Munyori: Laura McKinney
Zuva Rekusika: 4 Kubvumbi 2021
Gadziridza Zuva: 16 Chivabvu 2024
Anonim
All About Ninlaro (Ixazomib)
Vhidhiyo: All About Ninlaro (Ixazomib)

Zvemukati

Chii chinonzi Ninlaro?

Ninlaro izita rezita rekushandisa mishonga yekurapa yakawanda myeloma muvanhu vakuru. Aya mamiriro imhando isingawanzo kenza inobata mamwe machena masero eropa anonzi plasma masero. Iine akawanda myeloma, akajairwa maseru eplasma anova nekenza uye anonzi myeloma maseru.

Ninlaro inogamuchirwa kuti ishandiswe muvanhu vakatoyedza imwe chete kurapwa kweiyo yakawanda myeloma. Uku kurapa kunogona kuve mushonga kana maitiro.

Ninlaro ndeyekirasi yemishonga inonzi proteasome inhibitors. Iyo inotarisirwa kurapwa kweakawanda myeloma. Ninlaro zvinangwa (zvinoshanda pa) puroteni yakati mukati memasero emyeloma. Iyo inogadzira kuwanda kweprotein mumasero e myeloma, izvo zvinoita kuti iwo maseru afe.

Ninlaro inouya semacapsule anotorwa nemuromo. Iwe uchatora Ninlaro nemimwe miviri yakawanda myeloma mishonga: lenalidomide (Revlimid) uye dexamethasone (Decadron).

Kubudirira

Munguva yezvidzidzo, Ninlaro akawedzera kureba kwenguva yakagara vamwe vanhu vane myeloma yakawanda vasina chirwere chavo chichienderera mberi (ichiwedzera kuwedzera). Iyi yakareba yenguva inodaidzwa kufambira mberi-isina kupona.


Imwe kiriniki yekudzidza yakatarisa vanhu vane multiple myeloma avo vanga vatoshandisa imwe imwe kurapwa kwechirwere chavo. Vanhu vakapatsanurwa kuita mapoka maviri. Boka rekutanga rakapihwa Ninlaro neese lenalidomide uye dexamethasone. Boka rechipiri rakapihwa placebo (kurapwa pasina chinoshanda mushonga) neese lenalidomide uye dexamethasone.

Vanhu vakatora mubatanidzwa weNinlaro vakararama paavhareji yemwedzi makumi maviri nemakumi matanhatu vasati vaenda myeloma yakawanda. Vanhu vanotora musanganiswa we placebo vakararama avhareji yemwedzi 14.7 vasati vawanda myeloma yakafambira mberi.

Pakati pevanhu vakatora mubatanidzwa weNinlaro, 78% vakapindura pakurapwa. Izvi zvinoreva kuti vaive neinenge 50% yekuvandudza mumabvunzo avo erabhoritari aitsvaga masero emyeloma. Mune avo vakatora musanganiswa we placebo, 72% yevanhu vakapindura zvakafanana pakurapwa.

Ninlaro generic

Ninlaro inowanikwa chete sezita-zita remishonga. Haisi ikozvino inowanikwa mune generic fomu.

Ninlaro ine chinhu chinoshanda chinodhaka: ixazomib.


Ninlaro mhedzisiro

Ninlaro inogona kukonzera mhedzisiro kana yakakomba mhedzisiro. Aya anotevera mazita ane zvimwe zvakakosha mhedzisiro zvinogona kuitika uchitora Ninlaro. Aya mazita haabatanidzi ese anogona kuitika mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvinogona kuitika mhedzisiro yaNinlaro, taura nachiremba wako kana wemishonga. Ivo vanogona kukupa iwe matipi ekuti ungatarise sei nechero mhedzisiro mhedzisiro inogona kunetsa.

Zvakajairika mhedzisiro

Iyo yakajairika mhedzisiro mhedzisiro yeNinlaro inogona kusanganisira:

  • kurwadziwa shure
  • kusaona zvakanaka
  • maziso akaoma
  • conjunctivitis (inonziwo pink maziso)
  • shingles (herpes zoster virus), iyo inokonzeresa kurwadza kunorwadza
  • neutropenia (yakadzika chena masero eropa), izvo zvinogona kuwedzera njodzi yako yezvirwere

Mazhinji emhedzisiro iyi anogona kuenda mukati memazuva mashoma kana vhiki dzinoverengeka. Kana vakanyanya kuoma kana kuti vasingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Yakakomba mhedzisiro mhedzisiro inogona zvakare kuve yakajairika naNinlaro. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.


Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

  • Peripheral neuropathy (kukuvara kumitsipa yako). Zviratidzo zvinogona kusanganisira:
    • kurira kana kutsva
    • chiveve
    • kurwadziwa
    • kushaya simba mumaoko ako kana makumbo
  • Kuita kwakanyanya kweganda. Zviratidzo zvinogona kusanganisira:
    • kuputika kweganda nemapundu akatsvuka kuti piriviri (anonzi Sweet's syndrome)
    • kuputika kweganda nenzvimbo dzekupura uye maronda mukati memuromo wako (anonzi Stevens-Johnson syndrome)
  • Peripheral edema (kuzvimba). Zviratidzo zvinogona kusanganisira:
    • kuzvimba makumbo, tsoka, makumbo, maoko, kana maoko
    • kurema kuwedzera
  • Kukuvara kwechiropa. Zviratidzo zvinogona kusanganisira:
    • jaundice (yero yeganda rako kana machena emaziso ako)
    • kurwadziwa kurudyi kwedumbu rako repamusoro (dumbu)

Mimwe mhedzisiro yakakomba mhedzisiro, iyo inotsanangurwa zvakanyanya muchikamu che "Side effect details" pazasi, inogona kusanganisira:

  • thrombocytopenia (yakaderera maplatelet mazinga)
  • matambudziko ekugaya senge manyoka, kuzvimbirwa, kusvotwa, uye kurutsa

Rutivi mhedzisiro mhedzisiro

Unogona kushamisika kuti kangani mamwe maratidziro anoitika nemushonga uyu. Heano mamwe marondedzero pane mamwe emhedzisiro mhedzisiro iyi inogona kukonzera.

Thrombocytopenia

Iwe unogona kunge uine thrombocytopenia (yakaderera platelet level) paunenge uchitora Ninlaro. Iyi ndiyo yaive yakajairika mhedzisiro yeNinlaro panguva yekiriniki yekudzidza.

Munguva yezvidzidzo, vanhu vakapatsanurwa kuita mapoka maviri. Boka rekutanga rakapihwa Ninlaro neese lenalidomide uye dexamethasone. Boka rechipiri rakapihwa placebo (kurapwa pasina chinoshanda mushonga) neese lenalidomide uye dexamethasone.

Pakati peavo vanotora mubatanidzwa weNinlaro, 78% yevanhu vaive nezvikamu zvakaderera zvemaplatelet. Kune avo vakatora musanganiswa we placebo, 54% vaive nemazinga eplatelet mashoma.

Muzvidzidzo, vamwe vanhu vaida kuisirwa platelet kurapa kwavo thrombocytopenia. Nekuiswa kweplatelet, iwe unogashira maplatelet kubva kumupi kana kubva kune wako muviri (kana maplatelet akaunganidzwa kare). Pakati pevanhu vanotora mubatanidzwa weNinlaro, 6% yaida kuwedzerwa platelet. Pakati pevanhu vanotora musanganiswa we placebo, 5% yaida kuwedzerwa platelet.

