Munyori: Louise Ward
Zuva Rekusika: 6 Kukadzi 2021
Gadziridza Zuva: 14 Kukadzi 2025
Anonim
Neulasta (Pegfilgrastim) Injection
Vhidhiyo: Neulasta (Pegfilgrastim) Injection

Zvemukati

Chii chinonzi Neulasta?

Neulasta izita-zita mushonga mushonga. Iyo FDA-inogamuchirwa kune inotevera *:

  • Kuderedza njodzi yehutachiona nekuda kwechimiro chinonzi febrile neutropenia muvanhu vane cancer isiri-myeloid. Kuti ushandise Neulasta, unofanirwa kunge uchitora mushonga unorwisa kenza uyo unogona kukonzera febrile neutropenia (yakaderera masero eropa machena anonzi neutrophils).
  • Kurapa chirwere che radiation. Rudzi rwechirwere chemwaranzi icho Neulasta inoshandiswa nacho chinonzi hematopoietic subsyndrome.

Neulasta kirasi yemishonga uye mafomu

Neulasta ine chinhu chinoshanda chinodhaka: pegfilgrastim. Neulasta ndeyekirasi yezvinodhaka inonzi leukocyte kukura zvinhu. Kirasi yezvinodhaka iboka remishonga inoshanda nenzira yakafanana.

Neulasta inouya nenzira mbiri. Imwe yeti-imwe dhizaini yakasarudzwa. Iyi fomu inopihwa zuva mushure mekunge iwe uine chemotherapy seyakadzika jekiseni (jekiseni pasi peganda rako).

Mubatsiri wezvehutano anokupa jekiseni reNeulasta, kana kuti unogona kuzvipa jekiseni kumba mushure mekudzidziswa. Iyo sirinji inowanikwa mune rimwe simba: 6 mg / 0.6 mL.


Fomu rechipiri rinodaidzwa kuti Neulasta Onpro, inova in-body injector (OBI). Anopa hutano anozoishandisa padumbu rako kana kumashure kweruoko rwako musi iwoyo waunogamuchira chemotherapy.

Neulasta Onpro anounza muyero wemushonga rinenge zuva mushure mekunge OBI yaiswa. Izvi zvinoreva kuti haufanire kudzokera kuhofisi yechiremba wako kujekiseni. Neulasta Onpro inowanikwa mune rimwe simba: 6 mg / 0.6 mL.

Ongorora: Ipo syringe yeNeulasta inogona kushandiswa kurapa mamiriro ese ari maviri akanyorwa pamusoro, Neulasta Onpro haina kushandiswa kurapa radiation radiation.

Kubudirira

Kuti uwane ruzivo nezve kushanda kweNeulasta, ona iyo "Neulasta inoshandisa" chikamu pazasi.

Neulasta generic kana biosimilar

Neulasta inowanikwa sezita-zita mushonga. Neulasta ine matatu biosimilar vhezheni: Fulphila, Udenyca, uye Ziextenzo.

Biosimilar imushonga wakafanana nemushonga-wezita mushonga. Chigadzirwa chakajairwa, kune rumwe rutivi, ndiyo chaiyo kopi yechinhu chinoshanda mumushonga wezita-zita.


Biosimilars yakavakirwa pane biologic zvinodhaka, izvo zvakagadzirwa kubva kune zvikamu zvezvinhu zvipenyu. Mageneral akavakirwa pamishonga yenguva dzose inogadzirwa kubva kumakemikari. Biosimilars uye generic zvakare inowanzo kuita isingasviki pane yechiratidzo-zita zvinodhaka.

Neulasta ine chinhu chinoshanda chinodhaka: pegfilgrastim. Izvi zvinoreva kuti pegfilgrastim ndicho chinongedzo chinoita kuti Neulasta ishande.

Neulasta mhedzisiro

Neulasta inogona kukonzera munyoro kana zvakakomba mhedzisiro. Aya anotevera mazita ane zvimwe zvakakosha mhedzisiro mhedzisiro inogona kuitika uchitora Neulasta. Aya mazita haabatanidzi zvese zvinokanganisa mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvinogona kuitika mhedzisiro yeNeulasta, taura nachiremba wako kana wemishonga. Ivo vanogona kukupa iwe matipi ekuti ungatarise sei nechero mhedzisiro mhedzisiro inogona kunetsa.

Ongorora: Chikafu neDrug Administration (FDA) inoteedzera mhedzisiro yemishonga yavakagamuchira. Kana iwe uchida kuzivisa kune iyo FDA mhedzisiro mhedzisiro iwe yawakave nayo neNeulasta, unogona kuzviita kuburikidza neMedWatch.


Hunyoro mhedzisiro

Iyo mhedzisiro mhedzisiro yeNeulasta inogona kusanganisira:

  • kurwadziwa kwepfupa (rumwe ruzivo mu "Side maitiro ruzivo" pazasi)
  • kurwadziwa mumaoko ako kana makumbo

Mazhinji emhedzisiro iyi anogona kuenda mukati memazuva mashoma kana vhiki dzinoverengeka. Asi kana vakawedzera kuomarara kana kuti vasingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Yakakomba mhedzisiro kubva kuNeulasta haina kujairika, asi inogona kuitika. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une emergency emergency.

Matambudziko akakomba uye zviratidzo zvavo zvinogona kusanganisira:

  • Aortitis (kuzvimba kweaorta, tsinga huru yemoyo). Zviratidzo zvinogona kusanganisira:
    • kurwadziwa shure
    • malaise (kunzwa kwekusagadzikana kana kusagadzikana)
    • kupindwa nechando
    • kurwadziwa mudumbu

Mimwe mhedzisiro yakakomba mhedzisiro, yakatsanangurwa zvakadzama pazasi mu "Side athari ruzivo," inosanganisira:

  • neutachiona
  • acute kufema kunetseka syndrome (rudzi rwemapapu mamiriro)
  • capillary leak syndrome (mamiriro umo mitsipa yeropa shoma inodonha)
  • glomerulonephritis (boka reitsvo mamiriro)
  • leukocytosis (yakawedzera mwero wemasero machena eropa anonzi maleukocyte)
  • rupture spleen (kuvhurwa kwenhengo inonzi spleen)

Rutivi mhedzisiro mhedzisiro

Unogona kushamisika kuti kangani mamwe maratidziro anoitika nemushonga uyu. Heano mamwe marondedzero pane mamwe emhedzisiro mhedzisiro inogona kuitika pamwe neNeulasta kupfura kana chigamba.

Allergic reaction

Sezvo nemishonga yakawanda, vamwe vanhu vanogona kuita zvinopesana nehutachiona mushure mekutora Neulasta. Hazvizivikanwe kuti vangani vanhu vaive neanogadzirisa maitiro kuna Neulasta mumakiriniki ekuedzwa. Asi maitiro mazhinji akaitika muvanhu vakagamuchira muyero weNeulasta kekutanga.

Uye kune vamwe vanhu, maitiro acho akaitikazve mazuva akatevera, mushure mekumiswa kwemushonga wekusagadzikana. Acrylic yekunamatira inoshandiswa neNeulasta pa-muviri injekita (OBI) uye inogona kukonzeresa kusagadzikana kana mumwe munhu aine allergiki kune zvinonamatira.

Zviratidzo zvehunhu husina kugadzikana hunogona kusanganisira:

  • kuputika kweganda
  • kuvava
  • kuburitsa (kudziya uye kutsvuka mukati meganda rako)

Imwe yakanyanya kukonzeresa kusagadzikana isingawanzo asi inogoneka. Zviratidzo zveakanyanya kusagadzikana maitiro zvinogona kusanganisira:

  • kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka
  • kuzvimba kwerurimi rwako, muromo, kana huro
  • kunetseka kufema

Dana chiremba wako ipapo kana iwe uine chirwere chakakomba cheNeulasta. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une emergency emergency.

Kurwadziwa kwepfupa

Kutambudzika kwepfupa kunowanzoitika mhedzisiro yeNeulasta. Mune zvidzidzo zvemakiriniki, 31% yevanhu vakatora Neulasta vakarondedzera kurwadziwa kwepfupa kana zvichienzaniswa ne26% yevanhu vakatora placebo (kurapwa pasina mushonga unoshanda).

Hazvizivikanwe chaizvo kuti nei Neulasta inokonzeresa kurwadziwa kwemapfupa mune vamwe vanhu. Imwe dzidziso inosanganisira histamine, protein inogadzirwa nema immune system kubatsira kurwisa hutachiona.

Neulasta inokurudzira immune system yako mukugadzira akawanda machena maseru eropa, ayo anotungamira kune yakawanda histamine inogadzirwa. Uye kuburitswa kwe histamine kwakabatanidzwa nemabhonzo ekuzvimba uye kurwadziwa. Asi kumwe kutsvagurudza kunodiwa kusati kwazivikanwa zvechokwadi kuti nei Neulasta ichikonzera kurwadziwa kwepfupa.

Kana iwe uine kurwadziwa kwepfupa uchishandisa Neulasta, udza chiremba wako. Vanogona kupa mushonga wekurwadziwa, senge ibuprofen kana naproxen. Kana ivo vanogona kukuchinjira iwe kune mumwe mushonga asiri Neulasta.

