Kuongorora kweGenetic Kunotamba Sei Basa Mune Metastatic Breast Cancer Kurapa?

Zvemukati

• Chii chinonzi kuongorora majini?
• Mhando dzemageneti bvunzo yekenza yemazamu yemastastatic
• BRCA gene bvunzo
• HER2 bvunzo dzegene
• Ini ndinoda kuongororwa kwemajini kana ndine metastatic kenza yemazamu?
• Iyi bvunzo inoitwa sei?
• Ndinofanira here kuona chipangamazano?
• Tora woenda nazvo

Metastatic kenza yemazamu igomarara rakapararira kunze kwezamu rako kune dzimwe nhengo dzakaita semapapu ako, huropi, kana chiropa. Chiremba wako anogona kureva ichi kenza sedanho rechina, kana yekupedzisira-danho gomarara remazamu.

Bato rako rezvehutano rinoita bvunzo dzinoverengeka kuti uongorore gomarara repazamu rako, uone kuti rapararira zvakadii, uye uwane kurapwa kwakakodzera. Genetic bvunzo chimwe chikamu chekuongororwa maitiro. Iyi bvunzo inogona kutaurira chiremba wako kana kenza yako iine hukama negeneti mutation uye kurapwa kupi kungashanda zvakanyanya.

Haasi munhu wese anoda kuongororwa kwemajini. Chiremba wako uye chipangamazano wezvechibereko vachakurudzira bvunzo idzi zvichienderana nezera rako uye njodzi.

Chii chinonzi kuongorora majini?

Majini zvikamu zveDNA. Ivo vanogara mukati memukati memusero wega wega mumuviri wako. Majini anotakura rairo yekugadzira mapuroteni anodzora zvese zvinoitwa nemuviri wako.

Kuva neimwe geni shanduko, inonzi mutations, kunogona kuwedzera mukana wako wekutora cancer yemazamu. Genetic kuyedza kunotsvaga shanduko idzi kune mamwe magene. Gene bvunzo dzinoongororawo chromosomes - zvikamu zvikuru zveDNA - kutsvaga shanduko dzakabatana nekenza yemazamu.

Mhando dzemageneti bvunzo yekenza yemazamu yemastastatic

Chiremba wako anogona kuraira bvunzo kuti utsvage BRCA1, BRCA2, uye HER2 majini kuchinja. Mimwe bvunzo dzegene dzinowanikwa, asi hadzishandiswe kakawanda.

BRCA gene bvunzo

BRCA1 uye BRCA2 majini anogadzira mhando yeprotein inozivikanwa se tumor suppressor protein. Kana majini aya akajairika, anogadzirisa DNA yakanganisika uye anobatsira kudzivirira maseru egomarara kubva mukukura.

Kuchinja mune BRCA1 uye BRCA2 majini anokonzeresa kuwanda kwemasero kukura uye kuwedzera njodzi yako kune ese kanzura yemazamu uye ovari.

Bvunzo yegene ye BRCA inogona kubatsira chiremba wako kudzidza njodzi yekenza yemazamu. Kana iwe uchitova nekenza yemazamu, kuyedza iyi geni mutation kunogona kubatsira chiremba wako kufanotaura kana mamwe marapirwo ekenza yemazamu achizokushandira.

HER2 bvunzo dzegene

Epidermal yekukura kwechikonzero receptor 2 (HER2) makodhi ekugadzirwa kweiyo inogamuchira protein HER2. Iyi protein iri pamusoro pemasero emazamu. Kana iyo HER2 protein yashandurwa, inotaurira mazamu maseru kuti akure agovane.

Shanduko mu HER2 geni inoisa zvakawandisa HER2 receptors pamazamu maseru. Izvi zvinokonzera maseru emuzamu kukura asingadzoreke uye oita mamota.

Gomarara repazamu rinoyedza HER2 kunodaidzwa kuti HER2-yakanaka kenza yemazamu. Dzinokura nekukurumidza uye dzinogona kunge dzichipararira kupfuura HER2-isina kenza yemazamu.

Chiremba wako anoshandisa imwe yeiyi miviri bvunzo kutarisa yako HER2 chinzvimbo:

• Immunohistochemistry (IHC) inoongorora kuti une yakawandisa here yeHER2 protein pane ako maseru ekenza. Iyo IHC bvunzo inopa iyo kenza mamakisi e0 kusvika ku3+ zvichibva nezvakawanda sei HER2 zvaunazvo pagomarara rako. Chikamu che0 kusvika 1+ chiri HER2-chisina. Chikamu che2+ chiri pamuganhu. Uye mamakisi e3+ ndeye HER2-yakanaka.