Maplatelet anoshanda mumuviri wako kumisa kubuda kweropa nekubatsira kugadzira kuwanda kweropa. Kana yako platelet level ikave yakanyanya kuderera, unogona kunge uine kubuda ropa kwakakomba Paunenge uchitora Ninlaro, iwe uchafanirwa kuongororwa ropa nguva dzose kuti uone maplatelet ako mazinga.

Fonera chiremba wako ipapo kana uine chimwe chezviratidzo izvi zvepasi peplatelet mazinga:

  • kukuvadza zviri nyore
  • kubuda ropa kazhinji kazhinji kupfuura kuita (sekuve nemhino kana kubuda ropa kubva pamazino ako)

Kana yako platelet level ikave yakanyanya kuderera, chiremba wako anogona kudzikisira muyero weNinlaro kana kukurudzira kuwedzerwa kweplatelet. Ivo vanogona kutokumbira iwe kuti mira kutora Ninlaro kwechinguva.

Zvinetso zvekudya

Unogona kusangana nematambudziko nedumbu rako kana ura paunenge uchitora Ninlaro. Munguva yekiriniki zvidzidzo zvemushonga, vanhu vaiwanzo kuve nematambudziko ekugaya.

Muzvidzidzo, vanhu vakapatsanurwa kuita mapoka maviri. Boka rekutanga rakapihwa Ninlaro neese lenalidomide uye dexamethasone. Boka rechipiri rakapihwa placebo (kurapwa pasina chinoshanda mushonga) neese lenalidomide uye dexamethasone. Iyi inotevera mhedzisiro yakataurwa muzvidzidzo:

  • manyoka, akaitika mu 42% yevanhu vanotora Ninlaro mubatanidzwa (uye mu36% yevanhu vanotora mubatanidzwa we placebo)
  • kuvimbiswa, kwakaitika mu34% yevanhu vanotora Ninlaro mubatanidzwa (uye mu25% yevanhu vanotora mubatanidzwa we placebo)
  • kushungurudza, kwakaitika mu26% yevanhu vanotora Ninlaro mubatanidzwa (uye mu21% yevanhu vanotora mubatanidzwa we placebo)
  • kurutsa, kwakaitika mu22% yevanhu vanotora Ninlaro mubatanidzwa (uye mu11% yevanhu vanotora mubatanidzwa we placebo)

Kugadzirisa matambudziko ekugaya

Izvo zvakakosha kuti utaure nachiremba wako nezve maitiro ekugadzirisa aya matambudziko. Zvikasadaro, ivo vanogona kuve vakaomarara.

Nausea uye kurutsa zvinowanzo dzivirirwa kana kurapwa nekutora mimwe mishonga. Kunze kwekutora mishonga, pane zvimwe zvinhu zvaunogona kuita kana uchinzwa kusvotwa. Dzimwe nguva zvinobatsira kudya zvidiki zvechikafu kakawanda, pachinzvimbo chekudya kudya kukuru katatu zuva rega rega. IAmerican Cancer Society inopa mamwe akati wandei matipi ekubatsira kudzikisira kusvotwa.

Dhairrhea inogona kurapwa nemimwe mishonga, yakadai se loperamide (Imodium). Uye kana uine manyoka, ita shuwa kuti uri kunwa mvura zhinji. Izvi zvinokubatsira kuti usadzivirire kushomeka (kana muviri wako uine yakaderera mvura yakawanda).

Iwe unogona kubatsira kudzivirira kupatirwa nekunwa mvura zhinji, kudya zvine fiber yakawanda, uye kuita zvinyoro nyoro (sekufamba).

Kana matambudziko ako ekugaya akanyanya, chiremba wako anogona kudzikisira muyero weNinlaro. Ivo vanogona kutokukumbira iwe kuti urege kutora mushonga kwechinguva.

Shingles

Iwe unogona kuve nenjodzi yakawedzera yekuvandudza shingles (herpes zoster) paunenge uchitora Ninlaro. Shingles kuputika kweganda kunokonzera kupisa maronda uye maronda anoputika. Izvo zvakataurwa muvanhu vanotora Ninlaro panguva yekiriniki yekudzidza.

Vatori vechikamu vakakamurwa kuita mapoka maviri. Boka rekutanga rakapihwa Ninlaro neese lenalidomide uye dexamethasone. Boka rechipiri rakapihwa placebo (kurapwa pasina chinoshanda mushonga) neese lenalidomide uye dexamethasone.

Munguva yezvidzidzo, shingles yakataurwa mu4% yevanhu vanotora mubatanidzwa weNinlaro. Pakati peavo vanotora musanganiswa we placebo, 2% yevanhu vaive neshingi.

Iwe unogona kukudziridza shingles kana iwe wakambove nehukuku munguva yakapfuura. Shingles inoitika kana hutachiona hunokonzera chickenpox hwomukazve (flares up) mukati memuviri wako. Izvi zvinogona kuitika kana immune system yako isiri kushanda sezvazvinowanzoita, izvo zvinowanzoitika kune vanhu vane myeloma yakawanda.

Kana iwe wakambove nehukuku munguva yakapfuura uye urikushandisa Ninlaro, chiremba wako anogona kukunyorera mushonga wehutachiona kuti utore paunenge uchishandisa Ninlaro. Mushonga wehutachiona unobatsira kudzivirira shingles kubva mukukura mumuviri wako.

Ninlaro muyero

Iyo Ninlaro muyero unorayirwa nachiremba wako zvinoenderana nezvakawanda zvinhu. Izvi zvinosanganisira:

  • chiropa chako neitsvo zviri kushanda sei
  • kana uine mamwe mhedzisiro kubva kune yako Ninlaro kurapwa

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda.

Mafomu emishonga uye simba

Ninlaro inouya semuromo macapsule anowanikwa mune matatu masimba: 2.3 mg, 3 mg, uye 4 mg.

Dosage yeakawanda myeloma

Iyo yakajairwa yekutanga dosi yeNinlaro ndeyeimwe 4-mg capsule inotorwa kamwe pasvondo kwevhiki nhatu. Izvi zvinoteverwa nevhiki rimwe chete rekusatora mushonga. Iwe unodzokorora ino-ina-vhiki kutenderera kazhinji sekurudzira kwachiremba wako.

Panguva yekurapa, iwe unofanirwa kutora Ninlaro capsule pazuva rimwe chete vhiki imwe neimwe. Zvakanakisisa kutora Ninlaro panguva dzakatenderedza nguva yakafanana yezuva rega rega. Iwe unofanirwa kutora Ninlaro pane isina chinhu mudumbu, kweinenge awa imwe usati wadya kana angangoita maawa maviri iwe uchinge wadya.

Iwe uchatora Ninlaro pamwe chete nemimwe miviri yakawanda myeloma mishonga: lenalidomide (Revlimid) uye dexamethasone (Decadron). Iyi mishonga ine zvirongwa zvakasiyana zve dosing kupfuura zvinoita Ninlaro. Ive neshuwa yekutevera mirawo mirau yakapihwa nachiremba wako kune yega yeaya madhiragi.

Zvakanakisa kuve neyako dhesiki purogiramu yakanyorwa pasi pachati kana pakarenda. Izvi zvinokubatsira iwe kuti uzive mishonga yese yaunoda kutora uye chaizvo paunenge uchifanira kuinwa. Ipfungwa yakanaka kutarisa wega wega wega mushure mekutora.

Kana iwe uine matambudziko nechiropa chako kana itsvo, chiremba wako anogona kukurudzira kuti utore dosi yakaderera yeNinlaro. Chiremba wako anogona zvakare kudzikisa dosi yako kana kukumbira iwe kuti utore nguva kubva pakurapwa kana iwe ukawana mamwe mhedzisiro kubva kumushonga (senge yakaderera platelet nhanho). Nguva dzose tora Ninlaro chaizvo sekurairwa nachiremba wako.

