Autoimmune hepatitis: chii chiri, chikuru zviratidzo, kuongororwa uye kurapwa

Zvemukati

• Zviratidzo zvikuru
• Autoimmune hepatitis pakubata
• Maitiro ekusimbisa
• Kurapwa kunoitwa sei

Autoimmune hepatitis chirwere chinokonzeresa kuzvimba kwechiropa nekuda kweshanduko yemasoja emuviri, ayo anotanga kuziva ayo maseru sekune dzimwe nyika uye anovarwisa, zvichikonzera kuderera mukushanda kwechiropa uye kuoneka kwezviratidzo zvakaita se kurwadziwa mumimba, yero yero uye kushushikana kwakasimba.

Autoimmune hepatitis inowanzo kuoneka isati yasvika makore makumi matatu uye inowanzoitika kune vakadzi. Chikonzero chaicho chekutanga kwechirwere ichi, icho chingangove chine chekuita nekuchinja kwemajini, hachisati chazivikanwa, asi chinofanira kuyeukwa kuti hachisi chirwere chinotapukira uye, nekudaro, hachigone kutapurirwa kubva kune mumwe munhu kuenda kune mumwe.

Mukuwedzera, autoimmune hepatitis inogona kukamurwa kuita matatu madiki:

• Autoimmune hepatitis mhando 1: yakajairika pakati pemakore gumi nematanhatu kusvika makumi matatu ekuberekwa, ichizivikanwa nekuvapo kweFAN nema AML antibodies mukuyedzwa kweropa, uye inogona kuve nehukama nekuonekwa kwezvimwe autoimmune hosha, senge thyroiditis, celiac chirwere, synovitis uye ulcerative colitis;
• Autoimmune hepatitis mhando 2: inowanzoonekwa muvana vane makore maviri kusvika pamakore gumi nemana, iyo inorwisa antibody ndeyeAnti-LKM1, uye inogona kuoneka pamwe chete nerudzi rwe1 chirwere cheshuga, vitiligo uye autoimmune thyroiditis;

• Autoimmune hepatitis mhando 3: yakafanana nerudzi rwekutanga autoimmune hepatitis, ine yakanaka anti-SLA / LP antibody, asi inogona kunge yakanyanya kuomarara kupfuura mhando 1.

  
  

Kunyangwe pasina mushonga, autoimmune hepatitis inogona kunyatso kudzorwa nekurapwa, kunoitwa nemishonga yekudzivirira hutachiona, sePrednisone neAzathioprine, kuwedzera kune chikafu chakaringana, chakafuma muchero, miriwo uye zviyo, izvo zvinodzivirirwa. - kunwa doro, mafuta, kuwanda kwezvinochengetedza uye mishonga yekuuraya zvipuka. Kuvhiya kana kuisirwa chiropa kunongoratidzwa chete mune zvakakomba zviitiko.

Zviratidzo zvikuru

Zviratidzo zve autoimmune hepatitis zvinowanzo nonspecific uye yekiriniki pikicha inogona kusiyana kubva kune asymptomatic murwere kusvika pakuitika kwechiropa kutadza. Nekudaro, iyo mikuru zviratidzo uye zviratidzo zvinogona kuratidza autoimmune hepatitis ndeaya:

• Kuneta zvakanyanya;
• Kurasikirwa nechido;
• Kurwadziwa kwetsandanyama;
• Kugara uchirwadziwa mudumbu;
• Kusvotwa uye kurutsa;
• Ganda reyero nemaziso, anonziwo jaundice;
• Muviri unononoka;
• Joint kurwadziwa;
• Dumbu rakazvimba.

Kazhinji chirwere chinotanga zvishoma nezvishoma, chichifambira mberi zvishoma nezvishoma kubva kumavhiki kusvika kumwedzi kusvika icho chinotungamira kune fibrosis yechiropa uye kurasikirwa nebasa, kana chirwere chisina kuzivikanwa uye kurapwa. Nekudaro, mune dzimwe nguva, chirwere ichi chinogona kukurumidza kukurumidza, kuchinzi fulminant hepatitis, iyo yakakomba zvakanyanya uye inogona kuguma nerufu. Ziva zvazviri uye ndedzipi njodzi dzehypatitis yakazara.

