Psoriasis chirwere cheAutomatiki here?

Zvemukati

• Mhedziso
• Kunzwisisa autoimmune zvirwere
• Zvakajairika autoimmune mamiriro
• Psoriasis sechirwere chemuviri
• Mishonga inotarisa immune system
• Mishonga yekare
• Biologics
• TNF vanopikisa
• Nyowani biologics
• Psoriasis uye njodzi kune mamwe mamiriro e autoimmune
• Maonero

Mhedziso

Psoriasis chirwere cheganda chinosemesa chinoonekwa nechena mutsvuku zvigamba zveganda rakafukidzwa nesirivha-chena chikero Icho chirwere chisingaperi. Zviratidzo zvinogona kuuya uye kuenda, uye zvinogona kutenderera mukuomarara.

Psoriasis chiitiko chakajairika, chinokanganisa vangangoita 3 muzana yehuwandu hwepasi rose. Vanenge mamirioni 7.4 vanhu muUnited States vane psoriasis.

Icho chaicho chikonzero che psoriasis hachina chokwadi. Inofungidzirwa kuve mubatanidzwa wemageneti, zvinhu zvakatipoteredza, uye immune system yako.

Zvichienderana nezvakaitika mukutsvagurudza mumakore mashoma apfuura, psoriasis yakave yakarongedzwa sechirwere chemuviri. Izvi zvinoreva kuti immune system yako, anonzi T maseru, anokanganisa kurwisa ako ega maseru eganda sevapambi vekunze. Izvi zvinokonzeresa kuti maseru ako eganda akurumidze kuwanda, zvichitungamira kune hunhu psoriasis ganda maronda.

Havasi vese vaongorori vanofunga kuti psoriasis chirwere chemuviri. Vamwe vanobvuma kuti psoriasis mamiriro ekudzivirira muviri. Asi dzidziso yavo ndeyekuti psoriasis inoguma neyakaitika zvine chekuita nemajini kune hutachiona hweganda.

Kunzwisisa autoimmune zvirwere

Kazhinji immune system yako inoziva yako maseru uye haivarwise. Zvirwere zvekuzvidzivirira ndezvako apo immune yako inorwisa zvisirizvo maseru ane hutano sekunge ari kunze kwevanopinda vachirwisa muviri wako.

Kune zvinopfuura zana zvirwere zvemuviri. Zvimwe zvirwere zvekuzvidzivirira muviri zvinosanganisira chikamu chimwe chete chemuviri wako - senge ganda rako mupsoriasis. Zvimwe zvine hurongwa, zvinosanganisira muviri wako wese.

Izvo zvese autoimmune kusagadzikana zvine zvakafanana ndezvekuti zvinokonzerwa nekubatanidzwa kwemajini uye zvakatipoteredza zvinhu.

Chaizvoizvo maitiro emajini uye ezvakatipoteredza zvinofambidzana kukonzera hosha dzakasiyana siyana ndiwo musoro wenyaya yekuenderera mberi nekutsvaga.

Parizvino, izvo zvinozivikanwa ndezvekuti vanhu vane hutachiona hwehutachiona hwekuzvimiririra vanogona kuve nemaviri kana mashanu mukana wekuvandudza chirwere chemuviri sevanhu vasina hutachiona.

Boka remagen'a anobatanidzwa anonzi histocompatibility complex, inozivikanwa seHLA. HLA yakasiyana mumunhu wese.

A genetic predisposition to autoimmunity inogona kumhanya mumhuri, asi nhengo dzemhuri dzinogona kukura dzakasiyana autoimmune kusagadzikana. Zvakare, kana iwe uine autoimmune kusagadzikana, une mukana wepamusoro wekutora imwe.

Iko kune zvishoma zvinozivikanwa nezve chaiwo maratidziro ezvemamiriro ekunze ayo anokonzeresa autoimmune chirwere mune mumwe munhu ane chibodzwa chinotungamira kune autoimmunity.

Zvakajairika autoimmune mamiriro

Heano mamwe eanowanzoitika autoimmune kusagadzikana:

• chirwere ichi (a reaction to gluten)
• mhando 1 chirwere cheshuga
• kuzvimba ura, kusanganisira Crohn's
• lupus (systemic lupus erythematosus, iyo inobata ganda, itsvo, majoini, huropi uye dzimwe nhengo)
• rheumatoid arthritis (kuzvimba kwemajoini)
• Sjögren's syndrome (kuoma mumuromo mako, maziso, uye dzimwe nzvimbo)
• vitiligo (kurasikirwa kweganda pigment, iyo inokonzeresa machena mavara)

Psoriasis sechirwere chemuviri

Ruzhinji rwemasayendisiti nhasi vanotenda kuti psoriasis chirwere chemuviri. Yakagara ichizivikanwa kuti immune system inobatanidzwa mu psoriasis. Asi iyo chaiyo michina haina chokwadi.

Mumakumi maviri emakore apfuura, kutsvagisa kwakaratidza kuti magene nemageneti mapoka ane hukama ne psoriasis anogoverwa neanozivikanwa autoimmune kusagadzikana. Tsvagiridzo yakagadzawo kuti immunosuppressant madhiragi anoshanda matsva ekurapa psoriasis. Iyi mishonga inoshanda nekudzvinyirira immune system iri kurwisa hutano hwakanaka.