Acute kufema kunetseka syndrome (ARDS)

Acute kufema kunetseka syndrome (ARDS) inogona kuitika mhedzisiro yeNeulasta, asi haiwanzo kuitika. ARDS haina kutaurwa panguva yekiriniki miedzo yemushonga, asi mamiriro acho akataurwa mune vashoma vanhu vanotora Neulasta kubvira payakauya pamusika.

NeARDS, mapapu ako anozadzwa nemvura uye haagone kuendesa okisijeni yakakwana kune ese muviri wako. Izvi zvinogona kutungamira kune mamwe matambudziko emapapu senge pneumonia kana hutachiona.

Zviratidzo zveARDS zvinogona kusanganisira:

  • kuvhiringidzika
  • yakaoma, yekukosora kukosora
  • kunzwa kupera simba
  • kupindwa nechando
  • yakaderera BP

ARDS ndiyo inogona kutyisidzira hupenyu inoda kurapwa nekukurumidza. Kana iwe uri kutora Neulasta uye uchinetseka kufema, kukurumidza kufema kwekufema, kana kupfupika kwekufema, fonera 911 kana kuenda kuimba yekukurumidzira.

Capillary leak chirwere

Capillary leak syndrome isingawanzo asi yakakomba mhedzisiro mhedzisiro yeNeulasta. Hazvizivikanwe zvechokwadi kuti kangani zvakaitika muzvidzidzo zvekiriniki.

MaCapillaries madiki eropa tsinga. Capillary leak syndrome inoitika apo mvura uye mapuroteni anokwanisa kubuda kubva mum capillaries uye kupinda mumativi epanyama. Izvi zvinogona kukonzera yakaderera BP uye hypoalbuminemia (yakaderera maseru eprotein yakakosha inonzi albumin).

Zviratidzo zve capillary leak syndrome zvinogona kusanganisira:

  • edema (bloating uye fluid kuchengetedza)
  • manyoka
  • kuneta (kushaya simba)
  • kunzwa nyota zvakanyanya
  • kusvotwa
  • kurwadziwa mudumbu

Sezvambotaurwa pamusoro apa, capillary leak syndrome isingawanzoitika, asi inogona kuuraya. Saka kana iwe uchifunga kuti une zviratidzo zve capillary leak syndrome paunenge uchitora Neulasta, fonera 911 kana kuenda kuimba yekukurumidzira.

Glomerulonephritis

Kunyangwe glomerulonephritis isina kutaurwa muzvidzidzo zvekiriniki zveNeulasta, zvakataurwa muvanhu vakatora mushonga uyu kubva pawakauya pamusika.

Glomerulonephritis inoreva kuzvimba (kuzvimba) kweiyo glomeruli, ayo ari masumbu eropa mutsvo dzako. Glomeruli inobatsira kusefa marara zvigadzirwa kubva muropa rako uye kuapfuudza kuita weti.

Zviratidzo zve glomerulonephritis zvinogona kusanganisira:

  • kuzvimba uye kuzvimba nekuda kwekuchengetwa kwemvura, kunyanya kumeso, tsoka, maoko, kana dumbu
  • BP
  • weti inenge yakaita pink kana kuti brown brown muvara
  • weti inotaridzika kunge furo

Kana iwe uchifunga kuti une glomerulonephritis uchitora Neulasta, udza chiremba wako. Ivo vanogona kudzikisa yako dosi, iyo inowanzo gadzira kumusoro glomerulonephritis. Asi kana izvo zvikasashanda, chiremba wako anogona kunge akarega kutora Neulasta. Ivo vanogona kunge iwe uchiedza imwe mishonga pachinzvimbo.

Leukocytosis

Leukocytosis isingawanzo asi inogona kuve yakakomba mhedzisiro mhedzisiro yeNeulasta.

Mune kiriniki zvidzidzo, leukocytosis yakaitika mune isingasviki 1% yevanhu vakatora mushonga. Neulasta yakafananidzwa ne placebo, asi hazvizivikanwe kuti kana leukocytosis yakaitika sei kuvanhu vakatora placebo. Hapana zvinetswa zvine chekuita neleukocytosis zvakataurwa mune izvi zvidzidzo.

Leukocytosis mamiriro umo mwero wemasero machena eropa anonzi maleukocyte akakwirira kupfuura zvakajairwa. Izvi kazhinji chiratidzo chekuti muviri wako uri kuyedza kurwisa hutachiona. Nekudaro, leukocytosis inogona zvakare kuve chiratidzo cheleukemia (kenza inokanganisa mwongo wefupa kana ropa).

Zviratidzo zveleukocytosis zvinogona kusanganisira:

  • kubuda ropa kana kupwanya
  • kufema matambudziko sekufema
  • kupindwa nechando

Nekuti iwe uri pane yakanyanya njodzi yehutachiona uchitora Neulasta, udza chiremba wako ipapo kana iwe ukava nefivha kana zvimwe zviratidzo zveleukocytosis. Ivo vanozobatsira kuona chikonzero uye kurapwa kupi kwakakukodzera.

Ruptured spleen

Iyo yakawedzera spleen uye rakaputika spleen hazvina kutaurwa mumakiriniki miedzo yeNeulasta. Nekudaro, aya mamiriro akataurwa mune vanhu vakatora Neulasta kubva pakauya mushonga pamusika.

Iyo spleen inhengo iri kumusoro kwekuruboshwe kwedumbu rako, pasi pembabvu dzako. Inoshanda kusefa ropa uye kurwisa hutachiona.

Zviratidzo zvekuputswa kwepleen zvinogona kusanganisira:

  • kuvhiringidzika
  • kunzwa kunetseka kana kusagadzikana
  • musoro wakareruka
  • kusvotwa
  • kurwadziwa kunzvimbo yekumusoro kuruboshwe kwedumbu
  • ganda rakachenuruka
  • kurwadziwa kwepafudzi

Yakaputika spleen hupenyu hunotyisidzira hupenyu hunoda kurapwa nekukurumidza. Kana iwe uri kutora Neulasta uye uine marwadzo mubendekete rako rekuruboshwe kana kumusoro kuruboshwe dumbu nzvimbo, udza chiremba wako ipapo ipapo.

Fivha (kwete divi mhedzisiro)

Fivha haisi inotarisirwa divi mhedzisiro yekutora Neulasta.

Kukudziridza fivhiri panguva yako yeNeulasta kurapwa kunogona kureva kuti une hutachiona. Fivhiri inogona zvakare kuve chiratidzo cheasingawanzo asi zvakakomba mhedzisiro yeNeulasta, senge acute yekufema kushungurudzika chirwere (ARDS), aortitis, kana leukocytosis. (Kuti uwane zvakawanda nezve ARDS uye leukocytosis, ona izvo zvikamu pazasi.)

Kana iwe ukava nefivhiri uchitora Neulasta, udza chiremba wako ipapo ipapo. Vanogona kubatsira kuona kuti chii chiri kukonzera fivha yako uye nzira yakanakisa yekurapa.

Neulasta chipimo chemushonga

Iyo Neulasta muyero unorayirwa nachiremba wako inoenderana nezvakawanda zvinhu. Izvi zvinosanganisira:

  • mhando uye kuomarara kwechimiro chauri kushandisa Neulasta kurapa
  • zera rako
  • chimiro cheNeulasta chaunotora
  • mamwe marapirwo aungave uine

Kazhinji, chiremba wako anokutanga iwe pane yakaderera dosi. Ipapo vanobva vazvigadzirisa nekufamba kwenguva kuti vasvike pahuwandu hwakakodzera iwe. Chiremba wako anozopedzisira agadza dosi diki iyo inopa zvaunoda.

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe. Chiremba wako achasarudza yakanakisa dosi kuti ikwane zvaunoda.

Mafomu emishonga uye simba

Neulasta inouya nenzira mbiri. Imwe yeti-imwe dhizaini yakasarudzwa. Iyi fomu inopihwa zuva mushure mekunge iwe uine chemotherapy seyakadzika jekiseni (jekiseni pasi peganda rako).

Mubatsiri wezvehutano anokupa jekiseni reNeulasta, kana kuti unogona kuzvipa jekiseni kumba mushure mekudzidziswa. Iyo sirinji inowanikwa mune rimwe simba: 6 mg / 0.6 mL.

Fomu rechipiri rinodaidzwa kuti Neulasta Onpro, inova in-body injector (OBI). Anopa hutano anozoishandisa padumbu rako kana kumashure kweruoko rwako musi iwoyo waunogamuchira chemotherapy.

Neulasta Onpro anounza muyero wemushonga rinenge zuva mushure mekunge OBI yaiswa. Izvi zvinoreva kuti haufanire kudzokera kuhofisi yechiremba wako kujekiseni. Neulasta Onpro inowanikwa mune rimwe simba: 6 mg / 0.6 mL.

Izvo zvakakosha kuti uzive kuti Neulasta Onpro haina kushandiswa kurapa radiation radiation.

Chipimo chemushonga wekudzivirira hutachiona panguva yekemotherapy

Nekudzivirira hutachiona panguva yekemotherapy, Neulasta inopihwa seyero imwechete kamwechete chemotherapy kutenderera. Dozi imwe chete ingave jekiseni rimwe chete nesirinji kana kushandiswa kweimwe Neulasta Onpro.

Iwe haufanire kushandisa Neulasta kana mazuva gumi nemana pamberi kana 24 maawa mushure mekuita chemotherapy.

