Hormone vs. Isiri-Hormone Therapies yeAdvanced Prostate Cancer

Zvemukati

• Hormone yekurapa yekenza yeprostate cancer
• Kurapa kwehomoni kunoshanda sei?
• Kubvumidzwa kurapwa kwehomoni
• Zvinangwa zvekurapwa
• Mishonga inorapwa sei?
• Ndiani anokwikwidza?
• Zvakajairika mhedzisiro
• Asiri-mahormone ekurapa epamberi gomarara reprostate
• Yakagamuchirwa isiri-mahormone ekurapa
• Zvinangwa zvekurapwa
• Ndiani anokwikwidza?
• Mishonga inorapwa sei?
• Zvakajairika mhedzisiro
• Chinokosha

Kana gomarara reprostate rasvika padanho repamberi uye maseru egomarara apararira kune dzimwe nhengo dzemuviri, kurapwa chinhu chakakosha. Kumirira kwakamirira haisisiri sarudzo, kana iyo yaive nzira yekuziva nachiremba wako.

Neraki, varume vane gomarara repamberi reprostate vava nematanho ekurapa akawanda kupfuura nakare kose. Izvi zvinosanganisira zvese zviri zviviri zvekurapa kwehomoni uye sarudzo dzisiri-mahormone ekurapa. Kurapa chaiko kwauchatambira kunoenderana nedanho rako rekenza yeprostate uye chero mamiriro ezvinhu aunazvo. Rangarira kuti ruzivo rwako rwekurapwa runogona kuve rwakasiyana zvakanyanya newemumwe munhu.

Kuti usarudze nezvekurapa, iwe uchafanirwa kufunga nezve chinangwa chakazara chekurapa, mhedzisiro yacho, uye kuti kana uri mukwikwidzi akanaka kana kwete. Kuziviswa nezve marapirwo aripo kunogona kubatsira iwe nachiremba wako kusarudza kuti ndeupi kurapwa, kana musanganiswa wekurapa, wakanakira iwe.

Hormone yekurapa yekenza yeprostate cancer

Hormone kurapa inozivikanwawo seyrogen kunyimwa kurapa (ADT). Inowanzo tsanangurwa seyakakosha yekurapa kenza yemastastatic kenza.

Kurapa kwehomoni kunoshanda sei?

Hormone Therapy inoshanda nekuderedza iwo mazinga ehormone (androgens) mumuviri. Androgens inosanganisira testosterone uye dihydrotestosterone (DHT). Aya mahormone anokurudzira gomarara reprostate kuti riwande. Pasina uyerogen, bundu kukura kunononoka uye kenza inogona kutopinda mukuregererwa.

Kubvumidzwa kurapwa kwehomoni

Kune akatiwandei anogamuchirwa mahormone ekurapa kenza yeprostate. Izvi zvinosanganisira:

• GnRH agonists, senge leuprolide (Eligard, Lupron) uye goserelin (Zoladex). Izvi zvinoshanda nekuderedza huwandu hwe testosterone hwakagadzirwa nemachende.
• Anti-androgens, senge nilutamide (Nilandron) uye enzalutamide (Xtandi). Izvi zvinowanzo kuwedzerwa kuGnRH agonists kubatsira kudzivirira testosterone kubva pakubatanidza kune tumarara maseru.
• Imwe mhando yeGnRH agonist inonzi degarelix (Firmagon), iyo inovhara masigns kubva muhuropi kuenda kuma testes kuitira kuti kugadzirwa kwe androgens kumiswe.
• Kuvhiya kubvisa machende (orchiectomy). Mukuita, izvi zvinomisa kugadzirwa kwemahomoni echirume.
• Abiraterone (Zytiga), anopikisa LHRH anoshanda nekuvharidzira enzyme inonzi CYP17 kumisa kugadzirwa kwe androgens nemasero mumuviri.

