Aimovig (erenumab-aooe)

Zvemukati

• Chii chinonzi Aimovig?
• Rudzi rutsva rwemushonga
• Aimovig generic
• Aimovig mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Allergic reaction
• Kurera huremu / huremu
• Yenguva-refu mhedzisiro
• Kuzvimbirwa
• Bvudzi kurasikirwa
• Nausea
• Kuneta
• Manyoka
• Kusarara
• Kutambudzika kwemhasuru
• Itching
• Aimovig mutengo
• Rubatsiro rwemari
• Aimovig anoshandisa
• Aimovig yemigraine kutemwa nemusoro
• Zvishandiso zvisina kubvumidzwa
• Aimovig chipimo chemushonga
• Mafomu uye simba
• Dosage yemigraine
• Ko kana ndikapotsa dosi?
• Ndichada here kushandisa mushonga uyu kwenguva refu?
• Dzimwe nzira kune Aimovig
• CGRP vanopikisa
• Aimovig vs. mimwe mishonga
• Aimovig vs. Ajovy
• Aimovig vs. Botox
• Aimovig vs. Emgality
• Aimovig vs.Topamax
• Aimovig uye doro
• Aimovig kudyidzana
• Iyo Aimovig inogadziriswa sei
• Mirayiridzo yekutora Aimovig
• Jekiseni
• Nguva
• Kutora Aimovig nechikafu
• Kuchengetedza
• Mashandiro anoita Aimovig
• Zvinotora nguva yakareba sei kuti zvishande?
• Aimovig uye nhumbu
• Aimovig uye kuyamwisa
• Mibvunzo yakajairika nezveAimovig
• Kumisa Aimovig kunokonzeresa kubvisa here?
• Aimovig ndeye biologic here?
• Unogona here kushandisa Aimovig kurapa migraine?
• Aimovig anoporesa migraine here?
• Aimovig akasiyana sei nemamwe madhiragi zvinodhaka?
• Kana ndikatora Aimovig, ndinogona here kurega kutora yangu mimwe mishonga yekudzivirira?
• Aimovig ovhadhozi
• Ovhadhozi zviratidzo
• Zvekuita kana ovhadhozi
• Aimovig yambiro
• Aimovig kupera uye kuchengetedza
• Ruzivo rwehunyanzvi rweAimovig
• Nzira yekuita
• Pharmacokinetics uye metabolism
• Contraindications
• Kuchengetedza

Chii chinonzi Aimovig?

Aimovig izita rezita remushonga mushonga unoshandiswa kudzivirira migraine kutemwa nemusoro muvakuru. Iyo inouya mune yakasarudzika autoinjector peni. Iwe unoshandisa iyo autoinjector kuti uzvipe pachako jekiseni kumba kamwe pamwedzi. Aimovig inogona kunyorerwa mune imwe yematanho maviri: 70 mg pamwedzi kana 140 mg pamwedzi.

Aimovig ine mushonga erenumab. Erenumab ndeye monoclonal antibody, iri mhando yemushonga wakagadzirwa murabhoritari. MaMonoclonal antibodies mishonga inogadzirwa nema immune system maseru. Ivo vanoshanda nekudzivirira chiitiko chemamwe mapuroteni mumuviri wako.

Aimovig inogona kushandiswa kudzivirira ese episodic migraine uye chisingaperi migraine musoro. IAmerican Headache Society inokurudzira Aimovig kune vanhu avo:

• haikwanise kudzikisa huwandu hwavo hwemwedzi wemigraine kutemwa nemusoro nemimwe mishonga
• haigone kutora mimwe mishonga yemigraine nekuda kwemhedzisiro kana kusangana kwemishonga

Aimovig yakaratidzirwa kuve inoshanda muzvidzidzo zvekiriniki. Kune vanhu vane episodic migraine, pakati pe40 muzana uye 50 muzana yeavo vakatora Aimovig kwemwedzi mitanhatu vakatema huwandu hwemazuva emigraine nehafu. Uye kune vanhu vane chirwere chisingaperi chemigraine, vangangoita makumi mana muzana yeavo vakatora Aimovig vakatema mazuva avo emigraine nehafu kana kupfuura.

Rudzi rutsva rwemushonga

Aimovig chikamu chekirasi nyowani yemishonga inonzi calcitonin gene-related peptide (CGRP) vanopikisa. Rudzi urwu rwemushonga rwakagadzirirwa kudzivirira migraine kutemwa nemusoro.

Aimovig akagashira Kudya neDrug Administration (FDA) mvumo muna Chivabvu 2018. Waive mushonga wekutanga kubvumidzwa muCGRP antagonist kirasi yemishonga.

Mimwe mimwe mishonga miviri mukirasi ino yemishonga yakatenderwa mushure meAimovig: Emgality (galcanezumab) uye Ajovy (fremanezumab). Mushonga wechina, unonzi eptinezumab, parizvino uri kuongororwa mumakiriniki ekuedzwa.

Aimovig generic

Aimovig haisi kuwanikwa mune generic fomu. Izvo zvinongouya sezita-zita zita mishonga.

Aimovig ine mushonga erenumab, iyo inonziwo erenumab-aooe. Kuguma "-aooe" dzimwe nguva inowedzerwa kuratidza kuti mushonga wacho wakasiyana nemishonga yakafanana iyo inogona kugadzirwa mune ramangwana. Mimwe monoclonal antibody madhiragi anewo mafomati ezita seizvi.

Aimovig mhedzisiro

Aimovig inogona kukonzera zvinyoro kana zvakakomba mhedzisiro. Iri rinotevera runyorwa rine mamwe akakosha mhedzisiro mhedzisiro anogona kuitika uchitora Aimovig. Rondedzero iyi haisanganisi zvese zvinokanganisa mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvingangoitika mhedzisiro yeAimovig, kana matipi ekuti ungagadzirise sei zvinokanganisa mhedzisiro, taura nachiremba wako kana wemishonga.

Ongorora: Chikafu neDrug Administration (FDA) inoteedzera mhedzisiro yemishonga yavakagamuchira. Kana iwe uchida kuzivisa kune iyo FDA mhedzisiro iwe yawakave nayo neAimovig, unogona kuzviita kuburikidza neMedWatch.

Zvimwe zvakajairika mhedzisiro

Iyo inowanzoitika mhedzisiro mhedzisiro yeAimovig inogona kusanganisira:

• jekiseni saiti maitiro (kutsvuka, kunhuwa ganda, kurwadziwa)
• kuvimbiswa
• tsandanyama
• mhasuru

Mazhinji emhedzisiro iyi anogona kuenda mushure memazuva mashoma kana vhiki dzinoverengeka. Fonera chiremba wako kana wemishonga kana iwe uine zvakanyanya zvakakomba mhedzisiro kana mhedzisiro iyo isingaendi.

Yakakomba mhedzisiro

Yakakomba mhedzisiro kubva kuAimovig inogona kuitika, asi haina kujairika. Icho chakakomba chakakomba mhedzisiro mhedzisiro yeAimovig chirwere chakasimba chemuviri. Ona pazasi kuti uwane ruzivo.

Allergic reaction

Vamwe vanhu vane allergical reaction mushure mekutora Aimovig. Mhando iyi yekupindura inogoneka nemishonga yakawanda. Zviratidzo zvehunhu husina kugadzikana hunogona kusanganisira:

• uine mapundu paganda rako
• kunzwa kunhuwa
• kuputirwa (kuve nekudziya uye kutsvuka mukati meganda rako)

Kazhinji, zvakanyanya kukanganiswa nemhedzisiro zvinogona kuitika. Zviratidzo zveakanyanya kusagadzikana maitiro zvinogona kusanganisira:

• kuva nekuzvimba pasi peganda rako (kazhinji mumaziso ako, miromo, maoko, kana tsoka)
• kunzwa kufema kufema kana kunetseka kufema
• kuva nekuzvimba mururimi rwako, mukanwa, kana pahuro

Fonera chiremba wako ipapo ipapo kana iwe uchifunga kuti une chirwere chakanyanya kukanganiswa neAimovig. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana uine emergency emergency.

Kurera huremu / huremu

Kurera huremu uye kuwedzera huremu hazvina kutaurwa muzvidzidzo zvekiriniki zveAimovig. Nekudaro, vamwe vanhu vanogona kuona shanduko mukurema kwavo panguva yekurapwa kwaAimovig. Izvi zvinogona kunge zvichikonzerwa nemigraine pachayo kwete kuna Aimovig.

Vamwe vanhu vanogona kusanzwa nzara pamberi, panguva, kana mushure memusoro wemusoro. Kana izvi zvikaitika kazhinji zvakakwana, zvinogona kutungamira pakurasikirwa kwekurema kusingadiwe. Kana iwe ukarasikirwa nehavi yako kana iwe uine migraine musoro, shanda nachiremba wako kugadzira chirongwa chekudya icho chinoita chokwadi kuti iwe uwane zvese zvinovaka muviri iwe zvaunoda.

Kune rimwe divi remitambo, kurema kana kufutisa zvakajairika kune vanhu vane migraine. Uye zvidzidzo zvekiriniki zvakaratidza kuti kufutisa kungave kuri njodzi yekuwedzera migraine misoro kana kuwanda kwemusoro wemusoro.

Kana iwe uine hanya nezvekuti huremu hwako huri kukanganisa sei migraine yako musoro, taura nachiremba wako nezvenzira dzekugadzirisa uremu hwako.