Chipimo chemushonga we radiation

Nekurapa hematopoietic subsyndrome yeacute radiation syndrome (radiation radiation), Neulasta inopihwa semadosi maviri. Muchava navo 1 vhiki vakaparadzana. Dozi imwe chete jekiseni rimwe nesirinji.

Chiremba wevana

Neulasta inogamuchirwa kubatsira kudzivirira hutachiona muvana vanowana chemotherapy. Mushonga unobvumidzwawo kuti ushandiswe muvana vane chirwere che radiation. Iko hakuna makore-akavakirwa marambidzo ekushandisa Neulasta

NezveNeulasta dosages muvana vanorema mapaundi makumi mapfumbamwe nemapfumbamwe (45 kg), ona zvikamu zveyero pamusoro.

Dosages yevana vanorema isingasviki 99 pondo (45 kg) yakavakirwa pahuremu. Chiremba wemwana wako anozoona kuti chii Neulasta chipimo chakaringana kumwana wako.

Ko kana ndikapotsa dosi?

Ukatadza kuzvipa jekiseni reNeulasta ine sirinji, danaidza chiremba wako paunongoona izvi. Vanogona kukuraira iwe paunotora dosi yako.

Kana iwe ukarasikirwa musangano weiyo Neulasta jekiseni, fonera hofisi yechiremba wako. Vashandi vanogona kukugadzirisazve uye kugadzirisa nguva yekushanya mune ramangwana, kana zvichidikanwa.

Izvo zvakare zvinokwanisika kupotsa dosi iwe uchishandisa Neulasta Onpro. Izvi zvinodaro nekuti iyo-yemuviri injector dzimwe nguva inogona kutadza kushanda kana kudonha. Kana izvi zvikaitika, danaidza hofisi yechiremba wako ipapo. Vashandi vacharonga nguva yekuti iwe uuye kuzobayiwa jekiseni reNeulasta kuti ugamuchire dosi rako rakazara.

Kuti ubatsire kuve nechokwadi chekuti hauzorasikirwa nemushonga, edza kuseta chiyeuchidzo pafoni yako. Iwe unogona zvakare kunyora yako chirongwa chekurapa mukarenda.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Neulasta inofanirwa kushandiswa seyakareba kurapwa, chero bedzi iwe uri kugamuchira chemotherapy. Kana iwe nachiremba wako mukaona kuti Neulasta yakachengeteka uye inoshanda kwauri, unogona kuitora kwenguva refu.

Mibvunzo yakajairika nezveNeulasta

Heano mhinduro kumimwe inowanzo bvunzwa mibvunzo nezve Neulasta.

Claritin angandibatsire here kugadzirisa mhedzisiro yeNeulasta?

Pamwe. Neulasta inoshanda nekukonzeresa immune system yako kuti iite mamwe machena maseru eropa.

Mamwe mapuroteni anonzi histamines anosunungurwa neichi chiitiko. Hazvinyatso kuzivikanwa kuti nei kuburitswa kwe histamines kuchikonzera kumhedzisiro senge kurwadziwa kwepfupa. Asi kutsvagurudza kwakaratidza kuti histamine inosanganisirwa nekuzvimba, iyo inogona kukonzera kurwadziwa.

Claritin mushonga we antihistamine. Inoshanda nekudzivirira chiito che histamine. Nokuita kudaro, Claritin anogona kubatsira kudzikisa marwadzo emapfupa muvanhu vanotora Neulasta, asi kumwe kutsvagurudza kunodiwa.

Kana iwe uri kutora Neulasta uye uine kurwadziwa kwepfupa, taura nachiremba wako. Vanogona kuongorora marapirwo aripo uye nekubatsira kuona kuti ndeupi wakanakira iwe.

Inguva yakareba sei mhedzisiro yemhedzisiro yeNeulasta bara yekupedzisira?

Hazvizivikanwe nekuti hapana rakaringana dhata rekuti yakareba sei mhedzisiro mhedzisiro yeNeulasta bara yakapedzisira.

Mune zvidzidzo zvemakiriniki, vamwe vanhu vakataura kurwadziwa kwepfupa kana kurwadziwa mumaoko avo kana makumbo mushure mekugamuchira Neulasta. Asi vaongorori havana kunyora kuti mhedzisiro yakatora nguva yakareba sei.

Kuti uwane rumwe ruzivo nezve zvinogona kuitika mhedzisiro yeNeulasta, ndapota tarisa kune "Neulasta mhedzisiro" chikamu pamusoro. Iwe unogona zvakare kusvika kune wako chiremba.

Inguva yakareba sei Neulasta anogara mune yako system?

Nguva yacho inogona kusiyana. Zvidzidzo zvekiriniki zvakaratidza kuti kujekesa Neulasta kubva mumuviri kunokanganiswa nehuremu hwemuviri wako uye nhamba yema neutrophils (rudzi rwechena reropa) iripo muropa rako.

Kazhinji, mushure mejekiseni rimwe chete, Neulasta inobviswa zvachose kubva kune yako system mukati memazuva gumi nemana.

Pandinenge ndichibhururuka, ndinofanira here kuudza kuchengetedzeka panhandare kuti ndine Neulasta Onpro?

Ehe. Mugadziri weNeulasta ane kadhi yekuzivisa Yekufambisa Kwekufambisa (TSA) iwe yaunogona kuprinda nekupa kune vanochengetedza panhandare. Dzvanya apa kuti uwane kadhi.

Nekudaro, zvinokurudzirwa kuti urege kufamba (kusanganisira kutyaira) panguva ye26- kusvika 29-awa hwindo mushure mekutambira Neulasta Onpro. Chigadzirwa chiri kuendesa mushonga mumuviri wako panguva ino. Uye kufamba kunogona kuwedzera njodzi yeNeulasta Onpro kugogodzwa kubva pamuviri wako.

Kana iwe uine mibvunzo nezve yako Neulasta kurapwa paunenge uchifamba, taura nachiremba wako.

Nei ndichifanira kuchengeta Neulasta Onpro kure nemaserura uye zvimwe zvigadzirwa zvemagetsi?

Zviratidzo zvinobva kumagetsi aya zvinogona kukanganisa Neulasta Onpro uye nekuzvichengeta kubva pakupa dosi rako.

Zvinokurudzirwa kuti uchengetedze Neulasta Onpro angangoita 4 inches kubva kumagetsi emagetsi, anosanganisira nharembozha nema microwaves.

Kana iwe uine mibvunzo nezve kushandisa Neulasta Onpro, bvunza chiremba wako.

Ini ndinofanira kurasa sei Neulasta Onpro?

Mushure mekunge magamuchira yako yakazara dosi yeNeulasta uchishandisa Neulasta Onpro, iwe unofanirwa kurasa mudziyo nekuiisa mumudziyo weSharps.

Mugadziri weNeulasta ane chirongwa cheSharps Disposal Container Chirongwa chekukubatsira kurasa zvakachengeteka Neulasta Onpro. Izvi zvinopihwa pasina mumwe muripo kwauri. Unogona kudzvanya apa kusaina chirongwa ichi (ona iyo "Injector Disposal Program" chikamu), kana kufona 1-844-696-3852.

Neulasta anoshandisa

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai saNeulasta kurapa mamwe mamiriro. Neulasta inogona zvakare kushandiswa kure-chitaridzi kune mamwe mamiriro. Kunze-chitambi kushandiswa ndiko kana mushonga unobvumidzwa kurapa imwechete mamiriro unoshandiswa kurapa imwe mamiriro.

Neulasta yekudzivirira hutachiona panguva yekemotherapy

Chemotherapy mhando yekenza kurapwa iyo inoshandisa mishonga kuuraya inoparadzanisa cancer maseru. Izvi zvinobatsira kudzivirira cancer kubva mukukura nekupararira.

Zvisinei, chemotherapy haisi yakananga yekenza masero. Chemotherapy zvakare inoparadza mamwe masero anopatsanura mumuviri, kusanganisira masero anobatsira senge machena masero eropa.

Neutropenia chirwere cheropa umo neti neutrophil inodzikira. Neutrophils imhando yeropa chena reropa rinodzivirira muviri wako kubva kuhutachiona. Kana yako neutrophil mazinga ari pasi, muviri wako haugone kunyatsorwisa mabhakitiriya. Saka kuva neutropenia kunowedzera mukana wako wehutachiona.

Febrile neutropenia inoitika kana uine neutropenia uye uchikura fever, inova chiratidzo chehutachiona. Uye kuva neutropenia zvinoreva kuti haugone kurwisa hutachiona pamwe chete senguva dzose. Saka febrile neutropenia chiitiko chakakomba icho chiremba anofanira kutarisa ipapo ipapo.

Zvinoitwa naNeulasta

Neulasta inoshandiswa kubatsira kudzivirira hutachiona muvanhu vane mamwe kanzira vari kugamuchira chemotherapy. Iyo kanzuru inonzi isina-myeloid cancer, isingabatanidze mwongo wemapfupa (iwo munyama uri mukati memabhonzo anoita masero eropa). Muenzaniso wekenza isiri-myeloid kenza yemazamu.

