanyanya asthma inosanganisira:
    • beclomethasone dipropionate (Qvar Redihaler)
    • budesonide (Pulmicort Flexhaler)
    • ciclesonide (Alvesco)
    • fluticasone propionate (ArmonAir RespiClick, Arnuity Ellipta, Flovent Diskus, Flovent HFA)
    • mometasone furoate (Asmanex HFA, Asmanex Twisthaler)
    • prednisone (Rayos)
  • Beta-adrenergic bronchodilators. Iyo inonyanyo shandiswa yeakanyanya asthma inosanganisira:
    • salmeterol (Serevent)
    • formoterol (Foradil)
    • albuterol (ProAir HFA, ProAir RespiClick, Proventil HFA, Ventolin HFA)
    • levalbuterol (Xopenex, Xopenex HFA)
  • Leukotriene nzira nzira modifiers. Iyo inonyanyo shandiswa yeakanyanya asthma inosanganisira:
    • montelukast (Singulair)
    • zafirlukast (Yakaringana)
    • zileuton (Zyflo)
  • Muscarinic blockers, rudzi rweanticholinergic. Iyo inonyanyo shandiswa yeakanyanya asthma inosanganisira:
    • tiotropium bromide (Spiriva Respimat)
    • ipratropium
  • Kwayedza

Mazhinji emishonga iyi anouyawo semusanganiswa zvigadzirwa. Semuenzaniso, Symbicort (budesonide uye formoterol) uye Advair Diskus (fluticasone uye salmeterol).

Imwe mhando yemishonga yauchazoda kuramba uchishandisa neCinqair inunura inhaler. Kunyangwe Cinqair ichishanda kubatsira kudzivirira asthma flare-ups, iwe unogona kunge uchirwara neasthma. Kana izvi zvikaitika, iwe unozofanirwa kushandisa kununura inhaler kudzora asthma yako ipapo. Saka ive shuwa yekutakura yako yekununura inhaler newe nguva dzese.

Kana iwe uri kushandisa Cinqair, usamire kutora imwe yako mishonga yeasthma kutoti chiremba wako akakuudza. Uye kana iwe uine mibvunzo nezve huwandu hwemishonga yaunotora, bvunza chiremba wako.

Dzimwe nzira dzeCinqair

Mimwe mishonga inowanikwa inogona kurapa zvakanyanya eosinophilic asthma. Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira yeCinqair, taura nachiremba wako. Vanogona kukuudza nezvemimwe mishonga inogona kukushandira zvakanaka.

Mienzaniso yemimwe mishonga inogona kushandiswa kurapa zvakanyanya eosinophilic asthma inosanganisira:

  • mepolizumab (Nucala)
  • benralizumab (Fasenra)
  • omalizumab (Xolair)
  • dupilumab (Dupixent)

Cinqair vs. Nucala

Unogona kushamisika kuti Cinqair inofananidzwa sei nemimwe mishonga yakatemerwa kushandiswa kwakafanana. Pano tinotarisa kuti Cinqair naNucala zvakafanana uye zvakasiyana.

Zvishandiso

Chikafu neDrug Administration (FDA) yakabvumidza vese Cinqair naNucala kurapa chirwere cheasthophma chakasimba muvanhu vakuru. Nucala inobvumidzwawo kuti irape yakaoma eosinophilic asthma muvana vane makore gumi nemasere kusvika gumi nemasere. Mishonga yese iyi inoshandiswa pamwe chete nemimwe mishonga yeasima yauri kutora.

Mukuwedzera, Nucala anotenderwa kurapa chirwere chisingawanzo chinonzi eosinophilic granulomatosis ine polyangiitis (EGPA). Chirwere ichi chinozivikanwawo seChurg-Strauss syndrome, uye chinoita kuti tsinga dzako dzeropa dziite kuzvimba (kuzvimba).

Ivo vaviri Cinqair naNucala ndevekirasi yemishonga inonzi interleukin-5 antagonist monoclonal antibodies. Kirasi yezvinodhaka iboka remishonga inoshanda nenzira yakafanana.

Mafomu emishonga uye manejimendi

Cinqair ine chinodhaka chinoshanda reslizumab. Nucala ine mushonga unoshanda mepolizumab.

Cinqair inouya mumidziyo. Mubatsiri wako wezvehutano anokupa mhinduro sejekiseni mutsinga dzako (intravenous infusion). Cinqair infusions inowanzo kutora maminetsi makumi maviri kusvika makumi mashanu.