Zvinangwa zvekurapwa

Chinangwa chehomoni yekurapa ndiko kuregererwa. Kuregererwa zvinoreva kuti zvese zviratidzo nezviratidzo zvegomarara reprostate zvinoenda. Vanhu vakawana kuregererwa havana "kurapwa," asi vanogona kuenda makore mazhinji vasina kuratidza zviratidzo zvegomarara.

Hormone therapy inogona zvakare kushandiswa kudzikisa njodzi yekudzokazve mushure mekutanga kurapwa mune varume vari panjodzi huru yekudzokazve.

Mishonga inorapwa sei?

GnRH agonist anogona kuiswa jekiseni kana kuiswa semidziyo midiki pasi peganda. Anti-androgens inotorwa sepiritsi kamwe pazuva. Degarelix inopihwa sejekiseni. Chemotherapy mushonga unonzi docetaxel (Taxotere) dzimwe nguva unoshandiswa pamwe chete nemahomoni ekurapa aya.

Zytiga inotorwa nemuromo kamwe pazuva nekusangana nesteroid inonzi prednisone.

Kuvhiya kubvisa machende kunogona kuitwa senzira yekurapa varwere. Iwe unofanirwa kukwanisa kuenda kumba maawa mashoma mushure meiyo orchiectomy.

Ndiani anokwikwidza?

Vazhinji varume vane gomarara reprostate repamberi ndivo vanovhotera kurapwa kwehomoni. Inowanzo fungidzirwa kana gomarara reprostate rapararira kupfuura kweprostate, uye kuvhiyiwa kubvisa bundu hakuchakwanise.

Usati watanga kurapwa, iwe uchafanirwa kuve neropa rekuyedza basa pamwe nekuongororwa kweropa kuti uve nechokwadi chekuti chiropa chako chinogona kuputsa mishonga nemazvo.

Parizvino, enzalutamide (Xtandi) inogamuchirwa chete kuti ishandiswe nevarume vane gomarara reprostate rakatopararira kune dzimwe nhengo dzomuviri, uye vasisapindure kurapwa kana kuvhiya kudzikisa mwero we testosterone.

Mune zvimwe zviitiko, maseru emukenza eprostate anogona kuramba kurapwa kwehomoni uye kuwanda kunyangwe pasina mahormone echirume. Izvi zvinonzi gomarara risingadzivirire mahormone. Varume vane gomarara risingapindiki nekenza yeprostate havasi vakwikwidzi vezvekurapa mahormone.

Zvakajairika mhedzisiro

Mhedzisiro inowanzoitika yemhedzisiro yekurapa inosanganisira:

• kupisa kunopisa
• kuonda, kupwanya mapfupa (osteoporosis) nekuti yakadzika testosterone mazinga anokonzera kurasikirwa kwecalcium
• kurema kuwedzera
• kurasikirwa kwemhasuru
• kusagadzikana kwe erectile
• kurasikirwa pabonde drive

Asiri-mahormone ekurapa epamberi gomarara reprostate

Kana kurapwa kwehomoni kusiri kushanda kana kenza yako ichikura uye ichipararira nekukurumidza, kurapwa pamwe nedzimwe sarudzo dzisiri dzehormoni dzinogona kukurudzirwa.

Yakagamuchirwa isiri-mahormone ekurapa

Asiri-mahormone ekurapa kenza yeprostate inosanganisira:

• Chemotherapy, senge docetaxel (Taxotere), cabazitaxel (Jevtana), uye mitoxantrone (Novantrone). Chemotherapy dzimwe nguva inopihwa pamwe chete ne steroid inozivikanwa se prednisone.
• Radiation kurapa, iyo inoshandisa yakakwira-simba matanda kana radioactive mbeu kuparadza mamota. Radiation inowanzo shandiswa pamwe chete ne chemotherapy.
• Immunotherapy, kusanganisira sipuleucel-T (Provenge). Immunotherapy inoshanda nekushandisa iyo yemuviri immune system kuuraya cancer maseru.
• Radium Ra 223 (Xofigo), iyo ine chishoma che radiation uye inoshandiswa kuparadza gomarara reprostate maseru akapararira kusvika pfupa.

