Chekutanga-Kufambira mberi vs. Kudzokorora-Kugonesa MS

Zvemukati

• Ndeipi yekutanga-inofambira mberi MS?
• Ndezvipi zvakajairika PPMS zviratidzo?
• Ndiani anowana PPMS?
• Chii chinokonzera PPMS?
• Ndeapi maonero ePPMS?
• Ndeapi marapirwo anowanikwa kune PPMS?
• Chii chiri kudzokerazve-kuregera MS?
• Ndezvipi zvakajairika zviratidzo zveRRMS?
• Ndiani anowana RRMS?
• Chii chinokonzera RRMS?
• Ndeapi maonero eRRMS?
• Chii chinonzi RRMS kurapwa?
• Ndeupi musiyano uripo pakati pePPMS neRRMS?
• Zera rekutanga
• Zvinokonzera
• Outlook
• Kurapa nzira

Mhedziso

Multiple sclerosis (MS) chirwere chisingaperi chinokanganisa tsinga. Mhando ina dzeMS dzakakura ndeidzi:

• kliniki yakasarudzika chirwere (CIS)
• kudzokerazve-kuregera MS (RRMS)
• yekutanga-inofambira mberi MS (PPMS)
• yechipiri-inofambira mberi MS (SPMS)

Mhando yega yega yeMS inotungamira mukufungidzira kwakasiyana, matanho ekuomarara, uye nzira dzekurapa. Ramba uchiverenga kuti uone kuti PPMS yakasiyana sei neRRMS.

Ndeipi yekutanga-inofambira mberi MS?

PPMS ndeimwe yemhando dzisina kujairika dzeMS, inokanganisa ingangoita gumi muzana muzana yemunhu wese anoonekwa aine chirwere ichi. Nepo mamwe maMS mhando achiratidzwa nekurwiswa kwakanyanya, kunonzi kudzokazve, kuchiteverwa nenguva dzekusaita, kunzi kuregererwa, PPMS inokonzeresa kuwedzera zviratidzo.

PPMS inogona kuchinja nekufamba kwenguva. Nguva yekurarama nemamiriro aya inogona kuverengerwa se:

• kushanda pamwe nekufambira mberi kana paine kuwedzera zviratidzo kana chiitiko chitsva cheMRI kana kudzoka zvakare
• inoshanda pasina kufambira mberi kana zviratidzo kana chiitiko cheMRI chiripo, asi zviratidzo hazvina kunyanya kunyanyisa
• kusashanda pasina kufambira mberi kana pasina zviratidzo kana chiitiko cheMRI uye pasina hurema hunowedzera
• isingashande pamwe nekufambira mberi kana paine kudzokazve kana chiitiko cheMRI, uye zviratidzo zvanyanya

Ndezvipi zvakajairika PPMS zviratidzo?

PPMS zviratidzo zvinogona kusiyana, asi chaiwo zviratidzo zvinosanganisira:

• matambudziko ekuona
• kuoma kutaura
• matambudziko kufamba
• dambudziko nekuenzanisa
• kurwadziwa kwakanyanya
• makumbo akaoma uye asina simba
• kunetseka nendangariro
• kuneta
• dambudziko nedundira uye ura
• kuora mwoyo

Ndiani anowana PPMS?

Vanhu vanowanzoonekwa kuti vane PPMS mune yavo 40s uye 50s, nepo avo vakawanikwa vaine RRMS vanowanzove vari mukati mavo makumi maviri nemakumi matatu. Varume nevakadzi vanoonekwa vaine PPMS pamitengo yakafanana, kusiyana neRRMS, iyo inobata vakadzi vazhinji.

Chii chinokonzera PPMS?

Zvinokonzera MS hazvizivikanwe. Pfungwa inonyanya kuzivikanwa inoratidza kuti MS inotanga senge yekuzvimba yeiyo autoimmune system inokanganisa iyo myelin sheath. Ichi ndicho chifukidzo chekudzivirira chakakomberedza tsinga dzepakati tsinga system.