Nucala anouya nenzira nhatu dzakasiyana:

  • Rimwe-girazi ndiro yehupfu. Anopa hutano hwako achasanganisa hupfu nemvura isina kuchena. Ipapo ivo vachakupa mhinduro sejekiseni pasi peganda rako (subcutaneous jekiseni).
  • Iyo imwe-dosi yakasarudzika autoinjector peni. Anopa hutano hwako anotanga kukudzidzisa mashandisiro echinyoreso. Ipapo unogona kuzvipa majekiseni pasi peganda rako.
  • Iyo imwe-dosi yakasarudzwa sirinji. Anopa hutano hwako anotanga kukudzidzisa mashandisiro esiringi. Ipapo unogona kuzvipa majekiseni pasi peganda rako.

Cinqair inowanzo gadzirirwa mumadhosi e3 mg / kg, kamwe chete pavhiki ina. Huwandu hwemushonga iwe hwaunogamuchira zvinoenderana nekuti unorema zvakadii.

Nhamba yakakurudzirwa yeNucala yeasthma ndeye 100 mg, kamwe chete pavhiki ina.

Side migumisiro uye njodzi

Cinqair naNucala vese ndevekirasi imwechete yemishonga, saka vanoshanda zvakafanana. Iyo mishonga miviri inogona kukonzera akasiyana zvakanyanya kana akafanana mitezo. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemamwe maitiro anowanzoitika anogona kuitika neCinqair kana neNucala.

  • Zvinogona kuitika neCinqair:
    • marwadzo oropharyngeal (kurwadziwa muchikamu chehuro yako chiri kuseri kwemuromo wako)
  • Inogona kuitika neNucala:
    • musoro
    • kurwadziwa shure
    • kuneta (kushaya simba)
    • kugadzirisa kweganda panzvimbo yejekiseni, kusanganisira kurwadziwa, kutsvuka, kuzvimba, kuvaviwa, kunzwa kunopisa

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yemigumisiro yakakomba inogona kuitika neCinqair, neNucala, kana nemishonga yose (kana ichipiwa mumwe nomumwe).

  • Zvinogona kuitika neCinqair:
    • mamota
  • Inogona kuitika neNucala:
    • herpes zoster chirwere (shingles)
  • Zvinogona kuitika nezvose Cinqair naNucala:
    • kukanganisa kukuru, kusanganisira anaphylaxis *

Kubudirira

Cinqair naNucala vese anoshandiswa kurapa zvakanyanya eosinophilic asthma.

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki, asi ongororo yezvidzidzo yakawana vese Cinqair naNucala kuti vabudirire mukuderedza huwandu hweasthma flare-ups.

Mariro

Cinqair naNucala vese mazita emagetsi. Ikozvino hapana mafiosimilar mafomu eimwe mishonga.

Biosimilar imishonga yakafanana neiyo zita-zita zvinodhaka. Mushonga wegeneral, kune rimwe divi, ikopi chaiyo yechiratidzo-zita remushonga. Biosimilars akavakirwa pane biologic mishonga, iyo inogadzirwa kubva kune zvikamu zvehupenyu zvipenyu. Mageneral akavakirwa pamishonga yenguva dzose inogadzirwa kubva kumakemikari. Biosimilars uye generic zvese zviri zviviri zvakachengeteka uye zvinobudirira sezita rezita-zita zvinodhaka zvavari kuyedza kutevedzera. Zvakare, ivo vanowanzo kudhura zvakaderera pane zita-zita mishonga.

Maererano nekufungidzira paWellRx.com, Cinqair kazhinji inodhura zvishoma pane yeNucala. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa nenzvimbo yako.

Cinqair vs. Fasenra

Pamusoro peNucala (pamusoro), Fasenra mumwe mushonga unoshandisa zvakafanana neyaCinqair. Pano tinotarisa kuti Cinqair naFasenra vakafanana uye vakasiyana sei.

Zvishandiso

Chikafu neDrug Administration (FDA) yakabvumidza vese Cinqair naFasenra kurapa chakakomba eosinophilic asthma muvakuru. Fasenra inobvumidzwawo kuti irape yakaoma eosinophilic asthma muvana vane makore gumi nemasere kusvika gumi nemasere. Ose madhiragi aya anoshandiswa pamwe chete nemamwe mishonga yeasima yauri kutora.

Ivo vaviri Cinqair naFasenra ndevekirasi yemishonga inonzi interleukin-5 antagonist monoclonal antibodies. Kirasi yezvinodhaka iboka remishonga inoshanda nenzira yakafanana.

Mafomu emishonga uye manejimendi

Cinqair ine chinodhaka chinoshanda reslizumab. Fasenra ine chinoshanda chinodhaka benralizumab.