• Fluorescence in situ kusanganiswa (FISH) inotsvaga mamwe makopi eiyo HER2 geni. Mhedzisiro yacho inonzi zvakare seHER2-yakanaka kana HER2-isina.

Ini ndinoda kuongororwa kwemajini kana ndine metastatic kenza yemazamu?

Kana iwe uchinge waonekwa uine metastatic kenza yemazamu, zvinogona kubatsira kudzidza kuti ko kugarwa nhaka kwakakonzera kenza yako. Kuongorora genetic kunogona kubatsira kutungamira kurapwa kwako. Mimwe mishonga yegomarara inoshanda chete kana kuti inoshanda zvakanyanya mukenza yemazamu neakasarudzika majini.

Semuenzaniso, iyo PARP inhibitor zvinodhaka olaparib (Lynparza) uye talazoparib (Talzenna) ingori FDA-inogamuchirwa kurapa metastatic kenza yemazamu inokonzerwa ne BRCA gene mutation. Vanhu vane shanduko idzi vanogona zvakare kupindura zvirinani kune chemotherapy drug carboplatin pane docetaxel.

Maitiro ako ejeni anogona zvakare kubatsira kuona kuti ndeupi rudzi rwekuvhiya kwaunowana uye kuti unokodzera here kujoina mamwe makiriniki ekuedzwa Inogona zvakare kubatsira vana vako kana dzimwe hama dzepedyo kudzidza kuti vangave vari panjodzi huru yekenza yemazamu uye vanoda kuwedzerwa kuongororwa.

Nhungamiro kubva kuNational Comprehensive Cancer Network inokurudzira kuongororwa kwemajini kune vanhu vane kenza yemazamu avo:

• vakaonekwa pazera kana pasati pazera makumi mashanu
• vane katatu-isina kenza yemazamu yakawanikwa ichitangira kana isati yasvika makore makumi matanhatu
• uve nehama yepedyo ine zamu, ovari, prostate, kana gomarara repancreatic
• vane kenza mumazamu maviri
• ndevekumabvazuva kweEuropean madzinza echiJudha (Ashkenazi)

Nekudaro, 2019 nhungamiro kubva kuAmerican Society yeBreast Surgeons inokurudzira kuti vanhu vese vanoonekwa kuti vane gomarara repazamu vapihwe kuongororwa kwemajini. Taura nachiremba wako nezve kana uchifanira kuongororwa.

Iyi bvunzo inoitwa sei?

Zve BRCA genetic test, chiremba wako kana mukoti anotora muyenzaniso weropa rako kana swab yemate kubva mukati medama rako. Ropa kana mate sampuro inozoenda kurabhoritari, uko mahunyanzvi anoiyedza iyo BRCA majini kuchinja.

Chiremba wako anoita HER2 geni bvunzo pamazamu maseru akabviswa panguva yebiopsy. Pane nzira nhatu dzekuita biopsy:

• Yakanaka tsono yekutsvaira biopsy inobvisa maseru uye fluid ine tsono yakatetepa.
• Core tsono biopsy inobvisa kamuenzaniso kadiki kemazamu tishu nehombe, isina mhango tsono.
• Kuvhiya biopsy inoita kucheka kudiki muzamu panguva yekuvhiya uye inobvisa chimedu chetishu.

Iwe nachiremba wako muchawana kopi yemhedzisiro, iyo inouya iri muchimiro chemushumo wehurwere.Chirevo ichi chinosanganisira ruzivo rwemhando, saizi, chimiro, uye chitarisiko chemasero ako ekenza, uye nekukurumidza kuti vangangokura sei. Mhedzisiro yacho inogona kubatsira kutungamira kurapwa kwako.

Ndinofanira here kuona chipangamazano?

A genetic chipangamazano inyanzvi mukuongorora majini. Ivo vanogona kukubatsira iwe kusarudza kana iwe uchida magene ekuyedzwa uye zvakanakira uye njodzi dzekuyedza

Kana ongororo yako yapindamo, mutevedzeri wezvechibereko anogona kukubatsira kuti unzwisise zvavanoreva, uye matanho api aunotora zvinotevera. Ivo vanogona zvakare kubatsira kuzivisa hama dzako dzepedyo nezve njodzi yavo yekenza.

Tora woenda nazvo

Kana iwe wakamboonekwa uine metastatic kenza yemazamu, taura nachiremba wako nezve genetic test. Zvinogona kubatsira kutaura nemudzidzisi wezvechibereko kuti unzwisise zvinoreva bvunzo dzako.

Mhedzisiro yemajini ako bvunzo inogona kubatsira chiremba wako kuti awane kurapwa kwakakodzera kwauri. Mhedzisiro yako inogona zvakare kuzivisa dzimwe nhengo dzemhuri yako nezve njodzi yavo uye kuda kwekuwedzera gomarara repazamu.