Imwe dzidziso ndeyekuti mhinduro yemumuviri inokonzerwa nehutachiona hwehutachiona. Gare gare, kushomeka kwenzara kana kukuvara kunoitika.

Humwe humbowo hunoratidza kuti MS-yekutanga-inofambira mberi chikamu chemakiriniki eMS uye haina kusiyana nekudzokazve MS.

Ndeapi maonero ePPMS?

PPMS inobata munhu wese zvakasiyana. Nekuti PPMS iri kufambira mberi, zviratidzo zvinowanzo kuwedzera pane kuita zvirinani. Vanhu vazhinji vane dambudziko rekufamba. Vamwe vanhu vanewo kudengenyeka uye matambudziko ekuona.

Ndeapi marapirwo anowanikwa kune PPMS?

Kurapa kwePPMS kwakanyanya kuoma kupfuura RRMS. Inosanganisira kushandisa immunosuppressive Therapies. Ivo vanogona kupa rubatsiro rwechinguva asi vanogona kungoshandiswa zvakachengeteka kwemwedzi mishoma kusvika pagore panguva.

Ocrelizumab (Ocevus) ndiyo chete mishonga inogamuchirwa neDFA yekurapa PPMS.

Iko hakuna mushonga wePPMS, asi iwe unogona kubata mamiriro acho.

Zvimwe zvinodhaka-zvinoshandura zvinodhaka (DMDs) uye steroid zvinogona kubatsira kubata zviratidzo. Kuchengetedza mararamiro ane hutano anosanganisira kudya chikafu chakaringana uye kurovedza muviri kunogona kubatsira. Kugadziriswa kuburikidza nehutano hwepanyama uye hwepabasa kunogona kubatsira.

Chii chiri kudzokerazve-kuregera MS?

RRMS ndiyo yakajairika mhando yeMS. Iyo inobata kwakatenderedza 85 muzana yevanhu vese vanoonekwa vaine MS. Vanhu vazhinji vanotanga kuongororwa vaine RRMS. Iko kuongororwa kunowanzo shanduka mushure memakumi makumi emakore kuenda kune imwe nzira inofambira mberi.

Iro zita rekudzokororazve-remitting MS rinotsanangura mafambiro eiyo mamiriro. Inowanzo sanganisira nguva dzekudzokazve kwakanyanya uye nguva dzekuregererwa.

Panguva yekudzokazve, zviratidzo zvitsva zvinogona kupa, kana iwo iwo iwo zviratidzo anogona kuputika uye kuve akaomarara. Munguva yekuregererwa, vanhu vanogona kuve nezviratidzo zvishoma, kana zviratidzo zvinogona kunge zvisina kunyanyisa kwemavhiki, mwedzi, kana makore.

Zvimwe zveRRMS zviratidzo zvinogona kuve zvechigarire. Izvi zvinonzi zvasara zviratidzo.

RRMS inorondedzerwa se:

• inoshanda kana paine kudzokazve kana maronda anowanikwa pane MRI
• isingashande kana pasina kudzokerazve kana chiitiko cheMRI
• kuwedzera apo zviratidzo zvinowedzera zvishoma nezvishoma mushure mekudzokazve
• kwete kuwedzera kana zviratidzo zvikasawedzera zvishoma nezvishoma mushure mekudzokazve

Ndezvipi zvakajairika zviratidzo zveRRMS?

Zviratidzo zvinosiyana pamunhu wega wega, asi zvakajairika RRMS zviratidzo zvinosanganisira:

• matambudziko nekubatana uye kuenzanisa
• chiveve
• kuneta
• kutadza kufunga zvakajeka
• matambudziko nemaonero
• kuora mwoyo
• matambudziko nekuita weti
• dambudziko kutsungirira kupisa
• kushaya simba kwetsandanyama
• kunetseka kufamba

Ndiani anowana RRMS?