Yenguva-refu mhedzisiro

Aimovig mushonga uchangobva kugamuchirwa mukirasi nyowani yemishonga. Nekuda kweizvozvo, pane kushomeka kushoma kwenguva refu kunowanikwa pane kuchengetedzeka kwaAimovig, uye zvishoma zvinozivikanwa nezve ayo mhedzisiro-refu mhedzisiro

Mune imwe yenguva refu-yekuchengetedza yekudzidza yakatora makore angangoita matatu, akanyanya kuwanda mhedzisiro akataurwa naAimovig aive:

• kurwadziwa shure
• Zvirwere zvepamusoro zvekufema (senge furuu yechirwere kana hutachiona hwechivi)
• furu-kunge zviratidzo

Kana uine izvi zvinokanganisa uye vari zvakakomba kana usingaendi, taura nachiremba wako.

Kuzvimbirwa

Kuzvimbirwa kwakaitika mukati mevatatu muzana yevanhu vakatora Aimovig muzvidzidzo zvekuchipatara.

Iyi divi mhedzisiro inogona kunge yakakonzerwa nekuti Aimovig inobata sei calcitonin peptide inoenderana negene (CGRP) mumuviri wako. CGRP ipuroteni inogona kuwanikwa mumatumbo uye inoita chinzvimbo mune yakajairwa kufamba kweura. Aimovig inovhara chiitiko cheGRP, uye chiitiko ichi chinogona kudzivirira zvakajairika ura kufamba kubva kuitika.

Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchirapwa neAimovig, taura nachiremba wako kana wemishonga nezve mishonga inogona kubatsira kuibvisa.

Bvudzi kurasikirwa

Kurasikirwa kwebvudzi hakusi divi mhedzisiro iyo yanga yakabatana neAimovig. Kana iwe ukaona kuti uri kurasikirwa nevhudzi, taura nachiremba wako nezve zvinogona kukonzeresa uye kurapwa.

Nausea

Nausea haisi mhedzisiro mhedzisiro yakataurwa nekushandisa kweAimovig. Zvisinei, vanhu vazhinji vane migraine vanogona kunzwa kushungurudzika panguva yemusoro wemusoro.

Kana iwe uchinzwa kusvotwa panguva yemigraine kutemwa nemusoro, zvinogona kubatsira kugara murima, mukamuri rakanyarara, kana kuenda kunze kunofurwa nemhepo. Iwe unogona zvakare kubvunza chiremba wako kana wemishonga nezve mishonga inogona kubatsira kudzivirira kana kurapa kusvotwa.

Kuneta

Kuneta (kushomeka kwesimba) haisi mhedzisiro iyo yakabatana neAimovig. Asi kunzwa kuneta chiratidzo chakajairika chemigraine icho vanhu vazhinji vanonzwa pamberi, panguva, kana mushure mekurwadziwa nemusoro kunoitika.

Imwe kiriniki yekudzidza yakaratidza kuti vanhu vane migraine vane zvakanyanya kutemwa nemusoro vainyanya kunzwa kuneta.

Kana iwe uchinetswa nekuneta, taura nachiremba wako nezvenzira dzekuvandudza masimba ako esimba.

Manyoka

Dhairrhea haisi mhedzisiro iyo yakataurwa nekushandiswa kweAimovig. Zvisinei, icho chisingawanzo chiratidzo che migraine. Ikoko kunogona kutove nekubatana pakati pemigraine uye yekuzvimba ura chirwere uye kumwe kusagadzikana kwepamuviri.

Kana iwe uine manyoka anogara kwenguva yakareba kupfuura mazuva mashoma, taura nachiremba wako.

Kusarara

Kusarara (kunetseka kurara) haisi mhedzisiro iyo yakawanikwa muzvidzidzo zvekiriniki zveAimovig. Zvisinei, imwe kliniki yekudzidza yakawana kuti vanhu vane migraine vane kusuruvara vanowanzova nemagraine musoro kazhinji. Muchokwadi, kushomeka kwekurara kunogona kuita kuti kuve nemusoro wemusoro uye kuwedzera njodzi yekukura isingaperi migraine.

Kana iwe uine hope uye uchifunga kuti zvinogona kunge zvichikanganisa migraine yako musoro, taura nachiremba wako nezvenzira dzekurara zvirinani.

Kutambudzika kwemhasuru

Muzvidzidzo zvekiriniki, vanhu vakagamuchira Aimovig havana kuona kurwadziwa kwemhasuru. Vamwe vaive nemhasuru uye mhasuru, uye mukudzidza kwekuchengetedza kwenguva refu, vanhu vanotora Aimovig vakaona kurwadziwa musana.

Kana iwe uine kurwadziwa kwemhasuru uchitora Aimovig, zvinogona kunge zviri nekuda kwezvimwe zvikonzero. Semuenzaniso, kurwadziwa kwemhasuru mumutsipa kunogona kuve chiratidzo chemigraine kune vamwe vanhu. Zvakare, jekiseni saiti kusagadzikana, kusanganisira marwadzo munzvimbo yakatenderedza jekiseni, inogona kunzwa sekurwadziwa kwemhasuru. Rudzi urwu rwekurwadziwa runofanira kuenda mukati memazuva mashoma ejekiseni.

Kana iwe uine kurwadziwa kwemhasuru kusingaendi kana kuri kukanganisa hupenyu hwako, taura nachiremba wako nezve sarudzo dzekurwadziwa.

Itching

Kazhinji kunhuwa hakusi mhedzisiro mhedzisiro yakaonekwa muzvidzidzo zvekiriniki zveAimovig. Nekudaro, inocheka ganda munzvimbo iyo Aimovig jekiseni inowanzo kutaurwa.

Ganda rinocheka padyo nenzvimbo yejekiseni rinofanira kuenda mukati memazuva mashoma. Kana iwe uine hunhu husingaendi, kana kana iko kunetseka kuri kwakanyanya, taura nachiremba wako.

Aimovig mutengo

Sezvo nemishonga yese, mitengo yeAimovig inogona kusiyana.

Yako chaiyo mutengo inoenderana neinishuwarenzi yako yekuvhara, nzvimbo yako, uye pharmacy yaunoshandisa.

Rubatsiro rwemari

Kana iwe uchida rutsigiro rwemari kubhadhara Aimovig, rubatsiro runowanikwa.

Amgen naNovartis, vagadziri veAimovig, vanopa chirongwa cheAimovig Ally Access Card icho chinogona kukubatsira iwe kubhadhara zvishoma kune imwe neimwe tsamba yekuzadza. Kuti uwane rumwe ruzivo uye kuti uone kana iwe uchikodzera, fonera 833-246-6844 kana kushanyira iyo webhusaiti chirongwa.

Aimovig anoshandisa

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai saAimovig kurapa kana kudzivirira mamwe mamiriro.

Aimovig yemigraine kutemwa nemusoro

Aimovig is FDA-inogamuchirwa yekudzivirira migraine misoro muvanhu vakuru. Iyi misoro yakasimba ndiyo chiratidzo chinowanzoonekwa chemigraine, inova chirwere chetsinga.

Zvimwe zviratidzo zvinogona kuitika nemusoro wemagraine, senge:

• kusvotwa
• kurutsa
• kunzwisisika kuchiedza uye kurira
• kunetseka kutaura

Migraine inogona kusarudzwa senge episodic kana isingagumi, sekureva kweInternational Headache Society. Aimovig inobvumidzwa kudzivirira ese episodic migraine uye chisingaperi migraine musoro. Misiyano pakati pemhando idzi dzemigraine ndeiyi:

• episodic migraine inokonzeresa mashoma pane gumi nemashanu musoro kana mazuva emigraine pamwedzi
• chisingaperi migraine chinokonzeresa gumi nemashanu kana kupfuura mazuva emusoro pamwedzi pamusoro pemwedzi inokwana mitatu, aine angangoita masere emazuva ari migraine mazuva

Zvishandiso zvisina kubvumidzwa

Aimovig inogona zvakare kushandiswa kure-chitaridzi kune mamwe mamiriro. Kunze-chitambi kushandiswa ndiko kana mushonga unobvumidzwa kurapa imwechete mamiriro unorayirwa kurapa imwe mamiriro.

Aimovig yemasumbu emusoro

Aimovig haisi FDA-inogamuchirwa kudzivirira masumbu emusoro, asi inogona kushandiswa kure-chitaridzi nekuda kwechinangwa ichi. Hazvizivikanwe parizvino kana Aimovig inoshanda mukudzivirira masumbu emusoro.

Masumbu emusoro masumbu anorwadza kutemwa nemusoro kunoitika mumasumbu (mazhinji misoro kwenguva pfupi). Vanogona kunge vari episodic kana isingagumi. Episodic masumbu emusoro ane marefu kwenguva pakati pemasumbu emusoro. Asingaperi masumbu emusoro ane misoro ipfupi pakati pemasumbu emusoro.

Aimovig haina kuyedzwa kudzivirira kwecluster misoro mumakiriniki ekudzidza. Nekudaro, mimwe mishonga iri yekirasi imwechete yemishonga saAimovig, kusanganisira Emgality naAjovy, yakaedzwa.

Mune imwe kiriniki yekudzidza, Emgality yakawanikwa ichibatsira kudzivirira episodic masumbu emusoro. Asi kwekuyedzwa kwekiriniki kwaAjovy, mugadziri wezvinodhaka akamisa chidzidzo kare nekuti Ajovy aisashanda kudzikisa huwandu hwemisumbu yemasumbu isingaperi yevanhu vari muchidzidzo.