Neulasta inobatsira iwe mukugadzira akawanda neutrophils uye mamwe machena masero eropa. Izvi zvinobatsira muviri wako kuve wakagadzirira kwazvo kurwisa hutachiona, kubatsira kudzivirira febrile neutropenia, uye kupfupisa kuti une neutropenia kwenguva yakareba sei.

Kubudirira

Mune zvidzidzo zvemakiriniki, Neulasta yakaratidzirwa kudzikisa zvese njodzi yefebrile neutropenia uye kuti mamiriro acho anogara kwenguva yakareba sei kuvanhu vanoigadzira.

Imwe ongororo yakafananidza Neulasta ne filgrastim (Neupogen), unova mumwe mushonga unoratidzwa kubatsira kudzivirira nekubata febrile neutropenia. Vatsvagiri vaida kuona kana Neulasta yaishanda senge filgrastim pakupfupisa kuti febrile neutropenia inogara sei.

Muchidzidzo ichi, vanhu vakagamuchira chemotherapy regimen (chirongwa chekurapa) chine doxorubicin uye docetaxel mazuva ese makumi maviri nerimwe. Maitiro akafanana akabatanidzwa kune yakaoma neutropenia yakaitika mune zvese zviitiko.

Mamiriro acho akapedza mazuva mashanu kusvika kumanomwe paavhareji, uye vangangoita makumi matatu kubva muzana kusvika makumi mana muzana yevanhu vakatanga febrile neutropenia.

Vanhu vacho vakapihwa mukana wekutambira chero Neulasta kana filgrastim. Vatsvagiri vakaona kuti Neulasta yaive yakafanana inoshanda se filgrastim.

Vanhu vakagamuchira Neulasta uye vakagadzira zvakanyanya neutropenia vaive nemamiriro evhareji yemazuva 1.8. Vanhu vakagamuchira filgrastim uye vakagadzira zvakanyanya neutropenia vaive nemamiriro evhareji yemazuva 1.7.

Chidzidzo chechipiri neyakafanana setup zvakare chakawana zvakafanana mhedzisiro. Vanhu vakagamuchira Neulasta uye vakavandudza neutropenia yakaoma vaive nemamiriro evhareji yemazuva 1.7. Izvi zvakafananidzwa neavhareji yemazuva 1,6 muvanhu vakagamuchira filgrastim.

Neulasta yechirwere che radiation

Neulasta inobvumidzwawo neDFA yekurapa radiation radiation. Mamiriro acho anogona zvakare kutumidzwa seacute radiation syndrome kana radiation radiation.

Rudzi rwechirwere chemwaranzi icho Neulasta inoshandiswa nacho chinonzi hematopoietic subsyndrome. Huwandu hwekuratidzwa nemwaranzi hunokonzera iyi syndrome hunotsanangurwa se myelosuppressive, zvichireva kuti vanotungamira mapfupa ako kuita masero eropa mashoma.

Kurwara nemwaranzi kunoitika kana munhu achinge aoneswa mwero we radiation kwenguva pfupi pfupi yenguva (kazhinji maminetsi mashoma). Kuwedzera kwema radiation kunogona kuuraya maseru mumuviri wako. Kurwara kwemwaranzi kunogona kuuraya kana kusvibiswa nemwaranzi kwakanyanya zvakakwana.

Nezvikonzero zvetsika, vaongorori havana kukwanisa kuyedza kugona kwaNeulasta kwekurapa chirwere che radiation mune vanhu. Pane kudaro, mushonga uyu wakabvumidzwa kurapa radiation radiation zvichibva pane zvidzidzo zvemhuka, kuwedzera kune iyo data yakataurwa mu "Neulasta yekudzivirira hutachiona panguva yekemotherapy" chikamu chiri pamusoro.

Ongorora: Neulasta Onpro (iyo Neulasta pa-muviri injector) haifanire kushandiswa kurapa chirwere che radiation.

Kunze-chitaridzi kunoshandiswa kweNeulasta

Pamusoro pekushandisa kwakanyorwa pamusoro, Neulasta inogona kushandiswa kure-chitambi mune zvimwe zviitiko. Kunze-chitambi kushandiswa kwemishonga ndiko apo mushonga unobvumidzwa kushandiswa kumwe chete uchishandiswa kune wakasiyana uyo usingatenderwe.

Post-hematopoietic masero anochinja

Neulasta haisi FDA-inogamuchirwa kushandiswa post-hematopoietic cell transplant (HCT). Nekudaro, mushonga unogona kushandiswa kure-chitaridzi nekuda kwechinangwa ichi.

HCT inzira inoitwa mushure mekunge waita chemotherapy. Kamwe chemotherapy painoshandiswa kuuraya cancer maseru, masero emidzi anoiswa kwauri panguva yeHCT. Izvi zvinoitwa nekuti chemotherapy haingorwisi cancer maseru. Iyo inogona zvakare kuuraya maseru emadziro akagadzirwa nefupa rako.

Masero emashizha anowanzove maplatelet (masero eropa anobatsira ropa rako kugwamba), masero matsvuku eropa, uye masero machena eropa, izvo zvese zvakakosha kuti urambe uri mupenyu.

Kana HCT ikapihwa kune vanhu vane kenza yeropa, hutachiona hunogona kuitika. Izvi zvinodaro nekuti iwo maseru matsva haana kunyatsoita zvakanaka mushure mekuisirwa.

Kushandisa Neulasta mushure meHCT inobatsira muviri wako kugadzira maseru machena eropa, kusanganisira neutrophils. Chiyero chine neutrophils chinobatsira muviri wako kurwisa hutachiona zvirinani.

Kubudirira

Kunyangwe Neulasta isiri FDA-inogamuchirwa kuti ishandiswe mushure meHCT, zvidzidzo zvemakiriniki zvakaratidza kuti mushonga uyu unoshanda mukushandisa uku.

Imwe ongororo yakafananidza Neulasta nemushonga wakafanana, filgrastim (Neupogen), inova FDA-inogamuchirwa kuti ishandiswe mushure meHCT. Neulasta inopihwa senge jekiseni rimwe chete, nepo filgrastim ichipihwa majekiseni akawanda mumazuva akati wandei.

Muchidzidzo ichi, vanhu gumi nevana vasina Hodgkin lymphoma, myeloma yakawanda, kana amyloidosis vakagamuchira Neulasta mushure mekuve neHCT.

Vatsvagidzi vakafananidza zvawanikwa nevanhu ava nemhedzisiro yevanhu vakagamuchira filgrastim munguva yakapfuura. Izvi zvinoreva kuti pakange pasina boka re placebo (kurapwa pasina mushonga unoshanda).

Vatsvakurudzi vakaona kuti zvakatora avhareji yemazuva gumi nerimwe kuti neutrophils idzokere kumatunhu akachengeteka muvanhu vakagamuchira Neulasta. Mukuenzanisa, zvakatora avhareji yemazuva gumi nemana kune vanhu vakatora filgrastim munguva yakapfuura.

Kana iwe uine mibvunzo nezve kutora Neulasta mushure meHCT, taura nachiremba wako.

Neulasta nevana

Neulasta inogamuchirwa kubatsira kudzivirira hutachiona muvana vanowana chemotherapy. Mushonga unobvumidzwawo kuti ushandiswe muvana vane chirwere che radiation. Iko hakuna makore-akavakirwa marambidzo ekushandisa Neulasta

Neulasta shandisa nemimwe mishonga

Neulasta inowanzo shandiswa nemamwe madhiragi. Izvi zvinodaro nekuti Neulasta inongova chikamu chimwe chete chekenza kurapwa chirongwa (chirongwa).

Neulasta inowanzo shandiswa nekemotherapy nekuti Neulasta inobatsira kudzivirira kana kurapa mhedzisiro yemakemikari.

Inowanzo shandiswa chemotherapy mishonga inosanganisira:

  • bleomycin
  • carboplatin
  • cyclophosphamide
  • docetaxel (Mutero)
  • doxorubicin (Doxil)
  • gemcitabine (Gemzar)
  • paclanyre

Ramba uchifunga kuti ichi hachisi chinyorwa chakazara chemotherapy mishonga. Taura nachiremba wako kana iwe uine mibvunzo nezve chero chemotherapy mishonga uye kuti Neulasta ingakubatsira here.

Dzimwe nzira kuNeulasta

Mimwe mishonga iripo inogona kurapa mamiriro ako. Zvimwe zvinogona kunge zviri nani kwauri kune vamwe. Kana iwe uchifarira kutsvaga imwe nzira yeNeulasta, taura nachiremba wako. Vanogona kukuudza nezvemimwe mishonga inogona kukushandira zvakanaka.

Tarira: Mimwe yemishonga yakanyorwa pazasi inoshandiswa off-label kurapa aya chaiwo mamiriro. Kunze-chitambi kushandiswa ndiko kana mushonga unobvumidzwa kurapa imwechete mamiriro unoshandiswa kurapa imwe mamiriro.