Ko kana ndikapotsa dosi?

Kana iwe ukakanganwa kutora muyero weNinlaro, tevera iyi mirairo.

  • Kana paine maawa makumi manomwe nemaviri kana anopfuura kusvikira dosi yako inotevera yakwana, tora yako yawakarasa ipapo ipapo. Ipapo, tora yako inotevera dosi yeNinlaro panguva yakajairwa nguva.
  • Kana paine asingasviki maawa makumi manomwe nemaviri kusvikira dosi yako inotevera yakwana, ingosvetuka iro rakarasika dosi. Tora yako inotevera dosi yeNinlaro panguva yakajairwa nguva.

Usambofa wakatora inopfuura imwechete dhizaini yeNinlaro kuti uwane muripo wakarasika. Kuita izvi kunogona kuwedzera njodzi yako yemhedzisiro.

Kuti ubatsire kuve nechokwadi chekuti hauzorasikirwa nemushonga, edza kuseta chiyeuchidzo pafoni yako. Nguva yekurapa inogona kubatsira zvakare.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Ninlaro inofanirwa kushandiswa seyakareba kurapwa. Kana iwe nachiremba wako mukaona kuti Ninlaro yakachengeteka uye inoshanda kwauri, unogona kuitora kwenguva refu.

Dzimwe nzira kuna Ninlaro

Mimwe mishonga iripo inogona kurapa akawanda myeloma. Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira yaNinlaro, taura nachiremba wako. Vanogona kukuudza nezvemimwe mishonga inogona kukushandira zvakanaka.

Mienzaniso yemamwe madhiragi ayo anogona kushandiswa kurapa akawanda myeloma anosanganisira:

  • mamwe mishonga yemakemikari, akadai se:
    • cyclophosphamide (Cytoxan)
    • doxorubicin (Doxil)
    • melphalan (Alkeran)
  • mamwe corticosteroids, akadai se:
    • dexamethasone (Decadron)
  • mamwe maemunomodulatory Therapies (zvinodhaka zvinoshanda nema immune system), akadai se:
    • lenalidomide (Revlimid)
    • pomalidomide (Pomalyst)
    • thalidomide (Thalomid)
  • mamwe marapirwo akanangwa, akadai se:
    • bortezomib (Velcade)
    • carfilzomib (Kyprolis)
    • daratumumab (Darzalex)
    • elotuzumab (Empliciti)
    • panobinostat (Farydak)

Ninlaro vs. Velcade

Unogona kushamisika kuti Ninlaro anofananidzwa sei nemimwe mishonga inorayirwa kushandiswa kwakafanana. Pano tinotarisa kuti Ninlaro neVelcade vakafanana uye vakasiyana sei.

About

Ninlaro ine ixazomib, nepo Velcade iine bortezomib. Iyi mishonga iri mbiri yakanangwa ekurapa kweakawanda myeloma. Ivo ndevekirasi yemishonga inonzi proteasome inhibitors. Ninlaro uye Velcade vanoshanda zvakafanana nenzira mukati memuviri wako.

Zvishandiso

Ninlaro FDA-inogamuchirwa kurapa:

  • Multiple myeloma muvakuru vakatoyedza imwe kana imwe kurapwa kwechirwere chavo. Ninlaro inoshandiswa pamwe chete nelenalidomide (Revlimid) uye dexamethasone (Decadron).

Velcade is FDA-inogamuchirwa kurapa:

  • akawanda myeloma muvakuru avo:
    • havana kunge vaine imwe nzira yekurapa chirwere chavo; kune vanhu ava, Velcade inoshandiswa musanganiswa ne melphalan uye prednisone
    • une myeloma yakawanda yakadzokazve (kudzoka) mushure mekurapwa kwakapfuura
    • mantle cell lymphoma (kenza yeiyo lymph nodes) muvanhu vakuru

Mafomu emishonga uye manejimendi

Ninlaro inouya semacapsule anotorwa nemuromo. Iwe unowanzo tora kapisi imwe vhiki imwe neimwe kwevhiki nhatu. Izvi zvinotevera vhiki imwe chete vasingatore mushonga. Iyi ina-vhiki kutenderera inodzokororwa kakawanda sezvakakurudzirwa nachiremba wako.

Velcade inouya semhinduro yemvura inopihwa jekiseni. Inopihwa seimwe jekiseni pasi peganda rako (jekiseni rinotsvedza) kana jekiseni mumutsipa wako (jekiseni rinopinda mukati). Iwe uchagamuchira kurapwa uku kuhofisi yechiremba wako.

Yako dosing purogiramu yeVelcade ichasiyana zvichienderana nemamiriro ako ezvinhu:

  • Kana myeloma yako yakawanda isati yamborapwa kare, ungangoshandisa Velcade kwerinenge gore. Iwe unowanzo tevera matatu-vhiki yekurapa kutenderera. Iwe unozotanga kurapwa nekugamuchira Velcade kaviri pasvondo kwevhiki mbiri, uchiteverwa nevhiki rimwe kubva pamushonga. Iyi pateni inodzokororwa kwehuwandu hwemavhiki makumi maviri nemana. Mushure memasvondo makumi maviri nemana, iwe uchagamuchira Velcade kamwe pasvondo kwevhiki mbiri, uchiteverwa nevhiki rimwe wabva pamushonga. Izvi zvinodzokororwa kwevhiki dzese makumi matatu.
  • Kana iwe uri kushandisa Velcade nekuti yako yakawanda myeloma yadzoka mushure memamwe marapirwo (neVelcade kana zvimwe zvinodhaka), yako muyero purogiramu inogona kusiyana, zvinoenderana neyako yekurapa nhoroondo.

Side migumisiro uye njodzi

Ninlaro uye Velcade zvese zvine zvinodhaka kubva mukirasi imwechete. Naizvozvo, ese ari maviri mishonga anogona kukonzera akafanana akafanana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvakajairika mhedzisiro

Aya mazita ane mienzaniso yeimwe yakajairika mhedzisiro mhedzisiro inogona kuitika naNinlaro, neVelcade, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

  • Zvinogona kuitika naNinlaro:
    • maziso akaoma
  • Zvinogona kuitika neVelcade:
    • kurwadziwa kwemutsipa
    • kunzwa kupera simba kana kuneta
    • kupindwa nechando
    • kuderedza kudya
    • kupererwa neropa (yakadzika tsvuku masero eropa)
    • alopecia (kurasikirwa bvudzi)
  • Zvinogona kuitika nezvose Ninlaro uye Velcade:
    • kurwadziwa shure
    • kusaona zvakanaka
    • conjunctivitis (inonziwo pink maziso)
    • shingles (herpes zoster), iyo inokonzeresa kurwadza kunorwadza

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika naNinlaro, neVelcade, kana nezvose zvinodhaka (kana zvatorwa zvakasiyana). Mazhinji emhedzisiro iyi anowanzoitika kune vanhu vanotora mishonga iyi.

