Tardive dyskinesia

Tardive dyskinesia (TD) chirwere chinosanganisira kufamba kusingaite. Tardive zvinoreva kunonoka uye dyskinesia zvinoreva kufamba zvisina kujairika.

TD yakakomba divi mhedzisiro inoitika kana iwe ukatora mishonga inonzi neuroleptics. Iyi mishonga inonziwo antipsychotic kana makuru tranquilizers. Ivo anoshandiswa kurapa matambudziko epfungwa.

TD inowanzoitika kana iwe ukatora mushonga kwemwedzi yakawanda kana makore. Mune zvimwe zviitiko, zvinoitika mushure mekutora kwavo kweashoma semavhiki matanhatu.

Mishonga inonyanya kukonzera kusagadzikana iyi ndeyekare antipsychotic, kusanganisira:

• Chlorpromazine
• Fluphenazine
• Haloperidol
• Perphenazine
• Prochlorperazine
• Thioridazine
• Trifluoperazine

Nyowani antipsychotic inoita kunge isinganyanye kukonzeresa TD, asi haisi zvachose isina njodzi.

Mimwe mishonga inogona kukonzera TD inosanganisira:

• Metoclopramide (inobata chinetso chedumbu chinonzi gastroparesis)
• Mishonga inodzvinyirira yakadai seamitriptyline, fluoxetine, phenelzine, sertraline, trazodone
• Anti-Parkinson mishonga yakadai selevodopa
• Antiseizure mishonga yakadai se phenobarbital uye phenytoin

Zviratidzo zveTD zvinosanganisira kufamba kusingadzoreki kwechiso nemuviri senge:

• Kumeso grimacing (inowanzo sanganisira yakaderera maziso mhasuru)
• Kufamba kweminwe (kuridza piano kufamba)
• Kuzunungusa kana kukanda kwembambo (dhadha-senge gait)
• Shaya ichitenderera
• Kudzokorora kutsenga
• Rapid ziso kubwaira
• Rurimi ruchisundira
• Kusadzikama

Kana TD ichionekwa, mubatsiri wezvehutano anogona kunge achimumisa mushonga zvishoma nezvishoma kana kuchinjira kune mumwe.

Kana TD iri nyoro kana ine mwero, mishonga yakasiyana inogona kuyedzwa. Mushonga wedopamine-unopedza, tetrabenazine ndiwo unoshanda kurapwa kweTD. Wako mupi anogona kukuudza zvakawanda nezve izvi.

Kana TD yakanyanya kuoma, maitiro anonzi akadzika huropi kukurudzira DBS inogona kuyedzwa. DBS inoshandisa chishandiso chinonzi neurostimulator kuendesa magetsi emagetsi kunzvimbo dzehuropi dzinodzora kufamba.

Kana ikazivikanwa kutanga, TD inogona kudzoserwa nekumisa mushonga wakakonzera zviratidzo. Kunyangwe kana mushonga ukamiswa, kufamba kusingaite kunogona kuve kwechigarire, uye mune dzimwe nguva, kunogona kuwedzera.

TD; Tardive chirwere; Orofacial dyskinesia; Kusazvibata kufamba - tardive dyskinesia; Antipsychotic zvinodhaka - tardive dyskinesia; Neuroleptic zvinodhaka - tardive dyskinesia; Schizophrenia - tardive dyskinesia

• Central nervous system uye yekumusoro tsinga system

Aronson JK. Neuroleptic zvinodhaka. Mune: Aronson JK, ed. Meyler's Side Migumisiro yeMishonga. 16 ed. Waltham, MA: Elsevier BV ;; 2016: 53-119.

Freudenreich O, Kunaka AW. Varwere vane mafambiro asina kujairika. Mune: Stern TA, Freudenreich O, Smith FA, Fricchione GL, Rosenbaum JF, eds. Massachusetts General Hospital Bhuku reGeneral Hospital Psychiatry. 7th ed. Philadelphia, PA: Elsevier; 2018: chitsiko 21.

Freudenreich O, Goff DC, Henderson DC. Antipsychotic zvinodhaka. Mune: Stern TA, Fava M, Wilens TE, Rosenbaum JF, eds. Massachusetts General Hospital Yakakwana Clinical Psychiatry. 2nd ed. Philadelphia, PA: Elsevier; 2016: chitsuwa 42.

Okun MS, Lang AE. Zvimwe zvinetso zvekufamba. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chitsiko 382.