Aimovig yemusoro wevhestibular

Aimovig haisi FDA-inogamuchirwa kudzivirira kana kubata vestibular musoro. Vestibular kutemwa nemusoro kwakasiyana neyechinyakare migraine kutemwa nemusoro nekuti kazhinji hazvirwadzi. Vanhu vane vestibular musoro vanogona kunzwa dzungu kana kuona vertigo. Zviratidzo izvi zvinogona kupedza masekondi kusvika maawa.

Zvidzidzo zvekiriniki hazvina kuitwa kuratidza kuti Aimovig inoshanda mukudzivirira kana kurapa vestibular musoro. Asi vamwe vanachiremba vangangosarudza kupa mushonga uyu kure-chitambi cheichi chiitiko.

Aimovig chipimo chemushonga

Iyo Aimovig muyero unorayirwa nachiremba wako inoenderana nezvakawanda zvinhu. Izvi zvinosanganisira kuomarara kwechimiro chauri kushandisa Aimovig kurapa.

Kazhinji, chiremba wako anokutanga iwe pane yakaderera dosi uye uigadzirise nekufamba kwenguva kuti usvike padosi yakakunakira iwe. Ivo pakupedzisira vanozopa diki diki iyo inopa iyo yaunoda mhedzisiro.

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda.

Mafomu uye simba

Aimovig inouya mune imwe-dosi, yakagadzirirwa autoinjector iyo inoshandiswa kupa subcutaneous jekiseni (jekiseni rinoenda pasi peganda). Iyo autoinjector inouya mune rimwe simba: 70 mg pajekiseni. Imwe neimwe autoinjector inoitirwa kushandiswa kamwe chete uye zvobva zvaraswa.

Dosage yemigraine

Aimovig inogona kurongerwa muzvikamu zviviri: 70 mg kana 140 mg. Chero imwe dose inotorwa kamwe pamwedzi.

Kana chiremba wako akaraira 70 mg, iwe uchazvipa jekiseni rimwe pamwedzi (uchishandisa imwe autoinjector). Kana chiremba wako akaraira 140 mg, iwe uchazvipa majekiseni maviri pamwedzi, imwe ichitevera imwe (uchishandisa mairi maviri majekiseni).

Chiremba wako anotanga kurapwa kwako pa 70 mg pamwedzi. Kana muyero uyu ukasaderedza huwandu hwemazuva emigraine zvakakwana, chiremba wako anogona kuwedzera dosi yako kusvika ku140 mg pamwedzi.

Ko kana ndikapotsa dosi?

Tora dhivha paunongoona kuti warasa imwe. Yako inotevera dose inofanira kuve mwedzi mumwe mushure meiyo. Rangarira iyo nyowani zuva kuti iwe ugone kuronga nezve rako ramangwana dosi.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Kana Aimovig ichibudirira mukudzivirira migraine kutemwa nemusoro kwauri, iwe nachiremba wako mungasarudza kuenderera mberi nekurapwa naAimovig kwenguva refu.

Dzimwe nzira kune Aimovig

Mimwe mishonga inowanikwa kubatsira kudzivirira migraine kutemwa nemusoro. Vamwe vanogona kukushandira zvirinani pane vamwe. Kana iwe uchifarira kuyedza kurapwa kunze kweAimovig, taura nachiremba wako kuti udzidze zvakawanda nezve mimwe mishonga inogona kukushandira zvakanaka.

Mienzaniso yemimwe mishonga iyo FDA-inogamuchirwa yekudzivirira migraine misoro inosanganisira:

• mamwe macalcitonin epineti ane hukama negene (peptide) (CGRP) vanopikisa:
• fremanezumab-vrfm (Ajovy)
• galcanezumab-gnlm (Emgality)
• imwe mishonga yekubata, yakadai se:
• divalproex sodium (Depakote)
• topiramate (Topamax, Trokendi XR)
• iyo neurotoxin onabotulinumtoxinA (Botox)
• iyo beta-blocker propranolol (Inderal, Inderal LA)

Mimwe mishonga inoshandiswa isiri-yekudzivirira migraine kutemwa nemusoro. Iyi mishonga inosanganisira:

• mamwe mishonga yekudzvinyirira, senge amitriptyline kana venlafaxine (Effexor XR)
• imwe mishonga yekubvuta, yakadai sevalproate sodium
• mamwe beta-blockers, senge metoprolol (Lopressor, Toprol XL) kana atenolol (Tenormin)

CGRP vanopikisa

Aimovig chikamu chekirasi nyowani yemishonga inonzi calcitonin gene-related peptide (CGRP) vanopikisa. Aimovig yakagamuchirwa neDFA mu2018 kudzivirira migraine kutemwa nemusoro. Vamwe vaviri vanopokana neCGRP vanonzi Ajovy uye Emgality vakabvumidzwa munguva pfupi yapfuura. Mushonga wechina mukirasi ino (eptinezumab) unotarisirwa kubvumidzwa munguva pfupi iri kutevera.

Mashandiro avo

Vanopokana neCGRP vanopikisa vanoshanda nenzira dzakafanana dzekudzivirira migraine misoro.

CGRP ipuroteni mumuviri wako yakave yakabatana nekuzvimba uye vasodilation (kuwedzerwa kwemitsipa yeropa) muuropi. Uku kuzvimba uye vasodilation kunogona kukonzera marwadzo kubva ku migraine kutemwa nemusoro. Kuti ikonzere mhedzisiro iyi, CGRP inoda kusunga (kunamatira) kune ayo anogamuchira, ayo ari masosi ari pamusoro peamwe maseru ako ehuropi.

Ajovy uye Emgality zvese zvinoshanda nekusunga kuCGRP pachayo. Nekuda kweizvozvo, CGRP haigone kusunga kune ayo anogamuchira. Kusiyana nemamwe madhiragi maviri mukirasi ino, Aimovig inoshanda nekusunga kuuropi maseru receptors. Izvi zvinodzivirira iyo CGRP kubva pakuita izvi.

Nekuvharira CGRP kubva mukudyidzana neyakagashira yayo, ese matatu madhiragi anobatsira kumisa kuzvimba uye vasodilation. Izvi zvinogona kubatsira kudzivirira migraine misoro.

Pedyo ne pedyo

Iyo chati pazasi inofanidza ruzivo rwekutanga nezve matatu matatu-anogamuchirwa madhiragi mukirasi ino ayo anoshandiswa kudzivirira migraine kutemwa nemusoro. Kuti udzidze zvakawanda nezvekuti Aimovig anofananidzwa sei nemimwe iyi mishonga, ona chikamu chinotevera ("Aimovig vs. mimwe mishonga").

Mitengo inogona kusiyana zvichienderana nenzvimbo yauri, iyo mishonga inoshandiswa, yako inishuwarenzi kufukidza, uye zvirongwa zvekugadzira zvigadzirwa.

Aimovig vs. mimwe mishonga

Unogona kushamisika kuti Aimovig inofananidzwa sei nemimwe mishonga inorayirwa kushandiswa kwakafanana. Pazasi pane kuenzanisa pakati peAimovig nemimwe mishonga.

Aimovig vs. Ajovy

Aimovig ine chinodhaka erenumab, inova monoclonal antibody. Ajovy ine mushonga fremanezumab, inovawo monoclonal antibody. Monoclonal antibodies mishonga inogadzirwa murabhoritari. Iyi mishonga inogadzirwa kubva kumasero ezvirwere zvemuviri. Ivo vanoshanda nekudzivirira chiitiko chemamwe mapuroteni mumuviri wako.

Aimovig naAjovy vese vanomisa chiitiko cheprotein inonzi calcitonin peptide inoenderana negene (CGRP). CGRP inokonzera kuzvimba uye vasodilation (kuwedzerwa kwemitsipa yeropa) muuropi, izvo zvinogona kukonzera maronda emusoro. Kuvhara CGRP kunobatsira kudzivirira migraine misoro.

Zvishandiso

Aimovig naAjovy vese vari vaviri FDA-inogamuchirwa kudzivirira migraine misoro muvakuru.

Mafomu uye manejimendi

Aimovig naAjovy vese vanouya mune jekiseni fomu rinoiswa pasi peganda rako (subcutaneous). Unogona kuzvibaya jekiseni kumba. Ose madhiragi anogona kuzvibaya-jekiseni mune dzimwe nzvimbo, senge:

• dumbu rako
• kumberi kwezvidya zvako
• kumashure kwemaoko ako ekumusoro

Aimovig inopihwa seyadhi-imwe yakatemwa autoinjector. Inowanzo kupihwa se 70-mg jekiseni kamwe pamwedzi. Nekudaro, vamwe vanhu vanopihwa yakakwira dosi ye140 mg mwedzi wega.

Ajovy inopihwa seyesipimo-dhizaini yakasarudzika sirinji. Inogona kupihwa seimwe jekiseni ye225 mg kamwe chete pamwedzi. Kana inogona kupihwa majekiseni matatu e225 mg kamwe chete pamwedzi mitatu.