Kutsvagurudza kuri kuenderera mberi pamusoro pebasa remasero ezvirwere zvemuviri eT mu psoriasis. T maseru ndiwo "masoja" ezvirwere zvemuviri izvo zvinowanzo kurwisa hutachiona. Kana masero eT achirwadzisa uye pachinzvimbo achirwisa ganda rine hutano, anoburitsa mapuroteni akakosha anonzi cytokines. Izvi zvinokonzeresa kuti maseru eganda awande uye agadzire pamusoro peganda rako, zvichikonzera maronda eoriori.

Chinyorwa cha2017 chakataura pamusoro pekutsvaga kutsva kwakaratidza kudyidzana kwemamwe masero eT uye maelekiniki atozivikanwa kuti ave nechekuita nekuvandudzwa kweporiyo. Sekuwedzera kujekerwa kunozivikanwa, zvinogona kuve zvinogoneka kuvandudza mishonga mitsva yakanangwa.

Mishonga inotarisa immune system

Kurapa kwe psoriasis kunoenderana nerudzi uye kuomarara kwemamiriro acho, hutano hwako hwese, nezvimwe zvinhu.

Heano marapirwo akasiyana siyana anotarisa chaiwo mafomu mu immune system ayo anokonzera kuzvimba. Izvi zvinowanzo shandiswa kana ako psoriasis zviratidzo zviri pakati nepakati zvakanyanya. Ziva kuti mishonga mitsva inodhura.

Mishonga yekare

Mishonga miviri yakura inoshandiswa kudzora immune system uye yakajeka psoriasis zviratidzo ndeye methotrexate uye cyclosporine. Izvi zvese zvinoshanda, asi zvine chepfu mhedzisiro kana zvichishandiswa kwenguva refu.

Biologics

TNF vanopikisa

Chimwe chinodonhedza zvinodhaka chinokonzeresa kuzvimba kunodaidzwa kuti tumor necrosis factor (TNF). TNF cytokine inogadzirwa ne immune system zvikamu senge T masero. Iyi mishonga mitsva inonzi vanopesana neTNF.

Anti-TNF zvinodhaka zvinoshanda, asi zvishoma pane zvitsva biologics. TNF antagonist zvinodhaka zvinosanganisira:

• adalimumab (Humira)
• etanercept (Enbrel)
• infliximab (Remicade)
• certolizumab pegol (Cimzia)

Nyowani biologics

Zvimwe zvenguva pfupi yapfuura biologics tarisa uye vharira chaiyo T cell uye interleukin nzira dzinobatanidzwa mupsoriasis. Zvitatu biologics zvinotarisa IL-17 zvakagamuchirwa kubvira 2015:

• secukinumab (Cosentyx)
• ixekizumab (Taltz)
• brodalumab (Siliq)

Mimwe mishonga inotarisira kuvhara imwe nzira ye interleukin (I-23 uye IL-12):

• ustekinuman (Stelara) (IL-23 uye IL-12)
• guselkumab (Tremfya) (IL-23)
• Tildrakizumab-asmn (Ilumya) (IL-23)
• risankizumab-rzaa (Skyrizi) (IL-23)

Aya biologics aratidzira kuve akachengeteka uye anoshanda.

Psoriasis uye njodzi kune mamwe mamiriro e autoimmune

Kuva nechirwere chimwechete chemuviri senge psoriasis kunokuisa iwe kuti uwedzere chimwe chirwere chemuviri. Njodzi inowedzerwa kana yako psoriasis yakanyanyisa.

Iwo mapoka emajini anokufungidzira kuti uve ne autoimmune kusagadzikana akafanana pamhando dzakasiyana dzezvirwere zvemuviri. Mimwe yemaitiro ekuzvimba uye zvakatipoteredza zvinhu zvakafanana.

Matambudziko makuru e autoimmune ane hukama ne psoriasis ndeaya:

• psoriatic arthritis, iyo inobata makumi matatu kusvika makumi matatu kubva muzana yevanhu vane arthritis
• rheumatoid arthritis
• chirwere ichi
• Chirwere cheCrohn nezvimwe zvirwere zvemudumbu
• multiple sclerosis
• lupus (systemic lupus erythematosus kana SLE)
• autoimmune chirwere chetachiona
• Sjögren's chirwere
• autoimmune kurasikirwa kwebvudzi (alopecia areata)
• zvinotyisa pemphigoid

Iyo ine psoriasis ine rheumatoid arthritis.

Hukama hwe psoriasis kune zvimwe autoimmune hosha inyaya yekuenderera mberi kudzidza. Zvakare kuri kufundwa kusangana kwe psoriasis pamwe uye neakakwira kufa mwero kubva kune izvo zvirwere.

Maonero

Maonero evanhu vane psoriasis akanaka kwazvo. Mamiriro acho haakwanise kurapwa, asi kurapa kwazvino kunogona kazhinji kuchengetedza zviratidzo pasi pesimba.

Kutsvagisa kwekurapa kuri kuenderera mberi nekuwana zvimwe zvakanangana nezve izvo zvinokonzeresa psoriasis uye zvimwe autoimmune kusagadzikana. Izvi zvitsva zvinowanikwa zvino zvinobatsira mukugadzirwa kwemishonga mitsva iyo inonanga nekuvhara nzira dzezvirwere.

Semuenzaniso, akati wandei mimwe mishonga mitsva yakanangana ne interleukin-23 yava mumakiriniki ekuedzwa. Dzimwe nzira nyowani dzinogona kubuda mukutsvagisa kuri kuenderera kumatambudziko e autoimmune kazhinji.

Taura nachiremba wako nezve kutora chikamu mumakiriniki ari kuenderera mberi uye nezve zviitiko zvitsva. Iwe unogona zvakare kuda kujoina online psoriasis / PsA rutsigiro boka.