Zvinangwa zvekurapwa

Chinangwa chemotherapy, radiation, uye kumwe kurapa kusiri kwehomoni kudzora kukura kwegomarara uye kuwedzera hupenyu hwemunhu. Chemotherapy uye nevamwe vasiri-mahormone vamiririri vangangodaro vasingakwanise kurapa kenza, asi vanogona kurebesa hupenyu hwevarume vane metastatic kenza yeprostate.

Ndiani anokwikwidza?

Iwe unogona kuve mukwikwidzi kune asiri-mahormone ekurapa senge chemotherapy kana radiation kana

• yako PSA nhanho dziri kukwira nekukurumidza zvakanyanya kune mahormone ekurapa kuidzora
• kenza yako iri kupararira nekukurumidza
• zviratidzo zvako zviri kuramba zvichiwedzera
• mahormone ekurapa anokundikana kushanda
• kenza yapararira kumapfupa ako

Mishonga inorapwa sei?

Chemotherapy inowanzo kupihwa mumatunhu. Kutenderera kwega kwega kunotora mavhiki mashoma. Iwe ungangoda kutenderera kwakawanda kwekurapwa, asi panowanzo kuve nenguva yekuzorora pakati. Kana imwe mhando yekemotherapy ikamira kushanda, chiremba wako anogona kukurudzira dzimwe nzira dzekemotherapy.

Sipuleucel-T (Provenge) inopihwa sekuputirwa katatu mutsinga, paine anenge mavhiki maviri pakati peimwe infusion.

Radium Ra 223 inopihwa sejekiseni.

Zvakajairika mhedzisiro

Zvinowanzoitika mhedzisiro yemakemikari anosanganisira:

• kurasikirwa nevhudzi
• kusvotwa uye kurutsa
• manyoka
• kuneta
• kurasikirwa nenzara
• masero machena eropa (neutropenia) uye njodzi yepamusoro yekutapukirwa
• shanduko mundangariro
• chiveve kana kugwinha mumaoko nemakumbo
• kupwanya kuri nyore
• maronda emuromo

Radiation kurapwa kunogona kudzora yako tsvuku sero masero kuverenga uye kukonzera kupererwa neropa. Anemia inokonzera kuneta, dzungu, musoro, uye zvimwe zviratidzo. Radiation kurapwa kunogona zvakare kutungamira mukurasikirwa kwedundira kudzora (kusagadzikana) uye kusagadzikana kwe erectile.

Chinokosha

Hormone Therapies uye kuvhiya zvinowanzo kurudzirwa kutanga kurapa advanced prostate cancer. Zvinogona kushandiswa pamwe chete nekemotherapy. Asi mushure menguva yakati rebei, kanzuru zhinji dzeprostate dzinogona kuramba kurapwa nehomoni. Asiri-mahormone sarudzo inova sarudzo yakanakisa yevanhurume vane metastatic kenza yeprostate iyo isisapindure pakurapwa kwehomoni kana chemotherapy.

Kunyangwe nekurapwa, haazi ese kesi dzepamberi kenza yeprostate inogona kurapwa, asi kurapwa kunogona kudzora kukura kwekenza, kudzikisa zviratidzo, uye kugadzirisa kupona. Varume vazhinji vanorarama kwemakore nekenza yepamusoro yekenza.

Kuita sarudzo nezve kurapwa kunogona kuvhiringidza uye kunetsa nekuti pane zvakawanda zvekufunga. Rangarira kuti iwe haufanire kuita sarudzo wega. Nenhungamiro kubva kune yako oncologist uye timu yehutano, iwe unogona kuita sarudzo ine ruzivo pane akanyanya marapirwo chirongwa chako.