Side migumisiro uye njodzi

Aimovig naAjovy vanoshanda nenzira dzakafanana uye vanokonzeresa mamwe emhedzisiro. Izvo zvakajairika uye zvakakomba mhedzisiro yemaviri madhiragi ari pazasi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yezvinowanzoitika mhedzisiro mhedzisiro inogona kuitika neAimovig, neAjovy, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika naAimovig:
• kuvimbiswa
• tsandanyama kana mhasuru
• chirwere chepamusoro chekufema (senge furuu yechirwere kana hutachiona hwechivi)
• furu-kunge zviratidzo
• kurwadziwa shure
• Zvinogona kuitika naAjovy:
• hapana yakasarudzika yakajairika mhedzisiro
• Zvinogona kuitika pamwe neese Aimovig naAjovy:
• jekiseni saiti saiti senge kurwadziwa, kunhuwa, kana kutsvuka

Yakakomba mhedzisiro

Iyo yekutanga yakakomba mhedzisiro mhedzisiro kune vese Aimovig naAjovy inorwara zvakanyanya. Kuita kwakadai hakuna kujairika, asi zvinogoneka. (Kuti uwane rumwe ruzivo, ona "Allergic reaction" pasi pe "Aimovig mhedzisiro" pamusoro).

Immune reaction

Mumakiriniki miedzo yakaitirwa vese Aimovig naAjovy, vashoma vanhu vakave nema immune reaction kumishonga. Kuita uku kwakakonzera miviri yavo kukudziridza masoja ekudzivirira mishonga.

Maantibodies mapuroteni akagadzirwa nema immune system kurwisa zvinhu zvekunze mumuviri wako. Muviri wako unogona kukudziridza antibodies kune chero chinhu chekunze, kusanganisira monoclonal antibodies. Kana muviri wako ukaita maantibhakitiriya kuAimovig kana Ajovy, mushonga wacho haugone kukushandira.

Mumakiriniki miedzo yeAimovig, vanopfuura 6 muzana yevanhu vakagadzira ma antibodies kumushonga. Mukuenderera mberi kwezvidzidzo zvekiriniki, vashoma pane vaviri muzana muzana vevanhu vakagadzira ma antibodies kuna Ajovy.

Nekuti Aimovig naAjovy vakabvumidzwa muna2018, zvichiri zvekare kuti vazive kuti izvi zvingave zvakajairika sei uye kuti zvingakanganisa sei mashandisiro anoita vanhu mishonga iyi mune ramangwana.

Kubudirira

Aimovig naAjovy vese vari vaviri vanoshanda pakudzivirira migraine kutemwa nemusoro, asi ivo havana kuenzaniswa zvakananga mumakiriniki ekuedzwa.

Nekudaro, migraine yekurapa nhungamiro inokurudzira chero mushonga senzira yevamwe vanhu. Izvi zvinosanganisira vanhu vano:

• havagone kudzikisa yavo yemwedzi migraine mazuva akakwana nemimwe mishonga
• haigone kutsungirira mimwe mishonga nekuda kwemhedzisiro kana kusangana kwemishonga

Episodic migraine

Zvidzidzo zvakasiyana zveAimovig naAjovy zvakaratidza kushanda kwekudzivirira episodic migraine misoro.

• Mune kiriniki zvidzidzo zveAimovig, vangangoita makumi mana muzana yevanhu vane episodic migraine vakagamuchira 70 mg yemushonga pamwedzi vakatema mazuva avo emigraine neinenge hafu yemwedzi mitanhatu. Kusvika makumi mashanu muzana yevanhu vakagashira 140 mg vakave nemhedzisiro yakafanana.
• Mune kiriniki yekudzidza yeAjovy, vangangoita makumi mana neshanu muzana yevanhu vane episodic migraine vakagamuchira kurapwa kwemwedzi nemushonga vakatema mazuva avo emigraine neinenge hafu yemwedzi mitatu. Vanenge makumi mana nezvina muzana yevanhu vakagamuchira Ajovy mwedzi mitatu yega yega vakave nemhedzisiro yakafanana.

Chisingaperi migraine

Zvidzidzo zvakasiyana zveAimovig naAjovy zvakare zvakaratidza kushanda kwekudzivirira chisingaperi migraine misoro.

• Mumwedzi mitatu yemakiriniki yekudzidza yeAimovig, inenge makumi mana muzana yevanhu vane chirwere chisingaperi chemigraine vakagamuchira 70 mg kana 140 mg yemushonga pamwedzi vaive nehafu yemazuva emigraine kana mashoma.
• Mumwedzi mitatu yemakiriniki yekudzidza yeAjovy, vangangoita 41 muzana yevanhu vane chirwere chisingaperi chemigraine vakagashira mwedzi wega Ajovy kurapwa vaive nehafu yemazuva emigraine mushure mekurapwa kana vashoma. Pakati pevanhu vakagamuchira Ajovy mwedzi mitatu yega yega, vangangosvika makumi matatu nenomwe muzana vaive nemhedzisiro yakafanana.

Mariro

Aimovig naAjovy vese vari vaviri zita rezita mishonga. Iko hakuna generic mafomu eimwe mishonga iripo. Brand-zita mishonga kazhinji inodhura zvakanyanya kupfuura generic mafomu.

Kubva pane fungidziro kubva kuGoodRx.com, Aimovig neAjovy zvinodhura zvakaenzana zvakaenzana. Mutengo chaiwo waungabhadhare chero chinodhaka unobva pane hurongwa hweinishuwarenzi, kwaunogara, uye kufamasi yaunoshandisa. Mutengo wako weAimovig waizoenderanawo nedosi rako.

Aimovig vs. Botox

Aimovig ine monoclonal antibody inonzi erenumab. Monoclonal antibody rudzi rwemushonga wakagadzirwa murabhoritari. Iyi mishonga inogadzirwa nema immune system maseru. Aimovig inoshanda kudzivirira migraine kutemwa nemusoro nekuvharidzira chiitiko cheimwe puroteni inogona kuvakonzera.

Botox ine mushonga onabotulinumtoxinA. Mushonga uyu ndewekirasi yemishonga inonzi maurotoxin. Botox inoshanda nekuremadza kwenguva pfupi mhasuru iyo yakaiswa mukati. Izvi zvinodzivirira zviratidzo zvekurwadziwa mumhasuru kubva pakuitwa.Zvinofungidzirwa kuti maitiro aya anobatsira kudzivirira migraine kutemwa nemusoro vasati vatanga.

Zvishandiso

Aimovig inogamuchirwa neDFA kudzivirira episodic kana chisingaperi migraine misoro muvakuru.

Botox inonzi FDA-inogamuchirwa kudzivirira isingagumi migraine misoro muvanhu vakuru. Botox inobvumidzwawo kubata mamwe akati wandei mamiriro, akadai se:

• remuromo dystonia (inorwadza mutsipa mutsipa)
• eyelid spasms
• yakanyanyisa kuita dundira
• mhasuru kusimba
• vangadikitira zvakanyanya

Mafomu uye manejimendi

Aimovig inouya seyechete-dhizaini yakagadzirirwa autoinjector. Inopihwa sejekiseni pasi peganda rako (subcutaneous) raunogona kuzvipa uri kumba. Inopihwa pachiyero che 70 mg kana 140 mg pamwedzi.

Aimovig inogona kujowa mune dzimwe nzvimbo dzomuviri. Izvi ndeizvi:

• dumbu rako
• kumberi kwezvidya zvako
• kumashure kwemaoko ako ekumusoro

Botox inongopihwa muhofisi yechiremba. Inobayiwa nesirinji mumhasuru (intramuscular), kazhinji masvondo gumi nemaviri ese. Nzvimbo dzinowanzoitika jekiseni dzinosanganisira:

• huma yako
• kumashure kwemutsipa wako nemapfudzi
• kumusoro uye pedyo nenzeve dzako
• padhuze nemusoro wako webvudzi pazasi pemutsipa wako

Chiremba wako anowanzo kukupa majekiseni makumi matatu nematatu munzvimbo idzi panguva yega yega.

Side migumisiro uye njodzi

Aimovig neBotox ese ari maviri anoshandiswa kudzivirira migraine kutemwa nemusoro, asi anoshanda nenzira dzakasiyana. Naizvozvo, vane mamwe akafanana mhedzisiro uye mamwe akasiyana.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemigumisiro yakakomba inogona kuitika neAimovig, neBotox, kana nemishonga yose (kana inotorwa zvakasiyana).

• Zvinogona kuitika naAimovig:
• kuvimbiswa
• tsandanyama
• mhasuru mhasuru
• kurwadziwa shure
• chirwere chepamusoro chekufema (senge furuu yechirwere kana hutachiona hwechivi)
• Inogona kuitika neBotox:
• kurwadziwa nemusoro kana kuwedzera migraine
• eyelid ikadonha
• kumeso mhasuru kuoma mitezo
• kurwadziwa kwemutsipa
• kuomarara kwemhasuru
• kurwadziwa kwemhasuru uye kushaya simba
• Zvinogona kuitika pamwe neese Aimovig neBotox:
• jekiseni saiti maitiro
• furu-kunge zviratidzo

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yemigumisiro yakakomba inogona kuitika neAimovig, neBotox, kana nemishonga yose (kana inotorwa zvakasiyana).

• Zvinogona kuitika naAimovig:
• mashoma akasarudzika akakomba mhedzisiro
• Inogona kuitika neBotox:
• kupararira kwekuoma mitezo kune mhasuru dziri padyo *
• kunetseka kumedza uye kufema
• hutachiona hwakakomba
• Zvinogona kuitika pamwe neAimovig neBotox:
• zvakakomba zvemuviri kukanganiswa

Botox ine yambiro yebhokisi kubva kuDAA yekupararira kwekuoma mitezo kusvika kumhasuru dziri pedyo zvichitevera jekiseni. Nyevero yebhokisi ndiyo yambiro yakasimba iyo FDA inoda. Inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

Kubudirira

Mamiriro ezvinhu chete ayo ese Aimovig neBotox anoshandiswa kudzivirira ndeyekusingaperi migraine kutemwa nemusoro.

