HER2-Yakanaka vs. HER2-Negative Gomarara Remazamu: Zvinorevei Kwandiri?

Zvemukati

• Chii chinonzi HER2?
• Zvinorevei HER2-positive?
• Zvinorevei HER2-negative?
• Kuedzwa kweHER2
• Kurapa HER2-yakanaka kenza yemazamu
• Outlook

Mhedziso

Kana iwe kana munhu waunoda akagamuchirwa nekenza yemazamu, iwe ungangodaro wakanzwa izwi rekuti "HER2." Iwe unogona kunge uchinetseka kuti zvinorevei kuva neHER2-yakanaka kana HER2-isina kenza yemazamu.

Nzvimbo yako yeHER2, pamwe nekenza yako yekenza mamiriro, zvinobatsira kuona hutachiona hwekenza yako yemazamu. Nzvimbo yako yeHER2 inogona zvakare kubatsira kuona kuti kenza ine hukasha zvakadii. Chiremba wako achashandisa ruzivo urwu kuti aongorore sarudzo dzako dzekurapa.

Mumakore achangopfuura, pakave nezviitiko zvakakura pakurapa kenza yemazamu yeHER2. Izvi zvakakonzera kuona kwakanaka kwevanhu vane rudzi urwu rwechirwere.

Chii chinonzi HER2?

HER2 inomirira munhu epidermal kukura chinhu chinogamuchira 2. HER2 mapuroteni anowanikwa pamusoro pemasero emazamu. Vanobatanidzwa mukukura kwemasero asi vanogona "kuwedzererwa." Izvi zvinoreva kuti iwo mazinga epuroteni akakwirira kupfuura zvakajairwa.

HER2 yakawanikwa muma1980. Vatsvagiri vakafunga kuti kuvepo kweprotein yakawandisa yeHER2 kunogona kukonzera kenza kukura nekupararira nekukurumidza. Uku kuwanikwa kwakatungamira kutsvagurudzo yemaitiro ekudzora kana kushandura kukura kwemhando idzi dzekenza maseru.

Zvinorevei HER2-positive?

HER2-inovhenekera kenza yemazamu ine yakawandisa akakwirisa mazinga eHER2 mapuroteni. Izvi zvinogona kukonzera kuti maseru awedzere nekukurumidza. Kuwedzeredza kubereka kunogona kukonzera kenza yemazamu inokurumidza kukura iyo ingangopararira.

Inenge makumi maviri neshanu muzana emakenza emukaka emazamu ane HER2-yakanaka.

Mumakore makumi maviri apfuura, kufambira mberi kwakakosha kwakaitwa musarudzo dzekurapa kenza yemazamu yeHER2.

Zvinorevei HER2-negative?

Kana maseru ekenza yemazamu asina huwandu husingaenzanisike hweHER2 mapuroteni, ipapo kenza yemazamu inoonekwa seHER2-isina. Kana kenza yako iri HER2-isina, inogona kunge iine estrogen- kana progesterone-yakanaka. Kunyangwe kana kwete izvo zvinokanganisa sarudzo dzako dzekurapa.

Kuedzwa kweHER2

Kuyedza kunogona kuona chinzvimbo cheHER2 kunosanganisira:

• immunohistochemistry (IHC) bvunzo
• in situ kusanganiswa (ISH) bvunzo

Kune akatiwandei akasiyana IHC uye ISH bvunzo dzakabvumidzwa neKudya neDrug Administration. Izvo zvakakosha kuti uongorore kuwedzera kwekunyanyisa kweHER2 nekuti mhedzisiro inozoona kana iwe uchizobatsirwa kubva kune imwe mishonga.

Kurapa HER2-yakanaka kenza yemazamu

Kwemakore anopfuura makumi matatu, vaongorori vanga vachidzidza kenza yemazamu yeHER2-nzira dzekurapa. Mishonga yakanangwa zvino yachinja maonero echikamu chekutanga kusvika kumatatu egomarara remazamu kubva kuhurombo kuenda kune wakanaka.

Iyo yakanangwa zvinodhaka trastuzumab (Herceptin), kana ichishandiswa tandem nekemotherapy, yakavandudza maonero evaya vane HER2-yakanaka kenza yemazamu.

Chekutanga chakaratidza kuti kusangana uku kwekurapa kwakadzora kukura kweHER2-positive kenza yemazamu zvirinani pane chemotherapy chete. Kune vamwe, kushandiswa kweHerceptin nekemotherapy kwakonzera kuregererwa kwenguva refu.

Zvimwe zvidzidzo zvenguva pfupi yapfuura zvakaramba zvichiratidza kuti kurapwa naHerceptin mukuwedzera kune chemotherapy kwakagadzirisa maonero ese kune avo vane HER2-yakanaka kenza yemazamu. Kazhinji ndiyo yekurapa kwekutanga kwekenza yemazamu yeHER2.

Mune zvimwe zviitiko, pertuzumab (Perjeta) inogona kuwedzerwa pamwe chete naHerceptin. Izvi zvinogona kukurudzirwa kune HER2-yakanaka kenza yemazamu pane yakanyanya njodzi yekudzokazve, senge danho rechipiri uye pamusoro, kana yekenza yakapararira kuma lymph node.

Neratinib (Nerlynx) mumwe mushonga unogona kukurudzirwa mushure mekurapwa naHerceptin mune zviitiko zvine njodzi huru yekudzokazve.

Kune HER2-inovhenekera kenza yemazamu iyo iri zvakare estrogen- uye progesterone-yakanaka, kurapwa nehomoni yekurapa kunogona kukurudzirwa zvakare. Mamwe marapirwo akanangwa neHER2 anowanikwa kune avo vane kenza yemazamu yepamusoro.

Outlook

Kana iwe wakagamuchira kuongororwa kwekenza yemazamu inopinda, chiremba wako anozoongorora kenza yako HER2 chinzvimbo. Mhedzisiro yebvunzo ndiyo inosarudza sarudzo dzakanakisa dzekurapa kenza yako.

Zviitiko zvitsva mukurapa kweHER2-inovhenekera kenza yemazamu yakavandudza maonero evanhu vane chirwere ichi. Kutsvagisa kuri kuenderera mberi kwekurapwa kutsva, uye tarisiro yevanhu vane gomarara repazamu iri kuramba ichivandudza.

Kana iwe ukatambira kuongororwa kweHER-positive kenza yemazamu, dzidza zvese zvaunogona uye utaure pachena nezve mibvunzo yako nachiremba wako.