Uye zvakare, mune diki chikamu chezviitiko, hosha yacho inogona kusakonzera zviratidzo, ichiwanikwa mukuyedzwa kwese, izvo zvinoratidza kuwedzera kwemakemikari echiropa. Izvo zvakakosha kuti kuongororwa kwacho kunoitwa nekukurumidza kuitira kuti kurapwa kukurumidze kumisikidzwa nachiremba, kugona kudzivirira matambudziko, senge cirrhosis, ascites uye hepatic encephalopathy.

Autoimmune hepatitis pakubata

Zviratidzo zve autoimmune hepatitis pakuzvitakura zvakafanana neizvo zvechirwere kunze kwenguva ino uye zvakakosha kuti mukadzi aperekedzwe nachiremba anoona kuti hapana njodzi kuna iye nemwana, zvinova zvisingawanzoitika kana chirwere ichi achiri kuwana kumusoro padanho rekutanga.

Mune vakadzi vane nhumbu vane chirwere chakanyanyisa kukura uye vane cirrhosis sechinetso, kuongorora kunova kwakanyanya kukosha, sezvo paine njodzi huru yekuzvarwa nguva isati yakwana, huremu hwekuzvarwa hushoma uye kudiwa kwechikamu chekusiyiwa. Nekudaro, zvakakosha kuti chiremba anozvara aratidze kurapa kwakanyanya, uko kunowanzoitwa nekorticosteroid, senge Prednisone.

Maitiro ekusimbisa

Kuongororwa kwe autoimmune hepatitis kunoitwa nekuongorora zviratidzo nezviratidzo zvinoratidzwa nemunhu uye mhedzisiro yekuongororwa kwerabhoritari iyo inofanirwa kukumbirwa nachiremba. Imwe yemiedzo inosimbisa kuongororwa kwe autoimmune hepatitis iiropa biopsy, umo chidimbu chechikamu ichi chinounganidzwa uye chinotumirwa ku laboratori kuti chione shanduko munyama inoratidza autoimmune hepatitis.

Uye zvakare, chiremba anogona kuraira kuyerwa kwemakemikari echiropa, akadai seTGO, TGP uye alkaline phosphatase, kuwedzera kune kuyerwa kwema immunoglobulins, antibodies uye serology ye hepatitis A, B uye C mavhairasi.

Maitiro emararamiro emunhu anoonekwawo panguva yekuongororwa, senge kunwisa doro uye kushandisa mishonga ine chepfu kuchiropa, zvichiita kuti zvikwanise kubvisa zvimwe zvinokonzera matambudziko echiropa.

Kurapwa kunoitwa sei

Kurapa kwe autoimmune hepatitis kunoratidzwa ne hepatologist kana gastroenterologist, uye inotangwa nekushandiswa kwemishonga ye corticosteroid, senge Prednisone, kana maunosuppressants, akadai seAzathioprine, ayo anoderedza zvakanyanya chiropa kuzvimba nekuchichengeta pasi pesimba makore, uye zvinogona kuva zvinoitwa kumba. Mune zvimwe zviitiko, kunyanya kuvarwere vadiki, kushandiswa kwekusanganiswa kwePrednisone neAzathioprine kunogona kukurudzirwa kudzikisa mhedzisiro.

Uye zvakare, zvinokurudzirwa kuti varwere vane autoimmune hepatitis vadye kudya kwakasiyana uye kwakaringana, vachidzivirira kunwa doro kana kudya chikafu chine mafuta, senge masoseji uye zvinwiwa.

Muzviitiko zvakakomba kwazvo, umo zvisingaite kudzora kuzvimba nekushandisa kwemishonga, kuvhiya kwechiropa chekuisa, iyo inosanganisira kutsiva chiropa chinorwara neyakagwinya. Nekudaro, sezvo autoimmune hepatitis inoenderana ne immune immune uye kwete kuchiropa, mushure mekuiswazve zvinokwanisika kuti chirwere chichavezvezve kukura.