  • Zvinogona kuitika naNinlaro:
    • kukanganisa kwakakomba kweganda, kusanganisira Sweet's syndrome uye Stevens-Johnson syndrome
  • Zvinogona kuitika neVelcade:
    • kuderera kweropa (kunogona kukonzera dzungu kana kupera simba)
    • matambudziko emwoyo, akadai sekutadza kwemoyo kana isina kujairika moyo mutinhimira
    • matambudziko emapapu, akadai sekufema kushungurudzika chirwere, pneumonia, kana kuzvimba mumapapu ako
  • Zvinogona kuitika nezvose Ninlaro uye Velcade:
    • peripheral edema (kuzvimba mumakumbo ako, tsoka, makumbo, maoko, kana maoko)
    • thrombocytopenia (yakaderera platelet level)
    • matambudziko emudumbu kana ura, senge manyoka, kuzvimbirwa, kusvotwa, kana kurutsa
    • matambudziko etsinga, senge kurira kana kutsva manzwiro, chiveve, kurwadziwa, kana kushaya simba mumaoko ako kana makumbo
    • neutropenia (yakachena chena masero eropa), izvo zvinogona kuwedzera njodzi yako yekutapukirwa
    • kukuvara kwechiropa

Kubudirira

Ninlaro uye Velcade vane akasiyana FDA-anotenderwa mashandisiro, asi iwo ari maviri anoshandiswa kurapa akawanda myeloma muvakuru.

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki. Nekudaro, zvidzidzo zvakaona kuti ese Ninlaro uye Velcade anoshanda mukunonoka kufambira mberi (kuwedzera) kweakawanda myeloma. Mishonga iyi miviri inokurudzirwa nazvino marongero ekurapa ekushandisa muvanhu vane myeloma yakawanda.

Kune vamwe vanhu, nhungamiro yekurapa inokurudzira kushandisa Velcade-based regimen pamusoro pekushandisa musanganiswa weNinlaro nelenalidomide (Revlimid) uye dexamethasone (Decadron). Uku kukurudzira kunosanganisira vanhu vane anoshanda akawanda myeloma avo vari kurapwa kekutanga. Kushanda kwakawanda myeloma zvinoreva kuti munhu ane zviratidzo zvechirwere, senge matambudziko eitsvo, kukuvara kwepfupa, kupererwa neropa, kana zvimwewo zvinhu.

Kune vanhu vane myeloma yakawanda yadzoka mushure memamwe marapirwo, iwo marongero anokurudzira kurapwa pamwe neNinlaro kana Velcade, mukubatana nemimwe mishonga.

Mariro

Ninlaro uye Velcade ese ari maviri zita-zita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira paWellRx.com, Velcade kazhinji inodhura kupfuura Ninlaro. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa, kwaunogara, uye pharmacy yaunoshandisa.

Ninlaro mutengo

Sezvo nemishonga yese, mutengo weNinlaro unogona kusiyana. Kuti uwane mitengo yazvino yeNinlaro munharaunda yako, tarisa WellRx.com.

Mari yaunowana paWellRx.com ndiyo yaunogona kubhadhara pasina inishuwarenzi. Mutengo chaiwo wauchabhadhara unoenderana nehurongwa hweinishuwarenzi, nzvimbo yauri, uye khemisi yaunoshandisa.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara Ninlaro, kana kana iwe uchida rubatsiro kuti unzwisise yako inishuwarenzi kufukidza, rubatsiro rwuripo.

Takeda Pharmaceutical Company Limited, iyo inogadzira Ninlaro, inopa chirongwa chinonzi Takeda Oncology 1Point. Chirongwa ichi chinopa rubatsiro uye chingangokwanisa kubatsira kudzikisa mutengo wekurapwa kwako. Kuti uwane rumwe ruzivo uye kuti uzive kana iwe uchikodzera rutsigiro, fonera 844-817-6468 (844-T1POINT) kana kushanyira webhusaiti yechirongwa.

Ninlaro anoshandisa

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai saNinlaro kurapa mamwe mamiriro. Ninlaro inogona zvakare kushandiswa kure-chitaridzi kune mamwe mamiriro. Kunze-chitambi kushandiswa ndiko kana mushonga unobvumidzwa kurapa imwechete mamiriro unoshandiswa kurapa imwe mamiriro.

Ninlaro yeakawanda myeloma

Ninlaro FDA-inogamuchirwa kurapa myeloma yakawanda muvanhu vakuru vakatoyedza imwe kurapwa kumwe mamiriro. Uku kurapa kunogona kuve mushonga kana maitiro. Ninlaro inogamuchirwa kuti ishandiswe pamwe chete nemamwe madhiragi maviri: lenalidomide (Revlimid) uye dexamethasone (Decadron).

Multiple myeloma mhando isingawanzo kenza inowedzera mumasero ako eplasma. Aya maseru rudzi rwemuchena weropa. Izvo zvakagadzirwa nefupa rako remapfupa, chinova chinhu chechipanji chinowanikwa mukati memapfupa ako. Pfupa rako rinogadzira yako ese maseru eropa.

Dzimwe nguva masero eplasma anova asina kujairika uye anotanga kuwanda (kuita mamwe masero eplasma) asingadzoreki. Aya asina kujairika, ane cancer cancer maseru anonzi myeloma masero.

Myeloma maseru anogona kukura munzvimbo dzakawanda (dzinoverengeka) dzefupa rako uye mumapfupa akasiyana. Ichi ndicho chikonzero mamiriro acho anonzi akawanda myeloma.

Masero emyeloma anotora nzvimbo yakawanda mumapfupa ako. Izvi zvinoita kuti zviomere mapfupa ako kuita masero eropa akagwinya. Masero emyeloma anogona zvakare kukuvadza mapfupa ako, achiaita asina simba.

Kubudirira kweakawanda myeloma

Mune kiriniki yekudzidza, Ninlaro aishanda pakurapa akawanda myeloma. Chidzidzo chacho chakatarisa vanhu mazana manomwe nemakumi maviri nevaviri vaine myeloma yakawanda avo vaive vatova neimwe kurapwa kumwe. Mune vanhu ava, yavo yakawanda myeloma vanga varega kupindura (kuita zvirinani) kune mamwe marapirwo, kana kuti yakange yadzoka mushure mekutanga kugadzirisa nemamwe marapirwo.

Muchidzidzo ichi, vanhu vakapatsanurwa kuita mapoka maviri. Boka rekutanga rakapihwa Ninlaro nemamwe maviri akawanda myeloma mishonga: lenalidomide uye dexamethasone. Boka rechipiri rakapihwa placebo (kurapwa pasina chinoshanda mushonga) ine lenalidomide uye dexamethasone.

Vanhu vakatora mubatanidzwa weNinlaro vakararama paavhareji yemwedzi makumi maviri nemakumi matanhatu vasati vaenda myeloma yakawanda. Vanhu vanotora musanganiswa we placebo vakararama avhareji yemwedzi 14.7 chirwere chavo chisati chafambira mberi.

Makumi manomwe nesere muzana yevanhu vakatora mubatanidzwa weNinlaro vakapindura kurapwa. Izvi zvinoreva kuti vaive neinenge 50% yekuvandudza mumabvunzo avo erabhoritari aitsvaga masero emyeloma. Mune avo vakatora musanganiswa we placebo, 72% yevanhu vakapindura zvakafanana pakurapwa.

Kunze-chitaridzi kunoshandisa Ninlaro

Pamusoro pekushandisa kwakanyorwa pamusoro, Ninlaro inogona kushandiswa kure-chitaridzi kune zvimwe zvinoshandiswa. Kunze-chitambi kushandiswa kwemishonga ndipo panoshandiswa mushonga unobvumidzwa kushandiswa kumwechete kurapa imwe isingatenderwe.

Ninlaro yeakawanda myeloma mune mamwe mamiriro

Ninlaro FDA-inogamuchirwa kuti ishandiswe nelenalidomide uye dexamethasone kurapa myeloma yakawanda muvanhu vakambove nemamwe marapirwo. Iri kudzidza senzira yekurapa kune mamwe mamiriro anosanganisira akawanda myeloma.