Mirayiridzo yekurapa inokurudzira Aimovig sesarudzo kune vanhu vasingakwanise kudzikisa huwandu hwavo hwemigraine mazuva akakwana nemimwe mishonga. Inokurudzirwawo kune vanhu vasingakwanise kutora mimwe mishonga nekuda kwemhedzisiro kana kusangana kwemishonga.

Botox inokurudzirwa neAmerican Academy yeNeurology senzira yekurapa kune vanhu vane chirwere chisingaperi chemigraine.

Kubudirira kwemishonga iyi hakuna kuenzaniswa zvakananga muzvidzidzo zvekiriniki. Zvisinei, mune zvidzidzo zvakasiyana, Aimovig naBotox vose vakawana zvibereko zvinobudirira mukudzivirira kusingaperi kwemigraine misoro.

• Mune kiriniki yekudzidza yeAimovig, inenge makumi mana muzana yevanhu vane chirwere chisingaperi chemigraine vakagamuchira 70 mg kana 140 mg vaive nehafu yemazuva emigraine mazuva kana mashoma mushure memwedzi mitatu.
• Muzvidzidzo zvekiriniki zvevanhu vane chirwere chisingaperi chemigraine, Botox yakaderedza huwandu hwemazuva emusoro kusvika mazuva 9.2 paavhareji pamwedzi, pamusoro pemavhiki makumi maviri nemana. Mune kumwe kuongorora, kwakatenderedza 47 muzana yevanhu vakadzora huwandu hwemazuva ekurwadziwa nemusoro nehafu.

Mariro

Aimovig naBotox ese ari maviri zita-zita mishonga. Ikozvino hapana mafomu akajairika anowanikwa chero emushonga.

Zvinoenderana nekufungidzira kubva kuGoodRx.com, Botox kazhinji inodhura pane Aimovig. Mutengo chaiwo waungabhadhare chero chinodhaka unoenderana nedosi yako, chirongwa cheinishuwarenzi, kwaunogara, uye pharmacy yaunoshandisa.

Aimovig vs. Emgality

Aimovig ine monoclonal antibody inonzi erenumab. Emgality ine monoclonal antibody inonzi galcanezumab. Monoclonal antibody rudzi rwemushonga wakagadzirwa murabhoritari. Iyi mishonga inogadzirwa nema immune system maseru. Ivo vanoshanda nekudzivirira chiitiko chemamwe mapuroteni mumuviri wako.

Aimovig uye Emgality zvese zvinodzivirira chiitiko cheprotein mumuviri wako chinonzi calcitonin peptide inoenderana negene (CGRP). CGRP inokonzera kuzvimba uye vasodilation (kuwedzerwa kwemitsipa yeropa) muuropi, izvo zvinogona kukonzeresa migraine kutemwa nemusoro. Nekudzivirira chiitiko cheCGRP, iyi mishonga inobatsira kumisa kuzvimba uye vasodilation. Izvi zvinobatsira kudzivirira migraine misoro.

Zvishandiso

Aimovig uye Emgality zvese zviri zviviri FDA-inogamuchirwa kudzivirira migraine misoro muvanhu vakuru.

Mafomu uye manejimendi

Aimovig inopihwa mune imwechete-dhizaini yakagadzirirwa autoinjector. Emgality inopihwa mune imwechete-dhizaini yakasarudzika sirinji uye imwechete-dhiza yakadirwa peni. Ose madhiragi anopiwa se subcutaneous jekiseni (jekiseni pasi peganda). Unogona kuzvibaya kumba kamwe chete pamwedzi.

Mishonga iyi yese inogona kuiswa jekiseni pasi peganda pane dzimwe nzvimbo pamuviri wako. Izvi ndeizvi:

• dumbu rako
• kumberi kwezvidya zvako
• kumashure kwemaoko ako ekumusoro

Unhu hunogona zvakare kuiswa jekiseni pasi peganda remabvi ako.

Aimovig inorayirwa se 70-mg kana 140-mg jekiseni pamwedzi. Emgality inotsanangurwa se 120-mg jekiseni pamwedzi.

Side migumisiro uye njodzi

Aimovig uye Emgality mishonga yakafanana iyo inokonzeresa zvimwe zvakafanana uye zvakakomba mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemhedzisiro mhedzisiro mhedzisiro inogona kuitika neAimovig, neEggality, kana nezvose zviri zviviri zvinodhaka (kana zvatorwa zvakasiyana).

• Zvinogona kuitika naAimovig:
• kuvimbiswa
• tsandanyama
• mhasuru mhasuru
• furu-kunge zviratidzo
• Zvinogona kuitika neEggality:
• huro inorwadza
• Zvinogona kuitika pamwe neese Aimovig uye Emgality:
• jekiseni saiti maitiro
• kurwadziwa shure
• chirwere chepamusoro chekufema (senge furuu inowanzoitika kana hutachiona hwechivi)

Yakakomba mhedzisiro

Kuwedzera kweanorwara maitiro isingawanzo kukomba kwakakomba mhedzisiro kune ese Aimovig uye Emgality. (Kuti uwane rumwe ruzivo, ona "Allergic reaction" pasi pe "Aimovig mhedzisiro" pamusoro).

Immune reaction

Mumakiriniki miedzo yemushonga wega wega, vanhu vashoma vaive nehutachiona hwemuviri kuna Aimovig uye Emgality. Nemhando iyi yekupindura, immune immune system yakagadzira antibodies kupokana nemishonga.

Maantibodies mapuroteni muma immune system ako anorwisa zvinhu zvekunze mumuviri wako. Muviri wako unogona kugadzira maantibhakitiriya kune chero chinhu chekunze, kusanganisira monoclonal antibodies senge Aimovig uye Emgality.

Kana muviri wako ukaita ma antibodies kune imwe yemishonga iyi, zvinokwanisika kuti mushonga wacho hauchazoshanda kudzivirira migraine kutemwa nemusoro kwako.

Muzvidzidzo zvekiriniki zveAimovig, vanopfuura zvikamu zvitanhatu kubva muzana zvevanhu vanotora mushonga wakagadzira masoja. Uye muzvidzidzo zvekiriniki zveEggality, vangangoita mashanu muzana yevanhu vakagadzira maantibhakitiriya kune Emgality.

Nekuti Aimovig uye Emgality zvakagamuchirwa mu2018, zvakanyanyisa kukurumidza kuziva kuti vangani vanhu vangave nemhando iyi yekuita. Izvo zvakare zvekare kuti uzive kuti zvingakanganisa sei mashandisiro anoita vanhu madhiragi aya mune ramangwana.

Kubudirira

Aimovig uye Emgality hazvina kuenzaniswa muzvidzidzo zvekiriniki, asi zvese zviri zviviri zvinobatsira kudzivirira migraine kutemwa nemusoro.

Mirayiridzo yekurapa inokurudzira Aimovig uye Emgality sesarudzo dzevanhu vane episodic kana chisingaperi migraine avo:

• haigone kutora mimwe mishonga nekuda kwemhedzisiro kana kusangana kwemishonga
• haigone kudzikisa huwandu hwavo hwemwedzi wemigraine mazuva akakwana nemimwe mishonga

Episodic migraine

Zviparadzanisa zvakasiyana zveAimovig uye Emgality zvakaratidza kuti ese ari maviri mishonga anoshanda kudzivirira episodic migraine misoro:

• Mune kiriniki zvidzidzo zveAimovig, inosvika makumi mashanu muzana yevanhu vane episodic migraine vakagamuchira 140 mg yemushonga yakaderedza mazuva avo emigraine neinenge hafu yemwedzi mitanhatu. Vanenge makumi mana muzana yevanhu vakagashira 70 mg vakaona zvakafanana mhedzisiro.
• Mune Emgality's kiriniki zvidzidzo zvevanhu vane episodic migraine, vakatenderedza 60 muzana yevanhu vakaderedza huwandu hwavo hwemazuva emigraine neinenge hafu inopfuura mwedzi mitanhatu yekurapa kweEggality. Kusvikira ku16 muzana vaive vasina migraine- mushure memwedzi mitanhatu yekurapwa.

Chisingaperi migraine

Zviparadzanisa zvakasiyana zveAimovig uye Emgality zvakaratidza kuti ese ari maviri mishonga anobatsira kudzivirira chisingaperi migraine misoro:

• Mumwedzi mitatu yemakiriniki yekudzidza kwevanhu vane chirwere chisingaperi chemigraine, vangangoita makumi mana muzana yevanhu vakatora 70 mg kana 140 mg yeAimovig vaive nehafu yemazuva emigraine kana vashoma vaine kurapwa.
• Mune kiriniki yemwedzi mitatu yekudzidza kwevanhu vane chirwere chisingaperi chemigraine, vangangoita makumi matatu muzana yevanhu vakatora Emgality kwemwedzi mitatu vaive nehafu yemazuva emigraine kana vashoma nemushonga.

Mariro

Aimovig uye Emgality ese ari maviri zita-zita mishonga. Ikozvino hapana mafomu akajairika anowanikwa chero emushonga. Brand-zita zvinodhaka kazhinji zvinodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira kubva kuGoodRx.com, Aimovig uye Emgality zvinodhura zvakada kufanana. Mutengo chaiwo waungabhadhare chero chinodhaka unoenderana nedosi yako, chirongwa cheinishuwarenzi, kwaunogara, uye pharmacy yaunoshandisa.