Dzimwe nzira dzekudzivirira hutachiona panguva yekemotherapy

Mienzaniso yemimwe mishonga inogona kushandiswa kubatsira kudzivirira hutachiona panguva yekemotherapy inosanganisira:

  • tbo-filgrastim (Granix)
  • pegfilgrastim (Fulphila)
  • sargramostim (Leukine)
  • filgrastim (Neupogen)
  • filgrastim-aafi (Nivestym)
  • pegfilgrastim-cbqv (Udenyca)
  • filgrastim-sndz (Zarxio)
  • pegfilgrastim-bmez (Ziextenzo)

Dzimwe nzira dzekurwara nemwaranzi

Mienzaniso yemamwe madhiragi ayo anogona kushandiswa kurapa radiation radiation inosanganisira:

  • tbo-filgrastim (Granix)
  • potassium iodide
  • Prussian bhuruu
  • pegfilgrastim (Fulphila)
  • filgrastim (Neupogen)
  • filgrastim-aafi (Nivestym)
  • pegfilgrastim-cbqv (Udenyca)
  • filgrastim-sndz (Zarxio)
  • pegfilgrastim-bmez (Ziextenzo)

Neulasta vs. Granix

Unogona kushamisika kuti Neulasta inofananidzwa sei nemimwe mishonga inorayirwa kushandiswa kwakafanana. Pano tinotarisa kuti Neulasta naGranix vakafanana uye vakasiyana sei.

Zvinoshandiswa

Neulasta ine mushonga unoshanda pegfilgrastim. Granix ine chinodhaka chinoshanda tbo-filgrastim.

Zvese pegfilgrastim uye tbo-filgrastim ndezvekirasi yemishonga inozivikanwa segranulocyte-koloni inokurudzira zvinhu (G-CSFs). Kirasi yemishonga iboka remishonga inoshanda nenzira yakafanana.

G-CSF imushonga unokonzeresa neutrophils (rudzi rwechena ropa maseru) kukura mumafupa ako. Bone marora chiuno chiri mukati memapfupa chinoita masero eropa. G-CSFs akagadzirwa nevanhu makopi eG-CSF mahormoni anoitwa nemuviri wako zvakasikwa.

Zvishandiso

Ose Neulasta naGranix anotenderwa neKudya neDrug Administration (FDA) kudzikisa njodzi yekutapukirwa nekuda kwechimiro chinonzi febrile neutropenia muvanhu vane gomarara risiri myeloid. kenza mushonga uyo unogona kukonzera febrile neutropenia.

Neulasta zvakare FDA-inogamuchirwa kurapa chirwere che radiation. * Rudzi rwechirwere che radiation icho Neulasta inoshandiswa nacho chinonzi hematopoietic subsyndrome.

Mafomu emishonga uye manejimendi

Heano rumwe ruzivo nezve mafomu eNeulasta naGranix uye nemabatirwo avanopihwa.

Neulasta mafomu

Neulasta inouya nenzira mbiri. Imwe yeti-imwe dhizaini yakasarudzwa. Iyi fomu inopihwa zuva mushure mekunge iwe uine chemotherapy seyakadzika jekiseni (jekiseni pasi peganda rako).

Mubatsiri wezvehutano anokupa jekiseni reNeulasta, kana kuti unogona kuzvipa jekiseni kumba mushure mekudzidziswa.

Fomu rechipiri rinodaidzwa kuti Neulasta Onpro, inova in-body injector (OBI). Anopa hutano anozoishandisa padumbu rako kana kumashure kweruoko rwako musi iwoyo waunogamuchira chemotherapy.

Neulasta Onpro anounza muyero wemushonga rinenge zuva mushure mekunge OBI yaiswa. Izvi zvinoreva kuti haufanire kudzokera kuhofisi yechiremba wako kujekiseni.

Ongorora: Neulasta Onpro haina kushandiswa kurapa radiation radiation.

Granix mafomu

Granix inouyawo nenzira mbiri: imwe-dhizaini yakasarudzwa sirinji uye imwechete-dhiza vhiza yemvura mhinduro. Mafomu ese ari maviri anogona kupihwa nemubatsiri wezvehutano sejekiseni pasi, pasi peganda rako. Asi nekumwe kudzidziswa, unogona kukwanisa kuzvipa majekiseni kumba.

Dosage frequency

Mumwe musiyano wakakosha pakati peNeulasta naGranix ndeye kangani iyo mishonga inopihwa kudzikisa njodzi yehutachiona panguva yekemotherapy.

Neulasta inopihwa kamwe chete panguva yega yega chemotherapy kutenderera. Granix, kune rimwe divi, inopihwa zuva rega rega kudzamara mazinga ema neutrophil muropa rako achidzokera pane zvakajairwa.

Side migumisiro uye njodzi

Neulasta naGranix ese ari maviri anoshandiswa kubatsira kudzivirira hutachiona panguva yekemotherapy. Naizvozvo, iyi mishonga inogona kukonzera mamwe mhedzisiro, asi mamwe akasiyana zvakare. Pazasi pane mienzaniso yemhedzisiro iyi.

Hunyoro mhedzisiro

Aya mazita ane mienzaniso yezvinyoro zvikanganiso zvinogona kuitika neNeulasta, neGranix, kana nemishonga miviri (kana inotorwa zvakasiyana).

  • Zvinogona kuitika neNeulasta:
    • mashoma akasarudzika mhedzisiro
  • Zvinogona kuitika naGranix:
    • musoro
    • tsandanyama aches
    • kurutsa
  • Zvinogona kuitika pamwe neNeulasta naGranix:
    • kurwadziwa kwepfupa
    • kurwadziwa mumaoko ako kana makumbo

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika neNeulasta, ine Granix, kana nezvose zviri zviviri zvinodhaka (kana zvichitorwa zvakasiyana).

  • Zvinogona kuitika neNeulasta:
    • mashoma akasarudzika mhedzisiro
  • Zvinogona kuitika naGranix:
    • cutaneous vasculitis (kuzvimba kwemitsipa yeropa yeganda)
    • thrombocytopenia (yakaderera maplatelet mazinga)
    • sickle cell disorders (boka rezvirwere rinokanganisa masero matsvuku eropa, kunyanya hemoglobin)
  • Zvinogona kuitika pamwe neNeulasta naGranix:
    • neutachiona
    • leukocytosis (yakawedzera mwero wemasero machena eropa)
    • rupture spleen (kuvhurwa kwenhengo inonzi spleen)
    • acute kufema kunetseka syndrome (rudzi rwemapapu mamiriro)
    • glomerulonephritis (boka reitsvo mamiriro)
    • capillary leak syndrome (mamiriro umo mitsipa yeropa shoma inodonha)
    • aortitis (kuzvimba kweaorta, iyo huru arteri yemoyo)

Kubudirira

Izvo chete zvinoshandiswa zvese Neulasta uye Granix zvakagamuchirwa kuitira kudzora njodzi yehutachiona nekuda kwechimiro chinonzi febrile neutropenia muvanhu vane cancer isiri-myeloid.

Zviparadzanisa zvakasiyana zvemishonga iyi miviri zvakaenzaniswa mune hombe ongororo yezvidzidzo zvinodaidzwa kuti systemic ongororo. Vatsvakurudzi vakatarisa dhata kubva kuongororo gumi nesere.

Vanhu vaive vatambira pegfilgrastim (chinoshanda mushonga muNeulasta), filgrastim, kana mumwe mushonga wakafanana, kusanganisira Granix. Pegfilgrastim boka raive risinganyanyo kukura febrile neutropenia uye zvishoma mukana wekuda kugara muchipatara semhedzisiro yefebrile neutropenia. Izvi zvakafananidzwa nemamwe mapoka emishonga.

Mariro

Neulasta naGranix ese ari maviri zita-zita zvinodhaka.

Neulasta ine matatu biosimilar vhezheni: Fulphila, Udenyca, uye Ziextenzo.

Granix haisi nyanzvi inofungidzirwa kuva biosimilar, maererano neDFA.

Biosimilar imushonga wakafanana nemushonga-wezita mushonga. Chigadzirwa chakajairwa, kune rumwe rutivi, ndiyo chaiyo kopi yechinhu chinoshanda mumushonga wezita-zita.

Biosimilars yakavakirwa pane biologic zvinodhaka, izvo zvakagadzirwa kubva kune zvikamu zvezvinhu zvipenyu. Mageneral akavakirwa pamishonga yenguva dzose inogadzirwa kubva kumakemikari. Biosimilars uye generic zvakare inowanzo kuita isingasviki pane yechiratidzo-zita zvinodhaka.

Zvinoenderana nekufungidzira paGoodRx.com, mitengo yeNeulasta uye Granix inozosiyana zvichienderana nedosi yako yawakatemerwa. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane hurongwa hwako hweinishuwarenzi, nzvimbo yauri, uye chemishonga yaunoshandisa.

Neulasta vs.Fulphila

SaGranix (yakurukurwa pamusoro), mushonga Fulphila anoshandisa zvakafanana neyaNeulasta. Heano kufananidzwa kwekuti Neulasta naFulphila vakafanana uye vakasiyana sei.

Zvinoshandiswa

Neulasta naFulphila zvine zvakafanana zvinoshanda mushonga, pegfilgrastim.

Nehunyanzvi, Fulphila ine chinhu chinoshanda pegfilgrastim-jmdb. Izvi zvinodaro nekuti Fulphila imhando yemushonga inozivikanwa senge biosimilar. Biosimilar imushonga wakafanana nemushonga-wezita mushonga. Biosimilars yakavakirwa pane biologic zvinodhaka, izvo zvakagadzirwa kubva kune zvikamu zvezvinhu zvipenyu.