Cinqair inouya muhari. Mubatsiri wako wezvehutano anokupa mhinduro sejekiseni mutsinga dzako (intravenous infusion). Cinqair infusions inowanzo kutora maminetsi makumi maviri kusvika makumi mashanu.

Fasenra inouya mune sirinji yakasarudzika. Mubatsiri wezvehutano anokupa iwe mushonga sejekiseni pasi peganda rako (jekiseni rinotsvedza).

Cinqair inowanzo gadzirirwa mumadhosi e3 mg / kg, kamwe chete pavhiki ina. Huwandu hwemushonga iwe hwaunogamuchira zvinoenderana nekuti unorema zvakadii.

Kune ako matatu ekutanga madosi eFasenra, iwe unogashira 30 mg kamwe kamwe pavhiki ina. Mushure meizvozvo, unozogamuchira 30 mg yeFasenra kamwe chete pavhiki sere.

Side migumisiro uye njodzi

Cinqair naFasenra vese ndevekirasi imwechete yemishonga, saka vanoshanda zvakafanana. Iyo mishonga miviri inogona kukonzera akasiyana zvakanyanya kana akafanana mitezo. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yezvakawanda zvakajairika mhedzisiro inogona kuitika neCinqair kana neFasenra.

  • Zvinogona kuitika neCinqair:
    • marwadzo oropharyngeal (kurwadziwa muchikamu chehuro yako chiri kuseri kwemuromo wako)
  • Zvinogona kuitika neFasenra:
    • musoro
    • huro inorwadza

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika neCinqair, neFasenra, kana nezvose zviri zviviri zvinodhaka (kana zvapihwa zvakasiyana).

  • Zvinogona kuitika neCinqair:
    • mamota
  • Zvinogona kuitika neFasenra:
    • mashoma mashoma akasarudzika mhedzisiro
  • Zvinogona kuitika nezvose Cinqair naFasenra:
    • kukanganisa kukuru, kusanganisira anaphylaxis *

Kubudirira

Cinqair naFasenra ese ari maviri anoshandiswa kurapa zvakakomba eosinophilic asthma.

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki. Asi ongororo yezvidzidzo yakawana Cinqair kuti inyatsoita basa rekudzivirira asthma flare-ups kupfuura Fasenra.

Mariro

Cinqair naFasenra ese ari maviri zita-zita zvinodhaka. Ikozvino hapana mafiosimilar mafomu eimwe mishonga.

Biosimilar imishonga yakafanana neiyo zita-zita zvinodhaka. Mushonga wegeneral, kune rimwe divi, ikopi chaiyo yechiratidzo-zita remushonga. Biosimilars akavakirwa pane biologic mishonga, iyo inogadzirwa kubva kune zvikamu zvehupenyu zvipenyu. Mageneral akavakirwa pamishonga yenguva dzose inogadzirwa kubva kumakemikari. Biosimilars uye generic zvese zviri zviviri zvakachengeteka uye zvinobudirira sezita rezita-zita zvinodhaka zvavari kuyedza kutevedzera. Zvakare, ivo vanowanzo kudhura zvakaderera pane zita-zita mishonga.

Zvinoenderana nekufungidzira pa WellRx.com, Cinqair kazhinji inodhura zvakaderera pane Fasenra. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa nenzvimbo yako.

Cinqair uye doro

Iko hakuna kumwe kuwirirana kunozivikanwa pakati peCinqair nedoro panguva ino. Asi vamwe vanhu vane asthma vanogona kukurumidza kubuda pavanonwa doro kana mushure mekunge vambonwa doro. Waini, cider, uye doro zvinowanzo kukonzera izvi zvinokonzeresa kupfuura zvimwe zvinwiwa zvinodhaka.

Kana iwe uine asthma flare-up uchinwa doro, rega kunwa iyo doro ipapo. Rega chiremba wako azive nezve kubhururuka-panguva yaunoshanya.

Uyezve, taura nachiremba wako nezvekuti yakawanda sei uye rudzii rwedoro raunonwa. Vanogona kukuudza kuti yakadii yakachengeteka kuti iwe unwe panguva yekurapa kwako.

Cinqair kudyidzana

Iko hakuna kusangana kunozivikanwa pakati peCinqair nemimwe mishonga, mahebhu, zvinowedzera, kana zvekudya. Asi zvimwe zveizvi zvinogona kuwedzera mukana wako wekuve neasthma flare-up. Semuenzaniso, zvimwe zvekudya kana zvekurwisa zvinodhaka zvinogona kukonzera asthma flare-ups.

