Oral vs. Inorapwa MS Kurapwa: Ndeupi Musiyano?

Zvemukati

• Kusarudza mushonga weMS
• Mishonga yekuzvidzivirira
• Avonex (interferon beta-1a)
• Betaseron (interferon beta-1b)
• Copaxone (glatiramer acetate)
• Extavia (interferon beta-1b)
• Glatopa (glatiramer acetate)
• Kunaka (pegylated interferon beta-1a)
• Rebif (interferon beta-1a)
• Inravenous infusion mishonga
• Lemtrada (alemtuzumab)
• Mitoxantrone hydrochloride
• Ocrevus (ocrelizumab)
• Tysabri (natalizumab)
• Oral mishonga
• Aubagio (teriflunomide)
• Gilenya (fingolimod)
• Tecfidera (dimethyl fumarate)
• Kutora

Mhedziso

Multiple sclerosis (MS) chirwere che autoimmune umo immune system inorwisa iyo myelin inovhara tsinga dzako. Pakupedzisira, izvi zvinokanganisa tsinga pachadzo.

Hapana mushonga weMS, asi kurapwa kunogona kubatsira kubata zviratidzo uye kunonoka kufambira mberi kwechirwere.

Zvirwere-zvinoshandura marapirwo (DMTs) zvakagadzirirwa kudzora kufambira mberi kwechirwere kwenguva refu, kudzikamisa kudzokazve, uye kudzivirira kukuvara kutsva kuitika.

DMTs inogona kutorwa nemuromo kana jekiseni. Majekiseni anogona kuve anozvibaya-majekiseni kumba kana kupihwa sekubaya infusions munzvimbo yekiriniki.

Zvese zviri zviviri zvekunwa uye jekiseni mishonga ine mabhenefiti uye zvinogona kuva mhedzisiro. Vazhinji vanouya neyambiro chaiyo kubva kuFood and Drug Administration (FDA).

Kusarudza mushonga weMS

Pane zvakawanda zvinhu zvekufunga nezvazvo pakusarudza pakati pemuromo uye jekiseni kurapwa. Semuenzaniso, mishonga yemumuromo inotorwa zuva nezuva, nepo mishonga yakawanda inopinza inotorwa zvishoma.

Chiremba wako anogona kukubatsira kuyera njodzi maringe nezvakanakira uye nekufunga sarudzo yakanakira iwe.

Zvaunofarira zvakakosha mukusarudza chirongwa chekurapa. Zvinhu zvakakosha zvaunoda kufunga nezvazvo ndezvi:

• kushanda kwemushonga
• mhedzisiro yaro
• kuwanda kwemadhosi
• nzira inoshandiswa kupa mushonga

Mishonga yekuzvidzivirira

Mishonga yekuzvidzivirira inovhara chikamu chikuru cheDMTs. Izvo zvinoshandiswa kurapwa kwenguva refu kwekudzokazve-kuregedza MS (RRMS).

Nyanzvi yezvekurapa inokudzidzisa iwe jekiseni kuitira kuti ugone kudzora yako yakachengeteka. Mazhinji emishonga iyi anogona kukonzeresa kutsvuka, kuzvimba, uye kurwadziwa panzvimbo yejekiseni, kuwedzera kune mamwe mhedzisiro.

Avonex (interferon beta-1a)

• Batsirwa: inoshanda se immune system modulator, ine antiviral zvivakwa
• Dhiza frequency uye nzira: vhiki nevhiki, jekiseni repamuviri
• Zvakajairika mhedzisiro zvinogona kusanganisira: kurwadziwa nemusoro, zviratidzo zvakaita sefuruu
• Nyevero dzinosanganisira: chiropa enzymes uye yakazara ropa kuverenga (CBC) inogona kuda kuongororwa

Betaseron (interferon beta-1b)

• Batsirwa: inoshanda se immune system modulator, ine antiviral zvivakwa
• Dhiza frequency uye nzira: zuva rega rega, jekiseni rinotsvedza
• Zvakajairika mhedzisiro zvinogona kusanganisira: furu-kunge zviratidzo, yakachena chena ropa sero (WBC) kuverenga
• Nyevero dzinosanganisira: chiropa enzymes uye CBC inogona kuda kuongororwa

Copaxone (glatiramer acetate)