Mune ino kesi, Neulasta ndiyo biologic drug, uye Fulphila ndiyo biosimilar yacho. Pegfilgrastim uye pegfilgrastim-jmdb ese anoshanda nenzira imwechete.

Pegfilgrastim ndeyekirasi yemishonga inozivikanwa segranulocyte-koloni inosimudzira zvinhu (G-CSFs). Kirasi yemishonga iboka remishonga inoshanda nenzira yakafanana.

G-CSF imushonga unokonzeresa neutrophils (rudzi rwechena ropa maseru) kukura mumafupa ako. Bone marora chiuno chiri mukati memapfupa chinoita masero eropa. Uye G-CSFs makopi akagadzirwa nevanhu eG-CSF mahormoni muviri wako unozvigadzira.

Zvishandiso

Neulasta naFulphila vese vanotenderwa neFood and Drug Administration (FDA) kudzikisa njodzi yekutapukirwa nekuda kwechimiro chinonzi febrile neutropenia muvanhu vane gomarara risiri myeloid. kenza mushonga uyo unogona kukonzera febrile neutropenia.

Neulasta zvakare FDA-inogamuchirwa kurapa chirwere che radiation. * Rudzi rwechirwere che radiation icho Neulasta inoshandiswa nacho chinonzi hematopoietic subsyndrome.

Fulphila haina kubvumidzwa kubatsira kufambisa masero eropa kubva mumwongo wemapfupa kuenda muropa kune hematopoietic cell transplant (HCT).

Mafomu emishonga uye manejimendi

Ose maNeulasta naFulphila anouya seyadhi-imwe yakasarudzwa sirinji. Iyi fomu inopihwa zuva mushure mekunge iwe uine chemotherapy seyakadzika jekiseni (jekiseni pasi peganda rako).

Mubatsiri wezvehutano anokupa jekiseni reNeulasta, kana kuti unogona kuzvipa jekiseni kumba mushure mekudzidziswa.

Neulasta inouyawo mune imwe fomu inonzi Neulasta Onpro, inova iyo-yemuviri injector (OBI). Anopa hutano anozoishandisa padumbu rako kana kumashure kweruoko rwako musi iwoyo waunogamuchira chemotherapy.

Neulasta Onpro anounza muyero wemushonga rinenge zuva mushure mekunge OBI yaiswa. Izvi zvinoreva kuti haufanire kudzokera kuhofisi yechiremba wako kujekiseni.

Ongorora: Neulasta Onpro haina kushandiswa kurapa radiation radiation.

Side migumisiro uye njodzi

Neulasta neFulphila zvese zvine pegfilgrastim. Naizvozvo, iyi mishonga inogona kukonzera yakafanana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Hunyoro mhedzisiro

Urongwa urwu hune mienzaniso yehuremu mhedzisiro mhedzisiro inogona kuitika neNeulasta uye Fulphila (kana ikatorwa yega):

  • kurwadziwa kwepfupa
  • kurwadziwa mumaoko ako kana makumbo

Yakakomba mhedzisiro

Urongwa urwu hune mienzaniso yemhedzisiro mhedzisiro mhedzisiro inogona kuitika neNeulasta naFulphila (kana ikatorwa yega):

  • neutachiona
  • acute kufema kunetseka syndrome (rudzi rwemapapu mamiriro)
  • aortitis (kuzvimba kweaorta, iyo huru arteri yemoyo)
  • capillary leak syndrome (mamiriro umo mitsipa yeropa shoma inodonha)
  • glomerulonephritis (boka reitsvo mamiriro)
  • leukocytosis (yakawedzera mwero wemasero machena eropa)
  • rupture spleen (kuvhurwa kwenhengo inonzi spleen)

Kubudirira

Iko chete kushandisa kweNeulasta naFulphila kunotenderwa kuri kudzora njodzi yehutachiona nekuda kwechimiro chinonzi febrile neutropenia muvanhu vane cancer isiri-myeloid.

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki, asi zvidzidzo zvakawana zvese Neulasta naFulphila kuti vabudirire pakuderedza njodzi yehutachiona nekuda kwechimiro chinonzi febrile neutropenia muvanhu vane cancer isina-myeloid.

Mariro

Zvinoenderana nekufungidzira paGoodRx.com, Neulasta inodhura zvakanyanya kupfuura Fulphila. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane hurongwa hwako hweinishuwarenzi, nzvimbo yauri, uye chemishonga yaunoshandisa.

Zvizvarwa kana biosimilars

Mazhinji madhiragi akajairika anogadzirwa nemakemikari ane mageneral generic. Chigadzirwa chakajairika ikopi chaiyo yechinhu chinoshanda mumushonga wezita-zita. Inowanzo inodhura zvishoma pane iyo brand-zita vhezheni.

Nekudaro, Neulasta naFulphila ese ari maviri zita-zita biologic mishonga, iyo inogadzirwa kubva kune zvikamu zvehupenyu zvipenyu. Panzvimbo pemagetsi, biologic zvinodhaka zvine biosimilars. Biosimilar imushonga wakafanana nemushonga webiologic.

Kufanana nemageneral, biosimilars kazhinji anodhura zvakaderera pane iyo brand-zita biologic iyo yavakatemerwa.

Neulasta ine matatu biosimilar vhezheni: Fulphila, Udenyca, uye Ziextenzo. Saka Fulphila ndeye biosimilar yeNeulasta. Kana iwe uchida kudzidza zvakawanda nezve biosimilar vhezheni yeNeulasta, kusanganisira Fulphila, taura nachiremba wako kana wemishonga.

Mashandiro anoita Neulasta

Heano rumwe ruzivo nezve izvo zvinorapwa naNeulasta uye mashandiro anoita mushonga.

Febrile neutropenia

Neulasta inobatsira kudzikisa njodzi yehutachiona nekuda kwechimiro chinonzi febrile neutropenia muvanhu vane cancer isiri-myeloid.

Neutropenia chirwere cheropa umo neti neutrophil inodzikira. Neutrophils imhando yeropa chena reropa rinodzivirira muviri wako kubva kuhutachiona. Kana yako neutrophil mazinga ari pasi, muviri wako haugone kunyatsorwisa mabhakitiriya. Saka kuva neutropenia kunowedzera mukana wako wehutachiona.

Febrile neutropenia inoitika kana uine neutropenia uye uchikura fever, inova chiratidzo chehutachiona. Uye kuva neutropenia zvinoreva kuti haugone kurwisa hutachiona pamwe chete senguva dzose. Saka febrile neutropenia chiitiko chakakomba icho chiremba anofanira kutarisa ipapo ipapo.

Gomarara risiri-myeloid kanzura isingabatanidze mwongo wemapfupa, inova nyama iri mukati memabhonzo inoita masero eropa. Muenzaniso wekenza isiri-myeloid kenza yemazamu.

Kurwara kwemwaranzi

Neulasta inoshandiswawo kurapa radiation radiation, iyo mamiriro anoitika kana iwe uchinge wakanangana neakawanda mwero we radiation. Inogona zvakare kutumidzwa seacute radiation syndrome.

Rudzi rwechirwere chemwaranzi icho Neulasta inoshandiswa nacho chinonzi hematopoietic subsyndrome. Huwandu hwekuratidzwa nemwaranzi hunokonzera iyi syndrome hunotsanangurwa se myelosuppressive, zvichireva kuti vanotungamira mapfupa ako kuita masero eropa mashoma.

Mashandiro anoita Neulasta

Granulocyte-koloni inosimudzira chinhu (G-CSF) ihormone inokonzeresa kuti neutrophils ikure mumapfupa ako.

Mushonga unoshanda muNeulasta, pegfilgrastim, ikopi inogadzirwa nevanhu yeG-CSF hormone inoitwa nemuviri wako zvakasikwa. Pegfilgrastim inoshanda nenzira imwecheteyo inoitwa neG-CSF yechisikigo.

Neulasta inobatsira iwe mukugadzira akawanda neutrophils uye mamwe machena masero eropa. Izvi zvinobatsira kuti muviri wako uve wakagadzirira kurwisa hutachiona, kudzivirira febrile neutropenia, uye kupfupisa kuti une neutropenia kwenguva yakareba sei.

Kune hematopoietic subsyndrome nekuda kwechirwere chemwaranzi, Neulasta inobatsira muviri wako kutsiva machena masero eropa ayo akaparadzwa mumongo wemapfupa nekuratidzwa nemwaranzi.

Zvinotora nguva yakareba sei kuti zvishande?

Neulasta inotanga kushanda nguva pfupi mushure mekunge yaiswa mumuviri wako. Nekudaro, zvidzidzo zvekiriniki zvinoratidza kuti zvinogona kutora vhiki imwe chete kana maviri kuti mwero we neutrophil udzokere pane zvakajairwa mushure mekutambira dosi reNeulasta uchitevera kutenderera kwemakemikari.

Neulasta uye doro

Parizvino, hapana kuzivikanwa kusangana pakati peNeulasta nedoro.

Nekudaro, doro rinogona kukanganisa mamwe machemotherapy madhiragi kana kuita kuti mhedzisiro yavo iwedzere.

Taura nachiremba wako nezvekuti doro rakachengeteka here kuti iwe unwe panguva yako yekurapa chemotherapy. (Neulasta inopihwa mushure meyadhi yekemotherapy.)