Tsvagiridzo irikuitwa kuti uone kuti Ninlaro angashandiswe sei-kurembera mumamiriro ezvinhu anotevera:

  • kurapa nhanho dzakasiyana dze multiple myeloma
  • pamwe chete nemimwe mishonga isiri lenalidomide uye dexamethasone kurapa akawanda myeloma

Iwe unogona kupihwa Ninlaro off-label mune imwe yeidzi nzira.

Ninlaro ye systemic mwenje cheni amyloidosis

Ninlaro haisi FDA-inogamuchirwa kurapa systemic mwenje cheni amyloidosis. Nekudaro, dzimwe nguva inoshandiswa off-label kurapa mamiriro aya.

Izvi zvisingawanzoitika zvinokanganisa nzira maseru ako eplasma (anowanikwa mumwongo wako wepfupa) anogadzira mamwe mapuroteni anonzi mwenje keteni mapuroteni. Makopi asina kujairika emapuroteni aya anopinda muropa rako uye anogona kuvaka mumatumbu nemitezo mumuviri wako wese. Sezvo mapuroteni anovaka, anogadzira amyloid (masumbu emapuroteni), ayo anogona kukuvadza dzimwe nhengo senge moyo wako kana itsvo.

Ninlaro akaverengerwa mune yekurapa nhungamiro ye systemic mwenje cheni amyloidosis, mushure mekudzidza yakawana kuti yaive inoshanda pakurapa mamiriro aya. Ninlaro inzira yekurapa kune vanhu vane amyloidosis yarega kupindura kune yakasarudzika yekutanga-sarudzo yekurapa yemamiriro acho. Ichowo chisarudzo chekurapa chevanhu vane amyloidosis yadzoka mushure mekunge yagadziriswa pamwe nemvumo yekutanga-sarudzo yekurapa

Ninlaro inoshandiswa yega kana kusanganiswa ne dexamethasone painoshandiswa kurapa chirwere ichi.

Ninlaro shandisa nemimwe mishonga

Iwe unowanzo tora Ninlaro pamwe chete nemimwe mishonga iyo imwe neimwe inoshanda nenzira dzakasiyana kurapa myeloma yako yakawanda.

Ninlaro inobvumidzwa kushandiswa nelenalidomide (Revlimid) uye dexamethasone (Decadron). Munguva yezvidzidzo zvemakiriniki, kurapwa naNinlaro pamwe chete nemishonga iyi kwainyanya kushanda kupfuura kungoshandisa lenalidomide uye dexamethasone.

Chiremba wako anogona zvakare kukurudzira kuti iwe utore Ninlaro nemamwe akawanda akawanda myeloma zvinodhaka. Iyi ndiyo nzira yekurebera yekushandisa Ninlaro. Kunze-chitambi kushandiswa kwemishonga ndipo panoshandiswa mushonga unobvumidzwa kushandiswa kumwechete kurapa imwe isingatenderwe.

Ninlaro ine lenalidomide (Revlimid)

Lenalidomide (Revlimid) iri immunomodulatory chinodhaka. Rudzi urwu rwemushonga runoshanda nekubatsira immune system yako kuuraya myeloma maseru.

Revlimid inouya semacapsule anotorwa nemuromo akabatana naNinlaro. Iwe unotora Revlimid kamwe zuva nezuva kwevhiki nhatu, uchiteverwa nevhiki rimwe rekusatora mushonga.

Unogona kutora Revlimid uine kana usina chikafu.

Ninlaro ine dexamethasone (Decadron)

Dexamethasone (Decadron) rudzi rwemushonga unonzi corticosteroid. Iyi mishonga inoshandiswa kunyanya kudzikisa kuzvimba (kuzvimba) mumuviri wako. Nekudaro, kana ichipiwa mumadosi mashoma ekurapa kwakawanda kwemyeloma, dexamethasone inobatsira Ninlaro naRevlimid kuuraya masero emyeloma.

Dexamethasone inouya semapiritsi anotorwa nemuromo pamwechete neNinlaro. Iwe unotora dexamethasone kamwe chete pasvondo, pazuva rimwe chete revhiki raunotora Ninlaro. Iwe unotora dexamethasone vhiki rega rega, kusanganisira vhiki yausingatore Ninlaro.

Usatore dexamethasone dose yako panguva imwe chete yezuva sezvaunotora yako Ninlaro dose. Zviri nani kutora mishonga iyi panguva dzakasiyana dzezuva.Izvi zvinodaro nekuti dexamethasone inoda kutorwa nechikafu, nepo Ninlaro achifanira kutorwa asina chinhu mudumbu.

Ninlaro uye doro

Doro harizivikanwe kukanganisa mashandiro anoita Ninlaro mumuviri wako. Nekudaro, kana iwe uine mamwe mhedzisiro kubva kuNinlaro (senge kusvotwa kana manyoka), kunwa doro kunogona kuita kuti mhedzisiro iyi iwedzere.

Kana iwe ukanwa doro, taura nachiremba wako nezvekuti yakawanda sei doro yakachengeteka kwauri iwe paunenge uchishandisa Ninlaro.

Ninlaro kudyidzana

Ninlaro anogona kusangana nemimwe mishonga yakati wandei. Iyo inogona zvakare kuyanana pamwe nezvimwe zvinowedzera.

Kukurukurirana kwakasiyana kunogona kukonzera mhedzisiro. Semuenzaniso, kumwe kudyidzana kunogona kukanganisa mashandiro anoita mushonga. Kumwe kudyidzana kunogona kuwedzera mhedzisiro kana kuita kuti ive yakaoma.

Ninlaro nemimwe mishonga

Pazasi pane zvinyorwa zvemishonga inogona kusangana naNinlaro. Aya mazita haana mishonga yose inogona kuwirirana naNinlaro.

Usati watora Ninlaro, taura nachiremba wako uye wemishonga. Vaudze nezvese zvinyorwe, pamusoro-pe-counter, uye mimwe mishonga yaunotora. Vaudzewo nezve chero mavitamini, mahebhu, uye zvinowedzera zvaunoshandisa. Kugovera ruzivo urwu kunogona kubatsira iwe kudzivirira kusangana kunogona kuitika.

Kana iwe uine mibvunzo nezve kudyidzana kwezvinodhaka zvinogona kukukanganisa, bvunza chiremba wako kana wemishonga.

Ninlaro nemimwe mishonga yetibhii

Kutora imwe mishonga yetibhii neNinlaro kunogona kudzikisa mwero weNinlaro mumuviri wako. Izvi zvinogona kuita kuti Ninlaro asanyanya kushanda kwauri. Iwe unofanirwa kudzivirira kutora zvinotevera zvinodhaka naNinlaro:

  • rifabutin (Mycobutin)
  • rifampin (Rifadin)
  • rifapentine (Priftin)

Ninlaro nemimwe mishonga yekubatwa

Kutora mimwe mishonga yekubata neNinlaro kunogona kudzikisa huwandu hwaNinlaro mumuviri wako. Izvi zvinogona kuita kuti Ninlaro asanyanya kushanda kwauri. Iwe unofanirwa kudzivirira kutora zvinotevera zvinodhaka naNinlaro:

  • carbamazepine (Carbatrol, Equetro, Tegretol)
  • fosphenytoin (Cerebyx)
  • oxcarbazepine (Trileptal)
  • phenobarbital
  • phenytoin (Dilantin, Phenytek)
  • Primidone (Mysoline)

Ninlaro nemishonga uye zvinowedzera

Ninlaro anogona kusangana nemamwe maruva uye zvinowedzera, kusanganisira St. John's wort. Ita shuwa yekukurukura chero zvinowedzera zvaunotora nachiremba wako usati watanga kushandisa Ninlaro.