Vanhu vazhinji vanoonekwa kuti vane RRMS mumakore avo makumi maviri nemakumi matatu, iri diki pane ingangoonekwa yeimwe mhando dzeMS, senge PPMS. Vakadzi vane mukana wakapetwa kaviri wekuonekwa kupfuura varume.

Chii chinokonzera RRMS?

Imwe yedzidziso yakajairika ndeyekuti RRMS inogara isingaite autoimmune mamiriro ayo anoitika kana muviri uchitanga kuzvirwisa. Masoja ekudzivirira muviri anorwisa hutachiona hwehutachiona hwepakati uye masisitimu ekudzivirira, anonzi myelin, anochengetedza tsinga dzeshungu.

Uku kurwisa kunokonzera kuzvimba uye kugadzira nzvimbo diki dzekukuvara. Uku kukuvara kunoita kuti zviomere mitsipa kuendesa ruzivo kumuviri. Zviratidzo zveRRMS zvinosiyana zvichienderana nenzvimbo yekukuvara.

Chikonzero cheMS hachizivikanwe, asi panogona kunge paine mageneti pamwe nezvakatiparira zvinokonzeresa zveMS. Imwe dzidziso inoratidza hutachiona, senge Epstein-Barr, inogona kukonzeresa MS.

Ndeapi maonero eRRMS?

Aya mamiriro anobata munhu wega wega zvakasiyana. Vamwe vanhu vanogona kurarama hupenyu hune hutano nekungodzokazve kusingaite izvo zvisina kukonzera zvakakomba kunetseka. Vamwe vanogona kuve vachirwiswa kazhinji nezviratidzo zvinofambira mberi zvinotungamira kumatambudziko akakomba.

Chii chinonzi RRMS kurapwa?

Iko kune akati wandei FDA-inogamuchirwa mishonga inowanikwa yekurapa RRMS. Iyi mishonga inowanzo kudzikisira kuitika kwekudzokazve uye kusimudzira kwemaronda matsva. Ivo zvakare vanononoka kufambira mberi kweRRMS.

Ndeupi musiyano uripo pakati pePPMS neRRMS?

Kunyangwe PPMS neRRMS ese ari maviri marudzi eMMS, pane misiyano yakajeka pakati pawo, senge:

Zera rekutanga

PPMS kuongororwa kunowanzoitika kune vanhu vane makore makumi mana nemakumi mashanu, nepo RRMS ichikanganisa avo vane makore makumi maviri nemakumi matatu.

Zvinokonzera

Ose maviri PPMS neRRMS anokonzerwa nekuzvimba uye immune system kurwisa pane myelin uye nerve fibers. RRMS inowanzove nekuwedzera kuzvimba kupfuura PPMS.

Avo vane PPMS vane mamwe mavanga uye mabara, kana maronda, pamabote emusana, nepo avo vane RRMS vane maronda akawanda pauropi.

Outlook

PPMS iri kufambira mberi nezviratidzo zvichitowedzera kuwedzera nekufamba kwenguva, nepo RRMS inogona kuunza sekurwiswa kwakakomba pamwe nenguva refu dzekusaita. RRMS inogona kukura kuita mhando inofambira mberi yeMS, inonzi yechipiri inofambira mberi MS, kana SPMS, mushure menguva yakati.

Kurapa nzira

Kunyange zvazvo Ocrelizumab ndiyo chete mishonga inogamuchirwa neDFA yekurapa PPMS, kune akati wandei anogona kubatsira. Kune zvakare mimwe mishonga iri kuongororwa. RRMS ine anopfuura gumi nemaviri marapirwo anotenderwa.

Varwere vane ese PPMS neRRMS vanogona kubatsirwa kubva mukugadzirisa nehutano hwepanyama uye hwekuita basa. Kune mishonga yakawanda vanachiremba vanogona kushandisa kubatsira vanhu vane MS kubata zviratidzo zvavo.