Gastrointestinal Stromal Tumors: Zviratidzo, Zvinokonzera, uye Njodzi Zviitiko

Zvemukati

• Zviratidzo
• Zvinokonzera
• Njodzi zvinhu
• Zera
• Majini

Gastrointestinal stromal tumors (GISTs) mamota, kana masumbu emasero akakurisa, mudumbu (GI) turakiti. Zviratidzo zveGIST tumarara zvinosanganisira:

• zvituru zvine ropa
• kurwadziwa kana kusagadzikana mudumbu
• kusvotwa uye kurutsa
• kutenderera kwematumbo
• uremu mudumbu hwaunogona kunzwa
• kuneta kana kunzwa kuneta zvakanyanya
• kunzwa kuzara kwazvo mushure mekudya zvishoma
• kurwadziwa kana kuoma kana uchimedza

Iyo GI turakiti ndiyo sisitimu inoitisa kugaya uye kutora chikafu uye zvinovaka muviri. Inosanganisira esophagus, mudumbu, dumbu ura, uye colon.

GIST inotanga mumaseru akasarudzika ari chikamu chehurongwa hwekuzvitonga hunotonga. Aya maseru ari mumadziro eGI turakiti, uye iwo anodzora mhasuru kufamba kwekuzeya.

Ruzhinji rweGIST mafomu ari mudumbu. Dzimwe nguva vanoumba mune ura hudiki, asi maGIS anogadzira mukoloni, esophagus, uye rectum zvakanyanya kushomeka. GISTs inogona kunge iri yakaipa uye ine cancer kana benign uye kwete cancer.

Zviratidzo

Zviratidzo zvinoenderana nesaizi yebundu uye kwarinowanikwa. Nekuda kweizvi, ivo vanowanzosiyana mukuomarara uye kubva kune mumwe munhu kuenda kune mumwe. Zviratidzo zvakadai sekurwadziwa mudumbu, kuda kurutsa, uye kuneta zvinopindirana nemamwe mamiriro uye zvirwere.

Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchisangana nazvo. Ivo vanozobatsira kuona chikonzero chechiratidzo chako.

Kana iwe uine chero njodzi dzinokanganisa GIST kana chero imwe mamiriro anogona kukonzeresa izvi zviratidzo, ive shuwa kutaura izvozvo kuna chiremba wako.

Zvinokonzera

Icho chaicho chikonzero cheGISTs hachizivikanwe, kunyange paine kunge paine hukama nekuchinja mukutaura kweprotein yeKIT. Gomarara rinokura apo masero anotanga kukura kunze kwekudzora. Sezvo masero anoramba achikura asingadzoreke, anovaka kuti aite mukaka unonzi bundu.

GISTs inotanga mune iyo GI turakiti uye inogona kukura kunze ichienda kune zviri padhuze zvivakwa kana nhengo. Ivo vanowanzopararira kuchiropa uye peritoneum (iyo membranous lining yemudumbu mhango) asi kashoma kune iri pedyo node node.

Njodzi zvinhu

Kune mashoma chete anozivikanwa njodzi njodzi dzeGISTs:

Zera

Zera rakajairika kugadzira GIST riri pakati pemakumi mashanu kusvika makumi masere. Nepo GISTs ichigona kuitika muvanhu vadiki pane makumi mana, ivo vashoma zvakanyanya.

Majini

Mazhinji emaGIST anoitika zvisina mutsindo uye haana chikonzero chakajeka. Nekudaro, vamwe vanhu vanozvarwa vaine genet mutation iyo inogona kutungamira kuGISTs.

Mamwe emageneti nemamiriro akasanganiswa neGIST anosanganisira:

Neurofibromatosis 1: Ichi chirwere chemagene, chinonziwo chirwere cheVon Recklinghausen (VRD), chinokonzerwa nehurema mu NF1 geni. Mamiriro acho anogona kupfuudzwa kubva kumubereki kuenda kumwana asi haagare nhaka. Vanhu vane chirwere ichi vari panjodzi yakawedzera yekukura mabundu ane mutsinga mutsinga pazera diki. Aya mamota anogona kukonzera nzvimbo dzakasviba paganda uye kutenderera mukati meguruva kana pasi pemaoko. Aya mamiriro anowedzerawo njodzi yekuvandudza GIST.

Kuzivikanwa kwematumbu emimba stromal tumor syndrome: Iyi chirwere inokonzereswa kazhinji neyakajairika KIT gene inopfuudzwa kubva kumubereki kuenda kumwana. Ichi chiitiko chisingawanzo chinowedzera njodzi yeGIST. Aya maGIST anogona kuumbika pazera diki pane ruzhinji rwevanhu. Vanhu vane mamiriro aya vanogona kuve nemaGIS akawanda panguva yehupenyu hwavo.

Kuchinja-shanduka muiyo succinate dehydrogenase (SDH) magene: Vanhu vanozvarwa vaine shanduko mumaSDHB nemaSDHC magene vari pangozi yakakura yekuvandudza maGIST. Ivo zvakare vari panjodzi yakawedzera yekukudziridza mhando yemota yetsinga inonzi paraganglioma.