Ninlaro uye St. John's wort

Kutora wort yeSt.John naNinlaro kunogona kudzikisa mwero weNinlaro mumuviri wako uye woita kuti usanyanya kushanda kwauri. Dzivisa kutora iyi yemakwenzi yekuwedzera (inonzi zvakare Hypericum perforatum) paunenge uchishandisa Ninlaro.

Nzira yekutora Ninlaro

Iwe unofanirwa kutora Ninlaro zvinoenderana nachiremba wako kana rairo yemupi wezvehutano.

Nguva yekutora

Kunze kwekunge chiremba wako akakuudza neimwe nzira, tora dhizaini yako yeNinlaro kamwe chete pasvondo, pazuva rimwe chete vhiki imwe neimwe. Zviri nani kutora madosi ako panguva dzakatenderedza zuva.

Iwe unotora Ninlaro kamwechete pasvondo kwevhiki nhatu. Ipapo unenge uine vhiki wabva pamushonga. Iwe unodzokorora ino-ina-vhiki kutenderera kazhinji sekurudzira kwachiremba wako.

Kuti ubatsire kuve nechokwadi chekuti hauzorasikirwa nemushonga, edza kuseta chiyeuchidzo pafoni yako. Iyo yekurapa timer inogona kubatsira, zvakare.

Kutora Ninlaro nechikafu

Iwe haufanire kutora Ninlaro nechikafu. Inofanirwa kutorwa isina chinhu mudumbu nekuti chikafu chinogona kudzikisira huwandu hweNinlaro iyo inotorwa nemuviri wako. Izvi zvinogona kuita kuti Ninlaro asanyanya kushanda kwauri. Tora dhosi rega rega raNinlaro kweinenge awa imwe usati wadya kana kanenge maawa maviri uchinge wadya.

Ninlaro inogona kupwanywa, kupatsanurwa, kana kutsengwa here?

Kwete, haufanire kupwanya, kupaza kuvhura, kupatsanura, kana kutsenga Ninlaro capsules. Iwo macapsule anoitirwa kumedzwa izere nekunwa kwemvura.

Kana iyo Ninlaro capsule netsaona ikabvaruka yakavhurika, dzivisa kubata iyo poda iri mukati meiyo capsule. Kana chero hupfu hukapinda paganda rako, geza riite ipapo nesipo nemvura. Kana chero hupfu hukapinda mumaziso ako, ibudise nemvura ipapo ipapo.

Mashandiro anoita Ninlaro

Ninlaro anotenderwa kurapa akawanda myeloma. Inopihwa nemimwe mishonga miviri (lenalidomide uye dexamethasone) iyo inobatsira kuti ishande mukati memuviri wako.

Chii chinoitika mune dzakawanda myeloma

Pakati pemapfupa ako, pane chinhu chakapfava chinonzi mwongo wemabhonzo. Apa ndipo panogadzirwa yako masero eropa, kusanganisira ako machena masero eropa. Masero machena eropa anorwisa hutachiona.

Kune akawanda mhando dzakasiyana dzemasero machena eropa. Imwe mhando inonzi plasma masero. Masero ePlasma anogadzira masoja ekudzivirira chirwere, anova mapuroteni anobatsira muviri wako kuziva nekurwisa utachiona, senge hutachiona uye hutachiona.

Uine akawanda myeloma, asina kujairika eplasma maseru anogadzirwa mupfupa rako mwongo. Vanotanga kuwanda (kuita mamwe masero eplasma) asingadzoreki. Aya asina kujairika, ane cancer cancer maseru anonzi myeloma masero.

Myeloma masero anotora nzvimbo yakawandisa mumapfupa ako, izvo zvinoreva kuti pane nzvimbo shoma yemasero eropa ane hutano kugadzirwa. Masero emyeloma anokuvadzawo mapfupa ako. Izvi zvinoita kuti mapfupa ako aburitse calcium muropa rako, izvo zvinoita kuti mapfupa ako ashaike simba.

Zvinoitwa naNinlaro

Ninlaro anoshanda nekuderedza huwandu hwemasero emyeloma mumapfupa ako. Mushonga uyu unonongedza puroteni, inonzi proteasome, mukati memasero emyeloma.

MaProteasomes anoputsa mamwe mapuroteni ayo masero haachadi, pamwe nemapuroteni akakuvara. Ninlaro anonamira kumaproteasomes uye anomisa ivo kushanda nemazvo. Izvi zvinotungamira mukuwedzera kwemapuroteni akakuvara uye asina kudiwa mumasero e myeloma, izvo zvinoita kuti masero e myeloma afe.

Zvinotora nguva yakareba sei kuti zvishande?

Ninlaro anotanga kushanda mukati memuviri wako nekukurumidza paunotanga kuitora. Asi zvinotora kanguva kuvaka mhedzisiro inogona kucherechedzwa, senge kuvandudzwa kwezviratidzo zvako kana miedzo yebvunzo yebhu.

Mune kiriniki yekudzidza, vanhu vane multiple myeloma vakatora Ninlaro (pamwe chete nelenalidomide uye dexamethasone). Hafu yevanhu ava vakaona kuvandudzwa kwemamiriro avo mukati memwedzi kubva pavakatanga kutora Ninlaro.

Ninlaro uye nhumbu

Ninlaro haasati akadzidziswa mumadzimai akazvitakura. Zvisinei, mashandiro anoita Ninlaro mukati memuviri wako anotarisirwa kunge achikuvadza nhumbu iri kukura.

Muzvidzidzo zvemhuka, mushonga uyu wakakonzera kukuvara kune fetus painopihwa mhuka dzine nhumbu. Nepo zvidzidzo zvemhuka zvisingawanzo kufanotaura zvichaitika muvanhu, izvi zvidzidzo zvinoratidza kuti mushonga unogona kukuvadza nhumbu yemunhu.

Kana iwe uri nepamuviri, kana kuti ungave nepamuviri, taura nachiremba wako njodzi uye zvakanakira kutora Ninlaro.

Ninlaro uye kuberekwa

Nekuti Ninlaro anogona kukuvadza nhumbu iri kukura, zvakakosha kushandisa kuberekwa paunenge uchitora mushonga uyu.

Kudzora kuberekwa kwevakadzi

Kana iwe uri munhukadzi anokwanisa kuve nepamuviri, iwe unofanirwa kushandisa zvinobudirira kudzora kubereka paunenge uchitora Ninlaro. Iwe unofanirwa kuenderera uchishandisa kushandisa kuberekwa kweanenge mazuva makumi mapfumbamwe mushure mekumira kutora Ninlaro.

Ninlaro inotorwa pamwe chete nelenalidomide uye dexamethasone yekurapa kwakawanda myeloma. Dexamethasone inogona kuita mahormone ekudzivirira kuberekwa, kusanganisira mapiritsi ekudzivirira kubereka, asinganyanyoita kudzivirira nhumbu. Kana iwe uri kushandisa kudzora kuberekwa kwehormone, iwe unofanirwa zvakare kushandisa chipingamupinyi chekudzivirira nhumbu (semakondomu) sekuchengetwa kwekuberekwa.

Kudzora kubereka kwevarume

Kana iwe uri murume ari kuita zvepabonde nemukadzi anogona kuve nepamuviri, iwe unofanirwa kushandisa anoshanda ekuberekwa (senge makondomu) paunenge uchitora Ninlaro. Izvi zvakakosha, kunyangwe mukadzi wako mukadzi ari kushandisa dziviriro. Iwe unofanirwa kuenderera uchishandisa kushandisa kuberekwa kwemazuva makumi mapfumbamwe mushure mekupedzisira kwedosi rako reNinlaro.