• Batsirwa: inoshanda se immune system modulator, inovhara kurwisa pane myelin
• Dhiza frequency uye nzira: zuva nezuva kana katatu pasvondo, jekiseni rinotsvedza
• Zvakajairika mhedzisiro zvinogona kusanganisira: kumhanya, kupfupika kwemweya wekufema, mapundu, kurwadziwa pachipfuva
• Nyevero dzinosanganisira: jekiseni nzvimbo dzinogona kuve dzakatemerwa zvachose nekuti mafuta ane nyama anoparadzwa (semhedzisiro, kungwarira kutenderera kwenzvimbo dzejekiseni kunokurudzirwa)

Extavia (interferon beta-1b)

• Batsirwa: inoshanda se immune system modulator, ine antiviral zvivakwa
• Dhiza frequency uye nzira: zuva rega rega, jekiseni rinotsvedza
• Zvakajairika mhedzisiro zvinogona kusanganisira: furu-kunge zviratidzo, kurwadziwa nemusoro
• Nyevero dzinosanganisira: chiropa enzymes uye CBC inogona kuda kuongororwa

Glatopa (glatiramer acetate)

• Batsirwa: inoshanda se immune system modulator, inovhara kurwisa pane myelin
• Dhiza frequency uye nzira: zuva nezuva, jekiseni rinotsvedza
• Zvakajairika mhedzisiro zvinogona kusanganisira: kutsvuka, kuzvimba, kurwadziwa kunzvimbo yejekiseni
• Nyevero dzinosanganisira: jekiseni nzvimbo dzinogona kuve dzakatemerwa zvachose nekuti mafuta ane nyama anoparadzwa (semhedzisiro, kungwarira kutenderera kwenzvimbo dzejekiseni kunokurudzirwa)

Kunaka (pegylated interferon beta-1a)

• Batsirwa: inoshanda se immune system modulator, ine antiviral zvivakwa
• Dhiza frequency uye nzira: vhiki mbiri dzese, jekiseni rinotsvedza
• Zvakajairika mhedzisiro zvinogona kusanganisira: furu-kunge zviratidzo
• Nyevero dzinosanganisira: chiropa enzymes chingangoda kuongororwa

Rebif (interferon beta-1a)

• Batsirwa: inoshanda se immune system modulator, ine antiviral zvivakwa
• Dhiza frequency uye nzira: katatu pavhiki, jekiseni rinotsvedza
• Zvakajairika mhedzisiro zvinogona kusanganisira: furu-kunge zviratidzo
• Nyevero dzinosanganisira: chiropa enzymes chingangoda kuongororwa

Inravenous infusion mishonga

Imwe mhando yejekiseni sarudzo yekurapa MS kupinza mukati. Panzvimbo yekupinda yako system intramuscularly kana subcutaneously, infusions inoenda yakananga mutsinga.

Iyo infusions inofanirwa kupihwa mune yekiriniki marongero neanodzidziswa nyanzvi. Maitiro acho haana kupihwa kazhinji.

Kuvhara infusions kunogona kukonzera njodzi yekuwedzera kwehutachiona mukuwedzera kune mamwe mhedzisiro.

Ocrelizumab (Ocrevus) ndiyo chete mishonga inogamuchirwa neDFA kune vanhu vane MS yekufambira mberi (PPMS). Inotenderwawo kurapa RRMS.

Lemtrada (alemtuzumab)

• Batsirwa: inodzvinyirira myelin-inokuvadza maseru ekudzivirira
• Dose frequency: zuva nezuva kwemazuva mashanu; gore rimwe chete gare gare, zuva nezuva kwemazuva matatu
• Zvakajairika mhedzisiro zvinogona kusanganisira: kusvotwa, kurutsa, manyoka, kutemwa nemusoro, mapundu, kuvaviwa
• Nyevero dzinosanganisira: inogona kukonzera cancer uye idiopathic thrombocytopenic purpura (IPT), chirwere chekubuda ropa

Mitoxantrone hydrochloride

Uyu mushonga unongowanikwa chete seyakajairika mushonga.