Kana iwe uine chero chikafu kana chirwere chemushonga, udza chiremba wako. Uyezve taura chero mishonga, mahebhu, kana zvinowedzerwa zvaunotora. Chiremba wako anogona kukurudzira kugadzirisa kuchikafu chako, mushonga, kana mararamiro kana zvichidikanwa.

Iyo Cinqair inopihwa sei

Anopa hutano anokupa iwe Cinqair seinopinda (IV) kumisikidzwa muhofisi yechiremba wako kana kukiriniki. Uyu jekiseni mutsinga yako inodonha zvishoma nezvishoma mukati menguva.

Kutanga, mupi wako wezvehutano anoisa tsono mune imwe yetsinga dzako. Ipapo vanobva vabatanidza bhegi rine Cinqair netsono. Iyo mishonga inoyerera ichibva muhomwe ichienda kumuviri wako. Izvi zvinotora maminetsi makumi maviri kusvika makumi mashanu.

Mushure mekunge mawana dosi yenyu, mupi wezvehutano anogona kukutarisai kuti aone kana muchigadzira anaphylaxis. (Kune zvingangodaro zviratidzo, ona iyo "Cinqair mhedzisiro" chikamu pamusoro). Anaphylaxis inogona kuitika mushure mekuita chero chinhanho cheCinqair. Saka mupi wako wezvehutano anogona kukutarisa kunyangwe iwe wakagamuchira Cinqair kare.

Nguva yekuwana Cinqair

Cinqair inowanzo kupihwa kamwe chete pavhiki ina. Iwe nachiremba wako munogona kukurukura nguva yakanakisa yezuva yekuti iwe uwane infusion yako.

Iyo pfungwa yakangwara kunyora yako chirongwa chekurapa pakarenda. Iwe unogona zvakare kuseta chiyeuchidzo pafoni yako kuitira kuti usapotsa musangano.

Mashandiro anoita Cinqair

Chirwere chimiro apo iyo yemhepo inotungamira kumapapu ako inopiswa (kuzvimba). Tsandanyama dzakatenderedza nzira dzekufema dzinosvinwa, izvo zvinodzivirira mweya kuti usapfuure nepakati. Nekuda kweizvozvo, oxygen haigoni kusvika muropa rako.

Nechirwere chakakomba, asthma, zviratidzo zvinogona kunge zvakanyanya kupfuura neasthma yenguva dzose Uye dzimwe nguva mishonga inobatsira kurapa asima haishande kune asthma yakaoma. Saka kana uine asthma yakaoma, ungangoda imwe mishonga.

Imwe mhando yeasthma yakaoma yakanyanya eosinophilic asthma. Nemhando iyi yeasthma, une mazinga epamusoro emaosinophil muropa rako. Eosinophils ndiwo chaiwo mhando yemuchena weropa. (Masero machena eropa masero kubva ku immune system yako, ayo anobatsira kukudzivirira kubva kuchirwere.) Kuwedzera huwandu hweeosinophil hunounza kuzvimba mumhepo dzako nemapapu. Izvi zvinokonzera zviratidzo zvechirwere.

Chii chinoitwa naCinqair?

Huwandu hweeosinophils muropa rako zvinoenderana nezvinhu zvakawanda. Chinhu chakakosha kwazvo chine chekuita neprotein inonzi interleukin-5 (IL-5). IL-5 inobvumira eosinophils kukura uye kufamba kuropa rako.

Cinqair inosungira IL-5. Nekubatanidza kwariri, Cinqair inomisa IL-5 kubva mukushanda. Cinqair inobatsira kudzivirira IL-5 kubva mukurega maeosinophil akure uye achienda kuropa rako. Kana maeosinophil asingakwanise kusvika paropa rako, haakwanise kusvika pamapapu ako. Saka eosinophils haakwanise kukonzera kuzvimba mumhepo yako nemapapu.

Zvinotora nguva yakareba sei kuti zvishande?

Mushure meyero yako yekutanga yeCinqair, zvinogona kutora kusvika kumavhiki mana kuti zviratidzo zvako zveasima zvipere.

Cinqair inosvika paropa rako panguva iyo iwe yaunopihwa iwe. Mushonga unofamba neropa rako kusvika kumasero ako ipapo. Cinqair painosvika pamasero ako, inosungira kuI-5 uye inoimisa kuti isashanda ipapo ipapo.

Asi kana IL-5 ikangomira kushanda, panenge paine huwandu hwakawanda hweeosinophil muropa rako. Cinqair inobatsira kudzivirira iyi huwandu kubva pakuwedzera. Mushonga uyu unobatsirawo kudzikisa huwandu hweeosinophils, asi izvi hazviitike ipapo.