Aimovig vs.Topamax

Aimovig ine monoclonal antibody inonzi erenumab. Monoclonal antibody rudzi rwemushonga unogadzirwa kubva kumasero ezvirwere zvemuviri. Zvinodhaka zverudzi urwu zvinogadzirwa murabhoritari. Aimovig inobatsira kudzivirira migraine kutemwa nemusoro nekumisa chiitiko chemamwe mapuroteni anovakonzera.

Topamax ine topiramate, mhando yemushonga iyo inoshandiswawo kubata pfari. Hazvina kunyatsonzwisiswa kuti Topamax inoshanda sei kudzivirira migraine misoro. Zvinofungidzirwa kuti mushonga unoderedza mashandiro emasero etsinga muuropi izvo zvinogona kukonzeresa kutemwa nemusoro.

Zvishandiso

Ose maviri Aimovig neTopamax ari FDA-anotenderwa kudzivirira migraine kutemwa nemusoro. Aimovig inogamuchirwa kuti ishandiswe muvakuru, nepo Topamax ichibvumidzwa kushandiswa muvakuru nevana vane makore gumi nemaviri zvichikwira.

Topamax inogamuchirwawo kurapa pfari.

Mafomu uye manejimendi

Aimovig inouya mune imwechete-dhizaini yakagadzirirwa autoinjector. Inopihwa sejekiseni pasi peganda rako (subcutaneous) yaunozvipa pamba kamwe pamwedzi. Iyo chaiyo dhizeti ndeye 70 mg, asi vamwe vanhu vanogona kubatsirwa kubva ku140-mg dosi.

Topamax inouya semuromo wemuromo kana piritsi yemuromo. Iyo yakajairwa muyero ndeye 50 mg inotorwa kaviri pazuva. Zvichienderana nezvakakurudzirwa nachiremba wako, unogona kutanga pane yakaderera dosi uye wobva wawedzera kune yakajairwa muyero kwemwedzi yakati wandei.

Side migumisiro uye njodzi

Aimovig neTopamax vanoshanda munzira dzakasiyana mumuviri uye nekudaro vane mhedzisiro dzakasiyana. Mimwe yemhedzisiro uye yakakomba mhedzisiro yemishonga iyi iri pazasi. Chinyorwa chiri pazasi hachisanganise zvese zvinokanganisa mhedzisiro.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemigumisiro yakakomba iyo inogona kuitika neAimovig, neTopamax, kana nemishonga yose (kana inotorwa mumwe nomumwe).

• Zvinogona kuitika naAimovig:
• jekiseni saiti maitiro
• kurwadziwa shure
• kuvimbiswa
• tsandanyama
• mhasuru
• furu-kunge zviratidzo
• Zvinogona kuitika neTopamax:
• huro inorwadza
• kuneta
• paresthesia (kunzwa kwe "pini uye tsono")
• kusvotwa
• manyoka
• kuonda
• kurasikirwa nenzara
• kunetseka kuisa pfungwa
• Zvinogona kuitika pamwe neese Aimovig uye Topamax:
• kufema kweutachiona hutachiona (senge hwakawanda kutonhora kana chirwere chechivi)

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yemigumisiro yakakomba iyo inogona kuitika neAimovig, neTopamax, kana nemishonga yose (kana inotorwa mumwe nomumwe).

• Zvinogona kuitika naAimovig:
• mashoma akasarudzika akakomba mhedzisiro
• Zvinogona kuitika neTopamax:
• matambudziko ekuona, kusanganisira glaucoma
• kudzikira kudikitira (kusakwanisa kudzora tembiricha yemuviri)
• metabolic acidosis
• kuzviuraya pfungwa uye zviito
• kufunga matambudziko senge nyonganiso uye ndangariro nyaya
• kuora mwoyo
• encephalopathy (chirwere cheuropi)
• itsvo matombo
• kuwedzerwa kubatwa kana mushonga ukamiswa kamwe-kamwe (apo mushonga unoshandiswa pakurapa kubatwa)
• Zvinogona kuitika pamwe neese Aimovig uye Topamax:
• zvakakomba zvemuviri kukanganiswa

Kubudirira

Icho chete chinangwa Aimovig neTopamax ndeye FDA-inogamuchirwa ndeyekudzivirira migraine.

Mirayiridzo yekurapa inokurudzira Aimovig senzira yekudzivirira episodic kana chisingaperi migraine misoro mukati mevanhu vano:

• haigone kutora mimwe mishonga nekuda kwemhedzisiro kana kusangana kwemishonga
• haigone kudzikisa huwandu hwavo hwemwedzi wemigraine kutemwa nemusoro nemimwe mishonga

Mirayiridzo yekurapa inokurudzira Topiramate senzira yekudzivirira episodic migraine misoro.

Zvidzidzo zvekiriniki hazvina kuenzanisa zvakananga kushanda kwemishonga iyi miviri mukudzivirira migraine misoro. Asi mishonga iyi yakadzidzwa zvakasiyana.

Episodic migraine

Zviparadzanisa zvakasiyana zveAimovig neTopamax zvakaratidza kuti madhiragi ese ari maviri aibatsira mukudzivirira episodic migraine misoro:

• MuAimovig kiriniki zvidzidzo, zvinosvika makumi mashanu muzana yevanhu vane episodic migraine vakagamuchira 140 mg vakatema mazuva avo emigraine nehafu inopfuura mwedzi mitanhatu yekurapwa. Vanenge makumi mana muzana yevanhu vakagashira 70 mg vakaona zvakafanana mhedzisiro.
• Muzvidzidzo zvekiriniki zvevanhu vane episodic migraine vakatora Topamax, avo vane makore gumi nemaviri nemakore zvichikwira vaive nemaviri mashoma emusoro wemagraine mwedzi wega wega. Vana vane makore gumi nemaviri kusvika gumi nemanomwe vane episodic migraine vaive nemitatu mishoma yemusoro wemusoro mwedzi wega wega.

Chisingaperi migraine

Zviparadzanisa zvakasiyana zvemishonga zvakaratidza kuti ese Aimovig neTopamax aishanda mukudzivirira chisingaperi migraine misoro:

• Mumwedzi mitatu yemakiriniki yekudzidza yeAimovig, vangangoita makumi mana muzana yevanhu vane chirwere chemagraine chisingaperi vakagamuchira 70 mg kana 140 mg vaive nehafu yemazuva emigraine kana mashoma mushure mekurapwa.
• Mune chidzidzo chakatarisa mhedzisiro yemayedzo emakiriniki akati wandei akawana kuti kune vanhu vane chirwere chisingaperi chemigraine, Topamax yakadzora huwandu hwemigraine kutemwa nemusoro kana kutemwa nemusoro kungangoita mashanu kusvika mapfumbamwe pamwedzi.

Mariro

Aimovig neTopamax ese ari maviri zita-zita mishonga. Brand-zita mishonga kazhinji inodhura zvakanyanya kupfuura generic mishonga. Aimovig haisi kuwanikwa mune generic fomu, asi Topamax inouya seyakajairika inonzi topiramate.

Zvinoenderana nekufungidzira kubva kuGoodRx.com, Topamax inogona kudhura zvakanyanya kana kushoma pane Aimovig, zvinoenderana nedosi rako. Uye topiramate, iyo generic fomu yeTopamax, inodhura yakaderera pane ingave Topamax kana Aimovig.

Mutengo chaiwo waungabhadhare chero wemishonga iyi unoenderana nedosi yako, chirongwa chako cheinishuwarenzi, nzvimbo yauri, uye chemishonga yaunoshandisa.

Aimovig uye doro

Iko hakuna kudyidzana pakati peAimovig nedoro.

Zvakadaro, vamwe vanhu vanogona kunzwa kuti mushonga uyu haunyanyoita basa kana vakanwa doro vachitora Aimovig. Izvi zvinodaro nekuti doro rinogona kuita migraine inokonzeresa kune vanhu vazhinji. Kunyangwe zvidiki zvidhakwa zvinogona kukonzera migraine kwavari.

Iwe unofanirwa kudzivirira zvinwiwa zvine doro kana iwe ukaona kuti doro rinokonzeresa kurwadza kana kuwanda kwemigraine kutemwa nemusoro.

Aimovig kudyidzana

Mishonga yakawanda inogona kuwirirana nemimwe mishonga. Mhedzisiro dzakasiyana dzinogona kukonzerwa nekudyidzana kwakasiyana. Semuenzaniso, kumwe kudyidzana kunogona kukanganisa mashandiro anoita mushonga, asi mamwe anogona kukonzera mamwe mhedzisiro.

Aimovig haiwanzo kuve nekudyidzana kwezvinodhaka. Izvi zvinokonzerwa nenzira iyo Aimovig inogadziriswa mumuviri wako.

Iyo Aimovig inogadziriswa sei

Mazhinji madhiragi, mahebhu, uye zvinowedzerwa zvinogadziriswa (zvakagadziriswa) nema enzymes muchiropa chako. Asi monoclonal antibody zvinodhaka, senge Aimovig, hazviwanzo kugadziriswa muchiropa. Pane kudaro, mhando iyi yemushonga inogadziriswa mukati memamwe maseru mumuviri wako.

Nekuti Aimovig haina kugadziriswa muchiropa sezvakaita mimwe mishonga yakawanda, kazhinji haibatanidze nemimwe mishonga.

