Ini Ndingave Nayo Muchero Wemazambiringa Ndichitora Metformin?

Zvemukati

• Chii chinonzi metformin?
• Mashandisiro anoita zvinodhaka ne grapefruit anoshanda
• Ndeapi madhiragi anopindirana nemuzambiringa?
• Ko mazambiringa anobata sei metformin?
• Zvimwe zvinhu zvekudzivirira paunenge uri pane metformin
• Ma grapefruit angabatsira sei vanhu vane chirwere cheshuga
• Tora woenda nazvo

Muna Chivabvu 2020, iyo yakakurudzirwa kuti vamwe vanogadzira metformin yakawedzerwa kuburitswa vabvise mamwe mapiritsi avo kubva kumusika weU.S. Izvi zvinodaro nekuti mwero usingagamuchirike wecarcinogen inokonzeresa (kenza-inokonzeresa mumiriri) yakawanikwa mune mamwe akawedzeredzwa-kuburitsa metformin mapiritsi. Kana iwe parizvino uchitora mushonga uyu, fonera wako mupi wezvehutano. Ivo vanozopa zano kana iwe uchifanira kuenderera kutora mishonga yako kana kana iwe uchida mushonga mutsva.

Mazhinji mishonga, senge ma statins uye mamwe ma antihistamines, ane hukama husina kunaka ne grapefruit. Metformin inoshandiswa pakurapa kworudzi rwechipiri chirwere cheshuga.

Kuva nemuzambiringa paunenge uchitora metformin kunotungamira kune yakaipa mhedzisiro? Iko kune kushomeka kwekutsvaga, asi izvi ndizvo zvaunofanira kuziva.

Chii chinonzi metformin?

Metformin imishonga inorayirwa kurapa rudzi rwechipiri chirwere cheshuga. Vanhu vane rudzi rwechipiri chirwere cheshuga havagone kushandisa insulin zvakajairika. Izvi zvinoreva kuti havagone kudzora huwandu hweshuga muropa ravo. Metformin inobatsira vanhu vane chirwere cheshuga chechipiri kudzora huwandu hweshuga muropa ravo nenzira dzakasiyana, kusanganisira:

• kudzikisa huwandu hweshuga muviri wako unotora kubva kuchikafu
• kudzikisa huwandu hweshuga inogadzirwa nechiropa chako
• kuwedzera mhinduro yemuviri wako kune insulini iyo inogadzira zvakasikwa

Metformin haigone kukonzera chakakomba uye chinotyisa hupenyu chinonzi lactic acidosis. Vanhu vane chiropa, itsvo, kana matambudziko emwoyo vanofanirwa kudzivirira kutora metformin.

Mashandisiro anoita zvinodhaka ne grapefruit anoshanda

Kune zvakawanda kupfuura izvo zvinozivikanwa kuti zvinofambidzana ne grapefruit. Pamishonga iyi, inogona kutungamira kune zvakakomba zvakashata mhedzisiro. Mhando dzese dzemuzambiringa - kusanganisira jisi ichangosvinwa, kuomeswa nechando, uye muchero wese - zvinogona kutungamira mukudyidzana kwezvinodhaka.

Mamwe emakemikari anowanikwa muzambiringa mazambiringa anogona kusunga uye kusaita enzyme mumuviri wako iyo inowanikwa mumatumbu uye chiropa. Iyi enzyme inobatsira kuputsa mushonga waunotora.

Kazhinji paunotora mushonga nemuromo, unotyorwa zvishoma nema enzymes usati wasvika muropa rako. Izvi zvinoreva kuti iwe unogashira zvishoma zvishoma zvemushonga muropa rako kupfuura iyo yawakatanga kushandisa.

Asi kana iyo enzyme yatadziswa - sezvazviri kana ichipindirana nemakemikari ari muzambiringa mazambiringa - pane huwandu hukuru hunoshamisa hwemushonga uyo unopinda muropa rako. Izvi zvinotungamira kune yakanyanya njodzi yekuwedzeredza. Tora zvakanyanya kutarisa zvakadzama kudyidzana kwemazambiringa-zvinodhaka.

Ndeapi madhiragi anopindirana nemuzambiringa?

Zvinoenderana neiyo, anotevera marudzi emishonga anogona kuve nekudyidzana kwakashata ne grapefruit:

• statins, senge simvastatin (Zocor) uye atorvastatin (Lipitor)
• zvinodhaka zvekukwira kweropa, senge nifedipine (Procardia)
• immunosuppressive zvinodhaka, zvakadai se cyclosporine (Sandimmune)
• corticosteroids inoshandiswa kurapa chirwere cheCrohn kana ulcerative colitis, senge budesonide (Entocort EC)
• mishonga inobata zvisina kujairika moyo mutinhimira, senge amiodarone (Pacerone)
• antihistamines, senge fexofenadine (Allegra)
• zvimwe zvinodhaka zvinopesana nekuzvidya mwoyo, zvakadai sebuspirone (BuSpar)

Grapefruit muto hauna zvazvinoita pamushonga wega wega muzvikamu zviri pamusoro. Kukurukurirana nemuzambiringa mazambiringa muto-wakasarudzika, kwete zvinodhaka chikamu-chakanangana.

Kana uchitanga pamushonga mutsva, zvakakosha kuti ubvunze chiremba wako kana wemishonga kana uchikwanisa kudya grapefruit kana zvigadzirwa zvine chekuita nemazambiringa.

Ko mazambiringa anobata sei metformin?

Izvo zvakakosha kuti uzive kuti metformin haina kuputswa neiyo imwechete enzyme semishonga yakanyorwa pamusoro. Iyo haina kugadziriswa nemuviri wako uye inodzingwa mumuti wako weti.