Zvinogona kutora kusvika kumavhiki mana kudzikisa huwandu hweeosinophil muropa rako. Saka zviratidzo zvako zveasima zvinogona kutora kusvika kumavhiki mana kuti zvinyangarike mushure meyako yekutanga yeCinqair. Kana zviratidzo zvako zvangoenda, pamwe havangadzoke chero bedzi iwe uchiramba uchigamuchira Cinqair.

Cinqair uye nhumbu

Hazvina kukwana zvidzidzo zvemakiriniki zvakaitwa muvanhu kuratidza kuti Cinqair yakachengeteka here kushandisa panguva yekuzvitakura. Asi zvinozivikanwa kuti Cinqair inofamba nepasikati uye inosvika kumwana. Iyo placenta inhengo inokura muchibereko chako iwe uri nepamuviri.

Zvidzidzo mumhuka zvinoratidza kuti hapana zvinokuvadza zvichaitika kumwana. Asi zvidzidzo zvemhuka hazviwanzo kuratidza zvinoitika muvanhu.

Kana iwe uri kutora Cinqair uye ukava nepamuviri kana uchida kuve nepamuviri, taura nachiremba wako. Vanogona kukubatsira iwe kusarudza kana Cinqair kana mumwe mushonga weasima wakanakira iwe.

Cinqair uye kuyamwisa

Iko hakuna kiriniki zvidzidzo muvanhu zvinoratidza kana zvakachengeteka kuyamwisa uchitora Cinqair. Asi zvidzidzo zvevanhu zvinoratidza kuti mapuroteni akafanana neaya ari muCinqair aripo mumukaka wemunhu wemukaka. Zvakare, muzvidzidzo zvemhuka, Cinqair yakawanikwa mumukaka wemukaka wamai. Saka zvinotarisirwa kuti Cinqair inogona kuwanikwa mumukaka wemukaka wemunhu, futi. Hazvizivikanwe kuti izvi zvingakanganisa sei mwana.

Kana iwe uchida kuyamwisa uchigamuchira Cinqair, udza chiremba wako. Vanogona kukurukura zvayakanakira nezvayakaipira newe.

Mibvunzo yakajairika nezveCinqair

Heano mhinduro kumimwe inowanzo bvunzwa mibvunzo nezve Cinqair.

Cinqair mushonga webiologic here?

Ehe. Cinqair imhando yemushonga unonzi biologic, iyo inogadzirwa kubva kuzvinhu zvipenyu. Nguva dzose mishonga, kune rumwe rutivi, inogadzirwa kubva kumakemikari.

Cinqair zvakare monoclonal antibody. Urwu ndirwo rudzi rwebiologic iyo inopindirana neyako immune system. (Ma immune immune ako ndiwo anobatsira kudzivirira muviri wako kubva kuchirwere.) MaMonoclonal antibodies akaita seCinqair anonamira kumapuroteni mune immune system yako. Cinqair painobatirira kune aya mapuroteni, anovamisa kubva mukukonzera kuzvimba (kuzvimba) uye zvimwe zviratidzo zveasima.

Sei Cinqair isingauye seinhaler kana piritsi?

Muviri wako haugone kugadzirisa Cinqair inhaler kana fomu yepiritsi, saka mushonga wacho waisazokwanisa kubatsira kurapa asima.

Cinqair rudzi rweiyo biologic chinodhaka inozivikanwa seye monoclonal antibody. (Kuti uwane zvakawanda nezve biologics, ona "Is Cinqair is biologic drug?" Pamusoro.) Monoclonal antibodies mapuroteni mahombe. Kana iwe ukatora mishonga iyi semapiritsi, aizoenda akananga kudumbu rako uye ura. Ikoko, acids uye mamwe mapuroteni madiki aigona kupwanya monoclonal antibodies. Nemhaka yekuti masoja ekudzivirira chirwere anonzi monoclonal akaputswa kuita zvidimbu zvidiki, haachakwanise kurapa asima. Saka mune fomu yepiritsi, mhando iyi yemushonga yaisashanda zvakanaka.

Iwe haugone kufemera zvakanyanya monoclonal antibodies futi. Kana iwe ukadaro, mapuroteni mumapapu ako aigona kuputsa mushonga unofemerwa ipapo ipapo. Chishoma kwazvo chemushonga chingaite kuropa rako uye maseru. Izvi zvinoderedza mashandiro anoita mushonga mumuviri wako.

Nzira yakanakisa yekuti utore monoclonal antibodies, kusanganisira Cinqair, iri kuburikidza neiyo intravenous (IV) infusion. (Uyu jekiseni mutsinga yako inodonha zvishoma nezvishoma mukati menguva.) Mune chimiro ichi, mushonga unopinda wakananga muropa rako. Hapana acids kana mapuroteni anotyora mushonga pasi kweanenge mavhiki mashoma. Saka mushonga unogona kufamba kuburikidza neropa rako uye uchishanda muzvikamu zvemuviri wako unozvida.