Kana iwe uine chero zvinonetsa pamusoro pekubatanidza Aimovig nemimwe mishonga yaungave uri kutora, taura nachiremba wako. Uye ive shuwa yekuvaudza nezvese ekunyora mishonga, pamusoro-pe-counter, uye mimwe mishonga yaunotora. Iwe unofanirwa kuvaudzawo nezve chero maruva, mavitamini, uye zvinovaka muviri zvinowedzera zvaunoshandisa.

Mirayiridzo yekutora Aimovig

Aimovig inouya sejekiseni rinopihwa pasi peganda rako (subcutaneous). Unozvipa jekiseni kumba kamwe pamwedzi. Kekutanga iwe paunowana mushonga weAimovig, wako wekuchengetedza hutano anotsanangura kuti ungazvipa sei jekiseni.

Aimovig inouya mune imwechete-dosi (70 mg) autoinjector. Imwe neimwe autoinjector ine imwe chete dosi uye inoitirwa kushandiswa kamwe uyezve kuraswa. (Kana chiremba wako akaraira 140 mg pamwedzi, iwe unoshandisa maviri autoinjectors mwedzi wega.)

Pazasi pane ruzivo rwekuti ungashandise sei syringe yakasarudzika. Kune rumwe ruzivo, vhidhiyo, uye mifananidzo yemirayiridzo yejekiseni, ona webhusaiti yemugadziri.

Jekiseni

Chiremba wako achapa 70 mg kamwe pamwedzi kana 140 mg kamwe pamwedzi. Kana iwe wakatemerwa 70 mg pamwedzi, iwe uchazvipa iwe jekiseni rimwe. Kana iwe wakatemerwa 140 mg pamwedzi, iwe unozzvipa iwe maviri akasiyana majekiseni, imwe mushure meimwe.

Kugadzirira kubaya jekiseni

• Tora yako Aimovig autoinjector kubva mufiriji maminetsi makumi matatu usati waronga kuita jekiseni rako. Izvi zvinobvumidza mushonga kuti udziirwe kusvika tembiricha yemukati. Siya chivharo pane autoinjector mudziyo kusvikira wagadzirira kubaya mushonga.
• Usaedze kudziya iyo autoinjector nekukurumidza nekuichengeta kana kuisa mvura inopisa pamusoro payo. Zvakare, usazununguse iyo autoinjector. Kuita zvinhu izvi kunogona kuita kuti Aimovig isanyanya kuchengeteka uye ibudirire.
• Kana netsaona ukadonhedza autoinjector, usashandise. Zvidiki zvidiki zve autoinjector zvinogona kutyorwa mukati, kunyangwe kana iwe usingaone chero kukuvara.
• Paunenge wakamirira Aimovig kuti uuye kutembiricha yemukati, tsvaga zvimwe zvekushandisa zvauchazoda. Izvi zvinosanganisira:
• kupukuta doro
• donje mabhora kana gauze
• namira mabhandeji
• mudziyo wekurasa marara
• Tarisa autoinjector uye uve nechokwadi chekuti mushonga hauratidze kunge une makore. Inofanira kunge isina ruvara kune yakacheneruka yero muvara. Kana ichitaridzika kuve yakatsvuka, kune makore, kana iine zvidimbu zvakaoma mukati memvura, usashandise. Kana zvichidikanwa, bata chiremba wako nezve kuwana nyowani. Zvakare, tarisa zuva rekupera pachigadzirwa kuti uve nechokwadi chekuti mushonga hauna kupera.
• Mushure mekugeza maoko nesipo nemvura, sarudza nzvimbo yekubaiwa jekiseni. Aimovig inogona kubayiwa panzvimbo idzi:
• dumbu rako (angangoita 2 inches kure kubva padumbu rako bhatani)
• kumberi kwehudyu dzako (ingangoita 2 inches pamusoro pebvi rako kana 2 inches pazasi peguyo rako)
• kumashure kwemaoko ako epamusoro (kana mumwe munhu achikupa jekiseni)
• Shandisa yekupukuta doro kunatsa nzvimbo yaurikuda kubaya. Rega doro riome zvachose usati wapinza mushonga.
• Usabaya Aimovig munzvimbo yeganda rakakuvara, rakaoma, dzvuku, kana nyoro.

Uchishandisa iyo autoinjector

1. Dhonza kapu chena wakananga autoinjector. Ita izvi pasina anopfuura maminitsi mashanu usati washandisa chishandiso.
2. Tambanudza kana penda nzvimbo yeganda kwaunoronga kubaya mushonga. Gadzira nzvimbo yakasimba yeganda ingangoita 2 inches pajekiseni jekiseni rako.
3. Isa iyo autoinjector pane rako ganda pane 90-degree angle. Simbisa zvakasimba pasi paganda rako kusvika parinoenda.
4. Dhinda bhatani rekutanga repepuru kumusoro kweiyo autoinjector kudzamara iwe uchinzwa kubaya.
5. Bvisa bhatani rekutanga repepuru asi ramba wakabata autoinjector pasi paganda rako kusvikira hwindo pane autoinjector raita yero. Iwe unogona zvakare kunzwa kana kunzwa "kubaya." Izvi zvinogona kutora kusvika pamasekondi gumi nemashanu. Izvo zvakakosha kuti uite iyi nhanho kuve nechokwadi chekuti iwe unowana iyo yakazara dosi.
6. Bvisa autoinjector kubva paganda rako woirasa mumudziyo wako wekurasa.
7. Kana paine chero ropa panzvimbo yekubaya jekiseni bhora redonje kana gauze paganda, asi usazora. Shandisa bhanhire rekunamatira kana zvichidikanwa.
8. Kana dosi yako iri 140 mg pamwedzi, dzokorora nhanho idzi neyechipiri autoinjector. Usashandise yakafanana jekiseni saiti sekutanga jekiseni.

Nguva

Aimovig inofanira kutorwa kamwe pamwedzi. Inogona kutorwa chero nguva yezuva.

Kana iwe ukarasikirwa neiyo dose, tora Aimovig nekukurumidza sekurangarira kwako. Dozi inotevera inofanira kuve mwedzi mumwe mushure mekutora iyo. Kushandisa chiyeuchidzo chemishonga chingakubatsira kuyeuka kutora Aimovig panguva.

Kutora Aimovig nechikafu

Aimovig inogona kutorwa pamwe kana pasina chikafu.

Kuchengetedza

Aimovig inofanirwa kuchengetwa mufiriji. Inogona kutorwa kunze kwefiriji asi inofanira kushandiswa mukati memazuva manomwe. Usachiisa zvakare mufiriji kana changoburitswa kunze ndokuunzwa kukamuri tembiricha.

Usaisa chando Aimovig. Zvakare, chengeta muhomwe yayo yepakutanga kuti uichengetedze kubva pachiedza.

Mashandiro anoita Aimovig

Aimovig mushonga unonzi monoclonal antibody. Rudzi urwu rwemushonga runogadzirwa murabhoritari kubva kuzvirwere zvemuviri mapuroteni. Aimovig inoshanda nekumisa chiitiko cheprotein mumuviri wako chinonzi calcitonin peptide inoenderana negene (CGRP). CGRP inogona kukonzera kuzvimba uye vasodilation (kuwedzerwa kwemitsipa yeropa) muuropi hwako.

Iko kuzvimba uye vasodilation inounzwa neCGRP ndiyo inogona kukonzeresa yemusoro wemusoro. Muchokwadi, kana musoro wemigraine uchitanga kuitika, vanhu vane mwero wepamusoro weCGRP muropa ravo. Aimovig inobatsira kudzivirira migraine nekumisa chiitiko cheGRGRP.

Kunyange mishonga mizhinji ichishanda nekukanganisa zvinhu zvakawanda mumuviri wako, monoclonal antibodies senge Aimovig anoshanda papuroteni rimwe chete mumuviri. Nekuda kweizvi, Aimovig inogona kukonzeresa kudyidzana kwemushonga uye mhedzisiro. Izvi zvinogona kuzviita sarudzo yekurapa yakanaka kune vanhu vasingakwanise kutora mimwe mishonga nekuda kwemhedzisiro kana kusangana.

Aimovig inogona zvakare kuve yakanaka yekurapa sarudzo kune vanhu vasina kuwana mumwe mushonga unogona kudzora yavo migraine mazuva zvakakwana.

Zvinotora nguva yakareba sei kuti zvishande?

Mushure mekutanga kutora Aimovig, zvinogona kutora mavhiki mashoma kuti uone kuvandudzwa kwemusoro wako wemagraine. Aimovig inogona kutora zvizere mushure memwedzi yakati wandei.

Vanhu vazhinji vakatora Aimovig panguva yemakiriniki ekuedzwa vaive nemazuva mashoma emigraine mukati memwedzi mumwe wekutanga mushonga. Vanhu vaivewo nemazuva mashoma emigraine mushure mekuenderera mberi nekurapwa kwemwedzi yakati wandei.

Aimovig uye nhumbu

Iko hakuna kuve nezvakakwana zvidzidzo zvakaitwa kuti uzive kana Aimovig yakachengeteka kutora panguva yekuzvitakura. Zvidzidzo zvemhuka hazvina kuratidza chero njodzi kune iyo nhumbu apo Aimovig yakapihwa kune mukadzi ane nhumbu. Zvisinei, zvidzidzo zvemhuka hazviwanzo kufanotaura kana zvinodhaka zvichange zvakachengeteka muvanhu.

Kana iwe uri nepamuviri kana uchifunga kuve nepamuviri, taura nachiremba wako kuti uone kana Aimovig akakukodzera. Iwe ungangoda kumirira kudzamara usisiri nemimba kuti ushandise Aimovig.