• Batsirwa: inoshanda se immune system modulator uye inodzvinyirira
• Dose frequency: kamwe chete pamwedzi mitatu (muganhu wehupenyu hwe8 kusvika ku12 infusions pamusoro pemakore maviri kusvika matatu)
• Zvakajairika mhedzisiro zvinogona kusanganisira: kurasikirwa nevhudzi, kuda kurutsa, amenorrhea
• Nyevero dzinosanganisira: zvinogona kukonzera kukuvara kwemoyo uye leukemia; yakakodzera chete kune vanhu vane kesi dzakakomba dzeRRMS, nekuda kwenjodzi huru yemhedzisiro

Ocrevus (ocrelizumab)

• Batsirwa: inotarisa B masero, ayo ari eWBCs anokuvadza tsinga
• Dose frequency: vhiki mbiri dzakaparadzaniswa kwematanho maviri ekutanga; mwedzi mitanhatu yega yega yemamwe madosi anotevera
• Zvakajairika mhedzisiro zvinogona kusanganisira: furu-kunge zviratidzo, hutachiona
• Nyevero dzinosanganisira: inogona kukonzera cancer uye, mune zvisingawanzo zviitiko, kutyisidzira hupenyu infusion maitiro

Tysabri (natalizumab)

• Batsirwa: inhibits adhesion mamorekuru, ayo anovhiringidza immune system
• Dose frequency: mavhiki mana ega ega
• Zvakajairika mhedzisiro zvinogona kusanganisira: kurwadziwa nemusoro, kurwadza kwemajoini, kuneta, kushushikana, kusagadzikana kwemudumbu
• Nyevero dzinosanganisira: inogona kuwedzera njodzi yekufambira mberi multifocal leukoencephalopathy (PML), hutachiona hunogona kuuraya hutachiona

Oral mishonga

Kana usiri kugadzikana netsono, pane nzira dzemumuromo dzekurapa MS. Inotorwa zuva nezuva kana kaviri pazuva, mishonga yemumuromo ndiyo iri nyore kuzvitonga asi inoda kuti iwe uchengetedze dosing purogiramu.

Aubagio (teriflunomide)

• Batsirwa: inoshanda se immune system modulator, inhibits nerve degeneration
• Dose frequency: zuva nezuva
• Zvakajairika mhedzisiro zvinogona kusanganisira: kutemwa nemusoro, kushanduka kwechiropa (senge chakawedzera chiropa kana enzymes yechiropa yakasimudzwa), kuda kurutsa, kurasikirwa nebvudzi, yakadzora WBC kuverenga
• Nyevero dzinosanganisira: zvinogona kukonzera kukuvara kwechiropa kwakakomba uye hurema hwekuzvara

Gilenya (fingolimod)

• Batsirwa: inodzivirira T maseru kubva mukusiya lymph node
• Dose frequency: zuva nezuva
• Zvakajairika mhedzisiro zvinogona kusanganisira: furu-kunge zviratidzo, zvakakwirira zvechiropa enzymes
• Nyevero dzinosanganisira: zvinogona kukonzera shanduko muropa, kushanda kwechiropa, uye nemoyo basa

Tecfidera (dimethyl fumarate)

• Batsirwa: ine anti-inflammatory properties, inodzivirira tsinga uye myelin kubva kukuvara
• Dose frequency: kaviri pazuva
• Zvakajairika mhedzisiro zvinogona kusanganisira: gastrointestinal shanduko, yakaderedzwa WBC kuverenga, yakakwira chiropa enzymes
• Nyevero dzinosanganisira: zvinogona kukonzera kukanganiswa kweakanyanya, kusanganisira anaphylaxis

Kutora

Chinangwa cheMS kurapwa ndechekugadzirisa zviratidzo, kudzora kudzokazve, uye kunonoka kufambira mberi kwenguva refu kwechirwere.

Injectable MS kurapwa kunouya nenzira mbiri: kuzvidzivirira-injekiseni uye infravenous infusions. Mazhinji majekiseni haafanire kutorwa kazhinji senge mishonga yemumuromo, inotorwa zuva nezuva.

Mese mishonga yeMMS ine mabhenefiti, mhedzisiro, uye njodzi. Chinhu chakanyanya kukosha ndechekuti iwe utore kurapwa kwako sekurairwa, zvisinei nekuti uri kurapwa kupi.

Kana iyo mhedzisiro yakaringana kukukonzera iwe kuti udarike kurapwa, taura nachiremba wako. Ivo vanogona kukubatsira iwe kusarudza yakanyanya kunaka sarudzo kwauri.