Sei ndisingakwanise kuwana Cinqair kubva kupharmacy?

Nzira chete yekuwana Cinqair iri kuburikidza nachiremba wako. Anopa hutano anokupa iwe Cinqair seinopinda (IV) kumisikidzwa muhofisi yechiremba wako kana kukiriniki. Uyu jekiseni mutsinga yako inodonha zvishoma nezvishoma mukati menguva. Saka haugone kutenga Cinqair mupharmacy wozvitora wega.

Vana vanogona kushandisa Cinqair?

Kwete. Kudya neDrug Administration (FDA) yakangobvumidza Cinqair kurapa vanhu vakuru. Zvidzidzo zvekiriniki zvakaongorora kushandiswa kweCinqair muvana vane makore gumi nemasere kusvika gumi nemasere. Asi mhedzisiro haina kuratidza kana mushonga uyu wakashanda nemazvo uye wakachengeteka zvakakwana kushandisa muvana.

Kana mwana wako ane chirwere chakakomba eosinophilic asthma, taura nachiremba wavo. Ivo vanogona kukurudzira mishonga isiri iyo Cinqair iyo inogona kubatsira kubata mwana wako.

Ndicharamba ndichida kutora corticosteroid neCinqair?

Zvingangodaro. Iwe hauna kuitirwa kutora Cinqair pachayo. Iwe unofanirwa kushandisa mushonga pamwe neyako yazvino mishonga yeasthma, iyo inogona kusanganisira corticosteroid.

Cinqair inongobatsira kurerutsa chakakomba eosinophilic asthma. Iyi ndiyo mhando yeasthma iyo inokonzerwa neakakwira mwero emaosinophil (rudzi rwechena reropa reropa) muropa rako.

SaCinqair, corticosteroids inoshanda nekuderedza kuzvimba (kuzvimba) mumapapu ako. Zvisinei, corticosteroids inoderedza kuzvimba nenzira dzakasiyana zvishoma. Vanhu vazhinji vane asthma yakaoma vanoda Cinqair uye corticosteroid kubatsira kudzora asthma yavo. Naizvozvo, chiremba wako anogona kukunyorera mishonga iyi miviri. Usarega kutora corticosteroid kunze kwekunge chiremba wako akakuudza kuti uite.

Ndicharamba ndichida here kununura inhaler neni?

Ehe.Iwe unenge uchiri kuda kutakura yekununura inhaler kana iwe ukatambira Cinqair.

Kunyangwe hazvo Cinqair ichibatsira kubata zvakanyanya eosinophilic asthma kwenguva yakareba, unogona kunge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchanyanya kunyenga Uye Cinqair haishande nekukurumidza zvakakwana kurapa kamwe kamwe zviratidzo zveasima.

Kana iwe usinga gadzirise zviratidzo zveasthma flare-up ipapo, zvinogona kuwedzera. Saka nzira yakanakisa yekutora mubato pavari ndeyekushandisa kununura inhaler. Ichi chishandiso chinobatsira kurerutsa zviratidzo zvako zveasima.

Ramba uchifunga kuti iwe uchazoda kutora imwe yako mishonga yeasthma, kusanganisira Cinqair.

Cinqair matanho

Mushonga uyu unouya neyambiro zhinji.

FDA yambiro: Anaphylaxis

Mushonga uyu une yambiro yebhokisi. Iyi ndiyo yambiro yakanyanya kubva kuFood and Drug Administration (FDA). Yambiro yebhokisi inozivisa vanachiremba nevanhu nezvezvinodhaka zvinogona kuva nenjodzi.

Kurwara kwakanyanya kunodaidzwa kunzi anaphylaxis kunogona kuitika mushure mekugamuchira Cinqair. Mushonga unopihwa nemupi wezvehutano, saka vanozoongorora maitiro anoita muviri wako kuCinqair. Vanogona zvakare kubata anaphylaxis nekukurumidza kana iwe uchikudziridza.

Dzimwe yambiro

Usati watora Cinqair, taura nachiremba wako nezve nhoroondo yako yehutano. Cinqair inogona kunge isina kukuitira iwe kana uine mamwe marapirwo. Izvi zvinosanganisira:

Utachiona hweHelminth

Cinqair inogona kunge isina kukukodzera iwe kana uine hutachiona hwe helminth (hutachiona hwehutachiona hunokonzerwa nehonye). Chiremba wako anozoda kurapa hutachiona usati watanga kushandisa Cinqair.