Ninlaro uye kuyamwisa

Hazvizivikanwe kana Ninlaro achipfuura mumukaka wemukaka, kana kana uchikanganisa nzira iyo muviri wako unogadzira mukaka wemuzamu. Iwe unofanirwa kudzivirira kuyamwisa paunenge uchitora Ninlaro. Usamwisa mwana kusvika mazuva makumi mapfumbamwe mushure mekunge wamira kutora Ninlaro.

Mibvunzo yakajairika pamusoro paNinlaro

Heano mhinduro kumimwe mibvunzo inowanzo bvunzwa pamusoro paNinlaro.

Ninlaro rudzi rwemakemikari here?

Kwete, Ninlaro haisi mhando yekemotherapy. Chemotherapy inoshanda nekuuraya maseru mumuviri wako ari kuwanda (achigadzira mamwe maseru) nekukurumidza. Izvi zvinosanganisira mamwe maseru ane hutano, pamwe nemaseru ekenza. Nekuti chemotherapy inokanganisa mamwe maseru ako ane hutano, inogona kuve nemhedzisiro.

Ninlaro chirwere chinotarisirwa kune akawanda myeloma. Mishonga yekurapa inoshanda pazvinhu zvakasarudzika mumasero ekenza ayo akasiyana neaya ari mumasero ane hutano. Ninlaro anotarisa mamwe mapuroteni anonzi proteasomes.

MaProteasomes anobatanidzwa mukukura kwakajairika uye kugadzirwa kwemasero. Aya mapuroteni anonyanya kushanda mumasero ekenza kupfuura mumasero ane hutano. Izvi zvinoreva kuti kana Ninlaro yakanangana neproteasomes, inokanganisa masero echiropa kupfuura zvainoita masero ane hutano.

Ninlaro achiri kungakanganisa maseru ane hutano uye anogona kukonzeresa mhedzisiro. Zvisinei, kazhinji, kurapwa kwakanangwa (senge Ninlaro) kunowanzo kukonzeresa mhedzisiro pane yakajairwa chemotherapy mishonga.

Ndinogona here kutora Ninlaro kumberi kana mushure mekudzika kwechitokisi?

Iwe unogona kukwanisa. Ninlaro inogamuchirwa kuti ishandiswe muvanhu vanga vaine imwe kurapwa kumwe kune yavo yakawanda myeloma. Izvi zvinosanganisira vanhu vanga vaine stem cell transplant sekurapa.

Masero emadzinde maseru eropa asina kusimba anowanikwa muropa rako uye mumwongo wepfupa rako. Vanogona kukura kuita marudzi ese emasero eropa. A stem cell transplant kurapwa kweakawanda myeloma. Inovavarira kutsiva masero emyeloma ane maseru ane hutano, ayo anogona kuzokura kuita masero eropa ane hutano.

Yazvino kiriniki mirayiridzo inosanganisira Ninlaro senzira yekuchengetedza (yakareba-nguva) nzira yekurapa yekumisa maseru ekenza kubva pakuwanda mushure mekunge waita autologous stem cell yekuisa. (Mune ino maitiro, ako maseru maseru anounganidzwa kubva muropa rako wega kana mwongo wemapfupa uye ndokupihwa kwauri mukutapudza.) Zvisinei, mimwe mishonga inosarudzwa kupfuura Ninlaro mune ino kesi.

Ikozvino kiriniki nhungamiro zvakare inosanganisira Ninlaro senzira yekutanga kurapwa kurapwa kwauinayo kune yako yakawanda myeloma, usati wave nesitemusi yekuisa. Zvisinei, mimwe mishonga inosarudzwawo pamusoro paNinlaro mune iyi kesi. Uku kungave kuri kwekurebera-kushandisa Ninlaro. Kunze-chitambi kushandiswa kwemishonga ndipo panoshandiswa mushonga unobvumidzwa kushandiswa kumwechete kurapa imwe isingatenderwe.

Kana ndikarutsa mushure mekutora dosi, ndinofanira kutora imwe dosi here?

Kana iwe ukarutsa mushure mekutora Ninlaro, usatore imwe dosi yemushonga musi iwoyo. Ingo tora yako inotevera dosi kana iri yakakodzera pane yako dosing purogiramu.

Kana iwe uchiwanzo kukanda kumusoro uchitora Ninlaro, taura nachiremba wako. Vanogona kupa mishonga kuti ubatsire kuderedza kusvotwa kwako kana kukupa mazano ekugadzirisa kushungurudza panguva yekurapa.

Ini ndichada bvunzo bvunzo ini ndiri kutora Ninlaro?

Ehe. Paunenge uchitora Ninlaro, iwe uchafanirwa kunge uine kuongororwa kweropa nguva nenguva kuti uone ako masero eropa uye rako chiropa basa. Panguva yekurapwa, chiremba wako anoongorora zvinotevera zvinotevera:

  • Chikamu cheplatelet. Ninlaro anogona kudzikisa huwandu hweplatelet yako. Kana yako nhanho ikawira pasi zvakanyanya, unogona kuve nenjodzi yekuwedzera yekubuda ropa kwakanyanya. Chiremba wako anoongorora ako maplatelet kuverenga nguva dzose, kuitira kuti kana matambudziko akawanikwa, anogona kugadziriswa nekukurumidza. Kana ako mazinga ari pasi, chiremba wako anogona kudzora dhizaini yako yeNinlaro kana kuti iwe warega kutora Ninlaro kusvikira maplatelet ako adzokera padanho rakachengeteka. Dzimwe nguva, ungangoda kuwedzerwa ropa kuti ugamuchire maplatelet.
  • Chena masero eropa. Mumwe wemishonga (unonzi Revlimid) wauchatora naNinlaro unogona kudzikisa mwero wako wemasero machena eropa, ayo anogona kuwedzera mukana wako wekutapukirwa. Kana iwe uine mashoma maseru emasero aya, chiremba wako anogona kudzora muyero wako weRevlimid neNinlaro, kana kuti warega kutora mishonga, kudzamara masero machena eropa adzokera padanho rakachengeteka.
  • Chiropa basa bvunzo. Ninlaro dzimwe nguva inogona kukuvadza chiropa chako, zvichikonzera enzymes yechiropa kuburitswa muropa rako. Chiropa chinoshanda bvunzo dzinoongorora ropa rako kune aya ma enzymes. Kana bvunzo dzichiratidza kuti Ninlaro iri kukanganisa chiropa chako, chiremba wako anogona kudzikisa muyero wako wechirwere.
  • Kumwe kuongorora ropa. Iwe zvakare uchave nekumwe kuongororwa kweropa kuti utarise kuti mameloma ako akawanda arikupindura sei kurapwa neNinlaro.