Aimovig uye kuyamwisa

Hazvizivikanwe kana Aimovig achipfuura mumukaka wemukaka. Naizvozvo, hazvisi pachena kana Aimovig yakachengeteka kushandisa panguva yekuyamwisa.

Kana iwe uri kufunga nezvekurapa naAimovig iwe uchiri kuyamwisa mwana wako, taura nachiremba wako nezvezvakanakira uye njodzi. Ungangoda kumira kuyamwisa kana ukatanga kutora Aimovig.

Mibvunzo yakajairika nezveAimovig

Heano mhinduro kumimwe inowanzo bvunzwa mibvunzo nezve Aimovig.

Kumisa Aimovig kunokonzeresa kubvisa here?

Panga pasati pave nemishumo yekubvisa mhedzisiro mushure mekumisa Aimovig. Zvisinei, Aimovig yakangobvumidzwa neDFA munguva pfupi yapfuura, muna 2018. Huwandu hwevanhu vakashandisa nekumisa kurapwa kweAimovig kuchiri kushoma.

Aimovig ndeye biologic here?

Ehe. Aimovig ndeye monoclonal antibody, iri mhando yeiyo biologic. Biologic imushonga unogadzirwa kubva kuhupenyu zvinhu, kwete makemikari.

Nekuti ivo vanobatana neakanyanya chaiwo immune system maseru uye mapuroteni, biologics senge Aimovig inofungidzirwa kuve nemhedzisiro mhedzisiro kana ichienzaniswa nemishonga inokanganisa huwandu hwakawanda hwemasisitimu emuviri, sezvinoita mamwe migraine madhiragi anoita.

Unogona here kushandisa Aimovig kurapa migraine?

Kwete. Aimovig inoshandiswa chete kudzivirira kurwadziwa kwemusoro kusati kwatanga. Izvo hazvishande kurapa migraine iyo yatotanga.

Aimovig anoporesa migraine here?

Kwete, Aimovig haazorape migraine. Hapana mishonga iripo kurapa migraine.

Aimovig akasiyana sei nemamwe madhiragi zvinodhaka?

Aimovig yakasiyana nemamwe akawanda migraine madhiragi nekuti yaive yekutanga FDA-inogamuchirwa mishonga inogadzirirwa chaizvo kudzivirira migraine kutemwa nemusoro. Aimovig chikamu chekirasi nyowani yemishonga inonzi calcitonin gene-related peptide (CGRP) vanopikisa.

Mazhinji mamwe madhiragi anoshandiswa kudzivirira migraine kutemwa nemusoro ainyatso kugadzirirwa zvimwe zvikonzero, sekurapa pfari, kuwedzerwa kweropa, kana kushushikana. Mazhinji emishonga iyi anoshandiswa kure-chitambi kudzivirira migraine kutemwa nemusoro.

Kuve jekiseni remwedzi unoitawo kuti Aimovig asiyane nemamwe madhiragi ekudzivirira migraine. Mazhinji emimwe iyi mishonga inouya semapiritsi kana mapiritsi. Botox ndeimwe mushonga unouya sejekiseni. Zvisinei, inofanirwa kupihwa muhofisi yechiremba kamwe chete pamwedzi mitatu. Unogona kuzvipa majekiseni eAimovig kumba.

Uye kusiyana nemamwe madhiragi ekudzivirira migraine, Aimovig ndeye monoclonal antibody. Urwu ndirwo rudzi rwemishonga yakagadzirwa murabhorari. Yakagadzirwa kubva kumasero ezvirwere zvemuviri.

MaMonoclonal antibodies akaputsika mukati memazhinji maseru akasiyana mumuviri. Mimwe migraine yekudzivirira mishonga inoputswa nechiropa. Nekuda kweiyi misiyano, monoclonal antibodies senge Aimovig inowanzove nekushomeka kwekubatana kwezvinodhaka kupfuura mimwe mishonga inoshandiswa kudzivirira migraine kutemwa nemusoro.

Kana ndikatora Aimovig, ndinogona here kurega kutora yangu mimwe mishonga yekudzivirira?

Pamwe. Muviri wemunhu wega wega uchapindura kuna Aimovig zvakasiyana. Kana Aimovig akaderedza huwandu hwemigraine kutemwa nemusoro kwauinako, unogona kukwanisa kurega kutora mimwe mishonga yekudzivirira. Asi paunotanga kurapwa, chiremba wako angangokurudzira kuti utange kutora Aimovig pamwe chete nemimwe mishonga yekudzivirira.

Mushure mekutora Aimovig kwemwedzi miviri kana mitatu, chiremba wako achataura newe nezvekuti mushonga unoshanda sei kwauri. Iwe nachiremba wako munogona kukurukura nezvekumisa mimwe mishonga yekudzivirira yamunotora kana kudzikisira muyero wemishonga iyi.

Aimovig ovhadhozi

Kuisa majekiseni akawanda eAimovig kunogona kuwedzera njodzi yekujowa saiti saiti. Kana iwe uri weergergic kana hypersensitive kune Aimovig kana kune latex (chinhu chinowanikwa mupakeji yaAimovig), unogona kuve panjodzi yekuita zvakakomba zvakanyanya.

Ovhadhozi zviratidzo

Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

• kurwadziwa kwakanyanya, kuchenesa, kana kutsvuka munzvimbo iri padyo nejekiseni
• kufashaira
• mikoko
• angioedema (kuzvimba pasi peganda)
• kuzvimba kwerurimi, huro, kana muromo
• kunetseka kufema

Zvekuita kana ovhadhozi

Kana iwe uchifunga kuti watora zvakawandisa zvemushonga uyu, fonera chiremba wako kana kutsvaga nhungamiro kubva kuAmerican Association of Poison Control Centers pa800-222-1222 kana kuburikidza nechavo online chishandiso Asi kana zviratidzo zvako zvakakomba, fonera 911 kana kuenda kukamuri yepedyo yevanokurumidza ipapo.

Aimovig yambiro

Usati watora Aimovig, taura nachiremba wako nezve nhoroondo yako yehutano. Aimovig inogona kunge isingave yakakunakira iwe kana uine mamwe marapirwo. Izvi zvinosanganisira:

• Latex allergies. Iyo Aimovig autoinjector ine fomu yerabha iyo yakafanana nelatex. Izvi zvinogona kukonzeresa kugadzikana mune vanhu vari allergic kune latex. Kana iwe uine nhoroondo yekukanganisa kwakakomba kune zvigadzirwa zvine latex, Aimovig inogona kunge isiri iyo yakakodzera mishonga yako.

Aimovig kupera uye kuchengetedza

Kana Aimovig yapihwa kubva kupharmasi, wemishonga anowedzera zuva rekupera kune zvakanyorwa pabhodhoro. Zuva iri rinowanzo kuve gore rimwe kubva musi wakapihwa mushonga.

Chinangwa chemazuva ekupera akadaro ndechekuvimbisa kushanda kwemushonga panguva ino. Chimiro chazvino cheKudya neDrug Administration (FDA) ndechekudzivirira kushandisa akapera mishonga.

Inguva yakareba sei mushonga unoramba wakanaka unogona kubva pane zvakawanda zvinhu, zvinosanganisira kuti uye kupi mushonga unochengeterwa.

Aimovig yakagadzirirwa autoinjector inofanirwa kuchengetwa mufiriji. Inogona kuchengetwa kunze kwefiriji kusvika mazuva manomwe. Usadzosera mufiriji kana yangosvika tembiricha yemukati.

Usazunungusa kana kuomesa iyo Aimovig autoinjector. Uye chengeta autoinjector mune yekutanga kurongedza kuti uichengetedze kubva pachiedza.

Kana iwe usina kushandisa mishonga yakapfuura nguva yekupera, taura nachiremba wako nezvekuti ungangokwanisa kuishandisa.

Ruzivo rwehunyanzvi rweAimovig

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Nzira yekuita

Aimovig (erenumab) inorwisa munhu monoclonal antibody inosunga kune calcitonin gene-inoenderana peptide (CGRP) receptor uye inodzivirira iyo CGRP ligand kubva mukumisikidza iyo inogamuchira.

Pharmacokinetics uye metabolism

Aimovig inopihwa pamwedzi uye inosvika pakadzikama-mamiriro kukosheswa mushure mematanho matatu. Kufungidzirwa kwakanyanya kunosvika mumazuva matanhatu. Metabolism haina kuitika kuburikidza ne cytochrome P450 nzira.

Kusunga kuCGRP kunogoneka uye kunotyaira kubviswa panzvimbo dzakadzika. Pakukwirira kwakanyanya, Aimovig inobviswa kuburikidza neasina kusarudzika proteolytic nzira. Renal kana hepatic kukanganisika haitarisirwi kukanganisa pharmacokinetic zvivakwa.

Contraindications

Iko hakuna zvinopesana kune Aimovig kushandiswa.

Kuchengetedza

Aimovig yakagadzirirwa autoinjector inofanirwa kuchengetwa mufiriji patembiricha iri pakati pe36⁰F uye 46⁰F (2⁰C uye 8⁰C). Inogona kubviswa mufiriji uye inochengetwa pane tembiricha yemukati (kusvika pa77⁰F, kana 25⁰C) kwemazuva manomwe.

Chengeta Aimovig mupakeji yekutanga kuti uichengetedze kubva pachiedza. Usazvidzore mufiriji kana zvasvika tembiricha yemukati. Usaisa chando kana kuzunza iyo Aimovig autoinjector.

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.