Kana iwe ukawana hutachiona hwe helminth iwe uchishandisa Cinqair, chiremba wako anogona kumbomira kurapwa kwako. Vanogona zvakare kupa mishonga yekujekesa hutachiona. Kana hutachiona hwangoenda, chiremba wako anogona kuti utange kugamuchira Cinqair zvakare.

Chengetedza mupfungwa zviratidzo zvehutachiona hwe helminth kuitira kuti uzive zvekutarisa. Zviratidzo zvinogona kusanganisira manyoka, kurwadziwa mudumbu mako, kushaya zvinovaka muviri, uye kushaya simba.

Kubata

Hazvina kukwana zvidzidzo zvemakiriniki zvakaitwa muvanhu kuratidza kuti Cinqair yakachengeteka here kushandisa panguva yekuzvitakura. Kuti udzidze zvakawanda, ona "Cinqair uye nhumbu" chikamu chiri pamusoro.

Ongorora: Kuti uwane rumwe ruzivo nezve zvingangoitika zvakaipa zveCinqair, ona iyo "Cinqair mhedzisiro" chikamu pamusoro.

Ruzivo rwehunyanzvi rweCinqair

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Zviratidzo

Cinqair inoratidzirwa pakurapa kweasthma yakaoma. Mvumo yemushonga yakagadziriswa kumashandisirwo ayo seyekuwedzera-pane ekurapa kwekurapa kweasthma yakaoma. Cinqair haifanire kutsiva yazvino nzira yekurapa inotsanangurwa kuvarwere, kusanganisira kushandiswa kwecorticosteroids.

Cinqair mvumo ndeyekurapa vanhu vane eosinophilic phenotype. Mushonga haufanire kupihwa kune vanhu vane akasiyana phenotypes. Zvakare hazvifanirwe kupihwa kurapwa kweimwe hosha dzakabatana ne eosinophilic.

Zvakare, Cinqair haina kuratidzwa kurapa zvakanyanya bronchospasms kana chimiro asthmaticus. Kushandiswa kwemushonga kubvisa zviratidzo hakuna kuongororwa panguva yekiriniki yekudzidza.

Iko kushandiswa kweCinqair kunofanirwa kuchengeterwa vanhu vakura kupfuura makore gumi nemasere. Iyo haina Kudya neDrug Administration (FDA) mvumo kune vanhu vadiki pane iyo zera.

Nzira yekuita

Iyo chaiyo michina yekuita kweCinqair haisati yanyatso kujekeswa parizvino. Asi inofungidzirwa kuti inoshanda kuburikidza neiyo interleukin-5 (IL-5) nzira.

Cinqair inorwisa munhu IgG4-kappa monoclonal antibody inosunga kune IL-5. Iyo yekusunga ine dissociation inogara iine 81 picomolar (pM). Nekusunga kune IL-5, Cinqair inopesana neI-5 uye inodzivirira chiitiko chayo chaicho. Izvi zvinoitika nekuti Cinqair inodzivirira IL-5 kubva mukusunga kune iyo IL-5 receptor iripo mune yesero pamusoro peeosinophils.

IL-5 ndiyo yakakosha cytokine yekukura, kusiyanisa, kutora vanhu, kuita, uye kurarama kweeosinophils. Kushaikwa kwekudyidzana pakati peI-5 nemaeosinophils kunodzivirira IL-5 kuve nezviitwa zvemaseru mu eosinophil. Saka eosinophil cellular kutenderera uye zviitiko zvehupenyu zvinokanganiswa. Eosinophils mira kushanda nemazvo uye ufe.

Mune vanhu vane eosinophil prototype yeakanyanya asthma, eosinophils chikonzero chakakosha chechirwere. Eosinophils inokonzeresa kuzvimba mumapapu, izvo zvinotungamira kune asthma isingaperi. Nekuderedza huwandu uye mashandiro emaosinophils, Cinqair inoderedza kuzvimba mumapapu. Saka asima yakakomba inodzorwa kwechinguva.

Mast masero, macrophages, neutrophils, uye maLymphocyte anogona zvakare kupisa mapapu. Uye zvakare, eicosanoids, histamine, cytokines, uye leukotrienes zvinogona kukonzera kuzvimba uku. Hazvizivikanwe kana Cinqair ikaita pane aya maseru nevamiririri kudzora kuzvimba mumapapu.