Ninlaro matanho

Usati watora Ninlaro, taura nachiremba wako nezve nhoroondo yako yehutano. Ninlaro anogona kunge asiri akakukodzera kana uine mamwe marapirwo. Izvi zvinosanganisira:

  • Zvinetso zveitsvo. Kana itsvo yako ichikundikana zvakanyanya, kana kana uine hemodialysis kurapwa kweitsvo kukundikana, chiremba wako anokupa dosi yakaderera yeNinlaro iwe.
  • Zvinetso zvechiropa. Ninlaro inogona kukonzera matambudziko echiropa. Uye kana uine kukuvara kwechiropa, kutora Ninlaro kunogona kukuvadza mamiriro ako. Kana iwe uine zvine mwero kusvika kumatambudziko akakomba echiropa, chiremba wako anokuraira muyero wakaderera weNinlaro kwauri.
  • Kubata. Kana iwe uri nepamuviri kana kuti ungangove nepamuviri, Ninlaro inogona kukuvadza kubata kwako pamuviri. Kana iwe kana mumwe wako muchikwanisa kuve nepamuviri, munofanirwa kushandisa kubata pamuviri muchitora Ninlaro. Kuti uwane rumwe ruzivo, ndapota ona "Ninlaro nepamuviri" uye "Ninlaro uye nhumbu yekuzvarwa" zvikamu zviri pamusoro.

Ongorora: Kuti uwane rumwe ruzivo nezve zvingangoitika zvakaipa zveNinlaro, ona iyo "Ninlaro mhedzisiro" chikamu pamusoro.

Ninlaro ovhadhozi

Kutora zvinopfuura chiyero chakakurudzirwa cheNinlaro kunogona kutungamira kumatambudziko akakomba. Kune rondedzero yemhedzisiro yemhedzisiro inokonzerwa neNinlaro, ndapota ona iyo "Ninlaro mhedzisiro" chikamu pamusoro.

Ovhadhozi zviratidzo

Zviratidzo zvekuwedzeredza zvinogona kusanganisira kuwedzera kwechero ipi mhedzisiro mhedzisiro yeNinlaro. Kune rondedzero yezvingaitika mhedzisiro, ndapota ona iyo "Ninlaro mhedzisiro" chikamu pamusoro.

Zvekuita kana ovhadhozi

Kana iwe uchifunga kuti watora zvakawandisa zvemushonga uyu, fonera chiremba wako. Iwe unogona zvakare kufonera iyo American Association yePoison Control Centres pa800-222-1222 kana kushandisa yavo yepamhepo chishandiso. Asi kana zviratidzo zvako zvakakomba, fonera 911 kana kuenda kukamuri yepedyo yevanokurumidza ipapo.

Ninlaro kupera, kuchengetedza, uye kurasa

Paunotora Ninlaro kubva kuhemesi, wemishonga anowedzera zuva rekupera kune zvakanyorwa pamushonga wemishonga. Zuva iri rinowanzo kuve gore rimwe kubva pazuva ravakapa mushonga. Usatore Ninlaro kana rakadhindwa zuva rekupera rapfuura.

Zuva rekupera rinobatsira kuvimbisa kushanda kwemushonga panguva ino. Chimiro chazvino cheKudya neDrug Administration (FDA) ndechekudzivirira kushandisa akapera mishonga. Kana iwe usina kushandisa mishonga yakapfuura nguva yekupera, taura nachiremba wako nezvekuti ungangokwanisa kuishandisa.

Kuchengetedza

Inguva yakareba sei mushonga unoramba wakanaka unogona zvinoenderana nezvinhu zvakawanda, zvinosanganisira kuti unochengetera mushonga kupi uye kupi.

Ninlaro capsules anofanirwa kuchengetwa mumapakeji avo epakutanga. Zvichengetedze pane tembiricha yemukati kure nechiedza. Ninlaro haifanire kuchengetwa patembiricha inopfuura 86 ° F (30 ° C).

Dzivisa kuchengeta uyu mushonga munzvimbo dzaunganyorove kana kunyorova, senge mudzimba dzekugezera.

Kubvisa

Kana iwe usisiri kuda kutora Ninlaro uye uine mishonga yasara, zvakakosha kuirasa zvakachengeteka. Izvi zvinobatsira kudzivirira vamwe, kusanganisira vana nezvipfuwo, kubva pakutora mushonga netsaona. Izvo zvinobatsirawo kuchengetedza mushonga kubva mukukuvadza nharaunda.

Iyo FDA webhusaiti inopa akati wandei matipi anobatsira pakuraswa kwemishonga. Iwe unogona zvakare kubvunza wako wemishonga kuti uwane ruzivo rwekuti ungarase sei mushonga wako.

Ruzivo rwehunyanzvi rweNinlaro

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Zviratidzo

Ninlaro anotenderwa kurapa akawanda myeloma, anoshandiswa musanganiswa nelenalidomide uye dexamethasone, mune vanhu vakuru vanga vaine imwe kurapwa kweiyo mamiriro.

Iko kuchengetedzwa uye kushanda kweNinlaro hakuna kusimbiswa muvana.

Nzira yekuita

Ninlaro ine ixazomib, proteasome inhibitor. MaProteasomes ane chinzvimbo chakakosha kuputsa mapuroteni ayo anobatanidzwa mukutenderera kwemasero, kugadziriswa kweDNA, uye apoptosis. Ixazomib inosunga uye inodzivirira chiitiko cheiyo beta 5 subunit yeiyo 20S yepakati chikamu che26S proteasome.

Nekuvhiringidza chiitiko cheproteasome, ixazomib inokonzera kuwanda kweprotein yakawandisa kana kukuvara mukati mechitokisi, zvichikonzera kufa kwesero.

Chiitiko cheproteasome chinowedzerwa mumaseru akaipa kana ichienzaniswa nemaseru ane hutano. Multiple myeloma maseru anonyanya kukanganiswa nemhedzisiro yeproteasome inhibitors kupfuura maseru ane hutano.

Pharmacokinetics uye metabolism

Izvo zvinoreva bioavailability yexazxazib is 58% mushure mekutaurwa kwemuromo. Bioavailability inoderedzwa kana mushonga wacho uchitorwa nechikafu chine mafuta mazhinji. Muchiitiko ichi, iyo nzvimbo iri pasi peiyo curve (AUC) yeizxazomib yakadzikira ne28%, uye yayo yakanyanya kusangana (Cmax) yakadzikira ne69%. Naizvozvo, ixazomib inofanira kupihwa pane isina chinhu mudumbu.

Ixazomib ndeye 99% yakasungirirwa kumapuroteni eplasma.

Ixazomib inonyanya kujekeswa nehepatic metabolism inosanganisira akawanda maCYP enzymes uye asiri eCYP mapuroteni. Iyo yakawanda yemetabolite yayo inoburitswa mumuti weti, neimwe yakaburitswa mutsvina. Terminal hafu-hupenyu mazuva 9.5.

Pakati nepakati kusvika pakakomba hepatic kukanganisika kunowedzera zvinoreva ixazomib AUC ne20% kupfuura iyo inoreva AUC inoitika neyakajairika hepatic basa.

Zvinoreva ixazomib AUC inowedzerwa ne39% muvanhu vane hurema hwakakomba hwetsvo kana kupera kwechirwere chetsvo chinoda dialysis. Ixazomib haisi dialyzable.

Kuchenesa hakukanganisike zvakanyanya nezera, bonde, nhangemutange, kana muviri pamusoro penzvimbo. Zvidzidzo zveNinlaro zvaisanganisira vanhu vane makore 23 kusvika 91 makore, uye avo vane nzvimbo dzemuviri dzakatangira kubva pa1.2 kusvika 2.7 m².

Contraindications

Iko hakuna zvinopesana zveNinlaro. Nekudaro, huturu hwakanangana nekurapa senge neutropenia, thrombocytopenia, kukanganiswa kwehepatic, kuputika kweganda, kana peripheral neuropathy kungangoda kukanganisa kurapwa.

Kuchengetedza

Ninlaro capsules inofanirwa kuchengetwa mumapakeji avo epakutanga tembiricha yemukati Haifanire kuchengetwa patembiricha dzakakwirira kupfuura 86 ° F (30 ° C).

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro.Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.

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