Pane ruzivo rwakaganhurwa rwuripo rwekuti kuva nema grapefruit uchitora metformin kunokanganisa sei vanhu vane chirwere cheshuga chechipiri.

A yakakurukura mhedzisiro ye grapefruit ine metformin mune nondiabetic makonzo. Mamwe makonzo akafumurwa kune muto wemazambiringa uye metformin. Vamwe vakaratidzwa metformin voga. Vatsvagiri vakaona kuti pakanga paine kuwedzera kwehuwandu hwekugadzira lactic acid mumakonzo akafumurwa muto wemazambiringa uye metformin.

Vatsvakurudzi vakafungidzira kuti grapefruit muto unowedzerwa metformin kuunganidzwa muchiropa. Izvi, zvakare, zvakakonzera kuwedzera mukugadzirwa kwelactic acid. Nekuda kweizvi, vaongorori vakaratidza kuti kunwa jisi remuzambiringa wemazambiringa kunogona kukonzera njodzi yekuwedzera kweacicic acidosis muvanhu vanotora metformin.

Nekudaro, mhedzisiro iyi yakaonekwa mune nondiabetic makonzo, kwete muvanhu vane mhando 2 chirwere cheshuga. Kusvika pari zvino, hakuna kumbove nenyaya yekudzidza muvanhu inoratidza kuti kutora metformin nejusi remazambiringa kunotungamira kune lactic acidosis.

Zvimwe zvinhu zvekudzivirira paunenge uri pane metformin

Kutora mimwe mishonga uchitora metformin kunogona kuwedzera njodzi yekuita lactic acidosis. Iwe unofanirwa kuzivisa chiremba wako kana iwe uri kutora chero eanotevera mishonga:

• diuretics, senge acetazolamide
• corticosteroids, senge prednisone
• BP, mishonga yakadai saamlodipine (Norvasc)
• anticonvulsants, senge topiramate (Topamax) uye zonisamide (Zonegran)
• mishonga yekudzivirira
• antipsychotic zvinodhaka, senge chlorpromazine

Dzivisa kunwa yakawanda doro paunenge uri pane metformin. Kunwa doro uchitora metformin kunowedzera mukana wako wekukura yakaderera ropa shuga kana kunyange lactic acidosis.

Sekureva kweYunivhesiti yeMichigan, iwe unofanirwa kudzivirira kudya chikafu chepamusoro-fiber mushure mekutora metformin. Izvi zvinodaro nekuti fiber inogona kusunga kumishonga uye kudzikisa kwavo kusungwa. Metformin mwero inoderera painotorwa neakawanda fiber (yakakura kupfuura makumi matatu emamirigiramu pazuva).

Mimwe mirayiridzo yekudyiwa kwevanhu vane chirwere cheshuga ndeinotevera:

• Sanganisira makabhohaidhiretsi anobva kumiriwo, michero, uye zviyo zvakazara. Ive neshuwa yekutarisa yako makabhohaidhiretsi yaunodya, sezvo izvi zvichinyatso kukanganisa rako ropa shuga.
• Dzivisa chikafu chakakwirisa mumafuta akazara uye anotapira. Pane kudaro, pedza mafuta kubva kuhove, nzungu, uye maorivhi. Hedzino gumi nzira dzekuwedzera mafuta ane hutano kune chako chikafu.
• Kudya 25 kusvika makumi matatu emamirigiramu e fiber pazuva kunogona kubatsira kudzora huwandu hweropa. Ona iyi runyorwa rwe22 yepamusoro-fiber chikafu kuti utange.
• Dzivisa sodium. Edza kudya asingasviki mamirigiramu mazana maviri nemazana matatu pazuva.

Ma grapefruit angabatsira sei vanhu vane chirwere cheshuga

Kunwa jisi remuzambiringa wemazambiringa kunogona kubatsira kana uine chirwere cheshuga.

Anoratidza kuti gadziriro yekumwa yejekesa jisi remichero yemichero yakadzora zvese kutsanya glucose uye kuwedzera huremu. Mhedzisiro yakatarwa yakafanana nemhedzisiro yemetformin. Pakange pasina chakakwidziridzwa mhedzisiro apo grapefruit muto uye metformin yakaedzwa pamwechete.

Ndichiri kuvimbisa, zvakakosha kuti uzive kuti kucherechedza uku kwakaitwa mune yegonzo modhi yeshuga.

A yebasa remazambiringa muchero mukudya uye kudyidzana kwezvinodhaka zvinoratidzawo kuti mazambiringa anoenderana nekudzikisira uremu uye nekuvandudza insulin kudzvinyirira. Uyezve, wongororo iyi inoshumawo mukomboni mugrapefruit muto (naringin) yakawanikwa ichivandudza hyperglycemia uye yakakwira cholesterol mune yerudzi rwechipiri chirwere cheshuga mhuka. Dzidza zvakawanda nezve kurarama nechirwere cheshuga uye yakakwira cholesterol.

Tora woenda nazvo

Muchero wemazambiringa unotungamira mukusangana kwakashata nemimwe mishonga. Nekudaro, hapana zviitiko zvemakesi umo kunwa muto wemazambiringa paunenge uchitora metformin kwakatungamira mukukanganisa kwevanhu.

Pane humwe hunovimbisa humbowo hwekuyedza hunosanganisira grapefruit mune yako dhayeti inogona kubatsira kusimudzira uremu uye kuderedza kutsanya glucose mazinga.

Kana iwe uri kutora metformin uye uine hanya nekubatana kwezvinodhaka-zvinodhaka kana kudyidzana kwezvinodhaka, taura nemupi wako wezvehutano.