Neulasta kudyidzana

Iko hakuna kumwe kuzivikanwa kuwirirana pakati peNeulasta nemimwe mishonga, mishonga uye zvinowedzera, uye zvekudya.

Neulasta nemimwe mishonga

Hazvizivikanwe kana paine kudyidzana kwemishonga pakati peNeulasta nemimwe mishonga. Izvi zvinodaro nekuti hapana zvidzidzo zvepamutemo zvakaitwa kuti vaone kudyidzana kwezvinodhaka. Kubva pane mashandiro anoita mushonga, kusangana nemimwe mishonga hazvigoneke.

Kana iwe uine mibvunzo nezve kudyidzana kwezvinodhaka zvinogona kukukanganisa, bvunza chiremba wako kana wemishonga.

Neulasta nemishonga uye zvinowedzera

Iko hakuna chero mahebhu kana zvinowedzera izvo zvakanyatsotaurwa kuti zvinofambidzana neNeulasta. Zvisinei, iwe unofanirwa kutarisa nachiremba wako kana wemishonga usati washandisa chero chezvigadzirwa izvi paunotora Neulasta.

Neulasta uye chikafu

Iko hakuna chero chikafu chakataurwa chaizvo kuti chibatane neNeulasta. Kana iwe uine chero mibvunzo nezve kudya zvimwe zvekudya uchitora Neulasta, taura nachiremba wako.

Neulasta mutengo

Sezvo nemishonga yese, mutengo weNeulasta unogona kusiyana.

Mutengo chaiwo wauchabhadhara unoenderana nehurongwa hweinishuwarenzi, nzvimbo yauri, uye khemisi yaunoshandisa.

Izvo zvakakosha kuti uzive kuti iwe uchafanirwa kutora Neulasta pane yakasarudzika pharmacy. Rudzi urwu rwefamasi rwakagamuchirwa kutakura hunyanzvi mishonga. Iyi ndiyo mishonga inogona kudhura kana ingangoda rubatsiro kubva kuvashandi vezvehutano kuti ishandiswe zvakachengeteka uye zvinobudirira.

Yako inishuwarenzi chirongwa chinogona kuda kuti iwe uwane kumberi mvumo vasati vabvumidza kufukidzwa kweNeulasta. Izvi zvinoreva kuti chiremba wako uye kambani yeinishuwarenzi inoda kutaurirana nezve tsamba yako isati yanyorwa nekambani yeinishuwarenzi. Kambani yeinishuwarenzi ichaongorora chikumbiro ichi uye kukuzivisa iwe nachiremba wako kana chirongwa chako chichafukidza Neulasta.

Kana iwe usina chokwadi kana uchizoda kuwana mvumo yepamberi yeNeulasta, bata chirongwa chako cheinishuwarenzi.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara Neulasta, kana kana iwe uchida rubatsiro kuti unzwisise yako inishuwarenzi kufukidzwa, rubatsiro rwuripo.

Amgen Inc., iyo inogadzira Neulasta, inopa zvirongwa zvinodaidzwa kuti Amgen FIRST STEP uye Amgen Assist 360. Kuti uwane rumwe ruzivo uye kuti uzive kana iwe uchikodzera rutsigiro, fonera 888-657-8371 kana shanyira webhusaiti yechirongwa.

Shanduro yeBiosimilar

Neulasta inowanikwa mune matatu biosimilar vhezheni: Fulphila, Udenyca, uye Ziextenzo.

Biosimilar imushonga wakafanana nemushonga-wezita mushonga. Chigadzirwa chakajairwa, kune rumwe rutivi, ndiyo chaiyo kopi yechinhu chinoshanda mumushonga wezita-zita.

Biosimilars yakavakirwa pane biologic zvinodhaka, izvo zvakagadzirwa kubva kune zvikamu zvezvinhu zvipenyu. Zvigadzirwa zvinoenderana nemishonga yenguva dzose inogadzirwa nemakemikari. Biosimilars uye generic zvakare inowanzo kuita isingasviki pane yechiratidzo-zita zvinodhaka.

Kuti uone kuti mutengo weFulphila, Udenyca, uye Ziextenzo unofananidzwa sei nemutengo weNeulasta, shanyira GoodRx.com. Zvekare, mutengo waunowana paGoodRx.com ndizvo zvaunogona kubhadhara pasina inishuwarenzi. Mutengo chaiwo wauchabhadhara unoenderana nehurongwa hweinishuwarenzi, nzvimbo yauri, uye khemisi yaunoshandisa.

Kana chiremba wako akaraira Neulasta uye iwe uchifarira kushandisa Fulphila, Udenyca, uye Ziextenzo pachinzvimbo, taura nachiremba wako. Ivo vanogona kuve nesarudzo yeimwe vhezheni kana imwe yacho. Iwe zvakare unozoda kutarisa yako inishuwarenzi chirongwa, sezvo inogona kungovhara imwe kana imwe.

Maitiro ekutora Neulasta

Iwe unofanirwa kutora Neulasta zvinoenderana nachiremba wako kana rairo yemupi wezvehutano.

Nguva yekutora

Neulasta inouya nenzira mbiri. Imwe yeti-imwe dhizaini yakasarudzwa. Iyi fomu inopihwa zuva mushure mekunge iwe uine chemotherapy seyakadzika jekiseni (jekiseni pasi peganda rako). Mubatsiri wezvehutano anokupa jekiseni reNeulasta, kana kuti unogona kuzvipa jekiseni kumba mushure mekudzidziswa.

Fomu rechipiri rinonzi Neulasta Onpro. Icho chiri-chemuviri injector (OBI) icho mupi wezvehutano anozoshanda kudumbu rako kana kumashure kweruoko rwako. Vachaita izvi musi mumwe chete waunogamuchira chemotherapy.

Ipapo iyo OBI inozongoerekana yaendesa yako Neulasta dose maawa makumi maviri nemanomwe mushure mekubatanidzwa. Izvi zvinoreva kuti haufanire kudzokera kuhofisi yechiremba wako kujekiseni.

Izvo zvakakosha kuti uzive kuti Neulasta Onpro haina kushandiswa kurapa radiation radiation.

Neulasta uye nhumbu

Hazvizivikanwe kana Neulasta yakachengeteka kutora panguva yekuzvitakura.

Zvidzidzo zvakaitwa mumhuka dzine pamuviri dzakapihwa filgrastim (mushonga wakafanana naNeulasta). Vatsvagiri havana kuwana njodzi yakawedzera yekuremara kwekuzvarwa, kupererwa nemimba, kana matambudziko ehutano kumwana kana amai.

Zvisinei, zvidzidzo zvemhuka hazviwanzo kuratidza zvinoitika muvanhu. Kumwe kutsvagisa nezveNeulasta uye nhumbu inodiwa.

Kana iwe uine pamuviri kana kuronga kuva nepamuviri, taura nachiremba wako usati washandisa Neulasta. Vanogona kutsanangura njodzi pamwe nezvakanaka zvemushonga pamwe nedzimwe nzira dzekurapa.

Neulasta uye kuberekwa

Hazvizivikanwe kana Neulasta yakachengeteka kutora panguva yekuzvitakura. (Ona iyo "Neulasta uye nhumbu" chikamu chiri pamusoro kuti udzidze zvimwe.) Kana iwe uchiita bonde uye iwe kana mumwe wako muchigona kuve nepamuviri, taura nachiremba wako nezvezvido zvako zvekuberekwa paunenge uchishandisa Neulasta.

Neulasta uye kuyamwisa

Hazvizivikanwe kana zvakachengeteka kutora Neulasta uchiyamwisa.

Hatizive kana mushonga unoshanda muNeulasta, pegfilgrastim, uripo mumukaka wemukaka wemunhu.

Kana iwe uri kutora Neulasta uye uchifunga kuyamwisa, taura nachiremba wako.

Neulasta matanho

Mushonga uyu unouya pamwe nezvakawanda zvekuchengetedza. Usati watora Neulasta, taura nachiremba wako nezve nhoroondo yako yehutano. Neulasta inogona kunge isingave yakakunakira iwe kana uine mamwe marapirwo kana zvimwe zvinhu zvinokanganisa hutano hwako. Izvi zvinosanganisira:

  • Dzimwe gomarara reropa. Kana iwe uine kenza yemyeroid (kenza inosanganisira mwongo wemapfupa), haufanire kushandisa Neulasta. Iyo mishonga inogona kukonzera bundu kukura muvanhu vane mamwe maronda eropa, kunyanya myeloid cancer. Mamota imhomho yecancer tishu. Kumbira chiremba wako kuti ndeapi mamwe marapirwo angave sarudzo dziri nani kwauri.
  • Sickle cell kusagadzikana. Kutora Neulasta paunenge uine jeko maseru kusagadzikana kunogona kukonzera jeko maseru dambudziko, iro rinogona kuuraya. (Ichi chirwere chinokanganisa hemoglobin, iyo inowanikwa mumasero matsvuku eropa.) Kana iwe uine chirwere chekenza masero, taura nachiremba wako usati washandisa Neulasta. Vanogona kukurudzira nzira dzakanakisa dzekurapa iwe.
  • Allergy kune acrylics. Kana iwe uri weergisi kune acrylic adhesives, haufanire kushandisa Neulasta Onpro, iyo Neulasta iri-muviri injekiseni. Chigadzirwa chacho chinoshandisa acrylic adhesive. Kumbira chiremba wako kana iyo Neulasta yakatemwa sirinji isarudzo yakanaka kwauri.
  • Allergy kune latex. Kana iwe uine latex allergies, haufanire kushandisa Neulasta preilled majekiseni. Tsono chivharo pamajekiseni acho ane rabhora rechisikigo rakatorwa murabhora. Kumbira chiremba wako kana iyo Neulasta Onpro pane-muviri injector iri sarudzo yakanaka kwauri.
  • Allergy kuNeulasta. Kana iwe uri weergoria kuNeulasta kana chero zvigadzirwa zvacho, haufanire kushandisa mushonga. Kumbira chiremba wako nezve dzimwe nzira dzokurapa.
  • Kubata. Hazvizivikanwe kana Neulasta yakachengeteka kushandisa panguva yekuzvitakura. Kuti uwane rumwe ruzivo, ndapota ona iyo "Neulasta uye nhumbu" chikamu chiri pamusoro.
  • Kuyamwisa. Hazvizivikanwe kana zvakachengeteka kutora Neulasta uchiyamwisa. Kuti uwane rumwe ruzivo, ndapota ona iyo "Neulasta uye kuyamwisa" chikamu chiri pamusoro.