Pharmacokinetics uye metabolism

Cinqair inozadzisa kukwirira kwayo kwepamusoro panopera nguva yekumukisa. Akawanda manejimendi eCinqair anotungamira mukuunganidzwa kwawo mune serum ye 1.5- kusvika 1.9-fold. Iyo serum kuwanda kunodzikira mune biphasic curve. Izvi zvinomirira hazvichinje nekuvapo kwema anti-Cinqair antibodies.

Kamwe ikapihwa, Cinqair ine huwandu hwekuparadzirwa kwema 5 litita. Izvi zvinoreva kuti huwandu hwakawanda hweCinqair haugone kusvika kumaturakiti akawanda.

Sezvazvakaita nema monoclonal antibodies mazhinji, Cinqair inoshungurudzika neenzymatic degradation. Proteolytic enzyme inoishandura kuita madiki peptides uye amino acids. Kuzadza proteolysis yeCinqair kunotora nguva. Hafu yeupenyu hwayo ingangoita mazuva makumi maviri nemana. Zvakare, chiyero chayo chekubvisa chinosvika mamirita manomwe paawa (mL / hr). Target-Mediated clearance yeCinqair haigone kuitika. Izvi zvinodaro nekuti inosunga kune interleukin-5 (IL-5), inova yakasviba cytokine.

Pharmacokinetics zvidzidzo zveCinqair zvakafanana chaizvo pakati pevanhu vezera rakasiyana, murume kana mukadzi. Kusiyanisa pakati pevanhu kuri pakati pe20% kusvika 30% yehuwandu hwevasungwa uye kuratidzwa kwese.

Zvidzidzo zveFarmacokinetics zvinoratidza hapana musiyano wakakura pakati pevanhu vane zvakajairika uye zvinyoro nyoro kuwedzerwa kwechiropa basa bvunzo. Basa rakajairwa rinosanganisira mazinga ebilirubin uye aspirate aminotransferase yakaderera kana yakaenzana neiyo yepamusoro muganho wakajairwa (ULN). A zvinyoronyoro yakawedzera basa bvunzo inosanganisira zviyero zve bilirubin pamusoro peiyo ULN uye isingasviki kana yakaenzana ne 1.5-peta iyo ULN. Inogona zvakare kusanganisira mazinga easpartate aminotransferase yakakwira kupfuura iyo ULN.

Zvakare, pharmacokinetics zvidzidzo zvinoratidza hapana mutsauko pakati pevanhu vane zvakajairika kana kukanganisika basa retsvo. Zvakajairika renal basa zvinoreva kuti inofungidzirwa glomerular filtration rate (eGFR) yakakura kupfuura kana yakaenzana ne90 mL paminiti pa 1.73-mita yakaenzana. (mL / min / 1.73 m2). Zvinyoro uye zvine mwero renal mabasa anofungidzira inofungidzirwa eGFR iri pakati pe60 kusvika 89 mL / min / 1.73 m2 uye 30 kusvika 59 mL / min / 1.73 m2, zvichiteerana.

Contraindications

Cinqair inopesana mune vanhu vakambogadzira hypersensitivity kune chero chinhu chinoshanda kana chisina basa cheCinqair.

Hypersensitivity inogona kuitika mushure mekutungamirwa kweCinqair. Asi mune zvimwe zviitiko, zvinogona kuitika mukati maawa akati wandei zvichitevera manejimendi ekushandisa. Kuongororwa kwevarwere mushure meCinqair manejimendi kwakakosha kucherechedza kukura kwe hypersensitivity reaction.

Hypersensitivity ihosha yemitezo yemitezo inogona kukonzera anaphylaxis uye kufa neanaphylactic kuvhunduka. Vese varwere vane hypersensitivity kuCinqair vanofanirwa kukanganisa kurapwa nekukurumidza. Mune ino kesi, zviratidzo zve hypersensitivity zvinofanirwa kurapwa. Varwere ava havafanirwe kumbowana kurapwa kweCinqair zvakare.

Taura nevarwere vako nezvezviratidzo zve hypersensitivity uye anaphylaxis. Vaudze vafonere 911 nekukasira kana vachifunga kuti vari kuva nemamiriro aya. Zvakare, vaudze kuti vazivise avo vanopa hutano kana vakawana hypersensitivity kana anaphylaxis kuti vatsanangure zvakare nzira yekurapa.

Kuchengetedza

Cinqair inofanira kuiswa mufiriji pakati pe36 ° F kusvika 46 ° F (2 ° C kusvika 8 ° C). Izvo zvakakosha kuti mushonga hauna kuomeswa nechando kana kuzununguswa. Izvo zvakare zvakakosha kuti uchengete Cinqair mupakeji yayo yepakutanga kusvikira yashandiswa. Izvi zvinodzivirira mushonga kubva kukureruka kwechiedza.

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.

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