Ongorora: Kuti uwane rumwe ruzivo nezve zvingangoitika zvakaipa zveNeulasta, ona iyo "Neulasta mhedzisiro" chikamu pamusoro.

Neulasta ovhadhozi

Kushandisa kupfuura yakadomerwa dosi yeNeulasta kunogona kutungamira kune zvakakomba mhedzisiro.

Ovhadhozi zviratidzo

Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

  • bloating uye fluid chengetedzo
  • kurwadziwa kwepfupa
  • mweya wekufema
  • pleural effusion (mvura inovaka yakatenderedza mapapu)

Zvekuita kana ovhadhozi

Kana iwe uchifunga kuti watora zvakawandisa zvemushonga uyu, fonera chiremba wako. Iwe unogona zvakare kufonera iyo American Association yePoison Control Centres pa800-222-1222 kana kushandisa yavo yepamhepo chishandiso. Asi kana zviratidzo zvako zvakakomba, fonera 911 kana kuenda kukamuri yepedyo yevanokurumidza ipapo.

Neulasta kupera, kuchengetedza, uye kurasa

Paunowana Neulasta kubva kukhemisi, wemishonga anowedzera zuva rekupera kune zvakanyorwa pabhokisi kana mukatoni. Zuva iri rinowanzo kuve gore rimwe kubva pazuva ravakapa mushonga.

Zuva rekupera rinobatsira kuvimbisa kuti mushonga unoshanda panguva ino. Chimiro chazvino cheKudya neDrug Administration (FDA) ndechekudzivirira kushandisa akapera mishonga.

Kana iwe usina kushandisa mishonga yakapfuura nguva yekupera, taura nachiremba wako nezvekuti ungangokwanisa kuishandisa.

Kuchengetedza

Inguva yakareba sei mushonga unoramba wakanaka unogona zvinoenderana nezvinhu zvakawanda, zvinosanganisira kuti unochengetera mushonga kupi uye kupi.

Iwe unofanirwa kuchengeta maNeulasta akafuridzirwa majekiseni mufiriji (36 ° F kusvika 46 ° F / 2 ° C kusvika 8 ° C). Usavagadzire. Asi kana ivo vakaita chando, rega majekiseni asvike mufiriji usati waashandisa. Kana sirinji yapindwa nechando kanopfuura kamwe chete, chirase.

Iwe unofanirwa zvakare kurasa majekiseni chero awakachengeta pane tembiricha yemukati kwenguva yakareba kupfuura maawa makumi mana nemasere. Chekupedzisira, usambozunungusa majekiseni eNeulasta.

Kubvisa

Heano rumwe ruzivo rwekuti ungarase sei maNeulasta akasarudzika majekiseni uye Neulasta Onpro.

Neulasta akasarudza majekiseni

Pakarepo mushure mekunge washandisa sirinji yakasarudzika yeNeulasta, irase mumudziyo unobvumidzwa neFAFA-unobvumidzwa. Izvi zvinobatsira kudzivirira vamwe, kusanganisira vana nezvipfuyo, kubva pakutora mushonga netsaona kana kuzvikuvadza netsono.

Unogona kutenga mudziyo unopinza online, kana kubvunza chiremba wako, wemishonga, kana kambani yeinishuwarenzi yehutano kupi kwaunowana.

Ichi chinyorwa chinopa akati wandei matipi anobatsira pakuraswa kwemishonga. Iwe unogona zvakare kubvunza wako wemishonga kuti uwane ruzivo rwekuti ungarase sei majekiseni ako.

Neulasta Onpro

Kana iwe ukashandisa Neulasta Onpro, kune yakakosha kurasa mirairo. Mushure mekugashira yako yakazara dosi, iwe unofanirwa kuisa Neulasta Onpro mumudziyo unopinza.

Mugadziri weNeulasta Onpro ane Sharps Disposal Container Chirongwa chekukubatsira kurasa zvakachengeteka Neulasta Onpro. Izvi zvinopihwa pasina mumwe muripo kwauri. Unogona kudzvanya apa kusaina chirongwa ichi, kana kufonera 844-696-3852.

Ruzivo rwehunyanzvi rweNeulasta

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Zviratidzo

Neulasta inoratidzirwa yekudzora hutachiona hutachiona muvarwere vane asiri-myeloid malignancies ari kurapwa ne myelosuppressive anti-cancer kurapwa iyo inokonzeresa febrile neutropenia.

Neulasta inobvumidzwawo kuwedzera kupona muvanhu vane hematopoietic subsyndrome yeacute radiation syndrome (radiation radiation).

Nzira yekuita

Chinhu chinoshanda muNeulasta, pegfilgrastim, inogadzira koloni-inosimudzira chinhu. Iyo inosunga kune zvinogamuchirwa pane sero pamusoro pe hematopoietic maseru, zvichikonzera kuwanda kwavo, kusiyanisa, uye kumisikidza. Izvi zvinoguma nekuwedzera kwemhedzisiro neutrophil kuverenga (ANC).

Pharmacokinetics uye metabolism

Iyo serum hafu-yeupenyu yeNeulasta mushure mematanho epasi pehutongi ari pakati pe15 kusvika 80 maawa.

Varwere vane huremu hwepamusoro hwemuviri vakasangana neakakwira systemic kuratidzwa kuNeulasta mumakiriniki miedzo, ichiratidza kukosha kwekutevera uremu-hwakavakirwa dosing kurudziro yakapihwa nemugadziri.

Kunyangwe hazvo mugadziri asingape ruzivo rwakanangana nezvefarmacokinetic maringe nehurefu hwekuita, zvidzidzo zvemakiriniki zvakaratidza kuti ANC inotora mazuva angangosvika gumi kusvika gumi nemana kubva pazuva remakemikari manejimendi kudzoka kumatanho akajairwa apo Neulasta inopihwa zuva rinotevera chemotherapy.

Neulasta yepamusoro yevasungwa

Mushure mekutungamira kwepasi pega, peul yeNeulasta kuwanda kunoitika kutenderera 16 kusvika kuma120 maawa post-dose.

Contraindications

Neulasta inopesana nevarwere vane nhoroondo yeakakomba eergizia maitiro kune pegfilgrastim kana filgrastim.

Kuchengetedza

Neulasta majekiseni akafanirwa anofanira kuiswa mufiriji pakati pe36 ° F uye 46 ° F (2 ° C uye 8 ° C). Majekiseni acho anofanirwa kuchengetwa mukatoni yepakutanga kudzivirira kubva pachiedza. Sirinji dzakasiiwa patembiricha yemukati kwenguva yakareba kupfuura maawa makumi mana nemasere dzinofanirwa kuraswa.

Usaisa chando majekiseni. Asi kana majekiseni acho akaomeswa nechando, zvidzivirire mufiriji usati waishandisa. Rasa majekiseni api neapi akaomeswa nechando kanopfuura kamwe chete.

Neulasta Onpro kits inofanirwa kuve firiji pakati pe36 ° F uye 46 ° F (2 ° C uye 8 ° C) kusvika maminetsi makumi matatu usati waishandisa. Usachengetedze makiti pane tembiricha yemukati kweanopfuura maawa gumi nemaviri usati waashandisa. Kana iwo makiti akachengetwa mukamuri tembiricha kwenguva yakareba kupfuura maawa gumi nemaviri, urase.

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.

Positi Dzakakurumbira

Hove tapeworm hutachiona
Mushonga

Hove tapeworm hutachiona

Hove tapeworm hutachiona hutachiona hwemukati nehutachiona hunowanikwa muhove.Hove tapeworm (Diphyllobothrium latum) ndiye hutachiona hukuru hunobata vanhu. Vanhu vanotapukirwa pavanodya hove dzemumvu...
Arformoterol Oral Kufema
Mushonga

Arformoterol Oral Kufema

Arformoterol inhalation ino handi wa kudzora kufema, kufema, kuko ora, uye kuome a pachipfuva kunokonzerwa nechirwere chi ingaperi chi ingapindike chemapapu (COPD; boka rezvirwere zvemapapu, zvino ang...